Flavell, Richard A.

Transforming growth factor-β in T-cell biology

Gorelik, L., & Flavell, R. A. (2002) · Nature Reviews Immunology

T-cell and B-cell ImmunologyTGF-β signaling in diseases

Cited by 792

Development and function of human innate immune cells in a humanized mouse model

Rongvaux, A., Willinger, T., Martinek, J., Strowig, T., Gearty, S. V., Teichmann, L. L., Saito, Y., Marches, F., Halene, S., Palucka, A. K., et al. (2014) · Nature Biotechnology

Hematopoietic Stem Cell TransplantationImmune cells in cancer

Cited by 789

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

Gorelik, L., & Flavell, R. A. (2001) · Nature Medicine

TGF-β signaling in diseasesT-cell and B-cell Immunology

Cited by 770

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

O'Connor Jr, W., Kamanaka, M., Booth, C. J., Town, T., Nakae, S., Iwakura, Y., Kolls, J. K., & Flavell, R. A. (2009) · Nature Immunology

Psoriasis: Treatment and PathogenesisInflammatory Bowel Disease

Cited by 756

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

Wlodarska, M., Thaiss, C. A., Nowarski, R., Henao-Mejia, J., Zhang, J.-P., Brown, E. M., Frankel, G., Levy, M., Katz, M. N., Philbrick, W. M., et al. (2014) · Cell

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 708

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

Iyer, S. S., Pulskens, W. P., Sadler, J. J., Butter, L. M., Teske, G. J., Ulland, T. K., Eisenbarth, S. C., Florquin, S., Flavell, R. A., Leemans, J. C., et al. (2009) · Proceedings of the National Academy of Sciences

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 691

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

Solis, A. G., Bielecki, P., Steach, H. R., Sharma, L., Harman, C. C. D., Yun, S., de Zoete, M. R., Warnock, J. N., To, S. D. F., York, A. G., et al. (2019) · Nature

Ion Channels and ReceptorsErythrocyte Function and Pathophysiology

Cited by 678

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

Bosurgi, L., Cao, Y. G., Cabeza-Cabrerizo, M., Tucci, A., Hughes, L. D., Kong, Y., Weinstein, J. S., Licona-Limon, P., Schmid, E. T., Pelorosso, F., et al. (2017) · Science

Phagocytosis and Immune RegulationImmune cells in cancer

Cited by 560

Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

Li, M. O., & Flavell, R. A. (2008) · Immunity

T-cell and B-cell ImmunologyTGF-β signaling in diseases

Cited by 501

Interleukin 23 production by intestinal CD103+CD11b+ dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense

Kinnebrew, M. A., Buffie, C. G., Diehl, G. E., Zenewicz, L. A., Leiner, I., Hohl, T. M., Flavell, R. A., Littman, D. R., & Pamer, E. G. (2012) · Immunity

Immune Response and InflammationT-cell and B-cell Immunology

Cited by 491

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

Hu, B., Elinav, E., Huber, S., Booth, C. J., Strowig, T., Jin, C., Eisenbarth, S. C., & Flavell, R. A. (2010) · Proceedings of the National Academy of Sciences

Inflammasome and immune disordersCell death mechanisms and regulation

Cited by 452

Expression of Interleukin 9 in the Lungs of Transgenic Mice Causes Airway Inflammation, Mast Cell Hyperplasia, and Bronchial Hyperresponsiveness

Temann, U.-A., Geba, G. P., Rankin, J. A., & Flavell, R. A. (1998) · The Journal of Experimental Medicine

Asthma and respiratory diseasesIL-33, ST2, and ILC Pathways

Cited by 452

Molecular Mechanism of NLRP3 Inflammasome Activation

Jin, C., & Flavell, R. A. (2010) · Journal of Clinical Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 440

Circuit Design Features of a Stable Two-Cell System

Zhou, X., Franklin, R. A., Adler, M., Jacox, J. B., Bailis, W., Shyer, J. A., Flavell, R. A., Mayo, A., Alon, U., & Medzhitov, R. (2018) · Cell

Gene Regulatory Network AnalysisMathematical Biology Tumor Growth

Cited by 430

Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

Town, T., Laouar, Y., Pittenger, C., Mori, T., Szekely, C. A., Tan, J., Duman, R. S., & Flavell, R. A. (2008) · Nature Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 422

Free Cholesterol-loaded Macrophages Are an Abundant Source of Tumor Necrosis Factor-α and Interleukin-6

Li, Y., Schwabe, R. F., DeVries-Seimon, T., Yao, P. M., Gerbod-Giannone, M.-C., Tall, A. R., Davis, R. J., Flavell, R., Brenner, D. A., & Tabas, I. (2005) · Journal of Biological Chemistry

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 421

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

Amsen, D., Antov, A., Jankovic, D., Sher, A., Radtke, F., Souabni, A., Busslinger, M., McCright, B., Gridley, T., & Flavell, R. A. (2007) · Immunity

T-cell and B-cell ImmunologyDevelopmental Biology and Gene Regulation

Cited by 396

STAT3 deletion during hematopoiesis causes Crohn’s disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity

Welte, T., Zhang, S. S. M., Wang, T., Zhang, Z., Hesslein, D. G. T., Yin, Z., Kano, A., Iwamoto, Y., Li, E., Craft, J. E., et al. (2003) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsInflammatory Bowel Disease

Cited by 381

Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling

Breunig, J. J., Sarkisian, M. R., Arellano, J. I., Morozov, Y. M., Ayoub, A. E., Sojitra, S., Wang, B., Flavell, R. A., Rakic, P., & Town, T. (2008) · Proceedings of the National Academy of Sciences

Genetic and Kidney Cyst DiseasesHedgehog Signaling Pathway Studies

Cited by 344

The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR

Liu, G., Burns, S., Huang, G., Boyd, K., Proia, R. L., Flavell, R. A., & Chi, H. (2009) · Nature Immunology

T-cell and B-cell ImmunologySphingolipid Metabolism and Signaling

Cited by 339

STAT3 is required for Flt3L-dependent dendritic cell differentiation

Laouar, Y., Welte, T., Fu, X.-Y., & Flavell, R. A. (2003) · Immunity

Cytokine Signaling Pathways and InteractionsImmunotherapy and Immune Responses

Cited by 334

Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse

Weiss, E. H., Golden, L., Fahrner, K., Mellor, A. L., Devlin, J. J., Bullman, H., Tiddens, H., Bud, H., & Flavell, R. A. (1984) · Nature

vaccines and immunoinformatics approachesGenetic Associations and Epidemiology

Cited by 316

Immune-microbiota interactions in health and disease

Palm, N. W., de Zoete, M. R., & Flavell, R. A. (2015) · Clinical Immunology

Gut microbiota and healthProbiotics and Fermented Foods

Cited by 315

Stat3 controls lysosomal-mediated cell death in vivo

Kreuzaler, P. A., Staniszewska, A. D., Li, W., Omidvar, N., Kedjouar, B., Turkson, J., Poli, V., Flavell, R. A., Clarkson, R. W. E., & Watson, C. J. (2011) · Nature Cell Biology

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 312