Leisure-time physical activity and the risk of incident dementia: the mayo clinic study of aging
Open accessAbstract
We conducted a prospective cohort study derived from the population-based Mayo Clinic Study of Aging. We investigated if leisure-time physical activity among individuals with mild cognitive impairment (MCI) was associated with a decreased risk of developing dementia. 280 persons aged≥70 years (median 81 years, 165 males) with MCI and available data from neurologic evaluation, neuropsychological testing, and questionnaire-based physical activity assessment, were followed for a median of 3 years to the outcomes of incident dementia or censoring variables. We conducted Cox proportional hazards regression analyses with age as a time scale and adjusted for sex, education, medical comorbidity, depression, and APOE ɛ4 status. Moderate intensity midlife physical activity among MCI participants was significantly associated with a decreased risk of incident dementia (HR = 0.64; 95% CI, 0.41-0.98). There was a non-significant trend for a decreased risk of dementia for light and vigorous intensity midlife physical activity, as well as light and moderate intensity late-life physical activity. In conclusion, we observed that physical activity may be associated with a reduced risk of dementia among individuals with MCI. Furthermore, intensity and timing of physical activity may be important factors when investigating this association.
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Moderate intensity midlife physical activity is significantly associated with a decreased risk of incident dementia in patients with mild cognitive impairment.
“A recent paper derived from the population-based Mayo Clinic study of aging on 280 MCI patients showed that moderate intensity midlife physical activity was significantly associated with a decreased risk of incident dementia (25).”
From The Multidisciplinary Approach to Alzheimer’s Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment (2018) · cites this paper as [25]
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- Authors
- Krell-Roesch, J., Feder, N. T., Roberts, R. O., Mielke, M. M., Christianson, T. J., Knopman, D. S., Petersen, R. C., & Geda, Y. E.
- Affiliations
- Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, AZ, USA
- Mayo Clinic (US)
- Corresponding author
- Geda, Yonas E.
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2018-04-10
- Volume
- 63
- Issue
- 1
- Pages
- 149-155
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC5900557
- OpenAlex
- W2804900164
- Cited by
- 50
- References
- 34
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 6 · 2019: 3 · 2018: 3
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Alzheimer s Disease (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- Repository KITopen (Karlsruhe Institute of Technology) (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- KITopen
- Funders
- Robert Wood Johnson Foundation
- GHR Foundation
- National Institutes of Health
- National Institute on Aging (R01AG034676, U01AG006786, K01AG028573)
- National Institute of Mental Health (K01MH068351)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- leisure-time physical activity, dementia risk
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Cognition Disorders, Dementia, Female, Humans, Leisure Activities, Male, Neuropsychological Tests, Cohort Studies, Exercise, Incidence, Community Health Planning, Apolipoprotein E4, Self Report
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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