The DOI matches its Crossref record; 40 of the 44 references it cites were found in a registry or an index.
Effect of a 24-Month Physical Activity Intervention vs Health Education on Cognitive Outcomes in Sedentary Older Adults: The LIFE Randomized Trial
Open accessAbstract
IMPORTANCE: Epidemiological evidence suggests that physical activity benefits cognition, but results from randomized trials are limited and mixed. OBJECTIVE: To determine whether a 24-month physical activity program results in better cognitive function, lower risk of mild cognitive impairment (MCI) or dementia, or both, compared with a health education program. DESIGN, SETTING, AND PARTICIPANTS: A randomized clinical trial, the Lifestyle Interventions and Independence for Elders (LIFE) study, enrolled 1635 community-living participants at 8 US centers from February 2010 until December 2011. Participants were sedentary adults aged 70 to 89 years who were at risk for mobility disability but able to walk 400 m. INTERVENTIONS: A structured, moderate-intensity physical activity program (n = 818) that included walking, resistance training, and flexibility exercises or a health education program (n = 817) of educational workshops and upper-extremity stretching. MAIN OUTCOMES AND MEASURES: Prespecified secondary outcomes of the LIFE study included cognitive function measured by the Digit Symbol Coding (DSC) task subtest of the Wechsler Adult Intelligence Scale (score range: 0-133; higher scores indicate better function) and the revised Hopkins Verbal Learning Test (HVLT-R; 12-item word list recall task) assessed in 1476 participants (90.3%). Tertiary outcomes included global and executive cognitive function and incident MCI or dementia at 24 months. RESULTS: At 24 months, DSC task and HVLT-R scores (adjusted for clinic site, sex, and baseline values) were not different between groups. The mean DSC task scores were 46.26 points for the physical activity group vs 46.28 for the health education group (mean difference, -0.01 points [95% CI, -0.80 to 0.77 points], P = .97). The mean HVLT-R delayed recall scores were 7.22 for the physical activity group vs 7.25 for the health education group (mean difference, -0.03 words [95% CI, -0.29 to 0.24 words], P = .84). No differences for any other cognitive or composite measures were observed. Participants in the physical activity group who were 80 years or older (n = 307) and those with poorer baseline physical performance (n = 328) had better changes in executive function composite scores compared with the health education group (P = .01 for interaction for both comparisons). Incident MCI or dementia occurred in 98 participants (13.2%) in the physical activity group and 91 participants (12.1%) in the health education group (odds ratio, 1.08 [95% CI, 0.80 to 1.46]). CONCLUSIONS AND RELEVANCE: Among sedentary older adults, a 24-month moderate-intensity physical activity program compared with a health education program did not result in improvements in global or domain-specific cognitive function. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01072500.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Other interventional studies have often, but not always, found beneficial effects of aerobic exercise on cognition.96–99”
From Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (2017) · cites this paper as [99]
In the citing paper
“Some studies have shown larger benefits on executive tasks than other cognitive domains.97,99,102,103”
From Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (2017) · cites this paper as [99]
In the citing paper
“Encouraging results have been observed in some, but not all,99 RCTs targeting some of these conditions.”
From Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (2017) · cites this paper as [99]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657
Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.008 · Cited by 10,152
Effects of noise letters upon the identification of a target letter in a nonsearch task
Eriksen, B. A., & Eriksen, C. W. (1974) · Perception & Psychophysics · doi:10.3758/bf03203267 · Cited by 7,230
Kaplan, E., Goodglass, H., Weıntraub, S., & Segal, O. (2001) · Medical Entomology and Zoology · Cited by 4,378
Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability
Guralnik, J. M., Ferrucci, L., Simonsick, E. M., Salive, M. E., & Wallace, R. B. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503023320902 · Cited by 4,083
Self-citationFitness Effects on the Cognitive Function of Older Adults: A Meta-Analytic Study
Colcombe, S., & Kramer, A. F. (2003) · Psychological Science · doi:10.1111/1467-9280.t01-1-01430 · Cited by 3,782
Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60461-5 · Cited by 3,689
Cognitive reserve in ageing and Alzheimer's disease
Stern, Y. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70191-6 · Cited by 3,557
Costs of a predictible switch between simple cognitive tasks.
