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Microbleed Topography, Leukoaraiosis, and Cognition in Probable Alzheimer Disease From the Sunnybrook Dementia Study
Abstract
BACKGROUND: Microbleeds are hemosiderin deposits around small vessels and are well visualized with T2*-weighted gradient-recalled echo (GRE) imaging. OBJECTIVES: To determine frequency and topography of microbleeds in Alzheimer disease (AD) and to assess their association with leukoaraiosis and cognition. DESIGN: Case-control cross-sectional analysis. Microbleeds were counted using GRE imaging. Leukoaraiosis was rated on T2-weighted and proton density-weighted scans using the Age-Related White Matter Changes Rating Scale (ARWMC). Neuropsychological tests indexed cognition. SETTING: The Cognitive Neurology Clinic, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. PATIENTS: Individuals with probable AD (n = 80) and healthy controls (n = 25) from a longitudinal cohort with GRE sequences as part of standard imaging protocol (2002-2006). RESULTS: Microbleeds occurred in 29% of patients with AD and 12% of controls and were multiple (> 1) in 48% of patients with AD and 33% of controls. There was lobar (vs centrencephalic) predominance in 92% of AD patients, with occipital lobes accounting for 57% of these microbleeds. The ARWMC scores (P < .005) were significantly higher in AD patients with microbleeds than in those without, and microbleeds correlated with total (r = 0.39, P = .01) and parietooccipital (r = 0.28, P < .01) ARWMC scores. We were unable to demonstrate an association between microbleeds (or leukoaraiosis) and cognitive performance. CONCLUSIONS: Occipital predominance of microbleeds with corresponding parietooccipital leukoaraiosis has not been well described in prior imaging studies of AD. Microbleeds were frequent, often multiple, and predicted greater leukoaraiosis. These findings illustrate the complexity of AD vasculopathy and the need for additional studies in dementia and stroke populations.
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Cites
Alzheimer disease and cerebrovascular pathology: an update
Jellinger, K. A. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200068 · Cited by 680
Cerebral amyloid angiopathy and cognitive function: The HAAS autopsy study
Pfeifer, L. A., White, L. R., Ross, G. W., Petrovitch, H., & Launer, L. J. (2002) · Neurology · doi:10.1212/wnl.58.11.1629 · Cited by 338
Jeerakathil, T., Wolf, P. A., Beiser, A., Hald, J. K., Au, R., Kase, C. S., Massaro, J. M., & DeCarli, C. (2004) · Stroke · doi:10.1161/01.str.0000131809.35202.1b · Cited by 319
Prevalence and severity of microbleeds in a memory clinic setting
Cordonnier, C., van der Flier, W. M., Sluimer, J. D., Leys, D., Barkhof, F., & Scheltens, P. (2006) · Neurology · doi:10.1212/01.wnl.0000210535.20297.ae · Cited by 305
Clinical Significance of Microbleeds in Subcortical Vascular Dementia
Won Seo, S., Hwa Lee, B., Kim, E.-J., Chin, J., Sun Cho, Y., Yoon, U., & Na, D. L. (2007) · Stroke · doi:10.1161/strokeaha.106.477315 · Cited by 185
Cited by
Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076
Cerebral microbleeds: a guide to detection and interpretation
Greenberg, S. M., Vernooij, M. W., Cordonnier, C., Viswanathan, A., Al-Shahi Salman, R., Warach, S., Launer, L. J., Van Buchem, M. A., & Breteler, M. M. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70013-4 · Cited by 1,798
Sperling, R. A., Jack, C. R., Black, S. E., Frosch, M. P., Greenberg, S. M., Hyman, B. T., Scheltens, P., Carrillo, M. C., Thies, W., Bednar, M. M., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.05.2351 · Cited by 857
Self-citationCerebral amyloid angiopathy in the elderly
Viswanathan, A., & Greenberg, S. M. (2011) · Annals of Neurology · doi:10.1002/ana.22516 · Cited by 643
Association of Cerebral Microbleeds With Cognitive Decline and Dementia
Akoudad, S., Wolters, F. J., Viswanathan, A., de Bruijn, R. F., van der Lugt, A., Hofman, A., Koudstaal, P. J., Ikram, M. A., & Vernooij, M. W. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.1017 · Cited by 403
Black, S., Gao, F., & Bilbao, J. (2009) · Stroke · doi:10.1161/strokeaha.108.537704 · Cited by 379
Self-citationCerebral microbleeds are associated with worse cognitive function: The Rotterdam Scan Study
Poels, M. M. F., Ikram, M. A., van der Lugt, A., Hofman, A., Niessen, W. J., Krestin, G. P., Breteler, M. M. B., & Vernooij, M. W. (2012) · Neurology · doi:10.1212/wnl.0b013e3182452928 · Cited by 378
Cerebral Amyloid Angiopathy: Emerging Concepts
Yamada, M. (2015) · Journal of Stroke · doi:10.5853/jos.2015.17.1.17 · Cited by 367
Brain microbleeds and Alzheimer’s disease: innocent observation or key player?
