Thornton, Janet M.

PROCHECK: a program to check the stereochemical quality of protein structures

Laskowski, R. A., MacArthur, M. W., Moss, D. S., & Thornton, J. M. (1993) · Journal of Applied Crystallography

Enzyme Structure and FunctionProtein Structure and Dynamics

Cited by 24,581

Principles of protein-protein interactions

Jones, S., & Thornton, J. M. (1996) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 2,684

A new approach to protein fold recognition

Jones, D. T., Taylort, W. R., & Thornton, J. M. (1992) · Nature

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 1,221

Influence of proline residues on protein conformation

MacArthur, M. W., & Thornton, J. M. (1991) · Journal of Molecular Biology

Protein Structure and DynamicsChemical Synthesis and Analysis

Cited by 1,189

Metal ions in biological catalysis: from enzyme databases to general principles

Andreini, C., Bertini, I., Cavallaro, G., Holliday, G. L., & Thornton, J. M. (2008) · JBIC Journal of Biological Inorganic Chemistry

Metal-Catalyzed Oxygenation MechanismsEnzyme Structure and Function

Cited by 1,150

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 1,120

A structural biology community assessment of AlphaFold2 applications

Akdel, M., Pires, D. E. V., Pardo, E. P., Jänes, J., Zalevsky, A. O., Mészáros, B., Bryant, P., Good, L. L., Laskowski, R. A., Pozzati, G., et al. (2022) · Nature Structural & Molecular Biology

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 675

Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice

Selman, C., Lingard, S., Choudhury, A. I., Batterham, R. L., Claret, M., Clements, M., Ramadani, F., Okkenhaug, K., Schuster, E., Blanc, E., et al. (2008) · The FASEB Journal

Genetics, Aging, and Longevity in Model OrganismsGrowth Hormone and Insulin-like Growth Factors

Cited by 532

Construction, Visualisation, and Clustering of Transcription Networks from Microarray Expression Data

Freeman, T. C., Goldovsky, L., Brosch, M., van Dongen, S., Mazière, P., Grocock, R. J., Freilich, S., Thornton, J., & Enright, A. J. (2007) · PLoS Computational Biology

Bioinformatics and Genomic NetworksGene expression and cancer classification

Cited by 248

Protein Function Prediction Using Local 3D Templates

Laskowski, R. A., Watson, J. D., & Thornton, J. M. (2005) · Journal of Molecular Biology

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 213

AlphaFold heralds a data-driven revolution in biology and medicine

Thornton, J. M., Laskowski, R. A., & Borkakoti, N. (2021) · Nature Medicine

Protein Structure and DynamicsArtificial Intelligence in Healthcare and Education

Cited by 185

A structural biology community assessment of AlphaFold 2 applications

Akdel, M., Pires, D. E. V., Porta Pardo, E., Jänes, J., Zalevsky, A. O., Mészáros, B., Bryant, P., Good, L. L., Laskowski, R. A., Pozzati, G., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory)

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 122

Protein Superfamily Evolution and the Last Universal Common Ancestor (LUCA)

Ranea, J. A. G., Sillero, A., Thornton, J. M., & Orengo, C. A. (2006) · Journal of Molecular Evolution

Genomics and Phylogenetic StudiesOrigins and Evolution of Life

Cited by 122

PDBe-KB: collaboratively defining the biological context of structural data

PDBe-KB consortium, Varadi, M., Anyango, S., Armstrong, D., Berrisford, J., Choudhary, P., Deshpande, M., Nadzirin, N., Nair, S. S., Pravda, L., et al. (2022) · Nucleic Acids Research

Enzyme Structure and FunctionProtein Structure and Dynamics

Cited by 82

To what extent do structural changes in catalytic metal sites affect enzyme function?

Valasatava, Y., Rosato, A., Furnham, N., Thornton, J. M., & Andreini, C. (2018) · Journal of Inorganic Biochemistry

Enzyme Structure and FunctionProtein Structure and Dynamics

Cited by 77

Evolution of enzymes and pathways for the biosynthesis of cofactors

Holliday, G. L., Thornton, J. M., Marquet, A., Smith, A. G., Rébeillé, F., Mendel, R., Schubert, H. L., Lawrence, A. D., & Warren, M. J. (2007) · Natural Product Reports

Microbial Natural Products and BiosynthesisPlant biochemistry and biosynthesis

Cited by 68

Temporal changes in the gene expression heterogeneity during brain development and aging

Işıldak, U., Somel, M., Thornton, J. M., & Dönertaş, H. M. (2020) · Scientific Reports

Single-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms

Cited by 53

The 3D modules of enzyme catalysis: deconstructing active sites into distinct functional entities

Riziotis, I. G., Ribeiro, A. J. M., Borkakoti, N., & Thornton, J. M. (2023) · Journal of Molecular Biology

Enzyme Structure and FunctionProtein Structure and Dynamics

Cited by 15