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Effect of a Web-Based Guided Self-help Intervention for Prevention of Major Depression in Adults With Subthreshold Depression: A Randomized Clinical Trial
Open accessAbstract
IMPORTANCE: Evidence-based treatments for major depressive disorder (MDD) are not very successful in improving functional and health outcomes. Attention has increasingly been focused on the prevention of MDD. OBJECTIVE: To evaluate the effectiveness of a web-based guided self-help intervention for the prevention of MDD. DESIGN, SETTING, AND PARTICIPANTS: Two-group randomized clinical trial conducted between March 1, 2013, and March 4, 2015. Participants were recruited in Germany from the general population via a large statutory health insurance company (ie, insurance funded by joint employer-employee contributions). Participants included 406 self-selected adults with subthreshold depression (Centre for Epidemiologic Studies Depression Scale score ≥16, no current MDD according to Diagnostic and Statistical Manual of Mental Disorders [Fourth Edition, Text Revision] criteria). INTERVENTIONS: All participants had unrestricted access to usual care (visits to the primary care clinician) and were randomized to either a web-based guided self-help intervention (cognitive-behavioral and problem-solving therapy supported by an online trainer; n = 202) or a web-based psychoeducation program (n = 204). MAIN OUTCOMES AND MEASURES: The primary outcome was time to onset of MDD in the intervention group relative to the control group over a 12-month follow-up period as assessed by blinded diagnostic raters using the telephone-administered Structured Clinical Interview for DSM-IV Axis Disorders at 6- and 12-month follow-up, covering the period to the previous assessment. RESULTS: Among 406 randomized patients (mean age, 45 years; 73.9% women), 335 (82%) completed the telephone follow-up at 12 months. Fifty-five participants (27%) in the intervention group experienced MDD compared with 84 participants (41%) in the control group. Cox regression analyses controlling for baseline depressive symptom severity revealed a hazard ratio of 0.59 (95% CI, 0.42-0.82; P = .002) at 12-month follow-up. The number needed to treat to avoid 1 new case of MDD was 5.9 (95% CI, 3.9-14.6). CONCLUSIONS AND RELEVANCE: Among patients with subthreshold depression, the use of a web-based guided self-help intervention compared with enhanced usual care reduced the incidence of MDD over 12 months. Further research is needed to understand whether the effects are generalizable to both first onset of depression and depression recurrence as well as efficacy without the use of an online trainer. TRIAL REGISTRATION: German Clinical Trial Registry Identifier: DRKS00004709.
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“The German version of the TiC-P has been used in several studies (eg, see refs. 48 100 101).”
From Clinical and cost-effectiveness of a guided internet-based Acceptance and Commitment Therapy to improve chronic pain-related disability in green professions (PACT-A): Study protocol of a pragmatic randomised controlled trial (2020) · cites this paper as [101]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Mental health interventions provided on a computer or via the Internet, which we will henceforth denote as e-mental health interventions, have acquired a solid empirical basis for the prevention and treatment of various psychological conditions in adults, including depression (Buntrock et al., 2016; Karyotaki et al., 2017), anxiety (Grist et al., 2019), and alcohol use (Riper et al., 2018).”
From The effect of e-mental health interventions on academic performance in university and college students: A meta-analysis of randomized controlled trials (2020) · cites this paper as Buntrock et al., 2016
Experimental — accuracy not yet measuredIn the citing paper
“The intervention is based on “GET.ON Mood Enhancer,” a program that has been evaluated in multiple randomised controlled trials (62–64).”
From Personalised depression forecasting using mobile sensor data and ecological momentary assessment (2022) · cites this paper as [62]
In the citing paper
“On-line screening and intervention programs have been evaluated and shown to be feasible and effective for reducing symptoms (Andersson & Cuijpers, 2009; Spek et al., 2008) and prevent onset of full mental disorders (Buntrock et al., 2016).”
