Cited by 2,499Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsPsychological Testing and Assessment

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Diagnosis of Alzheimer's Disease

Khachaturian, Z. S.·1985·Archives of Neurology

DOI 10.1001/archneur.1985.04060100083029

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Abstract

Early and accurate diagnosis of Alzheimer's disease (AD) has a major impact on the progress of research on dementia. To address the problems involved in diagnosing AD in its earliest stages, the National Institute on Aging, the American Association of Retired Persons, the National Institute of Neurological and Communicative Disorders and Stroke, and the National Institute of Mental Health jointly sponsored a workshop for planning research. The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD. The 37 participants included some of the most knowledgeable and eminent scientists and physicians actively involved in the study of AD. The participants were divided among six panels representing the disciplines of neurochemistry, neuropathology, neuroradiology, neurology, neuropsychology, and psychiatry. Within each of the panels, participants discussed specific areas of research requiring further

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La Lunga Attesa : Towards a Molecular Approach to Neuroimaging and Therapeutics in Alzheimer's Disease
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Alzheimer movement re-examined 25 years later: is it a "disease" or a senile condition in medical nature?
Chen, M., & Fernandez, H. L. (2001) · Frontiers in Bioscience · doi:10.2741/a694 · Cited by 12
“It is clinically diagnosed mainly by excluding apparent causes and it is the only type of dementia that threats the society today and will in the future, but its origins remain a mystery (Table 1)(1, 28, 32).”
BackgroundInfluential
Hallazgos neuropatológicos en la enfermedad de Alzheimer de inicio temprano (mutación E280A-PS1)
Castaño, A. D., Roldán, M., Viana, J. C. A., Arcos‐Burgos, M., Cubillo, H., & Restrepo, F. L. (1999) · Revista de Neurología · doi:10.33588/rn.2901.99122 · Cited by 11
Production of paired helical filament, tau-like proteins by PC12 cells: A model of neurofibrillary degeneration
Bondareff, W., Matsuyama, S. S., & Dell’Albani, P. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980601)52:5 · Cited by 11
Cholinergic deficiency in Alzheimer's disease. Pathogenic model.
Schneider, L. S. (1998) · The American journal of geriatric psychiatry · doi:10.1097/00019442-199821001-00007 · Cited by 12
The olfactory bulb in Alzheimer’s disease
Kovács, I., Török, I., Zombori, J., & Yamaguchi, H. (1998) · Acta Biologica Hungarica · doi:10.1007/bf03542975 · Cited by 4
Discontinuous distribution of senile plaques within striate cortex hypercolumns in Alzheimer's disease
Kuljiš, R. O., & Tikoo, R. K. (1997) · Vision Research · doi:10.1016/s0042-6989(96)00177-0 · Cited by 13
Multiscale detection and analysis of the senile plaques of Alzheimer's disease
Hibbard, L., & McKeel, D. (1995) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.476130 · Cited by 12
Presence of neuronal proteins in serially cultured cells from autopsy human brain.
Blass, J., Markesbery, W., Ko, L., DeGiorgio, L., Sheu, K. R., & Darżynkiewicz, Z. (1994) · Journal of Neurological Sciences · doi:10.1016/0022-510x(94)90341-7 · Cited by 12
Noncanonical regulation of imprinted gene Igf2 by amyloid-beta 1–42 in Alzheimer’s disease
Fertan, E., Gendron, W. A. C., Wong, A. A., Hanson, G. M., Brown, R. E., & Weaver, I. C. G. (2023) · Scientific Reports · doi:10.1038/s41598-023-29248-x · Cited by 15
PyrPeg, a Blood–Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates
Choi, J.-W., Ju, Y. H., Choi, Y., Hyeon, S. J., Gadhe, C. G., Park, J., Kim, M. S., Baek, S., Kim, Y. S., Park, K. D., et al. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00211 · Cited by 23