Rogers, R. D., & Monsell, S. (1995) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.124.2.207 · Cited by 3,170
Measurement of Functional Activities in Older Adults in the Community
PFEFFER, R. I., Kurosaki, T., Harrah, C. H., Chance, J. M., & Filos, S. (1982) · Journal of Gerontology · doi:10.1093/geronj/37.3.323 · Cited by 2,978
Research works printed but not linked: 1
- [32]Yuan Y Multiple Imputation Using SAS Software J Statistical Software 2011 45 1 25 PMC3267837 22289957
Cited by
Sorted by citations
Knopman, D. S., Amieva, H., Petersen, R. C., Chételat, G., Holtzman, D. M., Hyman, B. T., Nixon, R. A., & Jones, D. T. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00269-y · Cited by 2,606
2020 ESC guidelines on sports cardiology and exercise in patients with cardiovascular disease
Pelliccia, A., Sharma, S., Gati, S., Bäck, M., Börjesson, M., Caselli, S., Collet, J.-P., Corrado, D., Drezner, J. A., Halle, M., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehaa605 · Cited by 1,958
Diagnosis and Management of Dementia: Review
Arvanitakis, Z., Shah, R. C., & Bennett, D. A. (2019) · JAMA · doi:10.1001/jama.2019.4782 · Cited by 1,561
Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease
Kivipelto, M., Mangialasche, F., & Ngandu, T. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0070-3 · Cited by 1,173
Vascular Cognitive Impairment and Dementia
Iadecola, C., Duering, M., Hachinski, V., Joutel, A., Pendlebury, S. T., Schneider, J. A., & Dichgans, M. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.04.034 · Cited by 865
van Charante, E. P. M., Richard, E., Eurelings, L. S., van Dalen, J.-W., Ligthart, S. A., van Bussel, E. F., Hoevenaar-Blom, M. P., Vermeulen, M., & van Gool, W. A. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30950-3 · Cited by 611
Association Between Sarcopenia and Cognitive Impairment: A Systematic Review and Meta-Analysis
Chang, K. C., Hsu, T.-H., Wu, W., Huang, K., & Han, D. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.09.013 · Cited by 448
Sabia, S., Dugravot, A., Dartigues, J., Abell, J. G., Elbaz, A., Mika Kivimaki, B., & Singh‐Manoux, A. (2017) · BMJ · doi:10.1136/bmj.j2709 · Cited by 466
Barha, C. K., Davis, J. C., Falck, R. S., Nagamatsu, L. S., & Liu-Ambrose, T. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.04.002 · Cited by 432
Santos, C. Y., Snyder, P. J., Wu, W., Zhang, M., Echeverria, A., & Alber, J. (2017) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.01.005 · Cited by 431
Gorelick, P. B., Furie, K. L., Iadecola, C., Smith, E. E., Waddy, S. P., Lloyd-Jones, D. M., Bae, H.-J., Bauman, M. A., Dichgans, M., Duncan, P. W., et al. (2017) · Stroke · doi:10.1161/str.0000000000000148 · Cited by 411
Falck, R. S., Davis, J. C., Best, J. R., Crockett, R. A., & Liu-Ambrose, T. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.03.007 · Cited by 437
The Mental Health Benefits of Physical Activity in Older Adults Survive the COVID-19 Pandemic
Callow, D. D., Arnold-Nedimala, N. A., Jordan, L. S., Pena, G. S., Won, J., Woodard, J. L., & Smith, J. C. (2020) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2020.06.024 · Cited by 365
Hoffmann, K., Sobol, N. A., Frederiksen, K. S., Beyer, N., Vogel, A., Vestergaard, K., Brændgaard, H., Gottrup, H., Lolk, A., Wermuth, L., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150817 · Cited by 374
Fitness Effects on the Cognitive Function of Older Adults: A Meta-Analytic Study—Revisited
