Extending the Lifespan of Long-Lived Mice
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The lifespan and healthspan of invertebrates are extended by mutations in pathways such as DAF-2, a gene that encodes for the IGF-1 pathway in C. elegans, or the mTOR signaling pathways that are linked to accelerating the aging process.
“The lifespan and healthspan of invertebrates are extended by mutations in pathways such as the DAF-2, a gene that encodes for the IGF-1 pathway in the nematode Caenorhabditis elegans (C. elegans), or the mTOR signaling pathways that are linked to accelerating the aging process (60, 62–65).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [63]
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- Authors
- Bartke, A., Wright, J. C., Mattison, J. A., Ingram, D. K., Miller, R. A., & Roth, G. S.
- Affiliations
- Southern Illinois University Carbondale (US)
- National Institutes of Health (US)
- University of Michigan (US)
- Corresponding author
- Bartke, Andrzej
- Venue
- Nature
- Published
- 2001-11-22
- Volume
- 414
- Issue
- 6862
- Pages
- 412-412
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1994357518
- Cited by
- 422
- References
- 11
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 12 · 2023: 10 · 2022: 5 · 2021: 15 · 2020: 11 · 2019: 15 · 2018: 20 · 2017: 9 · 2016: 9 · 2015: 18 · 2014: 14 · 2013: 19 · 2012: 12
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- Ames dwarf mice, lifespan extension, caloric restriction, PROP1, dietary restriction, aging mechanisms
- MeSH terms
- Animals, Energy Intake, Dwarfism, Female, Longevity, Male, Mice, Mutant Strains, Transcription Factors, Homeodomain Proteins, Mice
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