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The light spot test: Measuring anxiety in mice in an automated home-cage environment

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Cognitive flexibility deficits in a mouse model for the absence of full‐length dystrophin

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Long-term home cage activity scans reveal lowered exploratory behaviour in symptomatic female Rett mice

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Effects of genetic background and environmental novelty on wheel running as a rewarding behaviour in mice

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A High-Dimensional Quantification of Mouse Defensive Behaviors Reveals Enhanced Diversity and Stimulus Specificity

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Rodent tests of depression and anxiety: Construct validity and translational relevance

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Advancing preclinical chronic stress models to promote therapeutic discovery for human stress disorders

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Emerging Role of Translational Digital Biomarkers Within Home Cage Monitoring Technologies in Preclinical Drug Discovery and Development

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Perspectives on Primary Blast Injury of the Brain: Translational Insights Into Non-inertial Low-Intensity Blast Injury

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3Rs Principle and Legislative Decrees to Achieve High Standard of Animal Research

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Hybrid Offspring of C57BL/6J Mice Exhibit Improved Properties for Neurobehavioral Research

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The rough-and-tumble play of rats as a natural behavior suitable for studying the social brain

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Towards improved screening of toxins for Parkinson’s risk

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Using deep learning to study emotional behavior in rodent models

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JUN and PDGFRA as Crucial Candidate Genes for Childhood Autism Spectrum Disorder

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Environmental enrichment improves hippocampus-dependent spatial learning in female C57BL/6 mice in novel IntelliCage sweet reward-based behavioral tests

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Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging

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Selective Ablation of Sod2 in Astrocytes Induces Sex-Specific Effects on Cognitive Function, d-Serine Availability, and Astrogliosis

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Long-term tracking of social structure in groups of rats

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Intranasal application of stem cells and their derivatives as a new hope in the treatment of cerebral hypoxia/ischemia: a review

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The circuit basis for chronic pain and its comorbidities

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Long-Term Effects of Low-Intensity Blast Non-Inertial Brain Injury on Anxiety-Like Behaviors in Mice: Home-Cage Monitoring Assessments

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Effects of Human Observer Presence on Pain Assessment Using Facial Expressions in Rabbits

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Cognitive heterogeneity reveals molecular signatures of age-related impairment

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AI-powered home cage system for real-time tracking and analysis of rodent behavior

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Decoupling Behavioral Domains via Kynurenic Acid Analog Optimization: Implications for Schizophrenia and Parkinson’s Disease Therapeutics

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Editorial: Animal-friendly methods for rodent behavioral testing in neuroscience research

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Making a case for the free exploratory paradigm: animal welfare-friendly assays that enhance heterozygosity and ecological validity

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Measuring anxiety-like behavior in a mouse model of mTBI: Assessment in standard and home cage assays

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Bouts of rest and physical activity in C57BL/6J mice

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Mitochondrial calcium uniporter deficiency in dentate granule cells remodels neuronal metabolism and impairs reversal learning

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Towards substitution of invasive telemetry: An integrated home cage concept for unobtrusive monitoring of objective physiological parameters in rodents

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Actigraphic correlates of neuropsychiatric symptoms in adults with focal epilepsy

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Home-cage behavior in the Stargazer mutant mouse

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Disentangling rodent behaviors to improve automated behavior recognition

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Highly accurate and precise determination of mouse mass using computer vision

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A circadian behavioral analysis suite for real-time classification of daily rhythms in complex behaviors

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PiE: an open-source pipeline for home cage behavioral analysis

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The first rodent behavioral study (1822) and the diffusion of human-bred albino rats and mice in the 19th century

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3D mouse pose from single-view video and a new dataset

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Progressive cognitive impairment after recovery from neuroinvasive and non-neuroinvasive Listeria monocytogenes infection

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An 8-cage imaging system for automated analyses of mouse behavior

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The 3Rs in Experimental Liver Disease

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Role of the prefrontal cortical protease TACE/ADAM17 in neurobehavioral responses to chronic stress during adolescence

Sharafeddin, F., Sierra, J., Ghaly, M. H., Simon, T. B., Ontiveros‐Ángel, P., Edelbach, B. M., Febo, M., Labus, J. S., & Figueroa, J. D. (2024) · Brain and Behavior · doi:10.1002/brb3.3482 · Cited by 6 · see citing works

Steps into a Small World: First glimpses on everyday moment‐to‐moment decision making in an ecologically meaningful multi‐choice system for assessing animal preferences

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For neuroscience, social history matters