Kramer, A. F., & Colcombe, S. J. (2018) · Perspectives on Psychological Science · doi:10.1177/1745691617707316 · Cited by 288
Brasure, M., Desai, P., Davila, H., Nelson, V. A., Calvert, C., Jutkowitz, E., Butler, M., Fink, H. A., Ratner, E., Hemmy, L. S., et al. (2018) · Annals of Internal Medicine · doi:10.7326/m17-1528 · Cited by 280
Diamond, A. D., & Ling, D. S. (2019) · Oxford University Press eBooks · doi:10.1093/oso/9780199974467.003.0008 · Cited by 343
Exercise and Hippocampal Memory Systems
Voss, M. W., Soto, C., Yoo, S., Sodoma, M., Vivar, C., & van Praag, H. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.01.006 · Cited by 235
Physical Activity and Cognitive Decline Among Older Adults: A Systematic Review and Meta-Analysis
Iso-Markku, P., Aaltonen, S., Kujala, U. M., Halme, H.-L., Phipps, D., Knittle, K., Vuoksimaa, E., & Waller, K. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.54285 · Cited by 227
Midlife cardiovascular fitness and dementia: A 44-year longitudinal population study in women
Hörder, H., Johansson, L., Guo, X., Grimby, G., Kern, S., Östling, S., & Skoog, I. (2018) · Neurology · doi:10.1212/wnl.0000000000005290 · Cited by 188
Goldman, J. G., Vernaleo, B. A., Camicioli, R. M., Dahodwala, N. A., Dobkin, R. D., Ellis, T. D., Galvin, J. E., Marras, C., Edwards, J. D., Fields, J. A., et al. (2018) · npj Parkinson s Disease · doi:10.1038/s41531-018-0055-3 · Cited by 188
Measuring gait speed to better identify prodromal dementia
Grande, G., Triolo, F., Nuara, A., Welmer, A., Fratiglioni, L., & Vetrano, D. L. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.05.014 · Cited by 195
Dietary habits, lifestyle factors and neurodegenerative diseases
Popa‐Wagner, A., Dumbrava, D., Dumitrascu, D., Căpitănescu, B., Petcu, E. B., Surugiu, R., & Fang, W.-H. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266045 · Cited by 190
Lisko, I., Kulmala, J., Annetorp, M., Ngandu, T., Mangialasche, F., & Kivipelto, M. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13227 · Cited by 190
Cognitive Impairment in Older Adults
Palmer, N. P., Ortega, B. T., & Joshi, P. (2022) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2022.07.010 · Cited by 200
Cognitive Aging and the Promise of Physical Activity
Erickson, K. I., Donofry, S. D., Sewell, K. R., Brown, B. M., & Stillman, C. M. (2022) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-072720-014213 · Cited by 195
Relationships between physical activity, sleep and cognitive function: A narrative review
Sewell, K. R., Erickson, K. I., Rainey‐Smith, S. R., Peiffer, J. J., Sohrabi, H. R., & Brown, B. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.003 · Cited by 195
Aerobic exercise improves cognition and cerebrovascular regulation in older adults
Guadagni, V., Drogos, L. L., Tyndall, A. V., Davenport, M. H., Anderson, T. J., Eskes, G. A., Longman, R. S., Hill, M. D., Hogan, D. B., & Poulin, M. J. (2020) · Neurology · doi:10.1212/wnl.0000000000009478 · Cited by 170
Effects of Mindfulness Training and Exercise on Cognitive Function in Older Adults
Lenze, E. J., Voegtle, M. L., Miller, J. P., Ances, B. M., Balota, D. A., Barch, D. M., Depp, C. A., Diniz, B. S., Eyler, L. T., Foster, E. R., et al. (2022) · JAMA · doi:10.1001/jama.2022.21680 · Cited by 188
Bu, Z., Huang, A., Xue, M., Li, Q. Y., Bai, Y., & Xu, G. (2020) · Brain and Behavior · doi:10.1002/brb3.1926 · Cited by 174
An umbrella review of randomized control trials on the effects of physical exercise on cognition