D10S1423 identifies a susceptibility locus for Alzheimer's disease (AD7) in a prospective, longitudinal, double‐blind study of asymptomatic individuals: Results at 14 years
Zubenko, G. S., Hughes, H. B., & Zubenko, W. N. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31017 · Cited by 11
“Autopsies were performed by board-certified neuropathologists and neuropathologic diagnoses were made according to generally accepted criteria [Tomlinson and Corsellis, 1984; Khachaturian, 1985; Mirra et al., 1991].”
BackgroundMethod
Incipient Alzheimer's Disease as the Underlying Cause of a Motor Vehicle Crash
Kibayashi, K., & Shojo, H. (2002) · Medicine, Science and the Law · doi:10.1177/002580240204200307 · Cited by 11
“In our case, the brain of the patient showed no gross abnormalities, but the number of SP fulfilled two histopathological criteria that are widely used for the diagnosis of AD (Khachaturian, 1985; Mirra et al., 1991).”
BackgroundMethod
Establishing the limits of normal cerebral ageing and senile dementias
Ritchie, K. (1998) · British Journal of Psychiatry · doi:10.1192/bjp.173.2.97 · Cited by 11
“Internationally accepted neuropathological criteria for Alzheimer's disease provide age-adjusted threshold levels for plaques and tangles in specific parts of the brain based on density alone (Khachaturian, 1985).”
Background
Computed detection and quantitative morphometry of Alzheimer senile plaques.
Hibbard, L., Arnicar-Sulze, T. L., McKeel, D., & Burrell, L. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90128-7 · Cited by 11
The Role of Aβ and Tau Oligomers in the Pathogenesis of Alzheimer’s Disease
Bhaskar, K., & Lamb, B. T. (2011) · Springer eBooks · doi:10.1007/978-94-007-2774-8_5 · Cited by 8
Revisiting Alzheimer's Disease from a New Perspective: Can “Risk Factors” Play a Key Role?
Chen, M., & Fernández, H. L. (2000) · Journal of Alzheimer s Disease · doi:10.3233/jad-2000-2206 · Cited by 10
Gap-43 message levels in anterior cerebellum in Alzheimer's disease
Cheetham, J., Martzen, M. R., Kazee, A. M., & Coleman, P. D. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00257-s · Cited by 9
Anomalous binding of radiolabeled oligonucleotide probes to plaques and tangles in Alzheimer disease hippocampus.
Pardue, S., White, C. L., Bigio, E., & Morrison-Bogorad, M. (1994) · Molecular and Chemical Neuropathology · doi:10.1007/bf03160091 · Cited by 10
“and neocortex. These criteria included the clinical history and age of the patient, as defined by the criteria of the Research Workshop on the Diagnosis of Alzheimer's Disease ( Khachaturian, 1985 ), and the studies of Tomlinson et al. (1970).”
Method
Incidence and Distribution of Senile Plaques and Neurofibrillary Tangles in Late‐onset Diffuse Lewy Body Disease
Odawara, T., Iseki, E., Kosaka, K., Haga, C., & Ikeda, K. (1994) · doi:10.1111/j.1440-1789.1994.tb00237.x · Cited by 10
Analysis of staining methods for different cortical plaques in Alzheimer's disease
Halliday, G., Flowers, D., & Baum, L. (1994) · Acta Neuropathologica · doi:10.1007/bf00296188 · Cited by 10

Authors: Khachaturian, Z. S.
Corresponding author: Khachaturian, Z. S.
Venue: Archives of Neurology
Publisher: American Medical Association (AMA)
Published: 1985-11-01
Volume: 42
Issue: 11
Pages: 1097-1105
ISSN: 0003-9942 (ISSN-L)
DOI: 10.1001/archneur.1985.04060100083029
OpenAlex: W2171405125
Cited by: 2,499
References: 10
Citations by year: 2026: 10 · 2025: 27 · 2024: 26 · 2023: 31 · 2022: 38 · 2021: 46 · 2020: 43 · 2019: 35 · 2018: 29 · 2017: 27 · 2016: 36 · 2015: 27 · 2014: 41 · 2013: 34 · 2012: 41
FWCI: 40.91
Type: journal article
Language: en
Open access: closed
Locations: Archives of Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
Keywords: Alzheimer's disease, early diagnosis, dementia, neurochemistry, neuropathology, neuroradiology, neuropsychology
MeSH terms: Alzheimer Disease, Humans

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