Effectiveness of Web- and Mobile-Based Treatment of Subthreshold Depression With Adherence-Focused Guidance: A Single-Blind Randomized Controlled Trial
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Evidence for the impact of psychological Interventions for subthreshold depression (sD) is conflicting. Moreover, human resources to deliver such treatments are limited. This study aimed to evaluate the effectiveness of a web-based intervention with adherence-focused guidance in the treatment of sD. Participants with sD (CES-D≥ 16, no Major Depressive Disorder according to DSM-IV criteria, N = 204) recruited via a large health insurance were randomly allocated to a web-based mobile-supported cognitive-behavioral intervention or to a waitlist control condition with unrestricted access to usual care. The primary outcome was the reduction in depressive symptom severity as measured by blind diagnostic raters using the Quick Inventory of Depressive Symptomatology (QIDS) at posttreatment. There was a statistically significant between-group difference in QIDS scores at posttreatment in favor of the intervention group, F(1, 201) = 11.31, p = .001, corresponding to a medium effect size of d = 0.37 (95% CI 0.09-0.64) and a NNT of 7 (95%-CI 3.7-41.2). Significant effects in favour of the intervention group were also found for secondary outcomes such as quality of life, anxiety, and insomnia severity. Web-based self-help interventions with adherence-focused guidance could be an acceptable and effective approach to reduce a range of negative consequences associated with subclinical depression.
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The intervention is based on GET.ON Mood Enhancer, a program that has been evaluated in multiple randomised controlled trials.
“The intervention is based on “GET.ON Mood Enhancer,” a program that has been evaluated in multiple randomised controlled trials (62–64).”
From Personalised depression forecasting using mobile sensor data and ecological momentary assessment (2022) · cites this paper as [63]
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- Authors
- Ebert, D. D., Buntrock, C., Lehr, D., Smit, F., Riper, H., Baumeister, H., Cuijpers, P., & Berking, M.
- Affiliations
- Leuphana University of Lüneburg (DE)
- Trimbos Institute (NL)
- Universität Ulm (DE)
- Corresponding author
- Ebert, David Daniel
- ORCID
- Venue
- Behavior Therapy
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 49
- Issue
- 1
- Pages
- 71-83
- ISSN
- 0005-7894 (ISSN-L)
- OpenAlex
- W2619789891
- Cited by
- 75
- References
- 54
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 6 · 2023: 12 · 2022: 11 · 2021: 11 · 2020: 8 · 2019: 8 · 2018: 8
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- green
- research.vu.nl
- Licence
- Locations
- Behavior Therapy (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Multilingual Matters (Channel View Publications) (submittedVersion)
- VU Research Portal (submittedVersion, other-oa)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- subthreshold depression, online intervention, cognitive behavioral therapy, medication adherence, self-help, depression severity, quality of life, anxiety, insomnia, digital mental health
- MeSH terms
- Adult, Depression, Female, Humans, Male, Middle Aged, Patient Compliance, Cognitive Behavioral Therapy, Single-Blind Method, Outcome Assessment, Health Care, Internet, Mobile Applications
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