Ciria, L. F., Román-Caballero, R., Vadillo, M. A., Holgado, D., Luque-Casado, A., Perakakis, P., & Sanabria, D. (2023) · Nature Human Behaviour · doi:10.1038/s41562-023-01554-4 · Cited by 157
Doi, T., Verghese, J., Makizako, H., Tsutsumimoto, K., Hotta, R., Nakakubo, S., Suzuki, T., & Shimada, H. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.02.013 · Cited by 170
Self-citationJoubert, C., & Chainay, H. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s165399 · Cited by 170
Strategies for dementia prevention: latest evidence and implications
Rakesh, G., Szabo, S. T., Alexopoulos, G. S., & Zannas, A. S. (2017) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622317712442 · Cited by 164
Aerobic Exercise: Evidence for a Direct Brain Effect to Slow Parkinson Disease Progression
Ahlskog, J. E. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.12.015 · Cited by 162
Chen, L., Hwang, A., Lee, W., Peng, L., Lin, M., Neil, D. L., Shih, S., Loh, C., Chiou, S., & Taiwan Health Promotion Intervention Study for Elders research group (2020) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12534 · Cited by 134
Wheeler, M. J., GREEN, D. J., Ellis, K. A., Cerin, E., HEINONEN, I. H. A., Naylor, L. H., Larsen, R. N., Wennberg, P., Boraxbekk, C., Lewis, J., et al. (2019) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-100168 · Cited by 139
Toots, A., Littbrand, H., Boström, G., Hörnsten, C., Holmberg, H., Lundin‐Olsson, L., Lindelöf, N., Nordström, P., Gustafson, Y., & Rosendahl, E. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170014 · Cited by 128
Jin, X., He, W., Zhang, Y., Gong, E., Niu, Z., Ji, J. S., Li, Y., Zeng, Y., & Yan, L. L. (2021) · PLoS Medicine · doi:10.1371/journal.pmed.1003597 · Cited by 125
Protective actions of exercise-related FNDC5/irisin in memory and Alzheimer's disease
de Freitas, G. B., Lourenco, M. V., & De Felice, F. G. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15039 · Cited by 120
Merom, D., Grunseit, A. C., Eramudugolla, R., Jefferis, B. J. M. H., McNeill, J., & Anstey, K. J. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00026 · Cited by 134
Park, H., Park, J., Na, H. R., Shimada, H., Kim, G. M., Jung, M.-K., Kim, W. K., & Park, K. W. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8070940 · Cited by 120
Xiong, J., Ye, M., Wang, L., & Zheng, G. (2020) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2020.103810 · Cited by 143
Obesity-induced cognitive impairment in older adults: a microvascular perspective
Balasubramanian, P., Kiss, T., Tarantini, S., Nyúl‐Tóth, Á., Ahire, C., Yabluchanskiy, A., Csípő, T., Lipécz, Á., Tabák, Á. G., Institóris, Á., et al. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00736.2020 · Cited by 116
Promoting brain health through exercise and diet in older adults: a physiological perspective
Jackson, P. A., Pialoux, V., Corbett, D., Drogos, L. L., Erickson, K. I., Eskes, G. A., & Poulin, M. J. (2015) · The Journal of Physiology · doi:10.1113/jp271270 · Cited by 118
Espeland, M. A., Lipska, K. J., Miller, M. E., Rushing, J., Cohen, R. A., Verghese, J., McDermott, M. M., King, A. C., Strotmeyer, E. S., Blair, S. N., et al. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw179 · Cited by 117
Self-citationCawthon, P. M., Blackwell, T., Cummings, S. R., Orwoll, E. S., Duchowny, K. A., Kado, D. M., Stone, K. L., Ensrud, K. E., Cauley, J. A., & Evans, W. J. (2021) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glaa111 · Cited by 105
Physical activity and trajectories in cognitive function: English Longitudinal Study of Ageing
