Cited by 2,499Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsPsychological Testing and Assessment

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Diagnosis of Alzheimer's Disease

Khachaturian, Z. S.·1985·Archives of Neurology

DOI 10.1001/archneur.1985.04060100083029

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Abstract

Early and accurate diagnosis of Alzheimer's disease (AD) has a major impact on the progress of research on dementia. To address the problems involved in diagnosing AD in its earliest stages, the National Institute on Aging, the American Association of Retired Persons, the National Institute of Neurological and Communicative Disorders and Stroke, and the National Institute of Mental Health jointly sponsored a workshop for planning research. The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD. The 37 participants included some of the most knowledgeable and eminent scientists and physicians actively involved in the study of AD. The participants were divided among six panels representing the disciplines of neurochemistry, neuropathology, neuroradiology, neurology, neuropsychology, and psychiatry. Within each of the panels, participants discussed specific areas of research requiring further

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Armstrong, R., Kotzbauer, P. T., Perlmutter, J., Campbell, M. C., Hurth, K., Schmidt, R., & Cairns, N. (2013) · Journal of neural transmission · doi:10.1007/s00702-013-1084-z · Cited by 44
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Method
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Leduc, V., Legault, V., Dea, D., & Poirier, J. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.05.026 · Cited by 46
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Method
Isolated Executive Impairment and Associated Frontal Neuropathology
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“The postmortem interval was 19.5 ± 4.2 h. Neuropathological examination used standardized protocols [17, 18] and included the following criteria: NIA [ 20 , 36]; CERAD [28]; staging of neuritic plaques [3] and the recent NIA-RI classification [16].”
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Amyloid β‐protein deposition in the leptomeninges and cerebral cortex
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Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?
Castellani, R. J., Zhu, X., Lee, H., Moreira, P. I., Perry, G. L., & Smith, M. A. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.5.473 · Cited by 42
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BackgroundMethodResultInfluential
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Payão, S., Smith, M. D. A. C., Winter, L. M. F., & Bertolucci, P. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00095-5 · Cited by 42
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Cornett, C., Ehmann, W., Wekstein, D., & Markesbery, W. (1998) · Biological Trace Element Research · doi:10.1007/bf02820026 · Cited by 42
Microglial reaction in Pick's disease
Paulus, W., Bancher, C., & Jellinger, K. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90147-d · Cited by 42
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Kapasi, A., Poirier, J., Hedayat, A., Scherlek, A. A., Mondal, S., Wu, T., Gibbons, J., Barnes, L. L., Bennett, D. A., Leurgans, S. E., et al. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad086 · Cited by 48
Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer’s disease
Torreilles, F., & Touchon, J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00030-2 · Cited by 39
Inverse relation between Braak stage and cerebrovascular pathology in Alzheimer predominant dementia
Jellinger, K. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.6.799a · Cited by 41
Widespread deficits in somatostatin but not neuropeptide Y concentrations in Alzheimer's disease cerebral cortex
Gabriel, S. M., Bierer, L. M., Harotunian, V., Purohit, D. P., Perl, D. P., & Davis, K. L. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90686-f · Cited by 37
Diabetes and overweight associate with non‐APOE4 genotype in an alzheimer's disease population
Profenno, L. A., & Faraone, S. V. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30694 · Cited by 39
“In cases where brain autopsy was performed, Khachaturian criteria [Khachaturian, 1985] were used to assess pathological changes consistent with AD or other disorders.”
Method
Neuropathology of Alzheimer's Disease
Mott, R. T., & Hulette, C. M. (2005) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2005.09.003 · Cited by 71
Leukoencephalopathy with cerebral amyloid angiopathy: a semiquantitative and morphometric study
Imaoka, K., Kobayashi, S., Fujihara, S., Shimode, K., & Nagasaki, M. (1999) · Journal of Neurology · doi:10.1007/s004150050428 · Cited by 40
Strategies for Improving the Postmortem Neuropathological Diagnosis of Alzheimer’s Disease
Trojanowski, J. Q., Clark, C. M., Schmidt, M. L., Arnold, S. E., & LEE, V. M. ‐. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00075-4 · Cited by 39
Expression of activating transcription factor-2 (ATF-2), one of the cyclic AMP response element (CRE) binding proteins, in Alzheimer disease and non-neurological brain tissues.