From Severe role impairment associated with mental disorders: Results of the WHO World Mental Health Surveys International College Student Project (2018) · cites this paper as Buntrock et al., 2016
In the citing paper
“Symptom reduction was the primary outcome in all studies, with true prevention in the form of reduced 12-month incidence rates an outcome measure in only two studies [41, 52].”
From eHealth interventions for the prevention of depression and anxiety in the general population: a systematic review and meta-analysis (2017) · cites this paper as [41]
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Citations
Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139
CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
the CONSORT Group, Schulz, K. F., Altman, D. G., & Moher, D. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-18 · Cited by 13,371
Projections of Global Mortality and Burden of Disease from 2002 to 2030
Mathers, C. D., & Loncar, D. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030442 · Cited by 11,386
CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
Schulz, K. F., Altman, D. G., Moher, D., & for the CONSORT Group (2010) · BMJ · doi:10.1136/bmj.c332 · Cited by 9,329
Vos, T., Flaxman, A. D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61729-2 · Cited by 8,291
Validation of the Insomnia Severity Index as an outcome measure for insomnia research
Bastien, C. (2001) · Sleep Medicine · doi:10.1016/s1389-9457(00)00065-4 · Cited by 8,067
Pearlin, L. I., & Schooler, C. (1978) · Journal of Health and Social Behavior · doi:10.2307/2136319 · Cited by 7,791
Proportional hazards tests and diagnostics based on weighted residuals
GRAMBSCH, P. M., & THERNEAU, T. M. (1994) · Biometrika · doi:10.1093/biomet/81.3.515 · Cited by 5,885
Cross-Validation of Item Selection and Scoring for the SF-12 Health Survey in Nine Countries
Gandek, B., Ware, J. E., Aaronson, N. K., Apolone, G., Bjorner, J. B., Brazier, J. E., Bullinger, M., Kaasa, S., Leplege, A., Prieto, L., et al. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00109-7 · Cited by 2,907
Survival Analysis: A Self-Learning Text
Carpenter, M., & Kleinbaum, D. G. (1997) · Technometrics · doi:10.1080/00401706.1997.10485091 · Cited by 1,822
Improving the reporting of pragmatic trials: An extension of the CONSORT statement
Zwarenstein, M., Treweek, S., Gagnier, J. J., Altman, D. G., Tunis, S., Haynes, B., Oxman, A. D., Moher, D., & groups, F. T. C. A. P. T. I. H. (. (2008) · BMJ · doi:10.1136/bmj.a2390 · Cited by 1,813
Internet-based cognitive behaviour therapy for symptoms of depression and anxiety: A meta-analysis
SPEK, V., CUIJPERS, P., NYKLÍČEK, I., RIPER, H., KEYZER, J., & POP, V. (2007) · Psychological Medicine · doi:10.1017/s0033291706008944 · Cited by 1,586
Ferrari, A. J., Somerville, A. J., Baxter, A. J., Norman, R., Patten, S. B., Vos, T., & Whiteford, H. A. (2013) · Psychological Medicine · doi:10.1017/s0033291712001511 · Cited by 1,230
Lobbestael, J., Leurgans, M., & Arntz, A. (2011) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.693 · Cited by 1,124
Calculating the number needed to treat for trials where the outcome is time to an event
Altman, D. G., & Andersen, P. K. (1999) · BMJ · doi:10.1136/bmj.319.7223.1492 · Cited by 710
Kessler, R. C., Sampson, N. A., Berglund, P., Gruber, M. J., Al-Hamzawi, A., Andrade, L., Bunting, B., Demyttenaere, K., Florescu, S., de Girolamo, G., et al. (2015) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796015000189 · Cited by 636
Andrews, G., Issakidis, C., Sanderson, K., Corry, J., & Lapsley, H. (2004) · British Journal of Psychiatry · doi:10.1192/bjp.184.6.526 · Cited by 560
van Zoonen, K., Buntrock, C., Ebert, D. D., Smit, F., Reynolds, C. F., Beekman, A. T., & Cuijpers, P. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyt175 · Cited by 425
Gilbody, S., Littlewood, E., Hewitt, C., Brierley, G., Tharmanathan, P., Araya, R., Barkham, M., Bower, P., Cooper, C., Gask, L., et al. (2015) · BMJ · doi:10.1136/bmj.h5627 · Cited by 409
[Long-term treatment of depression].