Hamer, M., Terrera, G. M., & Demakakos, P. (2018) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2017-210228 · Cited by 112
Physical Activity and Sarcopenia in the Geriatric Population: A Systematic Review
Lee, S.-Y., Tung, H., Liu, C., & Chen, L. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.02.003 · Cited by 99
Gill, T. M., Pahor, M., Guralnik, J. M., McDermott, M. M., King, A. C., Buford, T. W., Strotmeyer, E. S., Nelson, M. E., Sink, K. M., Demons, J. L., et al. (2016) · BMJ · doi:10.1136/bmj.i245 · Cited by 97
Self-citationSarant, J. Z., Harris, D., Busby, P. A., Maruff, P. T., Schembri, A. J., Dowell, R. C., & Briggs, R. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00789 · Cited by 97
Dual-Task Exercise to Improve Cognition and Functional Capacity of Healthy Older Adults
Jardim, N. Y. V., Bento-Torres, N. V. O., da Costa, V. O., Carvalho, J. P. R., Pontes, H. T. S., Tomás, A. M., Sosthenes, M. C. K., Erickson, K. I., Bento‐Torres, J., & Diniz, C. W. P. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.589299 · Cited by 105
Harris, T., Kerry, S. M., Limb, E. S., Furness, C., Wahlich, C., Victor, C. R., Iliffe, S., Whincup, P. H., Ussher, M., Ekelund, U., et al. (2018) · PLoS Medicine · doi:10.1371/journal.pmed.1002526 · Cited by 95
A Life-Long Approach to Physical Activity for Brain Health
Macpherson, H., Teo, W.-P., Schneider, L. A., & Smith, A. E. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00147 · Cited by 104
Blood will out: vascular contributions to Alzheimer’s disease
Strickland, S. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97509 · Cited by 97
Exercise Improves Vascular Function, but does this Translate to the Brain?
Barnes, J. N., & Corkery, A. T. (2018) · Brain Plasticity · doi:10.3233/bpl-180075 · Cited by 105
for the LIFE Study investigators, Liu, Z., Hsu, F., Trombetti, A., King, A. C., Liu, C., Manini, T. M., Fielding, R. A., Pahor, M., Newman, A. B., et al. (2018) · BMC Medicine · doi:10.1186/s12916-018-1174-8 · Cited by 92
Self-citationDietary Patterns, Physical Activity, Sleep, and Risk for Dementia and Cognitive Decline
Zhao, C., Noble, J. M., Marder, K. S., Hartman, J. S., Gu, Y., & Scarmeas, N. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0247-9 · Cited by 92
Lee, W., Peng, L., Lin, C., Chen, R., Lin, S., Loh, C., Kao, S., Hung, T.-S., Chang, C.-Y., Huang, C.-F., et al. (2021) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00248-8 · Cited by 90
de Souto Barreto, P., Demougeot, L., Vellas, B., & Rolland, Y. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx234 · Cited by 85
Relationship between physical activity and cognitive functioning among older Indian adults
Kumar, M., Srivastava, S., & Muhammad, T. (2022) · Scientific Reports · doi:10.1038/s41598-022-06725-3 · Cited by 98
Veronese, N., Soysal, P., Demurtas, J., Solmi, M., Bruyère, O., Christodoulou, N., Ramalho, R., Fusar‐Poli, P., Lappas, A. S., Pinto, D., et al. (2023) · European Geriatric Medicine · doi:10.1007/s41999-023-00858-y · Cited by 97
Barha, C. K., Hsiung, G. R., Best, J. R., Davis, J. C., Eng, J. J., Jacova, C., Lee, P. E., Munkacsy, M., Cheung, W., & Liu-Ambrose, T. Y. L. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170221 · Cited by 94
Physical Activity and Alzheimer’s Disease: A Systematic Review
Stephen, R., Hongisto, K., Solomon, A., & Lönnroos, E. (2017) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw251 · Cited by 262
