Cited by 2,499Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsPsychological Testing and Assessment

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Diagnosis of Alzheimer's Disease

Khachaturian, Z. S.·1985·Archives of Neurology

DOI 10.1001/archneur.1985.04060100083029

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Abstract

Early and accurate diagnosis of Alzheimer's disease (AD) has a major impact on the progress of research on dementia. To address the problems involved in diagnosing AD in its earliest stages, the National Institute on Aging, the American Association of Retired Persons, the National Institute of Neurological and Communicative Disorders and Stroke, and the National Institute of Mental Health jointly sponsored a workshop for planning research. The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD. The 37 participants included some of the most knowledgeable and eminent scientists and physicians actively involved in the study of AD. The participants were divided among six panels representing the disciplines of neurochemistry, neuropathology, neuroradiology, neurology, neuropsychology, and psychiatry. Within each of the panels, participants discussed specific areas of research requiring further

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“Alzheimer’s disease (AD) represents a neurodegenerative condition and is the most 2 prevalent form of dementia impacting elderly people [1].”
Early Diagnosis of Alzheimer Disease using GA optimized Transfer Learning Techniques
Sivapatham, S., Baskar, C., Sasithradevi, A., Gupta, S., & Charan, R. (2022) · International Computer Science Conference · doi:10.1109/icsc56524.2022.10009561 · Cited by 3
“Suresha et al. [1] developed a framework based on unsupervised classification for Alzheimer disease detection.”
Background
A multiscale study on photophysical properties of a novel fluorescent probe for imaging amyloid‐ β in Alzheimer's disease
Zhang, Y.-J., Leng, J.-C., & Hu, W. (2020) · International Journal of Quantum Chemistry · doi:10.1002/qua.26344 · Cited by 3
Alteration in the Expression of Alzheimer's-Related Genes in Rat Hippocampus by Exercise and Morphine Treatments
Sasan, H., Gholami, A. S., & Hashemabadi, M. (2019) · The Neuroscience Journal of Shefaye Khatam · doi:10.29252/shefa.7.4.23 · Cited by 3
Bilan de 10ans de consultations mémoire en Franche-Comté : description et analyse de la base de données RAPID
Béreau, M., Sylvestre, G., Mauny, F., Puyraveau, M., Baudier, F., Magnin, É., Berger, É., Vandel, P., Galmiche, J., & Chopard, G. (2015) · doi:10.1016/j.neurol.2015.04.008 · Cited by 3
Synthesis and anticholinesterase activity of (−)-physostigmine analogues with modifications at C3a and C5
Wang, H.-J., Zhang, D., Wang, F.-S., Wu, Y., & Song, H. (2013) · Chemical Research in Chinese Universities · doi:10.1007/s40242-013-3066-y · Cited by 3
Neuropathological Basis of Alzheimer’s Disease and Alzheimer’s Disease Diagnosis
Schneider, J. A., Montine, T. J., Sperling, R. A., & Bennett, D. A. (2012) · Advances in biological psychiatry · doi:10.1159/000335384 · Cited by 4
Emotion and Behavior in Alzheimer's Disease and Other Dementias
Wright, C. I. (2011) · Wiley eBooks · doi:10.1002/9781444344110.ch14 · Cited by 2
Forensic Aspects of Adult and General Neuropathology
Leestma, J. (2008) · CRC Press eBooks · doi:10.1201/9781420008685.ch3 · Cited by 3
Diagnostic challenges of using CSF assay of tau and beta-amyloid(42) in atypical degenerative dementias of the Alzheimer type.
Wagner, M., Teichner, G., & Bachman, D. (2003) · Archives of Clinical Neuropsychology · doi:10.1016/s0887-6177(02)00168-3 · Cited by 3
“…the clinical criteria and histopathologic features that include “high” density of senile plaques composed of the -amyloid peptide and neurofibrillary tangles comprised of the microtubule-associated protein tau (Khachaturian, 1985; McKhann et al., 1984; Wisniewski, Rabe, Zigman, & Silverman, 1989).”