Keller, M. B. (1994) · PubMed · Cited by 362
Proportional Hazards Tests and Diagnostics Based on Weighted Residuals
Grambsch, P. M., & Therneau, T. M. (1994) · Biometrika · doi:10.2307/2337123 · Cited by 356
Survival Analysis, a Self-Learning Text
Kleinbaum, D. (1998) · Biometrical Journal · doi:10.1002/(sici)1521-4036(199804)40:1 · Cited by 337
Mack, S., Jacobi, F., Gerschler, A., Strehle, J., Höfler, M., Busch, M. A., Maske, U. E., Hapke, U., Seiffert, I., Gaebel, W., et al. (2014) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.1438 · Cited by 284
The Behavioral Activation for Depression Scale–Short Form: Development and Validation
Manos, R. C., Kanter, J. W., & Luo, W. (2011) · Behavior Therapy · doi:10.1016/j.beth.2011.04.004 · Cited by 276
Ebert, D. D., Berking, M., Cuijpers, P., Lehr, D., Pörtner, M., & Baumeister, H. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.01.056 · Cited by 268
The Life Chart Interview: A standardized method to describe the course of psychopathology.
Lyketsos, C. G., Nestadt, G., Cwi, J. S., & Heithoff, K. A. (1994) · International Journal of Methods in Psychiatric Research · Cited by 201
Minimal-contact psychotherapy for sub-threshold depression in primary care
Willemse, G., Smit, F., Cuijpers, P. J., & Tiemens, B. G. (2004) · The British Journal of Psychiatry · doi:10.1192/bjp.185.5.416 · Cited by 149
Preliminary validation of an ultra‐brief version of the Penn State Worry Questionnaire
Berle, D., Starcevic, V., Moses, K., Hannan, A., Milicevic, D., & Sammut, P. (2011) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.724 · Cited by 112
Crippa, J. A. S., de Lima Osório, F., Del-Ben, C. M., Filho, A. S., da Silva Freitas, M. C., & Loureiro, S. R. (2008) · Perspectives In Psychiatric Care · doi:10.1111/j.1744-6163.2008.00183.x · Cited by 109
Cuijpers, P., van Straten, A., Warmerdam, L., & van Rooy, M. J. (2010) · BMC Health Services Research · doi:10.1186/1472-6963-10-181 · Cited by 106
Buntrock, C., Ebert, D. D., Lehr, D., Riper, H. M., Smit, F., Cuijpers, P. J., & Berking, M. (2015) · Psychotherapy and Psychosomatics · doi:10.1159/000438673 · Cited by 106
Preventing postnatal depression in mothers of very preterm infants: a randomised controlled trial
Hagan, R., Evans, S. F., & Pope, S. (2004) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2004.00165.x · Cited by 79
Dam, E. A., Hosman, C. M. H., Hoogduin, C. A. L., & Schaap, C. P. D. R. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.06.020 · Cited by 78
The long-term treatment of depression.
Keller, M. B. (1999) · PubMed · Cited by 74
Zhang, D., Lewis, G., Araya, R., Tang, W. K., Mak, W. W. S., Cheung, F. M., Mercer, S. W., Griffiths, S. M., Woo, J., Lee, D., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.08.015 · Cited by 44
Otero, P., Smit, F., Cuijpers, P. J., Torres, Á., Blanco, V., & Vázquez, F. L. (2014) · Psychological Medicine · doi:10.1017/s0033291714002505 · Cited by 31
Treatment benefits of duloxetine in major depressive disorder as assessed by number needed to treat
Cookson, J., Gilaberte, I., Desaiah, D., & Kajdasz, D. K. (2006) · International Clinical Psychopharmacology · doi:10.1097/00004850-200609000-00004 · Cited by 29
de Jonge, P., Hadj, F. B., Boffa, D., Zdrojewski, C., Dorogi, Y., So, A. K. L., Ruiz, J. R. R., & Stiefel, F. (2009) · Psychosomatics · doi:10.1176/appi.psy.50.3.227 · Cited by 25
Minimal contact psychotherapy for sub-threshold depression in primary care: a randomised trial.
