Regulation of cancer cell metabolism by hypoxia-inducible factor 1

Targeting HIF-1 for cancer therapy

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212 · see citing works

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535 · see citing works

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180 · see citing works

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905 · see citing works

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333 · see citing works

Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

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Cellular and developmental control of O ₂ homeostasis by hypoxia-inducible factor 1α

Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476 · see citing works

Tumor cell metabolism: cancer's Achilles' heel

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267 · see citing works

Hypoxia in cancer: significance and impact on clinical outcome

Vaupel, P., & Mayer, A. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9055-1 · Cited by 2,240 · see citing works

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

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Purification and Characterization of Hypoxia-inducible Factor 1

Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,069 · see citing works

Hypoxia signalling in cancer and approaches to enforce tumour regression

Pouysségur, J., Dayan, F., & Mazure, N. M. (2006) · Nature · doi:10.1038/nature04871 · Cited by 1,676 · see citing works

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

Fantin, V. R., St-Pierre, J., & Leder, P. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.023 · Cited by 1,635 · see citing works

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (2002) · Genes & Development · doi:10.1101/gad.991402 · Cited by 1,550 · see citing works

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

Guzy, R. D., Hoyos, B., Robin, E., Chen, H., Liu, L., Mansfield, K. D., Simon, M. C., Hammerling, U., & Schumacker, P. T. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.001 · Cited by 1,545 · see citing works

HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells

Fukuda, R., Zhang, H., Kim, J.-W., Shimoda, L., Dang, C. V., & Semenza, G. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.047 · Cited by 1,225 · see citing works

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

Jiang, B. H., Semenza, G. L., Bauer, C., & Marti, H. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.4.c1172 · Cited by 1,213 · see citing works

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1

Manalo, D. J., Rowan, A., Lavoie, T., Natarajan, L., Kelly, B. D., Ye, S. Q., Garcia, J. G. N., & Semenza, G. L. (2005) · Blood · doi:10.1182/blood-2004-07-2958 · Cited by 1,154 · see citing works

c-Myc transactivation of <i>LDH-A</i> : Implications for tumor metabolism and growth

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Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

Dewhirst, M. W., Cao, Y., & Moeller, B. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2397 · Cited by 1,022 · see citing works

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., & Semenza, G. L. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.04.001 · Cited by 885 · see citing works

THE METABOLISM OF TUMORS

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HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation

Yu, F., White, S. B., Zhao, Q., & Lee, F. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181341498 · Cited by 796 · see citing works

Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway

Kallio, P. J., Wilson, W. J., O’Brien, S. L., Makino, Y., & Poellinger, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6519 · Cited by 754 · see citing works

Hypoxia: A key regulator of angiogenesis in cancer

Liao, D., & Johnson, R. S. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9066-y · Cited by 720 · see citing works

Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

Kamura, T., Sato, S., Iwaï, K., Czyzyk-Krzeska, M., Conaway, R. C., & Conaway, J. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190332597 · Cited by 652 · see citing works

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Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation

Mansfield, K. D., Guzy, R. D., Pan, Y., Young, R. M., Cash, T. P., Schumacker, P. T., & Simon, M. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.003 · Cited by 606 · see citing works

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Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

Brizel, D. M., Schroeder, T., Scher, R. L., Walenta, S., Clough, R. W., Dewhirst, M. W., & Mueller‐Klieser, W. (2001) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(01)01630-3 · Cited by 587 · see citing works

HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo

Gao, P., Zhang, H., Dinavahi, R., Li, F., Xiang, Y., Raman, V., Bhujwalla, Z. M., Felsher, D. W., Cheng, L., Pevsner, J., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.004 · Cited by 523 · see citing works

Levels of hypoxia‐inducible factor‐1α independently predict prognosis in patients with lymph node negative breast carcinoma

Bos, R., van der Groep, P., Greijer, A. E., Shvarts, A., Meijer, S., Pinedo, H. M., Semenza, G. L., van Diest, P. J., & van der Wall, E. (2003) · Cancer · doi:10.1002/cncr.11246 · Cited by 500 · see citing works

RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1α

Liu, Y. V., Baek, J. H., Zhang, H., Diez, R., Cole, R. N., & Semenza, G. L. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.001 · Cited by 477 · see citing works

Targeting tumor-associated carbonic anhydrase IX in cancer therapy

Thiry, A., Dogné, J., Masereel, B., & Supuran, C. T. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.09.002 · Cited by 396 · see citing works

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Heterozygous HIF‐1α deficiency impairs carotid body‐mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia

Peng, Y., Yuan, G., Ramakrishnan, D., Sharma, S. D., Bosch‐Marcé, M., Kumar, G. K., Semenza, G. L., & Prabhakar, N. R. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.114033 · Cited by 365 · see citing works

Evaluation of HIF-1 inhibitors as anticancer agents

Semenza, G. L. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.08.006 · Cited by 363 · see citing works

Vasculogenesis, angiogenesis, and arteriogenesis: Mechanisms of blood vessel formation and remodeling

Semenza, G. L. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21523 · Cited by 317 · see citing works

Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy.

Birner, P., Schindl, M., Obermair, A., Breitenecker, G., & Oberhuber, G. (2001) · PubMed · Cited by 310 · see citing works

Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression

Fang, J. S., Gillies, R. D., & Gatenby, R. A. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.03.011 · Cited by 279 · see citing works

Overexpression of hypoxia-inducible factor HIF-1α predicts early relapse in breast cancer: Retrospective study in a series of 745 patients

Dalès, J.-P., Garcia, S., Meunier-Carpentier, S., Andrac, L., Haddad, O., Lavaut, M., Allasia, C., Bonnier, P., & Charpin, C. (2005) · International Journal of Cancer · doi:10.1002/ijc.20984 · Cited by 263 · see citing works

Targeting hypoxia cell signaling for cancer therapy

Melillo, G. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9059-x · Cited by 230 · see citing works

Differential prognostic impact of hypoxia induced and diffuse HIF-1α expression in invasive breast cancer

Vleugel, M. M., Greijer, A. E., Shvarts, A., van der Groep, P., van Berkel, M., Aarbodem, Y., van Tinteren, H., Harris, A. L., van Diest, P. J., & van der Wall, E. (2005) · Journal of Clinical Pathology · doi:10.1136/jcp.2004.019885 · Cited by 227 · see citing works

Hypoxia-Inducible Factor 1? Expression Correlates with Angiogenesis and Unfavorable Prognosis in Bladder Cancer

Theodoropoulos, V. (2004) · European Urology · doi:10.1016/j.eururo.2004.04.008 · Cited by 223 · see citing works

Lactate Dehydrogenase 5 Expression in Operable Colorectal Cancer: Strong Association With Survival and Activated Vascular Endothelial Growth Factor Pathway—A Report of the Tumour Angiogenesis Research Group

Koukourakis, M. I., Giatromanolaki, A. N., Sivridis, E., Gatter, K. C., & Harris, A. L. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.05.9501 · Cited by 221 · see citing works

Association of hypoxia‐inducible factors 1α and 2α with activated angiogenic pathways and prognosis in patients with endometrial carcinoma

Sivridis, E., Giatromanolaki, A., Gatter, K. C., Harris, A. L., Koukourakis, M. I., & for the Tumor and Angiogenesis Research Group (2002) · Cancer · doi:10.1002/cncr.10774 · Cited by 218 · see citing works

OS-9 Interacts with Hypoxia-Inducible Factor 1α and Prolyl Hydroxylases to Promote Oxygen-Dependent Degradation of HIF-1α

Baek, J. H., Mahon, P. C., Oh, J. C., Kelly, B., Krishnamachary, B., Pearson, M., Chan, D. A., Giaccia, A. J., & Semenza, G. L. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.01.011 · Cited by 218 · see citing works

Expression of hypoxia-inducible factor-1α in oligodendrogliomas

Birner, P., Gatterbauer, B., Oberhuber, G., Schindl, M., Rössler, K., Prodinger, A., Budka, H., & Hainfellner, J. A. (2001) · Cancer · doi:10.1002/1097-0142(20010701)92:1 · Cited by 192 · see citing works

Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy

Cairns, R. A., Papandreou, I., Sutphin, P. D., & Denko, N. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611662104 · Cited by 182 · see citing works

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Hypoxia-inducible factors 1?? and 2?? are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin

Giatromanolaki, A. N., Sivridis, E., Kouskoukis, C., Gatter, K. C., Harris, A. L., & Koukourakis, M. I. (2003) · Melanoma Research · doi:10.1097/00008390-200310000-00008 · Cited by 152 · see citing works

Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis

Sun, H., Qiu, Z., Liu, J., Sun, J., Jiang, T., Huang, K., Yao, M., & Huang, C. L. (2007) · International Journal of Oncology · doi:10.3892/ijo.30.6.1359 · Cited by 129 · see citing works

Significant correlation of hypoxia-inducible factor-1α with treatment outcome in cervical cancer treated with radical radiotherapy

Burri, P., Djonov, V., Aebersold, D. M., Lindel, K., Studer, U., Altermatt, H. J., Mazzucchelli, L., Greiner, R. H., & Gruber, G. (2003) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)04579-0 · Cited by 124 · see citing works

Hypoxia-inducible factor-1α expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas

Griffiths, E. A., Pritchard, S. A., Valentine, H. R., Whitchelo, N., Bishop, P. W., Ebert, M., Price, P., Welch, I., & West, C. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603524 · Cited by 107 · see citing works

Lung cancer: An organized cellular and metabolic domain

Koukourakis, M. I., Giatromanolaki, A. N., Bougioukas, G., & Sivridis, E. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.9.4635 · Cited by 100 · see citing works

Hypoxia‐inducible factor 1α/vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis

Korkolopoulou, P. A., Patsouris, E., Konstantinidou, A. E., Pavlopoulos, P. M., Kavantzas, N., Boviatsis, E. I., Thymara, I., Perdiki, Μ., Thomas-Tsagli, E., Angelidakis, D., et al. (2004) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2003.00535.x · Cited by 95 · see citing works

Evaluation of hypoxia‐inducible factor 1α overexpression as a predictor of tumour recurrence and progression in superficial urothelial bladder carcinoma

Theodoropoulos, V., Lazaris, A. C., Kastriotis, I., Spiliadi, C., Theodoropoulos, G. E., Tsoukala, V. K., Patsouris, E., & Sofras, F. A. (2005) · British Journal of Urology · doi:10.1111/j.1464-410x.2005.05314.x · Cited by 80 · see citing works

Hypoxia-inducible factor-1α expression and angiogenesis in gastrointestinal stromal tumor of the stomach

Takahashi, R., Tanaka, S., Hiyama, T., Ito, M., Kitadai, Y., Sumii, M., Haruma, K., & Chayama, K. (2003) · Oncology Reports · doi:10.3892/or.10.4.797 · Cited by 78 · see citing works

Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α

Baek, J. H., Liu, Y. V., McDonald, K. R., Wesley, J. B., Hubbi, M. E., Byun, H., & Semenza, G. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703504200 · Cited by 65 · see citing works

Metastatic cancer cells from c-erbB-2 negative primary breast cancer maintain the original c-erbB-2/HIF1α phenotype

Giatromanolaki, A. N., Koukourakis, M. I., Simopoulos, C., & Sivridis, E. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.2.3620 · Cited by 4 · see citing works

Hypoxia‐inducible factor‐1α in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathways

Swinson, D. E. B., Jones, J. L., Cox, G., Richardson, D., Harris, A. L., & O'Byrne, K. J. (2004) · International Journal of Cancer · doi:10.1002/ijc.20052

Regulation of cancer cell metabolism

Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744 · see citing works

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

Semenza, G. L. (2010) · Oncogene · doi:10.1038/onc.2009.441 · Cited by 1,712 · see citing works

Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

Sabharwal, S. S., & Schumacker, P. T. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3803 · Cited by 1,643 · see citing works