Whitty, E., Mansour, H., Aguirre, E., Palomo, M., Charlesworth, G. M., Ramjee, S., Poppe, M., Brodaty, H., Kales, H. C., Morgan‐Trimmer, S., et al. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101113 · Cited by 84
Approach to Cognitive Impairment in Parkinson's Disease
Zhang, Q., Aldridge, G. M., Narayanan, N., Anderson, S. W., & Uc, E. Y. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00963-x · Cited by 87
Hippocampal Response to a 24-Month Physical Activity Intervention in Sedentary Older Adults
Rosano, C., Guralnik, J. M., Pahor, M., Glynn, N. W., Newman, A. B., Ibrahim, T. S., Erickson, K. I., Cohen, R. A., Shaaban, C. E., MacCloud, R. L., et al. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.11.007 · Cited by 82
Self-citationRandomized Controlled Trial of Exercise for ADHD and Disruptive Behavior Disorders
Bustamante, E. E., Davis, C. L., Frazier, S. L., Rusch, D. B., Fogg, L., Atkins, M. S., & MARQUEZ, D. X. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000891 · Cited by 89
Relationship between decline in cognitive resources and physical activity.
Cheval, B., Orsholits, D., Sieber, S., Courvoisier, D. S., Cullati, S., & Boisgontier, M. P. (2020) · Health Psychology · doi:10.1037/hea0000857 · Cited by 84
Effects of an Exercise Program on Brain Health Outcomes for Children With Overweight or Obesity
Ortega, F. B., Mora-González, J., Cadenas‐Sánchez, C., Esteban‐Cornejo, I., Migueles, J. H., Solis‐Urra, P., Verdejo‐Román, J., Rodríguez‐Ayllón, M., Molina‐García, P., Ruiz, J. R., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.27893 · Cited by 91
Biological Sex: A Potential Moderator of Physical Activity Efficacy on Brain Health
Barha, C. K., Hsu, C. L., ten Brinke, L., & Liu-Ambrose, T. Y. L. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00329 · Cited by 80
Puts, M. T. E., Alqurini, N., Strohschein, F. J., Koneru, R., Szumacher, E., Mariano, C. J., Monette, J., Hsu, T., Brennenstuhl, S., McLean, B., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.22.01007 · Cited by 77
Impact of physical activity programs and services for older adults: a rapid review
Pinheiro, M. B., Oliveira, J. S., Baldwin, J., Hassett, L. M., Costa, N., Gilchrist, H., Wang, B., Kwok, W. S., Albuquerque, B. S., Pivotto, L. R., et al. (2022) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-022-01318-9 · Cited by 97
Physical activity for brain health in older adults
Liu-Ambrose, T. Y. L., Barha, C. K., & Best, J. R. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0260 · Cited by 77
Health-Promoting Strategies for the Aging Brain
Chen, S. T., Volle, D. C., Jalil, J., Wu, P., & Small, G. W. (2018) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.12.016 · Cited by 75
Joint Trajectories of Cognition and Frailty and Associated Burden of Patient-Reported Outcomes
Liu, Z., Han, L., Gahbauer, E. A., Allore, H. G., & Gill, T. M. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.10.010 · Cited by 74
Healthy cognitive ageing in the Lothian Birth Cohort studies: marginal gains not magic bullet
Corley, J., Cox, S. R., & Deary, I. J. (2017) · Psychological Medicine · doi:10.1017/s0033291717001489 · Cited by 71
Lifestyle Choices and Brain Health
Mintzer, J. E., Donovan, K. A., Kindy, A. Z., Lock, S. L., Chura, L. R., & Barracca, N. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2019.00204 · Cited by 81
The effect of lifestyle on late-life cognitive change under different socioeconomic status
Weng, P., Chen, J., Chiou, J., Tu, Y., Chen, T., Chiu, M., Tang, S., Yeh, S., & Chen, Y. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197676 · Cited by 71
