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Cited by 263

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Left Hippocampal Volume as a Vulnerability Indicator for Schizophrenia: A Magnetic Resonance Imaging Morphometric Study of Nonpsychotic First-Degree Relatives

Seidman, Larry J., Faraone, Stephen V., Goldstein, Jill M., Kremen, William S., Horton, Nicholas J., Makris, Nikos, Toomey, Rosemary, Kennedy, David, Caviness, Verne S., Tsuang, Ming T.·2002·Archives of General Psychiatry
DOI 10.1001/archpsyc.59.9.839
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Abstract

BACKGROUND: Clues to the causes of schizophrenia can be derived from studying first-degree relatives because they are genetically related to an ill family member. Abnormalities observed in nonpsychotic relatives are indicators of possible genetic vulnerability to illness, independent of psychosis. We tested 4 hypotheses: (1) that hippocampal volume is smaller in nonpsychotic relatives than in controls, particularly in the left hemisphere; (2) that hippocampi will be smaller in multiplex relatives as compared with simplex relatives, and both will be smaller than in controls; (3) that hippocampal volumes and verbal declarative memory function will be positively correlated; and (4) that hippocampi will be smaller in patients with schizophrenia than in their nonpsychotic relatives or in controls. METHODS: Subjects were 45 nonpsychotic adult first-degree relatives from families with either 2 people ("multiplex," n = 17) or 1 person ("simplex," n = 28) diagnosed with schizophrenia, 18 schizophrenic relatives, and 48 normal controls. Sixty contiguous 3-mm coronal, T1-weighted 3-dimensional magnetic resonance images of the brain were acquired on a 1.5-T magnet. Volumes of the total cerebrum and the hippocampus were measured. RESULTS: Compared with controls, relatives, particularly from multiplex families, had significantly smaller left hippocampi. Verbal memory and left hippocampal volumes were significantly and positively correlated. Within families, hippocampal volumes did not differ between schizophrenic patients and their nonpsychotic relatives. CONCLUSIONS: Results support the hypothesis that the vulnerability to schizophrenia includes smaller left hippocampi and verbal memory deficits. Findings suggest that smaller left hippocampi and verbal memory deficits are an expression of early neurodevelopmental compromise, reflecting the degree of genetic liability to schizophrenia.

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Metadata

Authors
Seidman, L. J., Faraone, S. V., Goldstein, J. M., Kremen, W. S., Horton, N. J., Makris, N., Toomey, R., Kennedy, D., Caviness, V. S., & Tsuang, M. T.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
2002-09-01
Volume
59
Issue
9
Pages
839
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.59.9.839
OpenAlex
W2104452175
Cited by
263
References
3
FWCI
13.53
Type
journal article
Language
en
Open access
closed

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