Yamada, T., Yoshiyama, Y., & Kawaguchi, N. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01356-x · Cited by 40
Immunohistochemistry with an antibody to human liver carboxylesterase in human brain tissues.
Yamada, T., Hosokawa, M., Satoh, T., Moroo, I., Takahashi, M., Akatsu, H., & Yamamoto, T. (1994) · Brain Research · doi:10.1016/s0006-8993(09)90022-1 · Cited by 40
Blood markers in Alzheimer disease: Subnormal acetylcholinesterase and butyrylcholinesterase in lymphocytes and erythrocytes
Inestrosa, N. C., Alarcón, R., Arriagada, J., Donoso, A., Alvarez, J., & Campos, E. O. (1994) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(94)90044-2 · Cited by 40
Endothelin-1 is Elevated in Alzheimer's Disease Brain Microvessels and is Neuroprotective
Luo, J., & Grammas, P. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091486 · Cited by 39
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Is pathological aging a successful resistance against amyloid-beta or preclinical Alzheimer’s disease?
Murray, M., & Dickson, D. (2014) · Alzheimer's Research & Therapy · doi:10.1186/alzrt254 · Cited by 39
Accidental Fatal Hypothermia in Elderly People with Alzheimer's Disease
Kibayashi, K., & Shojo, H. (2003) · Medicine, Science and the Law · doi:10.1258/rsmmsl.43.2.127 · Cited by 39
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BackgroundMethod
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Zhang, W.-W., Lempessi, H., & Olsson, Y. (1998) · Acta Neuropathologica · doi:10.1007/s004010050935 · Cited by 39
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Janke, C., Holzer, M., Klose, J., & Arendt, T. (1996) · FEBS Letters · doi:10.1016/0014-5793(95)01522-1 · Cited by 39
Amyloid beta protein (25–35) stimulation of phospholipases A, C and D activities of LA‐N‐2 cells
Singh, I., McCartney, D., & Kanfer, J. N. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00432-9 · Cited by 39
The noncognitive features of dementia
Allen, N., & Burns, A. (1995) · Reviews in Clinical Gerontology · doi:10.1017/s0959259800003981 · Cited by 39
Apolipoprotein-E ε-4 is associated with increased neurofibrillary pathology in the Lewy body variant of Alzheimer's disease
Hansen, L., Galasko, D., Samuel, W., Xia, Y., Chen, X., & Saitoh, T. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90206-2 · Cited by 39
Degenerative changes in epinephrine tonic vasomotor neurons in Alzheimer's disease.
Burke, W., Galvin, N., Chung, H., Stoff, S. A., Gillespie, K., Cataldo, A., & Nixon, R. (1994) · Brain Research · doi:10.1016/0006-8993(94)91177-0 · Cited by 39
Cellular specificity and regional distribution of amyloid β protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation
Tanzi, R. E., Wenniger, J. J., & Hyman, B. T. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90196-v · Cited by 37
Fuzzy-VGG: A fast deep learning method for predicting the staging of Alzheimer's disease based on brain MRI
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BackgroundMethodInfluential
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“AD is pathologically characterized by the presence of abnormally large numbers of neuritic plaques and neurofibrillary tangles [”
Background
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Chen, J.-T., Wang, M., Ruan, D.-Y., & She, J.-Q. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00138-0 · Cited by 38
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Smith, M. A., & Perry, G. L. (1998) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(98)00061-1 · Cited by 36
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Jin, L.-W., Masliah, E., Iimoto, D., Deteresa, R., Mallory, M., Sundsmo, M., Mori, N., Sobel, A., & Saitoh, T. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00021-8 · Cited by 38
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Chen, X., Xia, Y., Alford, M. F., DeTeresa, R. M., Hansen, L. A., Klauber, M. R., Katzman, R., Thal, L. J., Masliah, E., & Saitoh, T. (1995) · Annals of Neurology · doi:10.1002/ana.410380415 · Cited by 35
Differential alterations in adenosine A1 and kappa 1 opioid receptors in the striatum in Alzheimer's disease.
