The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Monoamine Metabolites in CSF and Suicidal Behavior
Abstract
Cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 30 psychiatric patients who had attempted suicide and 45 healthy volunteers. The suicide attempters had a significantly lower CSF 5-HIAA level than the controls, especially those who had made more violent attempts. After adjustment for differences in body height and age between controls and patients, the difference in 5-HIAA level became even more marked. Concentrations of 5-HIAA also were lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbar puncture, while HVA levels were lowered only in the depressives. A follow-up study of these and 89 more patients (depressed and/or suicidal) revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962
"Serotonin Depression"—A Biochemical Subgroup Within the Affective Disorders?
Åsberg, M., Thorén, P., Traskman, L., Bertilsson, L., & Ringberger, V. (1976) · Science · doi:10.1126/science.1246632 · Cited by 682
Cited by
Risk factors for suicidal thoughts and behaviors: A meta-analysis of 50 years of research
Franklin, J. C., Ribeiro, J. D., Fox, K. R., Bentley, K. H., Kleiman, E. M., Huang, X., Musacchio, K. M., Jaroszewski, A. C., Chang, B. P., & Nock, M. K. (2017) · Psychological Bulletin · doi:10.1037/bul0000084 · Cited by 3,784
Neurobiology of suicidal behaviour
Mann, J. J. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1220 · Cited by 1,260
Wender, P. H. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800100013003 · Cited by 560
Lindqvist, D., Janelidze, S., Hagell, P., Erhardt, S., Samuelsson, M., Minthon, L., Hansson, O., Björkqvist, M., Träskman-Bendz, L., & Brundin, L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.030 · Cited by 524
The role of 5-HT receptors in depression
Yohn, C. N., Gergues, M. M., & Samuels, B. A. (2017) · Molecular Brain · doi:10.1186/s13041-017-0306-y · Cited by 485
Runeson, B., Tidemalm, D., Dahlin, M., Lichtenstein, P., & Langstrom, N. (2010) · BMJ · doi:10.1136/bmj.c3222 · Cited by 396
Connecting inflammation with glutamate agonism in suicidality
Erhardt, S., Lim, C. K., Linderholm, K. R., Janelidze, S., Lindqvist, D., Samuelsson, M., Lundberg, K., Postolache, T. T., Träskman-Bendz, L., Guillemin, G. J., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.248 · Cited by 345
Obsessive-compulsive disorder and serotonin: Is there a connection?
Insel, T. R., Mueller, E. A., Alterman, I., Linnoila, M., & Murphy, D. L. (1985) · Biological Psychiatry · doi:10.1016/0006-3223(85)90176-3 · Cited by 343
Low plasma BDNF is associated with suicidal behavior in major depression
Kim, Y.-K., Lee, H.-P., Won, S.-D., Park, E.-Y., Lee, H.-Y., Lee, B.-H., Lee, S.-W., Yoon, D., Han, C., Kim, D.-J., et al. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.06.024 · Cited by 300
Toward a Biosignature for Suicide
Oquendo, M. A., Sullivan, G. M., Sudol, K., Baca-Garcia, E., Stanley, B. H., Sublette, M. E., & Mann, J. J. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14020194 · Cited by 299
Hawton, K. (1987) · British Journal of Psychiatry · doi:10.1192/bjp.150.2.145 · Cited by 287
Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients
John Mann, J., & Malone, K. M. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00217-x · Cited by 278
Dopamine and depression: A review of recent evidence. I. Empirical studies
Willner, P. (1983) · Brain Research Reviews · doi:10.1016/0165-0173(83)90005-x · Cited by 273
Lower dopamine transporter binding potential in striatum during depression
Meyer, J. H., Krüger, S., Wilson, A. A., Christensen, B. K., Goulding, V. S., Schaffer, A., Minifie, C., Houle, S., Hussey, D., & Kennedy, S. H. (2001) · Neuroreport · doi:10.1097/00001756-200112210-00052 · Cited by 269
Meta-analysis of molecular imaging of serotonin transporters in major depression
Gryglewski, G., Lanzenberger, R., Kranz, G. S., & Cumming, P. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.82 · Cited by 227
Suicide in obsessive–compulsive disorder: A population-based study of 36 788 Swedish patients
Fernández de la Cruz, L., Rydell, M., Runeson, B., D'Onofrio, B. M., Brander, G., Rück, C., Lichtenstein, P., Larsson, H., & Mataix-Cols, D. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.115 · Cited by 210
Can biological tests assist prediction of suicide in mood disorders?
