Nestler, Eric J.

Hippocampal HDAC4 Contributes to Postnatal Fluoxetine-Evoked Depression-Like Behavior

Sarkar, A., Chachra, P., Kennedy, P., Pena, C. J., Desouza, L. A., Nestler, E. J., & Vaidya, V. A. (2014) · Neuropsychopharmacology

Treatment of Major DepressionHistone Deacetylase Inhibitors Research

Cited by 79

In vivo locus-specific editing of the neuroepigenome

Yim, Y. Y., Teague, C. D., & Nestler, E. J. (2020) · Nature Reviews Neuroscience

CRISPR and Genetic EngineeringEpigenetics and DNA Methylation

Cited by 76

Distinct Roles of Adenylyl Cyclases 1 and 8 in Opiate Dependence: Behavioral, Electrophysiological, and Molecular Studies

Zachariou, V., Liu, R., LaPlant, Q., Xiao, G., Renthal, W., Chan, G. C., Storm, D. R., Aghajanian, G., & Nestler, E. J. (2008) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 70

Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia: Fosb Regulates Expression of C5a Receptors

Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y. N., Kajitani, K., Tsuchimoto, D., Nestler, E. J., & Nakabeppu, Y. (2014) · Glia

Neuroinflammation and Neurodegeneration MechanismsComplement system in diseases

Cited by 68

Stress and cocaine trigger divergent and cell type-specific regulation of synaptic transmission at single spines in nucleus accumbens

Khibnik, L. A., Beaumont, M., Doyle, M., Heshmati, M., Slesinger, P. A., Nestler, E. J., & Russo, S. J. (2016) · Biological Psychiatry

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 67

Aberrant H3.3 dynamics in NAc promote vulnerability to depressive-like behavior

Lepack, A. E., Bagot, R. C., Peña, C. J., Loh, Y.-H. E., Farrelly, L. A., Lu, Y., Powell, S. K., Lorsch, Z. S., Issler, O., Cates, H. M., et al. (2016) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsTreatment of Major Depression

Cited by 63

Phospholipase Cγ in Distinct Regions of the Ventral Tegmental Area Differentially Modulates Mood-Related Behaviors

Bolaños, C. A., Perrotti, L. I., Edwards, S., Eisch, A. J., Barrot, M., Olson, V. G., Russell, D. S., Neve, R. L., & Nestler, E. J. (2003) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 62

Meeting report: can we make animal models of human mental illness?

Monteggia, L. M., Heimer, H., & Nestler, E. J. (2018) · Biological Psychiatry

Animal testing and alternativesNeurotransmitter Receptor Influence on Behavior

Cited by 60

Tet1 in Nucleus Accumbens Opposes Depression- and Anxiety-Like Behaviors

Feng, J., Pena, C. J., Purushothaman, I., Engmann, O., Walker, D., Brown, A. N., Issler, O., Doyle, M., Harrigan, E., Mouzon, E., et al. (2017) · Neuropsychopharmacology

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 58

Overexpression of DeltaFosB in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype of environmental enrichment

Zhang, Y., Crofton, E. J., Li, D., Lobo, M. K., Fan, X., Nestler, E. J., & Green, T. A. (2014) · Frontiers in Behavioral Neuroscience

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 58

Calcium-Sensitive Adenylyl Cyclases in Depression and Anxiety: Behavioral and Biochemical Consequences of Isoform Targeting

Krishnan, V., Graham, A., Mazei-Robison, M. S., Lagace, D. C., Kim, K.-S., Birnbaum, S., Eisch, A. J., Han, P.-L., Storm, D. R., Zachariou, V., et al. (2008) · Biological Psychiatry

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 56

CRACKing the histone code: Cocaine's effects on chromatin structure and function

LaPlant, Q., & Nestler, E. J. (2011) · Hormones and Behavior

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 52

VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine

Jiang, C., Lin, W.-J., Labonté, B., Tamminga, C. A., Turecki, G., Nestler, E. J., Russo, S. J., & Salton, S. R. (2019) · Neuropsychopharmacology

Treatment of Major DepressionNeuropeptides and Animal Physiology

Cited by 43

Lipid Nanoparticles Enhance mRNA Delivery to the Central Nervous System Upon Intrathecal Injection

Xue, Y., Wang, C., Li, H., Du, S., Zhong, Y., Zhang, Y., Wang, S., Guo, K., Hou, X., Kang, D. D., et al. (2025) · Advanced Materials

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 34

Neuroepigenetic Editing

Hamilton, P. J., Lim, C. J., Nestler, E. J., & Heller, E. A. (2018) · Methods in Molecular Biology

CRISPR and Genetic EngineeringEpigenetics and DNA Methylation

Cited by 28

Advancing drug discovery for schizophrenia

Marder, S. R., Roth, B., Sullivan, P. F., Scolnick, E. M., Nestler, E. J., Geyer, M. A., Welnberger, D. R., Karayiorgou, M., Guidotti, A., Gingrich, J., et al. (2011) · Annals of the New York Academy of Sciences

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 25

WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine

Ceglia, I., Lee, K.-W., Cahill, M. E., Graves, S. M., Dietz, D., Surmeier, D. J., Nestler, E. J., Nairn, A. C., Greengard, P., & Kim, Y. (2017) · Proceedings of the National Academy of Sciences

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 21

Crystallin Mu in Medial Amygdala Mediates the Effect of Social Experience on Cocaine Seeking in Males but Not in Females

Walker, D. M., Zhou, X., Cunningham, A. M., Ramakrishnan, A., Cates, H. M., Lardner, C. K., Peña, C. J., Bagot, R. C., Issler, O., Van der Zee, Y., et al. (2022) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behavior

Cited by 20

Establishing the relationship between brain cellular senescence and brain structure

Lund, A. N., Kopell, B. H., Golestani, N., Vornholt, E., Thompson, R. C., Liharska, L. E., Luo, Y., Cheng, E., Park, Y. J., Fennessy, B., et al. (2026) · Cell

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

Cited by 6

Epigenetic signatures of chronic social stress in stress-susceptible animals

O’Toole, N., Zhang, T.-Y., Wen, X., Diorio, J., Silveira, P. P., Labonté, B., Nestler, E. J., & Meaney, M. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory)

Epigenetics and DNA MethylationStress Responses and Cortisol

Cited by 6