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Irritable Bowel Syndrome: A Clinical Review
Abstract
IMPORTANCE: Irritable bowel syndrome (IBS) affects 7% to 21% of the general population. It is a chronic condition that can substantially reduce quality of life and work productivity. OBJECTIVES: To summarize the existing evidence on epidemiology, pathophysiology, and diagnosis of IBS and to provide practical treatment recommendations for generalists and specialists according to the best available evidence. EVIDENCE REVIEW: A search of Ovid (MEDLINE) and Cochrane Database of Systematic Reviews was performed for literature from 2000 to December 2014 for the terms pathophysiology, etiology, pathogenesis, diagnosis, irritable bowel syndrome, and IBS. The range was expanded from 1946 to December 2014 for IBS, irritable bowel syndrome, diet, treatment, and therapy. FINDINGS: The database search yielded 1303 articles, of which 139 were selected for inclusion. IBS is not a single disease but rather a symptom cluster resulting from diverse pathologies. Factors important to the development of IBS include alterations in the gut microbiome, intestinal permeability, gut immune function, motility, visceral sensation, brain-gut interactions, and psychosocial status. The diagnosis of IBS relies on symptom-based criteria, exclusion of concerning features (symptom onset after age 50 years, unexplained weight loss, family history of selected organic gastrointestinal diseases, evidence of gastrointestinal blood loss, and unexplained iron-deficiency anemia), and the performance of selected tests (complete blood cell count, C-reactive protein or fecal calprotectin, serologic testing for celiac disease, and age-appropriate colorectal cancer screening) to exclude organic diseases that can mimic IBS. Determining the predominant symptom (IBS with diarrhea, IBS with constipation, or mixed IBS) plays an important role in selection of diagnostic tests and treatments. Various dietary, lifestyle, medical, and behavioral interventions have proven effective in randomized clinical trials. CONCLUSIONS AND RELEVANCE: The diagnosis of IBS relies on the identification of characteristic symptoms and the exclusion of other organic diseases. Management of patients with IBS is optimized by an individualized, holistic approach that embraces dietary, lifestyle, medical, and behavioral interventions.
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Cites
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856
Self-citationStool form scale as a useful guide to intestinal transit time
Lewis, S. J., & Heaton, K. W. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529709011203 · Cited by 3,244
Global Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-analysis
Lovell, R. M., & Ford, A. C. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.02.029 · Cited by 2,155
Intestinal microbiota in functional bowel disorders: a Rome foundation report
Simrén, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J., & Zoetendal, E. G. (2013) · Gut · doi:10.1136/gutjnl-2012-302167 · Cited by 939
An Evidence-Based Position Statement on the Management of Irritable Bowel Syndrome
American College of Gastroenterology IBS Task Force (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.122 · Cited by 694
Fond, G., Loundou, A., Hamdani, N., Boukouaci, W., Dargel, A., Oliveira, J., Roger, M., Tamouza, R., Leboyer, M., & Boyer, L. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0502-z · Cited by 647
Halpin, S. J., & Ford, A. C. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.260 · Cited by 607
Physical Activity Improves Symptoms in Irritable Bowel Syndrome: A Randomized Controlled Trial
Johannesson, E., Simrén, M., Strid, H., Bajor, A., & Sadik, R. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.480 · Cited by 431
Tillisch, K., Mayer, E. A., & Labus, J. S. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.07.053 · Cited by 412
Ford, A. C., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R., & Moayyedi, P. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.148 · Cited by 405
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Impact of commonly used drugs on the composition and metabolic function of the gut microbiota
Vich Vila, A., Collij, V., Sanna, S., Sinha, T., Imhann, F., Bourgonje, A. R., Mujagic, Z., Jonkers, D. M. A. E., Masclee, A. A. M., Fu, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14177-z · Cited by 791
Vich Vila, A., Imhann, F., Collij, V., Jankipersadsing, S. A., Gurry, T., Mujagic, Z., Kurilshikov, A., Bonder, M. J., Jiang, X., Tigchelaar, E. F., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aap8914 · Cited by 587
Zamani, M., Alizadeh‐Tabari, S., & Zamani, V. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15325 · Cited by 496
Klem, F., Wadhwa, A., Prokop, L. J., Sundt, W. J., Farrugia, G., Camilleri, M., Singh, S., & Grover, M. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.12.039 · Cited by 474
Diagnosis and management of chronic constipation in adults
Rao, S. S. C., Rattanakovit, K., & Patcharatrakul, T. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.53 · Cited by 337
Nutritional Keys for Intestinal Barrier Modulation
De Santis, S., Cavalcanti, E., Mastronardi, M., Jirillo, E., & Chieppa, M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00612 · Cited by 232
Holvoet, T., Joossens, M., Vázquez-Castellanos, J. F., Christiaens, E., Heyerick, L., Boelens, J., Verhasselt, B., van Vlierberghe, H., De Vos, M., Raes, J., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.07.013 · Cited by 201