Ortiz‐Piña, M., Molina‐García, P., Femia, P., Ashe, M. C., Martín‐Martín, L., Salazar‐Graván, S., Salas‐Fariña, Z., Prieto‐Moreno, R., Castellote‐Caballero, Y., Estévez‐López, F., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18105493 · Cited by 74
Palta, P., Sharrett, A. R., Deal, J. A., Evenson, K. R., Gabriel, K. P., Folsom, A. R., Gross, A. L., Windham, B. G., Knopman, D. S., Mosley, T. H., et al. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.08.008 · Cited by 73
Migueles, J. H., Cadenas‐Sánchez, C., Lubans, D. R., Henriksson, P., Torres‐Lopez, L. V., Rodríguez‐Ayllón, M., Plaza‐Florido, A., Gil-Cosano, J. J., Henriksson, H., Escolano-Margarit, M. V., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.24839 · Cited by 83
Body–Brain Connections: The Effects of Obesity and Behavioral Interventions on Neurocognitive Aging
Stillman, C. M., Weinstein, A. M., Marsland, A. L., Gianaros, P. J., & Erickson, K. I. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00115 · Cited by 69
Health education as a strategy for the promotion of the health of the elderly: an integrative review
Seabra, C. A. M., Xavier, S. P. L., Sampaio, Y. P. C. C., de Oliveira, M. F., Quirino, G. D. S., & Machado, M. D. F. A. S. (2019) · Revista Brasileira de Geriatria e Gerontologia · doi:10.1590/1981-22562019022.190022 · Cited by 64
The road to precision medicine: Eliminating the “One Size Fits All” approach in Alzheimer’s disease
Behl, T., Kaur, I., Sehgal, A., Singh, S., Albarrati, A., Albratty, M., Najmi, A., Meraya, A. M., & BUNGAU, S. G. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113337 · Cited by 67
Physical Activity and Cognitive Function in Middle-Aged and Older Adults
Barreto, P. D. S., Delrieu, J., Andrieu, S., Vellas, B. J., & Rolland, Y. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.06.032 · Cited by 66
Coley, N., Giulioli, C., Aisen, P. S., Vellas, B., & Andrieu, S. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101777 · Cited by 62
Sipilä, S., Tirkkonen, A., Hänninen, T., Laukkanen, P., Alén, M., Fielding, R. A., Kivipelto, M., Kokko, K., Kulmala, J., Rantanen, T., et al. (2018) · BMC Geriatrics · doi:10.1186/s12877-018-0906-0 · Cited by 63
Longitudinal changes in physical function and physical activity in older adults
Metti, A. L., Best, J. R., Shaaban, C. E., Ganguli, M., & Rosano, C. (2018) · Age and Ageing · doi:10.1093/ageing/afy025 · Cited by 60
Do nonpharmacological interventions prevent cognitive decline? a systematic review and meta-analysis
Yao, S., Liu, Y., Zheng, X., Zhang, Y., Cui, S., Tang, C., Lu, L., & Xu, N. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0690-4 · Cited by 62
Bott, N. T., Hall, A., Madero, E. N., Glenn, J. M., Fuseya, N., Gills, J. L., & Gray, M. (2019) · Nutrients · doi:10.3390/nu11092258 · Cited by 58
Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise
Jensen, C. S., Simonsen, A. H., Siersma, V., Beyer, N., Frederiksen, K. S., Gottrup, H., Hoffman, K., Høgh, P., Frikke‐Schmidt, R., Sobol, N. A., et al. (2019) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.02.007 · Cited by 55
Hippocampal sub‐regional shape and physical activity in older adults
Varma, V. R., Tang, X., & Carlson, M. C. (2016) · Hippocampus · doi:10.1002/hipo.22586 · Cited by 54
Callisaya, M. L., Daly, R. M., Sharman, J. E., Bruce, D. G., Davis, T. M. E., Greenaway, T. M., Nolan, M. T., Beare, R. J., Schultz, M. G., Phan, T. G., et al. (2017) · BMC Geriatrics · doi:10.1186/s12877-017-0635-9 · Cited by 54
