Slagboom, P. Eline

Circulating metabolites and general cognitive ability and dementia: evidence from 11 cohort studies

van der Lee, S. J., Teunissen, C. E., Pool, R., Shipley, M. J., Teumer, A., Chouraki, V., Melo van Lent, D., Tynkkynen, J., Fischer, K., Hernesniemi, J., et al. (2018) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchMetabolomics and Mass Spectrometry Studies

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Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

Beekman, M., Blanché, H., Perola, M., Hervonen, A., Bezrukov, V., Sikora, E., Flachsbart, F., Christiansen, L., De Craen, A. J. M., Kirkwood, T. B. L., et al. (2013) · Aging Cell

Genetic Associations and EpidemiologyGenetics, Aging, and Longevity in Model Organisms

Cited by 190

Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk: A Cross-Sectional Study

Kurilshikov, A., van den Munckhof, I. C. L., Chen, L., Bonder, M. J., Schraa, K., Rutten, J. H. W., Riksen, N. P., de Graaf, J., Oosting, M., Sanna, S., et al. (2019) · Circulation Research

Gut microbiota and healthOral microbiology and periodontitis research

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Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

Joshi, P. K., Pirastu, N., Kentistou, K. A., Fischer, K., Hofer, E., Schraut, K. E., Clark, D. W., Nutile, T., Barnes, C. L. K., Timmers, P. R. H. J., et al. (2017) · Nature Communications

Genetic Associations and EpidemiologyGenetics, Aging, and Longevity in Model Organisms

Cited by 161

Effects of a Web-Based Intervention on Physical Activity and Metabolism in Older Adults: Randomized Controlled Trial

Wijsman, C. A., Westendorp, R. G., Verhagen, E. A., Catt, M., Slagboom, P. E., de Craen, A. J., Broekhuizen, K., van Mechelen, W., van Heemst, D., van der Ouderaa, F., et al. (2013) · Journal of Medical Internet Research

Physical Activity and HealthMobile Health and mHealth Applications

Cited by 156

VDR gene variants associate with cognitive function and depressive symptoms in old age

Kuningas, M., Mooijaart, S. P., Jolles, J., Slagboom, P. E., Westendorp, R. G. J., & van Heemst, D. (2009) · Neurobiology of Aging

Vitamin D Research StudiesDementia and Cognitive Impairment Research

Cited by 149

GWAS for executive function and processing speed suggests involvement of the CADM2 gene

Ibrahim-Verbaas, C. A., Bressler, J., Debette, S., Schuur, M., Smith, A. V., Bis, J. C., Davies, G., Trompet, S., Smith, J. A., Wolf, C., et al. (2016) · Molecular Psychiatry

Genetic Associations and EpidemiologyCognitive Abilities and Testing

Cited by 147

Heritabilities of Apolipoprotein and Lipid Levels in Three Countries

Beekman, M., Heijmans, B. T., Martin, N. G., Pedersen, N. L., Whitfield, J. B., DeFaire, U., van Baal, G. C. M., Snieder, H., Vogler, G. P., Slagboom, P. E., et al. (2002) · Twin Research

Genetic Associations and EpidemiologyLipoproteins and Cardiovascular Health

Cited by 133

Familial Longevity Is Associated with Decreased Thyroid Function

Rozing, M. P., Houwing-Duistermaat, J. J., Slagboom, P. E., Beekman, M., Frölich, M., de Craen, A. J. M., Westendorp, R. G. J., & van Heemst, D. (2010) · The Journal of Clinical Endocrinology & Metabolism

Thyroid Disorders and TreatmentsGenetics, Aging, and Longevity in Model Organisms

Cited by 132

ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age

Mooijaart, S. P., Berbée, J. F. P., van Heemst, D., Havekes, L. M., de Craen, A. J. M., Slagboom, P. E., Rensen, P. C. N., & Westendorp, R. G. J. (2006) · PLoS Medicine

Lipoproteins and Cardiovascular HealthParaoxonase enzyme and polymorphisms

Cited by 129

Metabolic Age Based on the BBMRI-NL 1 H-NMR Metabolomics Repository as Biomarker of Age-related Disease

van den Akker, E. B., Trompet, S., Barkey Wolf, J. J. H., Beekman, M., Suchiman, H. E. D., Deelen, J., Asselbergs, F. W., Boersma, E., Cats, D., Elders, P. M., et al. (2020) · Circulation: Genomic and Precision Medicine

Metabolomics and Mass Spectrometry StudiesHealth, Environment, Cognitive Aging

Cited by 109

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process

Bacalini, M. G., Deelen, J., Pirazzini, C., De Cecco, M., Giuliani, C., Lanzarini, C., Ravaioli, F., Marasco, E., van Heemst, D., Suchiman, H. E. D., et al. (2017) · The Journals of Gerontology: Series A