Background
Neuropathology of three clinical cases prospectively diagnosed as dementia with Lewy bodies.
McRitchie, D., Reid, W., Halliday, G., Hely, M., Brooks, W., & Morris, J. G. (1999) · Journal of clinical neuroscience · doi:10.1016/s0967-5868(99)90082-6 · Cited by 3
Rapid and Economical Silver Impregnation Technique to Demonstrate Nerve Fibers, Axons, Neurons, and Senile Plaques and Neurofibrillary Tangles of Alzheimer's Disease
Garvey, W., Bigelow, F., & Carpenter, B. (1999) · doi:10.1179/his.1999.22.1.37 · Cited by 3
15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN
Daniels, A. J., McDade, E., Llibre‐Guerra, J. J., Xiong, C., Perrin, R. J., Ibáñez, L., Supnet‐Bell, C., Cruchaga, C., Goate, A., Renton, A. E., et al. (2026) · npj Dementia · doi:10.1038/s44400-025-00047-7 · Cited by 11
A Fuzzy Cognitive Map-based Framework for Alzheimer’s Disease Diagnosis Using Multimodal Magnetic Resonance Imaging-Positron Emission Tomography Registration
Mahdavi, S. A., Maghooli, K., & Farokhi, F. (2025) · Journal of Medical Signals & Sensors · doi:10.4103/jmss.jmss_3_25 · Cited by 2
Presenilin 1 hemizygosity has no overt deleterious phenotypic outcomes in sheep: Potential implications for therapeutic targets in Alzheimer's disease
Mckean, N. E., Li, J., Rudiger, S. R., Kelly, J. M., McLaughlan, C. J., Verma, P. J., Hardy, J., Gusella, J. F., Zetterberg, H., Reid, S. J., et al. (2025) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2025.04.006 · Cited by 2
“Alzheimer ’ s disease (AD) is a late onset neurodegenerative condition, clinically characterised by progressive memory loss and cognitive decline leading to early death (Khachaturian, 1985).”
Perspective: Emerging challenges for a future ADNI
Khachaturian, Z., Carrillo, M. C., & Khachaturian, A. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.14534 · Cited by 2
Self-citation
A multi-target multi-task approach based on correlated multiple cognitive scores for AD progression prediction
Fan, X., Zhou, M.-H., Qi, J., Yang, Y., & Yang, P. (2024) · IEEE International Joint Conference on Neural Network · doi:10.1109/ijcnn60899.2024.10650319 · Cited by 2
Association of GLOD4 with Alzheimer’s Disease in Humans and Mice
Utyro, O., Włoczkowska-Łapińska, O., & Jakubowski, H. (2024) · bioRxiv · doi:10.1101/2024.06.07.597934 · Cited by 2
“…at autopsy by the Case Western Reserve University Brain Bank under an IRB-approved protocol, from clinically and pathologically confirmed cases of AD (n = 6) using criteria set up by the National Institute of Aging (NIA) and Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) [21].”
Method
Gini Based Learning for the Classification of Alzheimer's Disease and Features Identification with Automatic RGB Segmentation Algorithm
Karaca, Y., Moonis, M., Siddiqi, A. H., & Turan, B. (2018) · Communication Systems and Applications · doi:10.1007/978-3-319-95165-2_7 · Cited by 2

Authors: Khachaturian, Z. S.
Corresponding author: Khachaturian, Z. S.
Venue: Archives of Neurology
Publisher: American Medical Association (AMA)
Published: 1985-11-01
Volume: 42
Issue: 11
Pages: 1097-1105
ISSN: 0003-9942 (ISSN-L)
DOI: 10.1001/archneur.1985.04060100083029
OpenAlex: W2171405125
Cited by: 2,499
References: 10
Citations by year: 2026: 10 · 2025: 27 · 2024: 26 · 2023: 31 · 2022: 38 · 2021: 46 · 2020: 43 · 2019: 35 · 2018: 29 · 2017: 27 · 2016: 36 · 2015: 27 · 2014: 41 · 2013: 34 · 2012: 41
FWCI: 40.91
Type: journal article
Language: en
Open access: closed
Locations: Archives of Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
Keywords: Alzheimer's disease, early diagnosis, dementia, neurochemistry, neuropathology, neuroradiology, neuropsychology
MeSH terms: Alzheimer Disease, Humans

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