The relation between multiple pains and mental disorders: results from the World Mental Health Surveys
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It is unclear whether differences exist in the prevalence of mood, anxiety and alcohol use disorders among persons with multiple pain conditions compared with those with single pain problems. We conducted population surveys in 17 countries in Europe, the Americas, the Middle East, Africa, Asia, and the South Pacific. Participants were community-dwelling adults (N=85,088). Mental disorders were assessed with the Composite International Diagnostic Interview. Pain was assessed by self-report. Both multiple and single site pain problems were associated with mood and anxiety disorders, but not with alcohol abuse or dependence. In general, the prevalence of specific mood and anxiety disorders followed a linear pattern with the lowest rates found among persons with no pain, intermediate rates among those with one pain, and highest rates among those with multi-site pain problems. Relative to persons not reporting pain, the pooled estimates of the age-sex adjusted odds ratios were 1.8 (1.7-2.0) for mood disorders and 1.9 (1.8-2.1) for anxiety disorders for persons with single site pain; 3.7 (3.3-4.1) for mood disorders and 3.6 (3.3-4.0) for anxiety disorders among those with multi-site pain. Our results indicate that the presence of multiple pain conditions was strongly and comparably associated with mood and anxiety disorders in diverse cultures. This consistent pattern of associations suggests that diffuse pain and psychiatric disorders are generally associated, rather than diffuse pain representing an idiom for expressing distress that is specific to particular cultural settings or diffuse pain solely representing a form of masked depression.
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In a randomized controlled trial of low back pain patients and their spouses, a spouse-assisted intervention produced larger decreases in fear of pain and catastrophizing than standard multidisciplinary intervention.
“In a recent randomized controlled trial examining patients with LBP and their spouses, the spouse-assisted intervention produced larger decreases in fear of pain and catastrophizing than the standard multidisciplinary intervention 139.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [139]
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- Authors
- Gureje, O., Von Korff, M., Kola, L., Demyttenaere, K., He, Y., Posada-Villa, J., Lepine, J. P., Angermeyer, M. C., Levinson, D., de Girolamo, G., Iwata, N., Karam, A., Borges, G. L. G., de Graaf, R., Browne, M. O., Stein, D. J., Haro, J. M., Bromet, E. J., Kessler, R. C., & Alonso, J.
- Affiliations
- University of Ibadan (NG)
- University College Hospital, Ibadan (NG)
- Shanghai Mental Health Center (CN)
- Hôpital Fernand-Widal (FR)
- Leipzig University (DE)
- Israel Ministry of Health (IL)
- Hiroshima International University (JP)
- Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (MX)
- University of Cape Town (ZA)
- Stony Brook University (US)
- Municipal Institute for Medical Research (ES)
- Corresponding author
- Gureje, Oye
- ORCID
- Venue
- Pain
- Published
- 2008-03
- Volume
- 135
- Issue
- 1
- Pages
- 82-91
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2030283753
- Cited by
- 337
- References
- 42
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 19 · 2023: 22 · 2022: 17 · 2021: 20 · 2020: 8 · 2019: 21 · 2018: 21 · 2017: 23 · 2016: 23 · 2015: 15 · 2014: 22 · 2013: 20 · 2012: 14
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- green
- lirias.kuleuven.be
- Licence
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Funders
- John D. and Catherine T. MacArthur Foundation (R01 DA016558, R13-MH066849)
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- World Health Organization
- Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
- National Institutes of Health (5r13mh066849-04, 5r01mh069864-04, 5r01mh070884-05)
- Pfizer Foundation (R01‐MH069864, R01-DA016558, R13-MH066849)
- Pan American Health Organization
- National Institute of Mental Health (R13-MH-066849, R0 1-MH61905, R01‐MH070884, U01-MH-60220, R01MH061905, R01MH059575, U01MH060220, R01‐MH069864)
- National Institute on Drug Abuse (R01DA016558)
- Fogarty International Center (FIRCA R01-TW006481, R01-TW006481)
- Topics
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- chronic pain, mood disorders, anxiety disorders, alcoholism, mental illness, prevalence, diffuse pain, masked depression, cross-cultural comparison, community-dwelling adults
- MeSH terms
- Adult, Mental Disorders, Cross-Sectional Studies, Data Collection, Female, Health Surveys, Humans, Male, Middle Aged, Pain, Global Health, Prevalence, Sickness Impact Profile, Internationality
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