Allen, M. S., Laborde, S., & Walter, E. E. (2017) · Journal of Applied Gerontology · doi:10.1177/0733464817698816 · Cited by 53
Wang, Y., Du, Y., Li, J., & Qiu, C. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00129 · Cited by 54
Stephen, R., Barbera, M., Peters, R. K., Ee, N., Zheng, L., Lehtisalo, J., Kulmala, J., Håkansson, K., Chowdhary, N., Dua, T., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.763573 · Cited by 58
Kim, M.-J., Han, C.-W., Min, K.-Y., Cho, C.-Y., Lee, C.-W., Ogawa, Y., Mori, E., & Kohzuki, M. (2016) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000446508 · Cited by 51
Aguirre-Loaiza, H., Arenas, J., Padilla, I. A., Jiménez, A. M. F., Barbosa-Granados, S., Bermúdez, S. R., Ayala-Zuluaga, F., Núñez, C., & García-Más, A. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02774 · Cited by 64
Leisure-time physical activity and the risk of incident dementia: the mayo clinic study of aging
Krell-Roesch, J., Feder, N. T., Roberts, R. O., Mielke, M. M., Christianson, T. J., Knopman, D. S., Petersen, R. C., & Geda, Y. E. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171141 · Cited by 50
Metadata
- Authors
- Sink, K. M., Espeland, M. A., Castro, C. M., Church, T., Cohen, R., Dodson, J. A., Guralnik, J., Hendrie, H. C., Jennings, J., Katula, J., Lopez, O. L., McDermott, M. M., Pahor, M., Reid, K. F., Rushing, J., Verghese, J., Rapp, S., & Williamson, J. D.
- Affiliations
- Wake Forest University Health Sciences (US)
- Stanford Medicine (US)
- Pennington Biomedical Research Center (US)
- University of Florida (US)
- New York University (US)
- University of Maryland, Baltimore (US)
- Indiana University Indianapolis (US)
- Wake Forest University (US)
- Department of Health and Exercise Sciences, Wake Forest University, Winston-Salem, North Carolina
- Departments of Neurology and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania
- Northwestern University (US)
- Tufts University (US)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Sink, Kaycee M.
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2015-08-25
- Volume
- 314
- Issue
- 8
- Pages
- 781
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC4698980
- OpenAlex
- W2110665915
- Cited by
- 402
- References
- 44
- Citations by year
- 2026: 26 · 2025: 23 · 2024: 32 · 2023: 34 · 2022: 44 · 2021: 38 · 2020: 44 · 2019: 45 · 2018: 42 · 2017: 38 · 2016: 30 · 2015: 5
- FWCI
- 31.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- JAMA (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Agriculture (58-1950-7-707)
- National Institutes of Health (5p30ag031679-15)
- National Institute on Aging (1-P30-AG21332, U01AG022376, 1 P30 AG031679, 3U01AG022376-05A2S, UO1 AG22376, P30-AG031679, P30AG024827, P30AG028740, P30AG021332, P30AG021342)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- physical activity interventions, health education, cognitive function, older adults, sedentary lifestyle, mild cognitive impairment, dementia, walking, resistance training, flexibility training, executive function, verbal learning, life studies, community-dwelling older adults, cognitive aging, memory retrieval, attention and processing speed, walking speed
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Dementia, Exercise Therapy, Female, Health Education, Health Promotion, Humans, Male, Walking, Treatment Outcome, Upper Extremity, Muscle Stretching Exercises, Resistance Training, Executive Function, Sedentary Behavior, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
