Nestler, Eric J.

Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition

Covington, H. E., Vialou, V. F., LaPlant, Q., Ohnishi, Y. N., & Nestler, E. J. (2011) · Neuroscience Letters

Histone Deacetylase Inhibitors ResearchTreatment of Major Depression

Cited by 178

AKT Signaling within the Ventral Tegmental Area Regulates Cellular and Behavioral Responses to Stressful Stimuli

Krishnan, V., Han, M.-H., Mazei-Robison, M., Iñiguez, S. D., Ables, J. L., Vialou, V., Berton, O., Ghose, S., Covington, H. E., Wiley, M. D., et al. (2008) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Cited by 176

Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system

Wang, C., Xue, Y., Markovic, T., Li, H., Wang, S., Zhong, Y., Du, S., Zhang, Y., Hou, X., Yu, Y., et al. (2025) · Nature Materials

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 171

Epigenetic signaling in psychiatric disorders: stress and depression

Bagot, R. C., Labonté, B., Peña, C. J., & Nestler, E. J. (2014) · Dialogues in Clinical Neuroscience

Epigenetics and DNA MethylationStress Responses and Cortisol

Cited by 171

A Novel Role of the WNT-Dishevelled-GSK3 Signaling Cascade in the Mouse Nucleus Accumbens in a Social Defeat Model of Depression

Wilkinson, M. B., Dias, C., Magida, J., Mazei-Robison, M., Lobo, M., Kennedy, P., Dietz, D., Covington, H., Russo, S., Neve, R., et al. (2011) · Journal of Neuroscience

Treatment of Major DepressionWnt/β-catenin signaling in development and cancer

Cited by 170

Neuroanatomic differences associated with stress susceptibility and resilience

Anacker, C., Scholz, J., O’Donnell, K. J., Allemang-Grand, R., Diorio, J., Bagot, R. C., Nestler, E. J., Hen, R., Lerch, J. P., & Meaney, M. J. (2016) · Biological Psychiatry

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 167

Epigenetic Signaling in Psychiatric Disorders

Peña, C. J., Bagot, R. C., Labonté, B., & Nestler, E. J. (2014) · Journal of Molecular Biology

Epigenetics and DNA MethylationStress Responses and Cortisol

Cited by 163

The neural rejuvenation hypothesis of cocaine addiction

Dong, Y., & Nestler, E. J. (2014) · Trends in Pharmacological Sciences

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 163

Effects of Striatal ΔFosB Overexpression and Ketamine on Social Defeat Stress–Induced Anhedonia in Mice

Donahue, R. J., Muschamp, J. W., Russo, S. J., Nestler, E. J., & Carlezon, W. A. (2014) · Biological Psychiatry

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 161

Viral tools for neuroscience

Nectow, A. R., & Nestler, E. J. (2020) · Nature reviews. Neuroscience

Virus-based gene therapy researchNeuroscience and Neuropharmacology Research

Cited by 159

SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens

Kim, H.-D., Hesterman, J., Call, T., Magazu, S., Keeley, E., Armenta, K., Kronman, H., Neve, R. L., Nestler, E. J., & Ferguson, D. (2016) · Journal of Neuroscience

Sirtuins and Resveratrol in MedicineNeurotransmitter Receptor Influence on Behavior

Cited by 158

Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression

Issler, O., van der Zee, Y. Y., Ramakrishnan, A., Wang, J., Tan, C., Loh, Y.-H. E., Purushothaman, I., Walker, D. M., Lorsch, Z. S., Hamilton, P. J., et al. (2020) · Neuron

Treatment of Major DepressionCancer-related molecular mechanisms research

Cited by 156

Molecular control of locus coeruleus neurotransmission

Nestler, E. J., Alreja, M., & Aghajanian, G. K. (1999) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 155

DCC Confers Susceptibility to Depression-like Behaviors in Humans and Mice and Is Regulated by miR-218