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Novel and optimized mouse behavior enabled by fully autonomous HABITS: Home-cage assisted behavioral innovation and testing systemPreprint

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Non-aversive handling in laboratory animals and its effects on depressive-like and anxiety-related behaviors: A scoping review

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Chronic exposure to imipramine induces a switch from depression-like to mania-like behavior in female serotonin transporter knockout rats: Role of BDNF signaling in the infralimbic cortex

Sadighi, M., Mai, L., Xu, Y., Boillot, M., Targa, G., Mottarlini, F., Brambilla, P., Gass, P., Caffino, L., Fumagalli, F., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.186 · Cited by 5 · see citing works

Longitudinal quantitative assessment of TMEV-IDD-induced MS phenotypes in two inbred mouse strains using automated video tracking technology

Djabirska, I., Delaval, L., Tromme, A., Blomet, J., Desmecht, D. J.-M., & Laere, A.-S. V. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114851 · Cited by 5 · see citing works

An integrated and scalable rodent cage system enabling continuous computer vision-based behavioral analysis and AI-enhanced digital biomarker developmentPreprint

Robertson, T. L., Ellis, M., Bratcher-Petersen, N., Ruidíaz, M. E., Harada, K., Toburen, D., Oberhauser, J. P., Grzenda, D., Peltier, N. E., Raza, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.18.629281 · Cited by 8 · see citing works

Errors, Contaminations, and Confounding Factors in in vivo Studies: Challenges and Practical Solutions

Farokhmoradi, H., & Salari-Kakhk, F. (2025) · Journal of Lab Animal Research · doi:10.58803/jlar.v4i3.78 · Cited by 4 · see citing works

Refinement of the motorised laminectomy-assisted rat spinal cord injury model by analgesic treatment

Sreelatha, H. V., Palekkodan, H., Fasaludeen, A., Krishnan, L. K., & Abelson, K. (2024) · PLoS ONE · doi:10.1371/journal.pone.0294720 · Cited by 4 · see citing works

Simultaneous assessment of central nervous and respiratory systems using jacketed telemetry in socially-housed rats: Application of the “3Rs” principles in core battery safety pharmacology studies

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Female mice in established social groups use different ultrasonic vocalizations during peaceful and aggressive interactions

Викторовна, К. А., Lang, B., Jaap, A., Thöne‐Reineke, C., Lewejohann, L., & Mieske, P. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115904 · Cited by 5 · see citing works

Clinicopathologic Dissociation: Robust Lafora Body Accumulation in Malin KO Mice Without Observable Changes in Home‐Cage Behavior

Krishnan, V., Wu, J., Mazumder, A. G., Kamen, J. L., Schirmer, C., Adhyapak, N., Bass, J. S., Lee, S., Maheshwari, A., Molinaro, G., et al. (2024) · The Journal of Comparative Neurology · doi:10.1002/cne.25660 · Cited by 3 · see citing works

Characterization of alterations in spontaneous behaviors in a rat model of neuropathic pain - new outcome measures for pain evaluation?

Liptáková, A., Castelhano-Carlos, M. J., Fiúza-Fernandes, J., Sousa, N., Roche, M., Finn, D. P., & Leite‐Almeida, H. (2025) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2025.1550476 · Cited by 3 · see citing works

Cyber Operations Gyms to Train Autonomous Cyber Defense Agents for NATO

Velazquez, A., Loevenich, J. F., Hürten, T., Wrona, K., Rettore, P. H. L., Boshnakov, V., Nelson, F. F., Braun, T., & Lopes, R. R. F. (2025) · International Conference on Military Communications and Information Systems (ICMCIS) · doi:10.1109/icmcis64378.2025.11047884 · Cited by 3 · see citing works

Assessment of impulsivity using an automated, self-adjusting delay discounting procedure

Carr, M. R., van Mourik, Y., Gómez-Sotres, P., Solinas, M., Vries, T. J. D., & Pattij, T. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115405 · Cited by 3 · see citing works

Towards substitution of invasive telemetry: An integrated home cage concept for unobstrusive monitoring of objective physiological parameters in rodentsPreprint

Mösch, L., Kunczik, J., Breuer, L., Merhof, D., Gass, P., Potschka, H., Zechner, D., Vollmar, B., Tolba, R. H., Häager, C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.12.540546 · Cited by 3 · see citing works

Subchronic amphetamine decreases hyperactivity, anti-social behaviour and anhedonia in dopamine transporter knockout rats: role of prefrontal glutamate