Willemse, G. R. W. M., Smit, F., Cuijpers, W. J. M. J., & Tiemens, B. G. (2004) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) · Cited by 5
Detecting and describing heterogeneity in meta-analysis
Hardy, R. J., & Thompson, S. G. (1998) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(19980430)17:8
Flagged first, then by citations
1 of the 42 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Lohse MJ, Lorenzen A, Müller-Oerlinghausen B. Psychopharmaka. In: Schwabe U, Pfaffrath D, eds. Arzneiverordnungsreport-Report 2007. Heidelberg, Germany: Springer; 2008:775-813.
- Newcombe RG. Interval estimation for the difference between independent proportions: comparison of eleven methods [published correction appears in Stat Med. 1999;18(10):1293]. Stat Med. 1998;17(8):873-890.
Cited by
Sorted by citations
Auerbach, R. P., Collaborators, W. W.-I., Mortier, P., Bruffaerts, R., Alonso, J., Benjet, C., Cuijpers, P., Demyttenaere, K., Ebert, D. D., Green, J. G., et al. (2018) · Journal of Abnormal Psychology · doi:10.1037/abn0000362 · Cited by 2,522
Time for united action on depression: a Lancet–World Psychiatric Association Commission
Herrman, H., Patel, V., Kieling, C., Berk, M., Buchweitz, C., Cuijpers, P., Furukawa, T. A., Kessler, R. C., Kohrt, B. A., Maj, M., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02141-3 · Cited by 1,104
Preventive psychiatry: a blueprint for improving the mental health of young people
Fusar‐Poli, P., Correll, C. U., Arango, C., Berk, M., Patel, V., & Ioannidis, J. P. A. (2021) · World Psychiatry · doi:10.1002/wps.20869 · Cited by 497
Ebert, D. D., Van Daele, T., Nordgreen, T., Karekla, M., Compare, A., Zarbo, C., Brugnera, A., Øverland, S., Trebbi, G., Jensen, K. L., et al. (2018) · European Psychologist · doi:10.1027/1016-9040/a000318 · Cited by 437
Heber, E., Ebert, D. D., Lehr, D., Cuijpers, P., Berking, M., Nobis, S., & Riper, H. (2017) · Journal of Medical Internet Research · doi:10.2196/jmir.5774 · Cited by 408
Metadata
- Authors
- Buntrock, C., Ebert, D. D., Lehr, D., Smit, F., Riper, H., Berking, M., & Cuijpers, P.
- Affiliations
- Leuphana University of Lüneburg (DE)
- Trimbos Institute (NL)
- Corresponding author
- Ebert, David Daniel
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2016-05-03
- Volume
- 315
- Issue
- 17
- Pages
- 1854
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2345502178
- Cited by
- 232
- References
- 42
- Citations by year
- 2026: 16 · 2025: 20 · 2024: 10 · 2023: 15 · 2022: 17 · 2021: 21 · 2020: 33 · 2019: 25 · 2018: 27 · 2017: 39 · 2016: 9
- FWCI
- 51.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Pure Amsterdam UMC (acceptedVersion, other-oa)
- eScholarship@McGill (McGill) (submittedVersion)
- Multilingual Matters (Channel View Publications) (submittedVersion, other-oa)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- European Commission
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- subthreshold depression, cognitive behavioral therapy, problem-solving therapy, online psychoeducation, online intervention, primary care, adults, number needed to treat, workplace mental health promotion, cost-effectiveness, quality of life
- MeSH terms
- Adult, Depression, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Primary Health Care, Problem Solving, Recurrence, Self Care, Cognitive Behavioral Therapy, Internet
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