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Cited by 80Memory and Neural MechanismsChild and Animal Learning DevelopmentNeuroendocrine regulation and behavior

Post-weaning social isolation impairs observational fear conditioning

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Yusufishaq, Shabana, Rosenkranz, J. Amiel·2013·Behavioural Brain Research
DOI 10.1016/j.bbr.2012.12.050PMC PMC3566364
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Abstract

Many mammals can utilize social information to learn by observation of conspecifics (social learning). Social learning of fear is expected to be especially advantageous for survival. However, disruption of social development in early life can impair social cognition and might also be expected to disrupt social learning. Social isolation during a critical period of adolescence disrupts social development. The purpose of this study was to determine whether disruption of social development through post-weaning social isolation leads to impairments of social fear learning. Rats were reared in isolation or pair-housed from immediately post-weaning, for 3 weeks. Social fear learning in rats was acquired by observation of tone-footshock pairings administered to a conspecific. Isolation-reared rats displayed less conditioned freezing than pair-housed rats when tested the next day. This reduction of conditioned freezing was correlated with conspecific-oriented behaviors during conditioning, was measured despite similarities in demonstrator behaviors, and occurred despite a manipulation that equalized freezing during conditioning between the pair-housed and isolation-reared rats. The results could not be explained by abnormal sensitization to a repeated tone or deficits in freezing or direct fear conditioning. These results demonstrate that observational fear conditioning is impaired by social isolation, and provide a model to study impaired social affective learning. Impaired social cognition, manifested as inability to recognize or appropriately interpret social cues, is a symptom of several psychiatric disorders. Better understanding of the mechanisms of impaired social fear learning can lead to novel treatments for social cognition symptoms of psychiatric disorders.

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Authors
Yusufishaq, S., & Rosenkranz, J. A.
Affiliations
Rosalind Franklin University of Medicine and Science (US)
Corresponding author
Rosenkranz, J. Amiel
ORCID
Rosenkranz, J. Amiel
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2013-04
Volume
242
Pages
142-149
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2012.12.050
PMC
PMC3566364
OpenAlex
W1983936342
Cited by
80
References
10
Citations by year
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FWCI
4.21
Type
journal article
Language
en
Open access
Licence
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (MH084970)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Developmental and Educational Psychology › Child and Animal Learning Development
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
post-weaning social isolation, social learning, social cognition, social development (developmental psychology), conditioned freezing, mental illness
MeSH terms
Acoustic Stimulation, Analysis of Variance, Animals, Animals, Newborn, Conditioning, Psychological, Cues, Electroshock, Fear, Learning Disabilities, Male, Social Isolation, Statistics as Topic, Rats, Sprague-Dawley, Observation, Freezing Reaction, Cataleptic, Rats

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