Cited by 2,499Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsPsychological Testing and Assessment

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Diagnosis of Alzheimer's Disease

Khachaturian, Z. S.·1985·Archives of Neurology

DOI 10.1001/archneur.1985.04060100083029

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Abstract

Early and accurate diagnosis of Alzheimer's disease (AD) has a major impact on the progress of research on dementia. To address the problems involved in diagnosing AD in its earliest stages, the National Institute on Aging, the American Association of Retired Persons, the National Institute of Neurological and Communicative Disorders and Stroke, and the National Institute of Mental Health jointly sponsored a workshop for planning research. The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD. The 37 participants included some of the most knowledgeable and eminent scientists and physicians actively involved in the study of AD. The participants were divided among six panels representing the disciplines of neurochemistry, neuropathology, neuroradiology, neurology, neuropsychology, and psychiatry. Within each of the panels, participants discussed specific areas of research requiring further

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Method
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BackgroundMethod
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“These stages accompany different clinical aspects [3, 8]. The first two stages have never been found in association with clinical symptoms characteristic of AD, whereas stages 5 and 6 invariably meet the proposed histological diagnosis criteria of Khatchaturian [ 20 ] or Tierney et al. [38].”
BackgroundInfluential
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Method
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Method
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“The characteristic distribution and density of these lesions are used by pathologists for diagnosis of AD (Hyman et al., 2012; Hyman & Trojanowski, 1997; Khachaturian, 1985; Mirra et al., 1993; Montine et al., 2012).”
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Brain Endothelial Cells Synthesize Neurotoxic Thrombin in Alzheimer’s Disease
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“Alzheimer’s disease (AD) is associated with progressive cognitive decline and the accumulation of senile plaque (SP) and neurofibrillary tangle (NFT) neuropathology (Khachaturian, 1985; Mirra et al., 1991).”
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ALZHEIMER'S DISEASE, DENTAL AMALGAM AND MERCURY
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Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites.
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Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study
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Modeling the time-course of Alzheimer dementia
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The complexities of the pathology–pathogenesis relationship in Alzheimer disease
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Background
Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals.
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A critical analysis of the ‘amyloid cascade hypothesis’
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Positron Emission Tomography Radiopharmaceuticals for Imaging Brain Beta-Amyloid
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Levels of mRNAs encoding synaptic vesicle and synaptic plasma membrane proteins in the temporal cortex of elderly schizophrenic patients.
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Neuropeptide deficits in schizophrenia vs. Alzheimer's disease cerebral cortex
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Traumatic brain injury as a risk factor for Alzheimer disease. Comparison of two retrospective autopsy cohorts with evaluation of ApoE genotype
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The Role of ERK1/2 Pathway in the Pathophysiology of Alzheimer’s Disease: An Overview and Update on New Developments
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“Alzheimer’s disease (AD), the most common cause of dementia, is a neurodegenerative disease characterized by neuronal loss and cognitive decline (Khachaturian 1985).”
Background
A brief history of “Alzheimer disease”
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Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?
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“5 h), confirmed histopathologically at autopsy with NINCDS and CERAD criteria [26,27], along with 9 control cases (ages 44–86 years, mean 5 68 years; PMI 4–21 h, mean 5 11 h including 4 cases with a PMI of 5 h or less) were selected for study.”
Method
Neuropathologic assessment of participants in two multi‐center longitudinal observational studies: The Alzheimer Disease Neuroimaging Initiative (ADNI) and the Dominantly Inherited Alzheimer Network (DIAN)
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A quantitative study of neurofibrillary tangles, senile plaques and astrocytes in the hippocampal subdivisions and entorhinal cortex in Alzheimer's disease, normal controls and non‐Alzheimer neuropsychiatric diseases
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Selective cortical and hippocampal volume correlates of Mattis Dementia Rating Scale in Alzheimer disease.
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Apolipoprotein E genotype in diverse neurodegenerative disorders
Schneider, J. A., Gearing, M., Robbins, R. S., Delaune, W., & Mirra, S. (1995) · Annals of Neurology · doi:10.1002/ana.410380122 · Cited by 85

Authors: Khachaturian, Z. S.
Corresponding author: Khachaturian, Z. S.
Venue: Archives of Neurology
Publisher: American Medical Association (AMA)
Published: 1985-11-01
Volume: 42
Issue: 11
Pages: 1097-1105
ISSN: 0003-9942 (ISSN-L)
DOI: 10.1001/archneur.1985.04060100083029
OpenAlex: W2171405125
Cited by: 2,499
References: 10
Citations by year: 2026: 10 · 2025: 27 · 2024: 26 · 2023: 31 · 2022: 38 · 2021: 46 · 2020: 43 · 2019: 35 · 2018: 29 · 2017: 27 · 2016: 36 · 2015: 27 · 2014: 41 · 2013: 34 · 2012: 41
FWCI: 40.91
Type: journal article
Language: en
Open access: closed
Locations: Archives of Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
Keywords: Alzheimer's disease, early diagnosis, dementia, neurochemistry, neuropathology, neuroradiology, neuropsychology
MeSH terms: Alzheimer Disease, Humans

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