Mann, J. J., Currier, D., Stanley, B., Oquendo, M. A., Amsel, L. V., & Ellis, S. P. (2006) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005687 · Cited by 215
Brundin, L., Sellgren, C. M., Lim, C. K., Grit, J., Pålsson, E., Landén, M., Samuelsson, M., Lundgren, K., Brundin, P., Fuchs, D., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.133 · Cited by 195
Attempted Suicide Characteristics and Cerebrospinal Fluid Amine Metabolites in Depressed Inpatients
Mann, J. (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00102-9 · Cited by 178
More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides
Boldrini, M., Underwood, M. D., Mann, J. J., & Arango, V. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.083 · Cited by 174
Reduced cerebrospinal HVA concentrations and HVA/5-HIAA ratios in suicide attempters
Engström, G., Alling, C., Blennow, K., Regnéll, G., & Träskman-Bendz, L. (1999) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(99)00016-4 · Cited by 157
O’Connor, D. B., Green, J. A., Ferguson, E., O’Carroll, R. E., & O’Connor, R. C. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.10.019 · Cited by 146
Low CSF oxytocin reflects high intent in suicide attempters
Jokinen, J., Chatzittofis, A., Hellström, C., Nordström, P., Uvnäs-Moberg, K., & Åsberg, M. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.016 · Cited by 143
HPA axis hyperactivity and attempted suicide in young adult mood disorder inpatients
Jokinen, J., & Nordström, P. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.10.015 · Cited by 143
Suicide, suicidality and suicide prevention in affective disorders
Möller, H. J. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.108.s418.15.x · Cited by 127
Bohman, H., Jonsson, U., Päären, A., von Knorring, L., Olsson, G., & von Knorring, A.-L. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-90 · Cited by 126
Suicide and Alzheimer’s pathology in the elderly: a case–control study
Rubio, A., Vestner, A. L., Stewart, J. M., Forbes, N. T., Conwell, Y., & Cox, C. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00952-5 · Cited by 115
Lindqvist, D., Fernström, J., Grudet, C., Ljunggren, L., Träskman-Bendz, L., Ohlsson, L., & Westrin, Å. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.236 · Cited by 111
Insomnia as a predictor of high-lethality suicide attempts
Pompili, M., Innamorati, M., Forte, A., Longo, L., Mazzetta, C., Erbuto, D., Ricci, F., Palermo, M., Stefani, H., Seretti, M. E., et al. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12211 · Cited by 100
High interleukin-6 and impulsivity: determining the role of endophenotypes in attempted suicide
Isung, J., Aeinehband, S., Mobarrez, F., Nordström, P., Runeson, B., Åsberg, M., Piehl, F., & Jokinen, J. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.113 · Cited by 85
CSF biomarkers in suicide attempters – a principal component analysis
Lindqvist, D., Janelidze, S., Erhardt, S., Träskman‐Bendz, L., Engström, G., & Brundin, L. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01655.x · Cited by 86
CSF 5-HIAA, cortisol and DHEAS levels in suicide attempters
Chatzittofis, A., Nordström, P., Hellström, C., Arver, S., Åsberg, M., & Jokinen, J. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.02.002 · Cited by 84
Evidence-based pharmacotherapy for personality disorders
Ripoll, L. H., Triebwasser, J., & Siever, L. J. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000071 · Cited by 83
Altered Chemokine Levels in the Cerebrospinal Fluid and Plasma of Suicide Attempters
Janelidze, S., Ventorp, F., Erhardt, S., Hansson, O., Minthon, L., Flax, J., Samuelsson, M., Traskman-Bendz, L., & Brundin, L. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.09.010 · Cited by 69
Jokinen, J., Boström, A. E., Dadfar, A., Ciuculete, D. M., Chatzittofis, A., Åsberg, M., & Schiöth, H. B. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2017.12.018 · Cited by 67
Probert-Lindström, S., Berge, J., Westrin, Å., Öjehagen, A., & Skogman Pavulans, K. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-038794 · Cited by 63
Jokinen, J., Nordström, A.-L., & Nordström, P. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2007.10.007 · Cited by 54
Jokinen, J., Nordström, A.-L., & Nordström, P. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.06.008 · Cited by 45
Lower CSF MHPG predicts short-term risk for suicide attempt
Galfalvy, H., Currier, D., Oquendo, M. A., Sullivan, G., Huang, Y.-Y., & John Mann, J. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990228 · Cited by 38
Research Report: Self-harming behaviour: from lay perceptions to clinical practice
Rayner, G., & Warner, S. (2003) · Counselling Psychology Quarterly · doi:10.1080/0951507032000156862 · Cited by 21
MOLLER, H. (1994) · European Neuropsychopharmacology · doi:10.1016/0924-977x(94)90315-8 · Cited by 16
Cerebrospinal fluid monoamine metabolite concentrations in suicide attempt: a meta-analysis
Sharma, R., Tikka, S. K., Yadav, A. K., Bhute, A. R., Dhamija, P., & Bastia, B. K. (2021) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2021.102711 · Cited by 13
Metadata
- Authors
- Träskman, L.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1981-06-01
- Volume
- 38
- Issue
- 6
- Pages
- 631
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2000277154
- Cited by
- 689
- References
- 2
- FWCI
- 39.35
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
