Most cited biochemistry, genetics and molecular biology papers
- Verified
SolexaQA: at-a-glance quality assessment of Illumina second-generation sequencing data
Cox, M. P., Peterson, D. A., & Biggs, P. J. (2010) · BMC Bioinformatics
Genomics and Phylogenetic StudiesFractal and DNA sequence analysis
Cited by 1,357
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Charting a dynamic DNA methylation landscape of the human genome
Ziller, M. J., Gu, H., Müller, F., Donaghey, J., Tsai, L. T.-Y., Kohlbacher, O., De Jager, P. L., Rosen, E. D., Bennett, D. A., Bernstein, B. E., et al. (2013) · Nature
Epigenetics and DNA MethylationGenomics and Chromatin Dynamics
Cited by 1,357
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Ancient human genomes suggest three ancestral populations for present-day Europeans
Lazaridis, I., Patterson, N., Mittnik, A., Renaud, G., Mallick, S., Kirsanow, K., Sudmant, P. H., Schraiber, J. G., Castellano, S., Lipson, M., et al. (2014) · Nature
Forensic and Genetic ResearchGenetic diversity and population structure
Cited by 1,357
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RNAi-mediated gene silencing in non-human primates
Zimmermann, T. S., Lee, A. C. H., Akinc, A., Bramlage, B., Bumcrot, D., Fedoruk, M. N., Harborth, J., Heyes, J. A., Jeffs, L. B., John, M., et al. (2006) · Nature
RNA Interference and Gene DeliveryVirus-based gene therapy research
Cited by 1,357
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Endoplasmic reticulum stress signals in the tumour and its microenvironment
Chen, X., & Cubillos-Ruiz, J. R. (2021) · Nature Reviews Cancer
Endoplasmic Reticulum Stress and DiseaseIon Channels and Receptors
Cited by 1,356
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Catalytic in vivo protein knockdown by small-molecule PROTACs
Bondeson, D. P., Mares, A., Smith, I. E. D., Ko, E., Campos, S., Miah, A. H., Mulholland, K. E., Routly, N., Buckley, D. L., Gustafson, J. L., et al. (2015) · Nature Chemical Biology
Protein Degradation and InhibitorsUbiquitin and proteasome pathways
Cited by 1,356
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Transcriptional enhancers: from properties to genome-wide predictions
Shlyueva, D., Stampfel, G., & Stark, A. (2014) · Nature Reviews Genetics
Genomics and Chromatin DynamicsChromatin Remodeling and Cancer
Cited by 1,356
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Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain
Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R. C., Ju, S., Mu, J., Zhang, L., Steinman, L., et al. (2011) · Molecular Therapy
Extracellular vesicles in diseaseNanoparticle-Based Drug Delivery
Cited by 1,356
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Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
Cho, S. W., Kim, S., Kim, Y., Kweon, J., Kim, H. S., Bae, S., & Kim, J.-S. (2014) · Genome Research
CRISPR and Genetic EngineeringRNA regulation and disease
Cited by 1,356
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Supercomplexes in the respiratory chains of yeast and mammalian mitochondria
Schägger, H., & Pfeiffer, K. (2000) · The EMBO Journal
Mitochondrial Function and PathologyATP Synthase and ATPases Research
Cited by 1,356
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Horizontal gene transfer in eukaryotic evolution
Keeling, P. J., & Palmer, J. D. (2008) · Nature Reviews Genetics
Chromosomal and Genetic VariationsProtist diversity and phylogeny
Cited by 1,355
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Effects of protein aggregates: An immunologic perspective
Rosenberg, A. S. (2006) · The AAPS Journal
Protein purification and stabilityBiosimilars and Bioanalytical Methods
Cited by 1,355
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Regorafenib (BAY 73‐4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
Wilhelm, S. M., Dumas, J., Adnane, L., Lynch, M., Carter, C. A., Schütz, G., Thierauch, K., & Zopf, D. (2011) · International Journal of Cancer
Angiogenesis and VEGF in CancerColorectal Cancer Treatments and Studies
Cited by 1,355
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Enzyme promiscuity: A mechanistic and evolutionary perspective
Tawfik, O. K. A. D. S. (2010) · Annual Review of Biochemistry
Protein Structure and DynamicsEvolution and Genetic Dynamics
Cited by 1,355
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TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
Thomas, D. A., & Massagué, J. (2005) · Cancer Cell
TGF-β signaling in diseasesT-cell and B-cell Immunology
Cited by 1,355
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Autophagy maintains stemness by preventing senescence
García-Prat, L., Martínez-Vicente, M., Perdiguero, E., Ortet, L., Rodríguez-Ubreva, J., Rebollo, E., Ruiz-Bonilla, V., Gutarra, S., Ballestar, E., Serrano, A. L., et al. (2016) · Nature
Muscle Physiology and DisordersAutophagy in Disease and Therapy
Cited by 1,355
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Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
Li, Z., Bao, S., Wu, Q., Wang, H., Eyler, C., Sathornsumetee, S., Shi, Q., Cao, Y., Lathia, J., McLendon, R. E., et al. (2009) · Cancer Cell
Cancer, Hypoxia, and MetabolismGlioma Diagnosis and Treatment
Cited by 1,354
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Inflammatory networks during cellular senescence: causes and consequences.
Freund, A., Orjalo, A. V., Desprez, P.-Y., & Campisi, J. (2010) · Trends in Molecular Medicine
Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms
Cited by 1,354
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A Genomic View of the Human- Bacteroides thetaiotaomicron Symbiosis
Xu, J., Bjursell, M. K., Himrod, J., Deng, S., Carmichael, L. K., Chiang, H. C., Hooper, L. V., & Gordon, J. I. (2003) · Science
Gut microbiota and healthBacterial Genetics and Biotechnology
Cited by 1,353
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The role of glutathione-S-transferase in anti-cancer drug resistance
Townsend, D. M., & Tew, K. D. (2003) · Oncogene
Glutathione Transferases and PolymorphismsPharmacogenetics and Drug Metabolism
Cited by 1,353
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Mitochondrial ROS Signaling in Organismal Homeostasis
Shadel, G. S., & Horvath, T. L. (2015) · Cell
Redox biology and oxidative stressMitochondrial Function and Pathology
Cited by 1,353
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Analysis and design of RNA sequencing experiments for identifying isoform regulation
Katz, Y., Wang, E. T., Airoldi, E. M., & Burge, C. B. (2010) · Nature Methods
RNA Research and SplicingGenomics and Phylogenetic Studies
Cited by 1,353
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Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
Lu, A., Magupalli, V. G., Ruan, J., Yin, Q., Atianand, M. K., Vos, M. R., Schröder, G. F., Fitzgerald, K. A., Wu, H., & Egelman, E. H. (2014) · Cell
Inflammasome and immune disordersImmune Response and Inflammation
Cited by 1,353
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HITS-CLIP yields genome-wide insights into brain alternative RNA processing
Licatalosi, D. D., Mele, A., Fak, J. J., Ule, J., Kayikci, M., Chi, S. W., Clark, T. A., Schweitzer, A. C., Blume, J. E., Wang, X., et al. (2008) · Nature
RNA Research and SplicingRNA regulation and disease
Cited by 1,352
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