Henström, M., Diekmann, L., Bonfiglio, F., Hadizadeh, F., Kuech, E.-M., von Köckritz-Blickwede, M., Thingholm, L. B., Zheng, T., Assadi, G., Dierks, C., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-312456 · Cited by 173
Petersen, M. W., Schröder, A., Jørgensen, T., Ørnbøl, E., Meinertz Dantoft, T., Eliasen, M., Benros, M. E., & Fink, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-60318-6 · Cited by 170
Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders
Currò, D., Ianiro, G., Pecere, S., Bibbò, S., & Cammarota, G. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13632 · Cited by 160
Behavioral and Diet Therapies in Integrated Care for Patients With Irritable Bowel Syndrome
Chey, W. D., Keefer, L., Whelan, K., & Gibson, P. R. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.06.099 · Cited by 154
Self-citationLong-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs
Harvie, R. M., Chisholm, A. W., Bisanz, J. E., Burton, J. P., Herbison, P., Schultz, K., & Schultz, M. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i25.4632 · Cited by 143
Irritable bowel syndrome diagnosis and management: A simplified algorithm for clinical practice
Moayyedi, P., Mearin, F., Azpiroz, F., Andresen, V., Barbara, G., Corsetti, M., Emmanuel, A., Hungin, A. P. S., Layer, P., Stanghellini, V., et al. (2017) · United European Gastroenterology Journal · doi:10.1177/2050640617731968 · Cited by 135
Aziz, I., Törnblom, H., Palsson, O. S., Whitehead, W. E., & Simrén, M. (2018) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0074-z · Cited by 132
No distinct microbiome signature of irritable bowel syndrome found in a Swedish random population
Hugerth, L. W., Andreasson, A., Talley, N. J., Forsberg, A. M., Kjellström, L., Schmidt, P. T., Agreus, L., & Engstrand, L. (2020) · Gut · doi:10.1136/gutjnl-2019-318717 · Cited by 102
Ishaque, S. M., Khosruzzaman, S. M., Ahmed, D. S., & Sah, M. P. (2018) · BMC Gastroenterology · doi:10.1186/s12876-018-0788-9 · Cited by 109
Chey, W. D., Lembo, A. J., & Rosenbaum, D. P. (2017) · American Journal of Gastroenterology · doi:10.1038/ajg.2017.41 · Cited by 102
Self-citationA Meta-Analysis of the Clinical Use of Curcumin for Irritable Bowel Syndrome (IBS)
Ng, Q., Soh, A., Loke, W., Venkatanarayanan, N., Lim, D., & Yeo, W.-S. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7100298 · Cited by 95
Safety of Eluxadoline in Patients with Irritable Bowel Syndrome with Diarrhea
Cash, B. D., Lacy, B. E., Schoenfeld, P. S., Dove, L. S., & Covington, P. S. (2017) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.542 · Cited by 88
Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models
Touw, K., Ringus, D. L., Hubert, N., Wang, Y., Leone, V. A., Nadimpalli, A., Theriault, B. R., Huang, Y. E., Tune, J. D., Herring, P. B., et al. (2017) · Physiological Reports · doi:10.14814/phy2.13182 · Cited by 68
Ceuleers, H., Hanning, N., Heirbaut, J., Van Remoortel, S., Joossens, J., Van Der Veken, P., Francque, S. M., De bruyn, M., Lambeir, A., De Man, J. G., et al. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14396 · Cited by 49
Gastrointestinal dysfunction in postural tachycardia syndrome
Wang, L. B., Culbertson, C. J., Deb, A., Morgenshtern, K., Huang, H., & Hohler, A. D. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.10.052 · Cited by 45
The development of irritable bowel syndrome: a prospective community-based cohort study
Löwe, B., Lohse, A., Andresen, V., Vettorazzi, E., Rose, M., & Broicher, W. (2016) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.255 · Cited by 43
Tuteja, A. K., Talley, N. J., Stoddard, G. J., & Verne, G. N. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5344-5 · Cited by 42
Sadowski, A., Dunlap, C., Lacombe, A., & Hanes, D. (2021) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000275 · Cited by 45
“2) (3) with direct and indirect annual healthcare costs exceeding 20 billion dollars (4).”
Background(2017) · doi:10.1097/mog.0000000000000322 · Cited by 36
Yuan, T., Manohar, K., Latorre, R., Orock, A., & Greenwood-Van Meerveld, B. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.04.020 · Cited by 35
Eluxadoline in irritable bowel syndrome with diarrhea: rationale, evidence and place in therapy
Barshop, K., & Staller, K. (2017) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622317714389 · Cited by 25
Bassotti, G., Macchioni, L., Corazzi, L., Marconi, P., & Fettucciari, K. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2736-1 · Cited by 22
Kemppinen, A., Howell, C., Allgar, V., Dodd, M., Gregson, J., Knowles, C., McLaughlin, J., Pandya, P., Whorwell, P., Markaryan, E., et al. (2020) · Trials · doi:10.1186/s13063-020-4069-x · Cited by 14
Symptomatology Correlations Between the Diaphragm and Irritable Bowel Syndrome
Bordoni, B., & Morabito, B. (2018) · Cureus · doi:10.7759/cureus.3036 · Cited by 13
Yiannakou, Y., Agrawal, A., Allen, P. B., Arebi, N., Brown, S. R., Eugenicos, M. P., Farmer, A. D., McLain-Smith, S., McLaughlin, J., Sanders, D. S., et al. (2018) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284818798791 · Cited by 12
Shahkaram, H., Yaztappeh, J. S., Sadeghi, A., Kianimoghadam, A. S., Soltanabadi, S., Bakhtiari, M., & Arani, A. M. (2024) · BMC Gastroenterology · doi:10.1186/s12876-024-03142-w · Cited by 6
Metadata
- Authors
- Chey, W. D., Kurlander, J., & Eswaran, S.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2015-03-03
- Volume
- 313
- Issue
- 9
- Pages
- 949
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2144750725
- Cited by
- 1,081
- References
- 27
- FWCI
- 83.40
- Type
- journal article
- Language
- en
- Open access
- closed
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