Ikeda, M., Mackay, K. B., Dewar, D., & Mcculloch, J. (1993) · Brain Research · doi:10.1016/0006-8993(93)90211-5 · Cited by 38
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Tian, X., Liu, Y., Wang, L., Zeng, X., Huang, Y.-L., & Wang, Z. (2023) · Comput. Methods Programs Biomed. · doi:10.1016/j.cmpb.2023.107597 · Cited by 37
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“Alzheimer’s disease (AD) is the most prevalent dementia accompanied by neurodegenerative disorder, memory loss, and abnormal behavioral (Hardy and Higgins 1992; Khachaturian 1985).”
Background
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Fang, W.-K., Liu, L. L., Zhang, L., Liu, D., Liu, Y., & Tang, H. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c02679 · Cited by 44
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A Luminescence Turn-On Assay for Acetylcholinesterase Activity and Inhibitor Screening Based on Supramolecular Self-Assembly of Alkynylplatinum(II) Complexes on Coordination Polymer.
Law, A. S.-Y., Yeung, M., & Yam, V. (2019) · ACS Applied Materials and Interfaces · doi:10.1021/acsami.8b18739 · Cited by 36
Modeling Alzheimer's disease cognitive scores using multi-task sparse group lasso
Liu, X., Gonçalves, A. R., Cao, P., Zhao, D., & Banerjee, A. (2017) · Computerized Medical Imaging and Graphics · doi:10.1016/j.compmedimag.2017.11.001 · Cited by 42
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Background
High‐resolution localization of clathrin assembly protein AP180 in the presynaptic terminals of mammalian neurons
Yao, P. J., Coleman, P., & Calkins, D. J. (2002) · The Journal of comparative neurology · doi:10.1002/cne.10217 · Cited by 36
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Head, E., & Torp, R. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0476 · Cited by 32
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Neurons in Alzheimer disease emerge from senescence
Raina, A. K., Pardo, P. S., Rottkamp, C. A., Zhu, X., Pereira‐Smith, O. M., & Smith, M. A. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00333-5 · Cited by 34
Classification learning in Alzheimer's disease.
Kéri, S., Kálmán, J., Rapcsak, S., Antal, A., Benedek, G., & Janka, Z. (1999) · Brain : a journal of neurology · doi:10.1093/brain/122.6.1063 · Cited by 36
Rate of progression of Alzheimer's disease is associated with genetic risk.
Farrer, L., Cupples, L., van Duijn, C. M., Connor-Lacke, L., Kiely, D. K., & Growdon, J. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540330100021 · Cited by 36
Protective effect of the APOE-e3 allele in Alzheimer’s disease
de-Almada, B. V. P., de-Almeida, L. D., Camporez, D., DeMoraes, M., Morelato, R. L., Perrone, A. M. S., Belcavello, L., Louro, I. D., & de-Paula, F. (2011) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2011007500151 · Cited by 43
Herpes simplex virus and risk of Alzheimer's disease.
Itabashi, S., Arai, H., Matsui, T., Higuchi, S., & Sasaki, H. (1997) · The Lancet · doi:10.1016/s0140-6736(05)62325-2 · Cited by 35
Soluble and membrane-bound forms of brain acetylcholinesterase in Alzheimer's disease.
