Slominski, Andrzej T.

The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism

Slominski, A., Semak, I., Zjawiony, J., Wortsman, J., Li, W., Szczesniewski, A., & Tuckey, R. C. (2005) · The FEBS Journal

Vitamin D Research StudiesSteroid Chemistry and Biochemistry

Cited by 155

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity

Slominski, A. T., Janjetovic, Z., Fuller, B. E., Zmijewski, M. A., Tuckey, R. C., Nguyen, M. N., Sweatman, T., Li, W., Zjawiony, J., Miller, D., et al. (2010) · PLoS ONE

Vitamin D Research StudiesRetinoids in leukemia and cellular processes

Cited by 149

Cutaneous Expression of CRH and CRH‐R: Is There a “Skin Stress Response System?”

SLOMINSKI, A. T., BOTCHKAREV, V., CHOUDHRY, M., FAZAL, N., FECHNER, K., FURKERT, J., KRAUSE, E., ROLOFF, B., SAYEED, M., WEI, E., et al. (1999) · Annals of the New York Academy of Sciences

Stress Responses and CortisolNeuropeptides and Animal Physiology

Cited by 147

Protective Effects of Novel Derivatives of Vitamin D3 and Lumisterol Against UVB-Induced Damage in Human Keratinocytes Involve Activation of Nrf2 and P53 Defense Mechanisms

Chaiprasongsuk, A., Janjetovic, Z., Kim, T.-K., Jarrett, S. G., D'Orazio, J. A., Holick, M. F., Tang, E. K. Y., Tuckey, R. C., Panich, U., Li, W., et al. (2019) · Redox Biology

Skin Protection and AgingVitamin D Research Studies

Cited by 146

Endogenously produced nonclassical vitamin D hydroxy-metabolites act as “biased” agonists on VDR and inverse agonists on RORα and RORγ

Slominski, A. T., Kim, T.-K., Hobrath, J. V., Oak, A. S. W., Tang, E. K. Y., Tieu, E. W., Li, W., Tuckey, R. C., & Jetten, A. M. (2017) · The Journal of Steroid Biochemistry and Molecular Biology

Vitamin D Research StudiesPsoriasis: Treatment and Pathogenesis

Cited by 143

CRH stimulates POMC activity and corticosterone production in dermal fibroblasts

Slominski, A., Zbytek, B., Semak, I., Sweatman, T., & Wortsman, J. (2005) · Journal of Neuroimmunology

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 143

Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management

Slominski, A. T., Brożyna, A. A., Zmijewski, M. A., Jóźwicki, W., Jetten, A. M., Mason, R. S., Tuckey, R. C., & Elmets, C. A. (2017) · Laboratory Investigation

Vitamin D Research StudiesCutaneous Melanoma Detection and Management

Cited by 136

20-Hydroxycholecalciferol, Product of Vitamin D3 Hydroxylation by P450scc, Decreases NF-κB Activity by Increasing IκBα Levels in Human Keratinocytes

Janjetovic, Z., Zmijewski, M. A., Tuckey, R. C., DeLeon, D. A., Nguyen, M. N., Pfeffer, L. M., & Slominski, A. T. (2009) · PLoS ONE

NF-κB Signaling PathwaysVitamin D Research Studies

Cited by 130

UVB activates hypothalamic-pituitary-adrenal axis in C57BL/6 mice

Skobowiat, C., & Slominski, A. T. (2015) · Journal of Investigative Dermatology

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 126

Expression of vitamin D receptor decreases during progression of pigmented skin lesions

Brożyna, A. A., Jozwicki, W., Janjetovic, Z., & Slominski, A. T. (2011) · Human Pathology

Vitamin D Research StudiesCutaneous Melanoma Detection and Management

Cited by 120

20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation

Zbytek, B., Janjetovic, Z., Tuckey, R. C., Zmijewski, M. A., Sweatman, T. W., Jones, E., Nguyen, M. N., & Slominski, A. T. (2008) · Journal of Investigative Dermatology

Vitamin D Research StudiesSkin and Cellular Biology Research

Cited by 118

Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc

Tuckey, R. C., Li, W., Zjawiony, J. K., Zmijewski, M. A., Nguyen, M. N., Sweatman, T., Miller, D., & Slominski, A. (2008) · The FEBS Journal