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

Jiang, X., Wang, J., Deng, X., Xiong, F., Ge, J., Xiang, B., Wu, X., Ma, J., Zhou, M., Li, X., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-018-0928-4 · Cited by 1,465 · see citing works

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

Semenza, G. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67230 · Cited by 1,335 · see citing works

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

Suda, T., Takubo, K., & Semenza, G. L. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.09.010 · Cited by 844 · see citing works

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-κB/IL-8 Pathway that Drives Tumor Angiogenesis

Végran, F., Boidot, R., Michiels, C., Sonveaux, P., & Feron, O. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2828 · Cited by 816 · see citing works

The role of microenvironment in tumor angiogenesis

Jiang, X., Wang, J., Deng, X., Xiong, F., Zhang, S., Gong, Z., Li, X., Cao, K., Deng, H., He, Y., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01709-5 · Cited by 767 · see citing works

Metabolic reprogramming in clear cell renal cell carcinoma

Wettersten, H. I., Aboud, O. A., Lara, P. N., & Weiss, R. H. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.59 · Cited by 573 · see citing works

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

Courtnay, R., Ngo, D. C., Malik, N., Ververis, K., Tortorella, S. M., & Karagiannis, T. C. (2015) · Molecular Biology Reports · doi:10.1007/s11033-015-3858-x · Cited by 570 · see citing works

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

Bell, E. L., Emerling, B. M., Ricoult, S. J. H., & Guarente, L. (2011) · Oncogene · doi:10.1038/onc.2011.37 · Cited by 440 · see citing works

Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy

Meijer, T. W. H., Kaanders, J. H. A. M., Span, P. N., & Bussink, J. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0858 · Cited by 433 · see citing works

Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis

Ghosh, G., Subramanian, I. V., Adhikari, N., Zhang, X., Joshi, H. P., Basi, D. L., Chandrashekhar, Y., Hall, J. L., Roy, S., Zeng, Y., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42980 · Cited by 417 · see citing works

Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF

Schipani, E., Maes, C., Carmeliet, G., & Semenza, G. L. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090602 · Cited by 407 · see citing works

HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance

Nagao, A., Kobayashi, M., Koyasu, S., Chow, C. C. T., & Harada, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020238 · Cited by 411 · see citing works

PI3K/Akt and HIF‑1 signaling pathway in hypoxia‑ischemia (Review)

Zhang, Z., Li, Y., Yang, J., Wang, Z., & Du, G. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9375 · Cited by 408 · see citing works

Metabolism of [U‐ ¹³ C]glucose in human brain tumors <i>in vivo</i>

Maher, E. A., Marin‐Valencia, I., Bachoo, R. M., Mashimo, T., Raisanen, J., Hatanpaa, K. J., Jindal, A., Jeffrey, F. M., Choi, C., Madden, C., et al. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2794 · Cited by 341 · see citing works

The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy

Ralph, S. J., Rodríguez‐Enríquez, S., Neužil, J., Saavedra, E., & Moreno‐Sánchez, R. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.02.008 · Cited by 335 · see citing works

Metabolomics in cancer biomarker discovery: Current trends and future perspectives

Armitage, E. G., & Barbas, C. (2013) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2013.08.041 · Cited by 330 · see citing works

Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells

Chen, J., & Russo, J. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.06.004 · Cited by 330 · see citing works

Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy

Marengo, B., Nitti, M., Furfaro, A. L., Colla, R., Ciucis, C. D., Marinari, U. M., Pronzato, M. A., Traverso, N., & Domenicotti, C. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6235641 · Cited by 319 · see citing works

Hypoxia-driven pathways in bone development, regeneration and disease

Maes, C., Carmeliet, G., & Schipani, E. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.36 · Cited by 300 · see citing works

Parkin and mitophagy in cancer

Bernardini, J. P., Lazarou, M., & Dewson, G. (2016) · Oncogene · doi:10.1038/onc.2016.302 · Cited by 282 · see citing works

Cancer metabolism: The Warburg effect today

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