Sadighi, M., Foka, K., Mottarlini, F., van den Burg, E. H., Taddini, S., Leo, D., Sanna, F., Caffino, L., Fumagalli, F., & Homberg, J. R. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110597 · Cited by 3 · see citing works

State Estimation of an Agent with Stochastic Dynamics Using Recurrent Filters

Krasnov, D. I., Volynsky, M. A., & Gusev, A. (2025) · Informatics and Automation · doi:10.15622/ia.24.5.4 · Cited by 2 · see citing works

Innovating pain research: bridging gaps and shaping the future

Rodríguez-Palma, E. J., Allen, H. N., Nelson, T. S., & Khanna, R. (2025) · Pain · doi:10.1097/j.pain.0000000000003661 · Cited by 2 · see citing works

Robust noninvasive detection of hyperglycemia in mouse models of metabolic dysregulation using the novel Urination Index biomarker

Brachs, S., Dall, M., Zimbalski, L.-K., Santin, Y., Oeing, C. U., Mai, K., Parini, A., Gaburro, S., & Nielsen, T. S. (2025) · Lab Animal · doi:10.1038/s41684-025-01648-8 · Cited by 2 · see citing works

SqueakPose Studio, an end-to-end platform for pose estimation and real-time edge-AI deployment

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Investigation of Mild Traumatic Brain Injury Home Cage Behavior: The Home Cage Assay Advantages

Richmond-Hacham, B., Tseitlin, L., Bikovski, L., & Pick, C. G. (2024) · Journal of Neurotrauma · doi:10.1089/neu.2023.0459 · Cited by 2 · see citing works

The SnackerTracker: A novel home-cage monitoring device for measuring food-intake and food-seeking behaviour in mice

Mueller, M., Tir, S., Pothecary, C. A., Meijer, E. J., Brown, L. A., Foster, K., Vyazovskiy, V. V., Peirson, S. N., & Molnár, Z. (2025) · Wellcome Open Research · doi:10.12688/wellcomeopenres.23850.1 · Cited by 2 · see citing works

Robust non-invasive detection of hyperglycemia in mouse models of metabolic dysregulation: the novel Urination Index biomarkerPreprint

Brachs, S., Dall, M., Zimbalski, L.-K., Santin, Y., Oeing, C. U., Mai, K., Parini, A., Gaburro, S., & Nielsen, T. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.02.646666 · Cited by 2 · see citing works

Behavioral comorbidities of early-life seizures: Insights from developmental studies in rats

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Establishment of a second-generation transgenic marmoset with germline transmission that models polyglutamine disease

Minakawa, E. N., Owari, K., Nogami, N., Nakatani, T., Koizumi, M., Kawanobe, A., Saga, Y., Kudo, M., Noguchi, S., Hanakawa, T., et al. (2025) · Disease Models & Mechanisms · doi:10.1242/dmm.052470 · Cited by 1 · see citing works

Using Artificial Intelligence Systems in Modern Neurobehavioral Research

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Effect of the Icelandic Mutation APPA673T in the Murine APP Gene on Phenotype of Line 66 Tau Mice

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Detection of the first changes in the dynamics of metabolic characteristics in the system of increasing consequences of traumatic brain injury

Tsoy, M. O., Merkulova, K. O., Evsukova, A., & Zlatogorskaya, D. (2026) · The European Physical Journal Special Topics · doi:10.1140/epjs/s11734-026-02210-4 · Cited by 1 · see citing works

Challenges and expectations on the use of automated home cage monitoring for advancing laboratory animal care and welfare

Tremoleda, J. L., Brønstad, A., Potschka, H., Seebeck, P., Stiedl, O., Võikar, V., Wells, S. E., & Subgroup, T. A. W. (2026) · Laboratory Animals · doi:10.1177/00236772251396319 · Cited by 1 · see citing works

Gender-Specific Behavior Reductions in Spontaneous Locomotive and Rearing in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy: A Pilot Study

Kim, S., CAO, K., Dougherty, P. M., McDonough, K., & Javed, S. (2026) · Journal of Pain Research · doi:10.2147/jpr.s565512 · Cited by 1 · see citing works

Optimization of overhead enclosure monitoring in juvenile male Dunkin Hartley guinea pigs ( Cavia porcellus )

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Categorized and individualized behavioral phenotyping approaches for control and triple-hit schizophrenia-like model rats in acute and chronic reward-based systems: A pilot study

Hernadi, Z., Körmöczi, L., Adlan, L. G., Kékesi, G., Büki, A., Liszli, P., Nyúl, L. G., Braunitzer, G., & Horváth, G. (2025) · PLoS ONE · doi:10.1371/journal.pone.0328460 · Cited by 1 · see citing works