Schegg, K., Harrington, L., Neilsen, S., Zweig, R., & Peacock, J. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90092-c · Cited by 35
Neuronal degeneration in human diseases and animal models
Price, D. L., Martin, L. J., Clatterbuck, R. E., Koliatsos, V. E., Sisodia, S. S., Walker, L. C., & Cork, L. C. (1992) · Journal of Neurobiology · doi:10.1002/neu.480230916 · Cited by 34
Ursolic acid ameliorates amyloid β-induced pathological symptoms in Caenorhabditis elegans by activating the proteasome
Wang, N., Wang, E., Wang, R., Muhammad, F., Li, T., Yue, J., Zhou, Y., Zhi, D., & Li, H. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.12.004 · Cited by 40
Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer’s Disease
Rombouts, F. J. R., Andrés, J.-I., Ariza, M., Alonso, J. M., Austin, N. E., Bottelbergs, A., Chen, L., Chupakhin, V., Cleiren, E., Fierens, K., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01173 · Cited by 42
Distribution, levels and phosphorylation of Raf‐1 in Alzheimer's disease
Mei, M., Su, B., Harrison, K. H., Chao, M. P., Siedlak, S., Previll, L. A., Jackson, L., Cai, D., & Zhu, X.-W. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04174.x · Cited by 34
“All cases were characterized based on clinical and pathological criteria established by CERAD and an NIA consensus panel (Khachaturian 1985; Mirra et al. 1991).”
Method
Heme from Alzheimer's brain inhibits muscarinic receptor binding via thiyl radical generation1An abstract of some of these findings was published in Mol. Biol. Cell, 7:S (1996) #3765.1
Venters, H., Bonilla, L., Jensen, T., Garner, H. P., Bordayo, E. Z., Najarian, M., Ala, T., Mason, R., & Frey, W. H., II (1997) · doi:10.1016/s0006-8993(97)00425-3 · Cited by 34
Decreased protein synthetic activity of the hypothalamic tuberomamillary nucleus in Alzheimer's disease as suggested by smaller Golgi apparatus.
Salehi, A., Heyn, S., Gonatas, N., & Swaab, D. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11659-k · Cited by 34
Glucocorticoid receptor mRNA in Alzheimer's diseased hippocampus
Wetzel, D. M., Bohn, M. C., Kazee, A. M., & Hamill, R. W. (1995) · Brain Research · doi:10.1016/0006-8993(95)00230-n · Cited by 29
Exploring the differences between mouse mAβ1–42 and human hAβ1–42 for Alzheimer's disease related properties and neuronal cytotoxicity
Lv, X., Li, W., Luo, Y., Wang, D., Zhu, C., Huang, Z., & Tan, X. (2013) · Chemical Communications · doi:10.1039/c3cc40779a · Cited by 33
Association of interleukin 1β polymorphisms and haplotypes with Alzheimer's disease
Payão, S. L. M., Gonçalves, G. M., de Lábio, R. W., Horiguchi, L., Mizumoto, I., Rasmussen, L. T., Pinhel, M. A. D. S., Souza, D. R. S., Bechara, M. D., Chen, E., et al. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.03.012 · Cited by 34
“Sporadic cases frequently present late-onset disease whereas familial cases usually show early-onset disease (Khachaturian, 1985; Kay, 1986).”
Characterization of the Alzheimer's Disease-associated CLAC Protein and Identification of an Amyloid β-Peptide-binding Site
Söderberg, L., Kakuyama, H., Möller, A., Itô, A., Winblad, B. G., Tjernberg, L. O., & Näslund, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403628200 · Cited by 36
Increased Total 7α-Hydroxy-Dehydroepiandrosterone in Serum of Patients With Alzheimer's Disease
Attal-Khémis, S., Dalmeyda, V., Michot, J., Roudier, M., & Morfin, R. (1998) · The Journals of Gerontology Series A · doi:10.1093/gerona/53a.2.b125 · Cited by 33
“This process may occur in brains of AD patients where depositions of senile plaques (43) containing major quantities of B-amyloid protein were described (44,45).”
