Verkhratsky, Alexei

The homeostatic astroglia emerges from evolutionary specialization of neural cells

Verkhratsky, A., & Nedergaard, M. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 133

Disruption of oligodendrocyte progenitor cells is an early sign of pathology in the triple transgenic mouse model of Alzheimer's disease

Vanzulli, I., Papanikolaou, M., De-La-Rocha, I. C., Pieropan, F., Rivera, A. D., Gomez-Nicola, D., Verkhratsky, A., Rodríguez, J. J., & Butt, A. M. (2020) · Neurobiology of Aging

Neurogenesis and neuroplasticity mechanismsAlzheimer's disease research and treatments

Cited by 130

Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease

Rodríguez, J. J., Witton, J., Olabarria, M., Noristani, H. N., & Verkhratsky, A. (2010) · Cell Death & Disease

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 114

Electroacupuncture prevents astrocyte atrophy to alleviate depression

Lin, S.-S., Zhou, B., Chen, B.-J., Jiang, R.-T., Li, B., Illes, P., Semyanov, A., Tang, Y., & Verkhratsky, A. (2023) · Cell Death & Disease

Treatment of Major DepressionAcupuncture Treatment Research Studies

Cited by 102

Astroglial Calcium Signaling in Aging and Alzheimer's Disease

Verkhratsky, A. (2019) · Cold Spring Harbor Perspectives in Biology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 99

Enriched environment and physical activity reverse astrogliodegeneration in the hippocampus of AD transgenic mice

Rodríguez, J. J., Terzieva, S., Olabarria, M., Lanza, R. G., & Verkhratsky, A. (2013) · Cell Death & Disease

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 99

General Pathophysiology of Astroglia

Verkhratsky, A., Ho, M. S., Vardjan, N., Zorec, R., & Parpura, V. (2019) · Advances in Experimental Medicine and Biology

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 66

Loss of calretinin and parvalbumin positive interneurones in the hippocampal CA1 of aged Alzheimer’s disease mice

Zallo, F., Gardenal, E., Verkhratsky, A., & Rodríguez, J. J. (2018) · Neuroscience Letters

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 57

Astroglial Calcium Signalling in Alzheimer's Disease

Verkhratsky, A., Rodríguez-Arellano, J. J., Parpura, V., & Zorec, R. (2017) · Biochemical and Biophysical Research Communications

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 55

Sleep Deprivation Selectively Down-Regulates Astrocytic 5-HT2B Receptors and Triggers Depressive-Like Behaviors via Stimulating P2X7 Receptors in Mice

Xia, M., Li, Z., Li, S., Liang, S., Li, X., Chen, B., Zhang, M., Dong, C., Verkhratsky, A., Guan, D., et al. (2020) · Neuroscience Bulletin

Adenosine and Purinergic SignalingSleep and Wakefulness Research

Cited by 55

Leptin Increases Expression of 5-HT2B Receptors in Astrocytes Thus Enhancing Action of Fluoxetine on the Depressive Behavior Induced by Sleep Deprivation

Li, X., Liang, S., Li, Z., Li, S., Xia, M., Verkhratsky, A., & Li, B. (2019) · Frontiers in Psychiatry

Treatment of Major DepressionTryptophan and brain disorders

Cited by 54

The ameliorative effect of fluoxetine on neuroinflammation induced by sleep deprivation

Xia, M., Li, X., Yang, L., Ren, J., Sun, G., Qi, S., Verkhratsky, A., & Li, B. (2018) · Journal of Neurochemistry

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 53

Accelerated Dystrophy and Decay of Oligodendrocyte Precursor Cells in the APP/PS1 Model of Alzheimer’s-Like Pathology

Chacon-De-La-Rocha, I., Fryatt, G., Rivera, A. D., Verkhratsky, A., Raineteau, O., Gomez-Nicola, D., & Butt, A. M. (2020) · Frontiers in Cellular Neuroscience

Neurogenesis and neuroplasticity mechanismsAlzheimer's disease research and treatments

Cited by 52

Iron Aggravates the Depressive Phenotype of Stressed Mice by Compromising the Glymphatic System

Liang, S., Lu, Y., Li, Z., Li, S., Chen, B., Zhang, M., Chen, B., Ji, M., Gong, W., Xia, M., et al. (2020) · Neuroscience Bulletin

Cerebrospinal fluid and hydrocephalusStress Responses and Cortisol

Cited by 41

Segregation of calcium signalling mechanisms in magnocellular neurones and terminals

Dayanithi, G., Forostyak, O., Ueta, Y., Verkhratsky, A., & Toescu, E. C. (2012) · Cell Calcium

Ion Channels and ReceptorsIon channel regulation and function

Cited by 38

The neuroprotective mechanism of lithium after ischaemic stroke

Chen, B., Zhang, M., Ji, M., Zhang, D., Chen, B., Gong, W., Li, X., Zhou, Y., Dong, C., Wen, G., et al. (2022) · Communications Biology

Neuroprotection in Cerebral IschemiaNeuroinflammation and Neurodegeneration Mechanisms

Cited by 37

Decrease of gene expression of astrocytic 5-HT2B receptors parallels development of depressive phenotype in a mouse model of Parkinson’s disease

Zhang, X., Song, D., Gu, L., Ren, Y., Verkhratsky, A., & Peng, L. (2015) · Frontiers in Cellular Neuroscience

Neurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Cited by 35

Cell type-specific in vivo expression of genes encoding signalling molecules in the brain in response to chronic mild stress and chronic treatment with fluoxetine

Dong, L., Li, B., Verkhratsky, A., & Peng, L. (2015) · Psychopharmacology

Neurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Cited by 32

APOE from patient-derived astrocytic extracellular vesicles alleviates neuromyelitis optica spectrum disorder in a mouse model

Jiang, S., Li, X., Li, Y., Chang, Z., Yuan, M., Zhang, Y., Zhu, H., Xiu, Y., Cong, H., Yin, L., et al. (2024) · Science Translational Medicine

Multiple Sclerosis Research StudiesExtracellular vesicles in disease

Cited by 30

A novel murine model of mania

Li, X., Chen, B., Zhang, D., Wang, S., Feng, Y., Wu, X., Cui, L., Ji, M., Gong, W., Verkhratsky, A., et al. (2023) · Molecular Psychiatry

Bipolar Disorder and TreatmentTreatment of Major Depression

Cited by 27

Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution

Ciuba, K., Piotrowska, A., Chaudhury, D., Dehingia, B., Duński, E., Behr, R., Soroczyńska, K., Czystowska-Kuźmicz, M., Abbas, M., Bulanda, E., et al. (2025) · Cell Stem Cell

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 25

Principles of Astrogliopathology

Verkhratsky, A., Li, B., Scuderi, C., & Parpura, V. (2021) · Advances in Neurobiology

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 21

Fluoxetine improves behavioural deficits induced by chronic alcohol treatment by alleviating RNA editing of 5-HT2C receptors

Li, Z., Lu, Y., Liang, S., Li, S., Chen, B., Zhang, M., Xia, M., Guan, D., Verkhratsky, A., & Li, B. (2020) · Neurochemistry International

RNA regulation and diseaseNeurotransmitter Receptor Influence on Behavior

Cited by 21

Astroglial Serotonin Receptors as the Central Target of Classic Antidepressants

Verkhratsky, A., Parpura, V., Scuderi, C., & Li, B. (2021) · Advances in Neurobiology

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 19