Vitamin D Research StudiesSteroid Chemistry and Biochemistry

Cited by 118

Skin as an endocrine organ: implications for its function

Slominski, A., Wortsman, J., Paus, R., Elias, P. M., Tobin, D. J., & Feingold, K. R. (2008) · Drug Discovery Today Disease Mechanisms

Stress Responses and CortisolDermatology and Skin Diseases

Cited by 116

Ultraviolet radiation regulates cortisol activity in a waveband-dependent manner in human skin ex vivo: Ultraviolet radiation regulates cutaneous cortisol activity

Skobowiat, C., Sayre, R. M., Dowdy, J. C., & Slominski, A. T. (2013) · British Journal of Dermatology

Skin Protection and Agingmelanin and skin pigmentation

Cited by 115

Potential mechanism of skin response to stress

SLOMINSKI, A., & MIHM, M. C. (1996) · International Journal of Dermatology

Stress Responses and CortisolDermatology and Skin Diseases

Cited by 115

20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells

Slominski, A. T., Kim, T.-K., Janjetovic, Z., Tuckey, R. C., Bieniek, R., Yue, J., Li, W., Chen, J., Nguyen, M. N., Tang, E. K. Y., et al. (2011) · American Journal of Physiology-Cell Physiology

Vitamin D Research StudiesSkin Protection and Aging

Cited by 113

EXPRESSION OF CONCERN: Melatonin and its derivatives counteract the ultraviolet B radiation‐induced damage in human and porcine skin ex vivo

Skobowiat, C., Brożyna, A. A., Janjetovic, Z., Jeayeng, S., Oak, A. S. W., Kim, T., Panich, U., Reiter, R. J., & Slominski, A. T. (2018) · Journal of Pineal Research

Skin Protection and AgingCircadian rhythm and melatonin

Cited by 105

20,23‐dihydroxyvitamin D3, novel P450scc product, stimulates differentiation and inhibits proliferation and NF‐κB activity in human keratinocytes

Janjetovic, Z., Tuckey, R. C., Nguyen, M. N., Thorpe, E. M., & Slominski, A. T. (2010) · Journal of Cellular Physiology

Vitamin D Research StudiesPsoriasis: Treatment and Pathogenesis

Cited by 103

In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes Caco-2 colon cells and the adrenal gland

Slominski, A. T., Kim, T.-K., Shehabi, H. Z., Tang, E. K. Y., Benson, H. A. E., Semak, I., Lin, Z., Yates, C. R., Wang, J., Li, W., et al. (2014) · Molecular and Cellular Endocrinology

Vitamin D Research StudiesPharmacogenetics and Drug Metabolism

Cited by 100

An alternative pathway of vitamin D2 metabolism: Cytochrome P450scc (CYP11A1)‐mediated conversion to 20‐hydroxyvitamin D2 and 17,20‐dihydroxyvitamin D2

Slominski, A., Semak, I., Wortsman, J., Zjawiony, J., Li, W., Zbytek, B., & Tuckey, R. C. (2006) · The FEBS Journal

Vitamin D Research StudiesSteroid Chemistry and Biochemistry

Cited by 98

Environmental Air Pollutants Affecting Skin Functions with Systemic Implications

Bocheva, G., Slominski, R. M., & Slominski, A. T. (2023) · International Journal of Molecular Sciences

Skin Protection and AgingDermatology and Skin Diseases

Cited by 94

Stress-linked cortisol concentrations in hair: what we know and what we need to know

Sharpley, C. F., McFarlane, J. R., & Slominski, A. (2012) · revneuro

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 92

High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives

Janjetovic, Z., Brozyna, A. A., Tuckey, R. C., Kim, T.-K., Nguyen, M. N., Jozwicki, W., Pfeffer, S. R., Pfeffer, L. M., & Slominski, A. T. (2011) · British Journal of Cancer

NF-κB Signaling PathwaysVitamin D Research Studies

Cited by 91

Sequential metabolism of 7-dehydrocholesterol to steroidal 5, 7-dienes in adrenal glands and its biological implication in the skin

Slominski, A. T., Zmijewski, M. A., Semak, I., Sweatman, T., Janjetovic, Z., Li, W., Zjawiony, J. K., & Tuckey, R. C. (2009) · PLoS ONE

Steroid Chemistry and BiochemistryCholesterol and Lipid Metabolism

Cited by 90