Background
Serum Protein Leakage in Alzheimer's Disease Revisited
Munoz, D. G., Erkinjuntti, T., GAYTAN‐GARCIA, S., & Hachinski, V. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48469.x · Cited by 33
Amyloid β-protein ending at Thr43 is a minor component of some diffuse plaques in the Alzheimer's disease brain, but is not found in cerebrovascular amyloid
Iizuka, T., Shoji, M., Harigaya, Y., Kawarabayashi, T., Watanabe, M., Kanai, M., & Hirai, S. (1995) · Brain Research · doi:10.1016/0006-8993(95)01163-2 · Cited by 33
Cytoskeletal Neurofilament Gene Expression in Brain Tissue from Alzheimer's Disease Patients. I. Decrease in NF-L and NF-M Message
Kittur, S., Hoh, J., Endo, H., Tourtellotte, W., Weeks, B., Markesbery, W., & Adler, W. H. (1994) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879400700305 · Cited by 33
Clinicopathological Studies of the Dementias from an Epidemiological Viewpoint
Brayne, C. (1993) · The British Journal of Psychiatry · doi:10.1192/bjp.162.4.439 · Cited by 29
What is Alzheimer's disease? An analysis of nosological perspectives from the 20th and 21st centuries
Villain, N., & Michalon, R. (2024) · European Journal of Neurology · doi:10.1111/ene.16302 · Cited by 43
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Yu, N.-Y., & Chang, S.-H. (2016) · doi:10.1007/s40846-016-0143-y · Cited by 32
Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities
Zhan, Z., Bian, H.-L., Wang, J., & Shan, W. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.01.097 · Cited by 38
Stimulation of β-amyloid precursor protein α-processing by phorbol ester involves calcium and calpain activation
Chen, M., & Fernández, H. (2004) · doi:10.1016/j.bbrc.2004.02.052 · Cited by 32
“Plaques and tangles are the only diagnostic markers to distinguish Alzheimer’s disease from other types of dementia [1], so elucidating the mechanisms of plaque and tangle formation is critical for understanding the disease origins.”
Background
Neuropsychological functioning in elderly patients with schizophrenia and Alzheimer's disease
McBride, T. C., Moberg, P. J., Arnold, S. E., Mozley, L. H., Mahr, R. N., Gibney, M., Kumar, A. A., & Gur, R. E. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00232-8 · Cited by 33
Gene identification in Alzheimer’s disease
Saunders, A. M. (2001) · Pharmacogenomics · doi:10.1517/14622416.2.3.239 · Cited by 30
Tau immunoreactivity and SDS solubility of two populations of paired helical filaments that differ in morphology.
Księżak-Reding, H., Morgan, K., & Dickson, D. (1994) · Brain Research · doi:10.1016/0006-8993(94)91063-4 · Cited by 32
Evidence that transmitter-containing dystrophic neurites precede those containing paired helical filaments within senile plaques in the entorhinal cortex of nondemented elderly and Alzheimer's disease patients
Benzing, W. C., Brady, D. R., Mufson, E. J., & Armstrong, D. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91595-j · Cited by 33
Perisomatic sprouts immunoreactive for nerve growth factor receptor and neurofibrillary degeneration affect different neuronal populations in the basal nucleus in patients with Alzheimer's disease
Arendt, T., & Brückner, M. K. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90805-h · Cited by 32
β-Amyloid-acetylcholine molecular interaction: new role of cholinergic mediators in anti-Alzheimer therapy?
Grimaldi, M., Marino, S. D., Florenzano, F., Ciotta, M., Nori, S., Rodriquez, M., Sorrentino, G., D'Ursi, A., & Scrima, M. (2016) · Future Medicinal Chemistry · doi:10.4155/fmc-2016-0006 · Cited by 31
Expression, purification, and characterization of recombinant human β-amyloid42 peptide in Escherichia coli
Zhang, L., Yu, H., Song, C., Lin, X., Chen, B., Tan, C., Cao, G.-X., & Wang, Z. (2008) · Protein Expression and Purification · doi:10.1016/j.pep.2008.10.007 · Cited by 29
HORMONE REPLACEMENT THERAPY AND OTHER POTENTIAL TREATMENTS FOR DEMENTIAS
McBee, W. L., Dailey, M. E., Dugan, E., & Shumaker, S. A. (1997) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70250-4 · Cited by 28
Emerging drugs for alzheimer’s disease: Mechanisms of Action and Prospects for Cognitive Enhancing Medications
Schneider, L. S. S., & Tariot, P. N. (1994) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30142-0 · Cited by 34
Frequency analysis of catecholamine axonal morphology in human brain. II: Alzheimer's disease and hippocampal sympathetic ingrowth
Booze, R., Mactutus, C., Gutman, C. R., & Davis, J. N. (1993) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(93)90198-8 · Cited by 31
“Independent neuropathological examinations of brain tissue from these subjects, conducted according to established criteria (Khachaturian 1985; Terry et al. 1981), confirmed the established clinical diagnosis of Alzheimer's disease.”