Cordonnier, C., & van der Flier, W. M. (2011) · Brain · doi:10.1093/brain/awq321 · Cited by 310
Cerebral Microbleeds: Imaging and Clinical Significance
Haller, S., Vernooij, M. W., Kuijer, J. P. A., Larsson, E.-M., Jäger, H. R., & Barkhof, F. (2018) · Radiology · doi:10.1148/radiol.2018170803 · Cited by 308
β-Amyloid, Blood Vessels, and Brain Function
Smith, E. E., & Greenberg, S. M. (2009) · Stroke · doi:10.1161/strokeaha.108.536839 · Cited by 293
SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells
Bell, R. D., Deane, R., Chow, N., Long, X., Sagare, A., Singh, I., Streb, J. W., Guo, H., Rubio, A., Van Nostrand, W., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1819 · Cited by 261
Goos, J. D. C., Kester, M. I., Barkhof, F., Klein, M., Blankenstein, M. A., Scheltens, P., & van der Flier, W. M. (2009) · Stroke · doi:10.1161/strokeaha.109.558197 · Cited by 213
Cerebrospinal fluid amyloid β40 is decreased in cerebral amyloid angiopathy
Verbeek, M. M., Kremer, B. P. H., Rikkert, M. O., Van Domburg, P. H. M. F., Skehan, M. E., & Greenberg, S. M. (2009) · Annals of Neurology · doi:10.1002/ana.21694 · Cited by 202
Topography of dilated perivascular spaces in subjects from a memory clinic cohort
Martinez-Ramirez, S., Pontes-Neto, O. M., Dumas, A. P., Auriel, E., Halpin, A., Quimby, M., Gurol, M. E., Greenberg, S. M., & Viswanathan, A. (2013) · Neurology · doi:10.1212/wnl.0b013e31828f1876 · Cited by 163
11 C-PIB binding is increased in patients with cerebral amyloid angiopathy–related hemorrhage
Ly, J. V., Donnan, G. A., Villemagne, V. L., Zavala, J. A., Ma, H., O'Keefe, G., Gong, S. J., Gunawan, R. M., Saunder, T., Ackerman, U., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181cef7e3 · Cited by 157
Alzheimer’s disease, cerebrovascular disease, and the β-amyloid cascade
Honjo, K., Black, S. E., & Verhoeff, N. P. L. G. (2012) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100015547 · Cited by 152
Self-citationCerebral microbleeds and vascular cognitive impairment.
Werring, D. J., Gregoire, S. M., & Cipolotti, L. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.08.034 · Cited by 143
EFNS task force: the use of neuroimaging in the diagnosis of dementia
Filippi, M., Agosta, F., Barkhof, F., Dubois, B., Fox, N. C., Frisoni, G. B., Jack, C. R., Johannsen, P., Miller, B. L., Nestor, P. J., et al. (2012) · European Journal of Neurology · doi:10.1111/j.1468-1331.2012.03859.x · Cited by 141
Serial Susceptibility Weighted MRI Measures Brain Iron and Microbleeds in Dementia
Kirsch, W., McAuley, G., Holshouser, B., Petersen, F., Ayaz, M., Vinters, H. V., Dickson, C., Haacke, E. M., Britt III, W., Larsen, J., et al. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1073 · Cited by 139
Shams, S., Martola, J., Granberg, T., Li, X., Shams, M., Fereshtehnejad, S. M., Cavallin, L., Aspelin, P., Kristoffersen-Wiberg, M., & Wahlund, L. O. (2015) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4176 · Cited by 132
Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease
Yates, P. A., Sirisriro, R., Villemagne, V. L., Farquharson, S., Masters, C. L., Rowe, C. C., & For the AIBL Research Group (2011) · Neurology · doi:10.1212/wnl.0b013e318221ad36 · Cited by 130
Blood-brain barrier leakage in Alzheimer’s disease: From discovery to clinical relevance
Nehra, G., Bauer, B., & Hartz, A. M. S. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108119 · Cited by 127
Sun, Y.-W., Qin, L.-D., Zhou, Y., Xu, Q., Qian, L.-J., Tao, J., & Xu, J.-R. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.05.006 · Cited by 117
Cerebral Microbleeds and Cognition in Patients With Symptomatic Small Vessel Disease
Patel, B., Lawrence, A. J., Chung, A. W., Rich, P., MacKinnon, A. D., Morris, R. G., Barrick, T. R., & Markus, H. S. (2013) · Stroke · doi:10.1161/strokeaha.112.670216 · Cited by 105