A modular gate system for autonomous control of rodent behaviorPreprint

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Establishment of a second-generation transgenic marmoset model of polyglutamine disease recapitulating neurological symptoms and pathologyPreprint

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The effect of the Icelandic mutation APP A673T in the line 66 model of tauopathyPreprint

Anschuetz, A., Robinson, L., Mondésir, M., Melis, V., Platt, B., Harrington, C. R., Riedel, G., & Schwab, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.09.681356 · Cited by 1 · see citing works

Context-dependent reorganization of behavioral strategy during transfer from home-cage to head-fixed performancePreprint

Peretz‐Rivlin, N., Marsh‐Yvgi, I., Fatal, Y., Levin, S., Atlan, G., & Citri, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.05.697827 · Cited by 1 · see citing works

Pain assessment in laboratory species

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iMOUSE - Reforming the Strategy of Refinement and Reduction for indispensable laboratory animal-based studies in translational researchPreprint

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Establishing New Isosexual Pairs in Adult Male Guinea Pigs (Cavia porcellus) to Facilitate Social Housing

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Time Perception Test in IntelliCage System for Preclinical Study: Linking Depression and Serotonergic Modulation

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Novel and optimized mouse behavior enabled by fully autonomous HABITS: Home-cage Assisted Behavioral Innovation and Testing SystemPreprint

Yu, B., Li, P., Xu, H., Wang, Y., Xu, K., & Hao, Y. (2025) · eLife · doi:10.7554/elife.104833.1

EGR3 Deletion Rescues Developmental and Epileptic Encephalopathy in Kcna1 -null MicePreprint

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Vocalisations as a potential indicator of parturition in C57BL/6J mice

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Female Mice in Established Social Groups Use Different Ultrasonic Vocalizations During Peaceful and Aggressive InteractionsPreprint

Викторовна, К. А., Lang, B., Jaap, A., Thöne‐Reineke, C., Lewejohann, L., & Mieske, P. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5346780

Mineralocorticoid receptor deletion alters spontaneous behavior in an automated home-cage monitoring apparatus

Kendricks, D. R., Sleiman, S. J., Fry, S. A., Stallone, J., Bernstein, B. J., Stevanovic, K. D., Wilson, L. R., Alexander, G. M., McCann, K. E., Dudek, S. M., et al. (2025) · Hormones and Behavior · doi:10.1016/j.yhbeh.2025.105794

Novel and optimized mouse behavior enabled by fully autonomous HABITS: Home-cage Assisted Behavioral Innovation and Testing SystemPreprint

Yu, B., Li, P., Xu, H., Wang, Y., Xu, K., & Hao, Y. (2025) · eLife · doi:10.7554/elife.104833.2

Automated home-cage-like monitoring for assessing innate behaviors in a murine hangover model

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Behavioral characterization of triple-hit schizophrenia-like Lisket rats derived from the Long Evans strain through acute and chronic behavioral tests

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SMART CAGES, BETTER WELFARE: SUPPORTING THE 3RS IN ANIMAL RESEARCH WITH HOME-CAGE MONITORING AND SYSTEM SELECTION

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Individual and social contributions to learning of mice in Intellicages: the general framework and mean field theoryPreprint

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Ethical Considerations of Mitigating Data Loss: VLADISLAV, a Manifesto for Reliable Home Cage SystemsPreprint

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Rôle et mécanismes d'action du métabolite microbien p-crésol dans les déficits d'interaction sociale associés a l'autisme

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Home-cage monitoring methods reveal age- and strain-related differences in motor, thermal, and cognitive functions in male mice of two inbred strains

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Technologies for Home Cage Monitoring in Preclinical Research

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Study Design and Data Analysis in Home Cage Monitoring Experiments

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Home Cage Monitoring in Pharmaceutical Industries and Contract Research Organizations

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Home Cage Monitoring in Practice in Core Labs: Training, Infrastructure, and Research Workflow

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Tracking Spatial and Activity Patterns in Captive Reptiles Using Deep Learning

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Three Pillars of Automated Home-Cage Phenotyping of Mice: Novel Findings, Refinement, and Reproducibility Based on Literature and Experience

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Automated Home-Cage Testing as a Tool to Improve Reproducibility of Behavioral Research?

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Focus on novel approaches: Home-cage monitoring of laboratory micePreprint

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smart-Kage: Autonomous behavioural phenotyping in a rodent home-cage environment

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