Torres-Berrío, A., Lopez, J. P., Bagot, R. C., Nouel, D., Dal Bo, G., Cuesta, S., Zhu, L., Manitt, C., Eng, C., Cooper, H. M., et al. (2017) · Biological Psychiatry

Treatment of Major DepressionMicroRNA in disease regulation

Cited by 153

The Presynaptic Active Zone Protein RIM1α Is Critical for Normal Learning and Memory

Powell, C. M., Schoch, S., Monteggia, L., Barrot, M., Matos, M. F., Feldmann, N., Südhof, T. C., & Nestler, E. J. (2004) · Neuron

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 143

Epigenetics and addiction

Hamilton, P. J., & Nestler, E. J. (2019) · Current Opinion in Neurobiology

Neurotransmitter Receptor Influence on BehaviorEpigenetics and DNA Methylation

Cited by 137

Role of Nuclear Factor κB in Ovarian Hormone-Mediated Stress Hypersensitivity in Female Mice

LaPlant, Q., Chakravarty, S., Vialou, V., Mukherjee, S., Koo, J. W., Kalahasti, G., Bradbury, K. R., Taylor, S. V., Maze, I., Kumar, A., et al. (2009) · Biological Psychiatry

Stress Responses and CortisolTreatment of Major Depression

Cited by 136

Coordinate Regulation of the Cyclic AMP System with Firing Rate and Expression of Tyrosine Hydroxylase in the Rat Locus Coeruleus: Effects of Chronic Stress and Drug Treatments

Melia, K. R., Rasmussen, K., Terwilliger, R. Z., Haycock, J. W., Nestler, E. J., & Duman, R. S. (1992) · Journal of Neurochemistry

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 133

Induction of ΔFosB in the Periaqueductal Gray by Stress Promotes Active Coping Responses

Berton, O., Covington, H. E., Ebner, K., Tsankova, N. M., Carle, T. L., Ulery, P., Bhonsle, A., Barrot, M., Krishnan, V., Singewald, G. M., et al. (2007) · Neuron

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 129

dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients

Manitt, C., Eng, C., Pokinko, M., Ryan, R. T., Torres-Berrío, A., Lopez, J. P., Yogendran, S. V., Daubaras, M. J. J., Grant, A., Schmidt, E. R. E., et al. (2013) · Translational Psychiatry

Neurotransmitter Receptor Influence on BehaviorAxon Guidance and Neuronal Signaling

Cited by 125

Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action

Kim, K.-S., Lee, K.-W., Lee, K.-W., Im, J.-Y., Yoo, J. Y., Kim, S.-W., Lee, J.-K., Nestler, E. J., & Han, P.-L. (2006) · Proceedings of the National Academy of Sciences

Neuropeptides and Animal PhysiologyReceptor Mechanisms and Signaling

Cited by 123

In vivo fiber photometry reveals signature of future stress susceptibility in nucleus accumbens

Muir, J., Lorsch, Z. S., Ramakrishnan, C., Deisseroth, K., Nestler, E. J., Calipari, E. S., & Bagot, R. C. (2018) · Neuropsychopharmacology

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 116

A β3-Adrenergic-Leptin-Melanocortin Circuit Regulates Behavioral and Metabolic Changes Induced by Chronic Stress

Chuang, J.-C., Krishnan, V., Yu, H. G., Mason, B., Cui, H., Wilkinson, M. B., Zigman, J. M., Elmquist, J. K., Nestler, E. J., & Lutter, M. (2010) · Biological Psychiatry

Regulation of Appetite and ObesityStress Responses and Cortisol

Cited by 114

Cell-Type-Specific Epigenetic Editing at the Fosb Gene Controls Susceptibility to Social Defeat Stress

Hamilton, P. J., Burek, D. J., Lombroso, S. I., Neve, R. L., Robison, A. J., Nestler, E. J., & Heller, E. A. (2018) · Neuropsychopharmacology

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 113