Epigenetics and DNA MethylationTelomeres, Telomerase, and Senescence

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Association of common genetic variants with brain microbleeds: a genome-wide association study

Knol, M. J., Lu, D., Traylor, M., Adams, H. H. H., Romero, J. R. J., Smith, A. V., Fornage, M., Hofer, E., Liu, J., Hostettler, I. C., et al. (2020) · Neurology

Intracerebral and Subarachnoid Hemorrhage ResearchCerebrovascular and genetic disorders

Cited by 94

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

Jansen, S. W., Akintola, A. A., Roelfsema, F., van der Spoel, E., Cobbaert, C. M., Ballieux, B. E., Egri, P., Kvarta-Papp, Z., Gereben, B., Fekete, C., et al. (2015) · Scientific Reports

Thyroid Disorders and TreatmentsGenetics, Aging, and Longevity in Model Organisms

Cited by 82

Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.

Sterenborg, R. B. T. M., Steinbrenner, I., Li, Y., Bujnis, M. N., Naito, T., Marouli, E., Galesloot, T. E., Babajide, O., Andreasen, L., Astrup, A., et al. (2024) · Nature Communications

Genetic Associations and EpidemiologyThyroid Disorders and Treatments

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Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency

Kiezun, A., Pulit, S. L., Francioli, L. C., van Dijk, F., Swertz, M., Boomsma, D. I., van Duijn, C. M., Slagboom, P. E., van Ommen, G. J. B., Wijmenga, C., et al. (2013) · PLoS Genetics

Evolution and Genetic DynamicsGenomics and Rare Diseases

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PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population

Postmus, I., Trompet, S., de Craen, A. J. M., Buckley, B. M., Ford, I., Stott, D. J., Sattar, N., Slagboom, P. E., Westendorp, R. G. J., & Jukema, J. W. (2013) · Journal of Lipid Research

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 67

DNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons

Oh, G., Wang, S.-C., Pal, M., Chen, Z. F., Khare, T., Tochigi, M., Ng, C., Yang, Y. A., Kwan, A., Kaminsky, Z. A., et al. (2015) · Biological Psychiatry

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

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Men have a stronger monocyte-derived cytokine production response upon stimulation with the gram-negative stimulus lipopolysaccharide than women: a pooled analysis including 15 study populations

Beenakker, K. G. M., Westendorp, R. G. J., de Craen, A. J. M., Chen, S., Raz, Y., Ballieux, B. E. P. B., Nelissen, R. G. H. H., Later, A. F. L., Huizinga, T. W., Slagboom, P. E., et al. (2020) · Journal of Innate Immunity

Immune Response and InflammationSex and Gender in Healthcare

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Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2

van den Akker, E. B., Pitts, S. J., Deelen, J., Moed, M. H., Potluri, S., van Rooij, J., Suchiman, H. E. D., Lakenberg, N., de Dijcker, W. J., Uitterlinden, A. G., et al. (2016) · Blood

Acute Myeloid Leukemia ResearchCancer Genomics and Diagnostics

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Selection for Genetic Variation Inducing Pro-Inflammatory Responses under Adverse Environmental Conditions in a Ghanaian Population

Kuningas, M., May, L., Tamm, R., van Bodegom, D., van den Biggelaar, A. H. J., Meij, J. J., Frölich, M., Ziem, J. B., Suchiman, H. E. D., Metspalu, A., et al. (2009) · PLoS ONE

Genetic Associations and EpidemiologyEvolution and Genetic Dynamics

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Familial longevity is associated with higher tsh secretion and strong TSH-fT3 relationship

Jansen, S. W., Roelfsema, F., van der Spoel, E., Akintola, A. A., Postmus, I., Ballieux, B. E., Slagboom, P. E., Cobbaert, C. M., van der Grond, J., Westendorp, R. G., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism

Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth Factors

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Genetic Linkage and Association Analysis for Loneliness in Dutch Twin and Sibling Pairs Points to a Region on Chromosome 12q23–24

Boomsma, D. I., Cacioppo, J. T., Slagboom, P. E., & Posthuma, D. (2006) · Behavior Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 39

Plasma Trimethylamine N-Oxide (TMAO): Associations with Cognition, Neuroimaging, and Dementia

Yaqub, A., Vojinovic, D., Vernooij, M. W., Slagboom, P. E., Ghanbari, M., Beekman, M., van der Grond, J., Hankemeier, T., van Duijn, C. M., Ikram, M. A., et al. (2024) · Alzheimer's Research & Therapy

Dementia and Cognitive Impairment ResearchNutritional Studies and Diet

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