Estradiol shortens the period of hamster circadian rhythms
Abstract
Continuous administration of estradiol benzoate by means of subcutaneously implanted capsules shortened the free-running circadian period of locomotor activity of blind hamsters (Mesocricetus auratus) that had had their ovaries removed. Estradiol also advanced the phase of the wheel running of sighted female hamsters without ovaries that were entrained to a photoperiod with 12 hours of light and 12 of darkness. These results, and findings from hamsters undergoing natural estrous cycles, indicate that endogenous estradiol is involved in the regulation of circadian periodicity.
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In adult laboratory rodents, a wide variety of gonadal hormones can affect the phase of circadian rhythms.
“Indeed, in adult laboratory rodents a wide variety of gonadal hormones can affect the phase of circadian rhythms, including estrogens, progestins, androgens, and non-traditional neuroactive steroids (e.g., rats: [8, 17], hamsters: [49, 51, 129], mice: [23, 47, 78, 90], degus: [80, 100]).”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [129]
Gonadal hormones can influence other circadian parameters including endogenous period, rhythm amplitude, range of entrainment, zeitgeber sensitivity, and oscillator coupling.
“Gonadal hormones can influence other circadian parameters as well, including endogenous period [7, 23, 47, 49, 91, 129, 212], rhythm amplitude [8, 17, 100], range of entrainment [49], zeitgeber sensitivity [23, 51, 79, 81], and oscillator coupling [126, 128, 187].”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [129]
Gonadal hormones are already known to have species-specific effects during adulthood.
“This would not be an unprecedented conclusion, as gonadal hormones are already known to have species-specific effects during adulthood.”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [129]
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Self-citation
- Authors
- Morin, L. P., Fitzgerald, K. M., & Zucker, I.
- Affiliations
- University of California, Berkeley (US)
- Venue
- Science
- Published
- 1977-04-15
- Volume
- 196
- Issue
- 4287
- Pages
- 305-307
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1971281111
- Cited by
- 350
- References
- 18
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 13 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 10 · 2012: 9
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- estradiol, circadian rhythm, free-running period, locomotor activity, wheel running, ovariectomy, estrous cycle, photoperiod entrainment, golden hamster, endogenous estradiol
- MeSH terms
- Animals, Blindness, Castration, Circadian Rhythm, Estradiol, Estrus, Female, Cricetinae, Light, Mesocricetus, Motor Activity, Pregnancy
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