Approach to the Patient with Subclinical Hyperthyroidism

Cooper, David S.

doi:10.1210/jc.2006-2472

Cited by 84Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryThyroid Cancer Diagnosis and Treatment

Approach to the Patient with Subclinical Hyperthyroidism

Cooper, David S.·2007·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2006-2472

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Abstract

Endogenous subclinical hyperthyroidism, defined by normal circulating levels of free T4 and T3 and low levels of TSH, is a common clinical entity and is typically caused by the same conditions that account for the majority of cases of overt hyperthyroidism: Graves’ disease, toxic multinodular goiter, and solitary autonomously functioning thyroid nodules. Subclinical hyperthyroidism has been associated with an increased risk of atrial fibrillation and mortality, decreased bone mineral density in postmenopausal women, and mild hyperthyroid symptoms. Treatment of subclinical hyperthyroidism remains controversial, given the lack of prospective randomized controlled trials showing clinical benefit with restoration of the euthyroid state. Nevertheless, it seems reasonable to treat older individuals whose serum TSH levels are less than 0.1 mU/liter and certain high-risk patients, even when the serum TSH is between 0.1 and the lower limit of the normal range.

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Femoral and lumbar spine BMDs were increased by 1.9% and 1.6%, respectively, 1 year after RAI treatment.
“Femoral and lumbar spine BMDs were increased by 1.9 and 1.6%, respectively, 1 year after RAI treatment [99,110] .”
From The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism (2015) · cites this paper as [110]

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Authors: Cooper, D. S.
Affiliations: Johns Hopkins University (US)
Corresponding author: Cooper, David S.
ORCID: Cooper, David S.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2007-01-01
Volume: 92
Issue: 1
Pages: 3-9
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2006-2472
OpenAlex: W1993626635
Semantic Scholar: 2a6d67be7980943bd10a61ead19a7d9b1d4e7a9e
Cited by: 83
References: 51
Citations by year: 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 4 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 8
FWCI: 8.83
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords: subclinical hyperthyroidism, TSH suppression therapy, Graves' disease, toxic multinodular goiter, autonomously functioning thyroid nodules, atrial fibrillation, bone mineral density, mortality risk, treatment indications, euthyroidism
MeSH terms: Aged, Bone and Bones, Diagnosis, Differential, Female, Humans, Hyperthyroidism, Quality of Life, Thyrotropin, Bone Remodeling

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