Alterations in the activity of adenylate cyclase and high affinity GTPase in Alzheimer's disease.
Ross, B., Mclaughlin, M., Roberts, M. J., Milligan, G., Mcculloch, J., & Knowler, J. (1993) · Brain Research · doi:10.1016/0006-8993(93)90798-r · Cited by 31
Controversial Past, Splendid Present, Unpredictable Future: A Brief Review of Alzheimer Disease History
Bermejo‐Pareja, F., & del Ser, T. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020536 · Cited by 39
A Machine Learning Approach to Identify a Circulating MicroRNA Signature for Alzheimer Disease
Zhao, X., Kang, J. J., Svetnik, V., Warden, D. R., Wilcock, G. K., Smith, A. D., Savage, M. J., & Laterza, O. (2019) · The Journal of Applied Laboratory Medicine · doi:10.1373/jalm.2019.029595 · Cited by 30
Receptor-based pharmacophore modeling, virtual screening, and molecular docking studies for the discovery of novel GSK-3β inhibitors
Kerdawy, A. M. E., Osman, A. A., & Zaater, M. A. (2019) · Journal of Molecular Modeling · doi:10.1007/s00894-019-4032-5 · Cited by 37
Monitoring disease progression in mild cognitive impairment: Associations between atrophy patterns, cognition, APOE and amyloid
Falahati, F., Ferreira, D., Muehlboeck, J.-S., Eriksdotter, M., Simmons, A., Wahlund, L., & Westman, E. (2017) · NeuroImage: Clinical · doi:10.1016/j.nicl.2017.08.014 · Cited by 30
“While the definitive AD diagnosis requires postmortem autopsy-confirmed existence of amyloid plaques and neurofibrillary tangles in the brain tissue (Khachaturian, 1985; Markesbery, 1997), the diagnosis of possible or probable AD is based on clinical signs and symptoms.”
TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease.
Reid, S., van Roon-Mom, W. V., Wood, P. C., Rees, M., Owen, M., Faull, R., Dragunow, M., & Snell, R. (2004) · Brain Research. Molecular Brain Research · doi:10.1016/j.molbrainres.2004.03.018 · Cited by 30
Environmental Effects on the Assessment of People With Dementia: A Pilot Study
Hoppes, S., Davis, L. A., & Thompson, D. (2003) · American Journal of Occupational Therapy · doi:10.5014/ajot.57.4.396 · Cited by 30
Severe pathological changes of parabrachial nucleus in Alzheimer's disease
Parvizi, J., van Hoesen, G. V., & Damasio, A. (1998) · NeuroReport · doi:10.1097/00001756-199812210-00028 · Cited by 30

Authors: Khachaturian, Z. S.
Corresponding author: Khachaturian, Z. S.
Venue: Archives of Neurology
Publisher: American Medical Association (AMA)
Published: 1985-11-01
Volume: 42
Issue: 11
Pages: 1097-1105
ISSN: 0003-9942 (ISSN-L)
DOI: 10.1001/archneur.1985.04060100083029
OpenAlex: W2171405125
Cited by: 2,499
References: 10
Citations by year: 2026: 10 · 2025: 27 · 2024: 26 · 2023: 31 · 2022: 38 · 2021: 46 · 2020: 43 · 2019: 35 · 2018: 29 · 2017: 27 · 2016: 36 · 2015: 27 · 2014: 41 · 2013: 34 · 2012: 41
FWCI: 40.91
Type: journal article
Language: en
Open access: closed
Locations: Archives of Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
Keywords: Alzheimer's disease, early diagnosis, dementia, neurochemistry, neuropathology, neuroradiology, neuropsychology
MeSH terms: Alzheimer Disease, Humans

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