Heringa, S. M., on behalf of the Utrecht Vascular Cognitive Impairment (VCI) Study Group, Reijmer, Y. D., Leemans, A., Koek, H. L., Kappelle, L. J., & Biessels, G. J. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-130542 · Cited by 100
MRI Markers of Small Vessel Disease in Lobar and Deep Hemispheric Intracerebral Hemorrhage
Smith, E. E., Nandigam, K. R. N., Chen, Y.-W., Jeng, J., Salat, D., Halpin, A., Frosch, M., Wendell, L., Fazen, L., Rosand, J., et al. (2010) · Stroke · doi:10.1161/strokeaha.110.579078 · Cited by 95
Csiszar, A., Tarantini, S., Fülöp, G. A., Kiss, T., Valcarcel-Ares, M. N., Galvan, V., Ungvari, Z., & Yabluchanskiy, A. (2017) · GeroScience · doi:10.1007/s11357-017-9991-9 · Cited by 93
Multiple or mixed cerebral microbleeds and dementia in patients with vascular risk factors
Miwa, K., Tanaka, M., Okazaki, S., Yagita, Y., Sakaguchi, M., Mochizuki, H., & Kitagawa, K. (2014) · Neurology · doi:10.1212/wnl.0000000000000692 · Cited by 86
Cerebral amyloid angiopathy as a cause of neurodegeneration
Smith, E. E. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14157 · Cited by 86
Klohs, J., Deistung, A., Schweser, F., Grandjean, J., Dominietto, M., Waschkies, C., Nitsch, R. M., Knuesel, I., Reichenbach, J. R., & Rudin, M. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.118 · Cited by 83
Imaging of cerebrovascular pathology in animal models of Alzheimer's disease
Klohs, J., Rudin, M., Shimshek, D. R., & Beckmann, N. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00032 · Cited by 82
Prevalence of cortical superficial siderosis in a memory clinic population
Zonneveld, H. I., Goos, J. D. C., Wattjes, M. P., Prins, N. D., Scheltens, P., van der Flier, W. M., Kuijer, J. P. A., Muller, M., & Barkhof, F. (2014) · Neurology · doi:10.1212/wnl.0000000000000150 · Cited by 78
De Reuck, J., Auger, F., Cordonnier, C., Deramecourt, V., Durieux, N., Pasquier, F., Bordet, R., Maurage, C. A., & Leys, D. (2011) · Cerebrovascular Diseases · doi:10.1159/000324391 · Cited by 76
Uetani, H., Hirai, T., Hashimoto, M., Ikeda, M., Kitajima, M., Sakamoto, F., Utsunomiya, D., Oda, S., Sugiyama, S., Matsubara, J., et al. (2013) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3332 · Cited by 48
Cerebral Microbleeds as a Biomarker in Alzheimer’S Disease? A Review in The Field
Shams, S., & Wahlund, L.-O. (2016) · Biomarkers in Medicine · doi:10.2217/bmm.15.101 · Cited by 32
Gungor, I., Sarro, L., Graff-Radford, J., Zuk, S. M., Tosakulwong, N., Przybelski, S. A., Lesnick, T., Boeve, B. F., Ferman, T. J., Smith, G. E., et al. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.07.008 · Cited by 31
Cerebral Vascular Leak in a Mouse Model of Amyloid Neuropathology
Tanifum, E. A., Starosolski, Z. A., Fowler, S. W., Jankowsky, J. L., & Annapragada, A. V. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.125 · Cited by 28
Morrone, C. D., Liu, M., Black, S. E., & McLaurin, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00064 · Cited by 26
Self-citationThe role of cerebral microbleeds in the incidence of post-stroke dementia
Yatawara, C., Guevarra, A. C., Ng, K. P., Chander, R., Lam, B. Y. K., Wong, A., Mok, V., & Kandiah, N. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.116736 · Cited by 18
Metadata
- Authors
- Pettersen, J. A., Sathiyamoorthy, G., Gao, F.-Q., Szilagyi, G., Nadkarni, N. K., St George-Hyslop, P., Rogaeva, E., & Black, S. E.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2008-06-01
- Volume
- 65
- Issue
- 6
- Pages
- 790-5
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2164273040
- Cited by
- 264
- References
- 5
- FWCI
- 12.12
- Type
- journal article
- Language
- en
- Open access
- closed
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