Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells
Open accessAbstract
Tissue repair is a subset of a broad repertoire of interleukin-4 (IL-4)- and IL-13-dependent host responses during helminth infection. Here we show that IL-4 or IL-13 alone was not sufficient, but IL-4 or IL-13 together with apoptotic cells induced the tissue repair program in macrophages. Genetic ablation of sensors of apoptotic cells impaired the proliferation of tissue-resident macrophages and the induction of anti-inflammatory and tissue repair genes in the lungs after helminth infection or in the gut after induction of colitis. By contrast, the recognition of apoptotic cells was dispensable for cytokine-dependent induction of pattern recognition receptor, cell adhesion, or chemotaxis genes in macrophages. Detection of apoptotic cells can therefore spatially compartmentalize or prevent premature or ectopic activity of pleiotropic, soluble cytokines such as IL-4 or IL-13.
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Anti-inflammatory processes mediated by IL-4 provide benefits in models representing early stages of neurodegenerative conditions such as AD and amyotrophic lateral sclerosis.
“Anti-inflammatory processes are associated with tissue repair, such as those mediated by IL-4, working through microglia and macrophages, and have been shown to provide benefits in models representing the early stages of neurodegenerative conditions, such as AD and amyotrophic lateral sclerosis, and other disorders related to cell death (45,72,73).”
From <i>Trem2</i> promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions (2020) · cites this paper as [72]
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- Authors
- Bosurgi, L., Cao, Y. G., Cabeza-Cabrerizo, M., Tucci, A., Hughes, L. D., Kong, Y., Weinstein, J. S., Licona-Limon, P., Schmid, E. T., Pelorosso, F., Gagliani, N., Craft, J. E., Flavell, R. A., Ghosh, S., & Rothlin, C. V.
- Affiliations
- Yale University (US)
- Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA.
- Universidad de Buenos Aires (AR)
- University Medical Center Hamburg-Eppendorf (DE)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Ghosh, Sourav
- Rothlin, Carla V.
- ORCID
- Venue
- Science
- Published
- 2017-06-09
- Volume
- 356
- Issue
- 6342
- Pages
- 1072-1076
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5556699
- OpenAlex
- W2612072527
- Cited by
- 560
- References
- 33
- Citations by year
- 2026: 46 · 2025: 66 · 2024: 53 · 2023: 61 · 2022: 67 · 2021: 76 · 2020: 69 · 2019: 57 · 2018: 38 · 2017: 27
- FWCI
- 23.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (award305303, DGE-1122492)
- National Institutes of Health (award305299, R01 AI089824, award305300, R01CA212376, award309995, R37 AR40072, award305301, T32AI007019)
- Howard Hughes Medical Institute (award305304)
- American Italian Cancer Foundation (award305302)
- NIH (award309994, R37 AR40072)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Keywords
- macrophage function, tissue repair, tissue remodeling, IL-4, IL-13, apoptotic cells, phagocytosis, helminthiasis, colitis, tissue-resident macrophages, anti-inflammatory genes, pattern recognition receptors, cytokine signaling, lung, intestine
- MeSH terms
- Animals, Inflammation, Macrophages, Nippostrongylus, Regeneration, Thioglycolates, Interleukin-4, Strongylida Infections, Apoptosis, Interleukin-13, Mice
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