Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring
Abstract
CONTEXT: Atrial fibrillation (AF) is the most common cardiac dysrhythmia in the United States. Whereas rare cases of familial AF have been reported, it is unknown if AF among unselected individuals is a heritable condition. OBJECTIVE: To determine whether parental AF increases the risk for the development of offspring AF. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study (1983-2002) within the Framingham Heart Study, a population-based epidemiologic study. Participants were 2243 offspring (1165 women, 1078 men) at least 30 years of age and free of AF whose parents had both been evaluated in the original cohort. MAIN OUTCOME MEASURES: Development of new-onset AF in the offspring was prospectively examined in association with previously documented parental AF. RESULTS: Among 2243 offspring participants, 681 (30%) had at least 1 parent with documented AF; 70 offspring participants (23 women; mean age, 62 [range, 40-81] years) developed AF in follow-up. Compared with no parental AF, AF in at least 1 parent increased the risk of offspring AF (multivariable-adjusted odds ratio [OR], 1.85; 95% confidence interval [CI], 1.12-3.06; P =.02). These results were stronger when age was limited to younger than 75 years in both parents and offspring (multivariable-adjusted OR, 3.23; 95% CI, 1.87-5.58; P<.001) and when the sample was further limited to those without antecedent myocardial infarction, heart failure, or valve disease (multivariable-adjusted OR, 3.17; 95% CI, 1.71-5.86; P<.001). CONCLUSIONS: Parental AF increases the future risk for offspring AF, an observation supporting a genetic susceptibility to developing this dysrhythmia. Further research into the genetic factors predisposing to AF is warranted.
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AF, especially early-onset AF, has a strong heritable component, independent of concomitant cardiovascular conditions.
“AF, especially early-onset AF, has a strong heritable component, independent of concomitant cardiovascular conditions.58,59”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [58]
Several studies evaluating familial aggregation of AF have reported substantially increased risk of AF in individuals with affected family members.
“Several studies evaluating familial aggregation of AF have reported substantially increased risk of AF in individuals with affected family members.8,9,50–55”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [55]
Cites
Go, A. S., Hylek, E. M., Phillips, K. A., Chang, Y., Henault, L. E., Selby, J. V., & Singer, D. E. (2001) · JAMA · doi:10.1001/jama.285.18.2370 · Cited by 6,205 · see citing works
Impact of Atrial Fibrillation on the Risk of Death: The Framingham Heart Study
Benjamin, E. J., Wolf, P. A., D’Agostino, R. B., Silbershatz, H., Kannel, W. B., & Levy, D. (1998) · Circulation · doi:10.1161/01.cir.98.10.946 · Cited by 4,575 · see citing works
Benjamin, E. J. (1994) · JAMA · doi:10.1001/jama.1994.03510350050036 · Cited by 2,613 · see citing works
Feinberg, W. M. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.155.5.469 · Cited by 2,282 · see citing works
Stewart, S., Hart, C. L., Hole, D. J., & McMurray, J. J. V. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01236-6 · Cited by 1,562 · see citing works
Krahn, A. D., Manfreda, J., TATE, R. B., Mathewson, F. A. L., & Cuddy, T. E. (1995) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)80348-9 · Cited by 1,478 · see citing works
Incidence of and risk factors for atrial fibrillation in older adults
Psaty, B. M., Manolio, T. A., Kuller, L. H., Kronmal, R. A., Cushman, M., Fried, L. P., White, R., Furberg, C. D., & Rautaharju, P. M. (1997) · Circulation · doi:10.1161/01.cir.96.7.2455 · Cited by 1,462 · see citing works
C-Reactive Protein Elevation in Patients With Atrial Arrhythmias
Chung, M. K., Martin, D. O., Sprecher, D. L., Wazni, O. M., KANDERIAN, A. S., Carnes, C. A., Bauer, J. A., TCHOU, P. J., Niebauer, M. J., Natale, A., et al. (2001) · Circulation · doi:10.1161/hc4901.101760 · Cited by 1,375 · see citing works
Echocardiographic predictors of nonrheumatic atrial fibrillation. The Framingham Heart Study.
Vaziri, S. M., Larson, M. G., Benjamin, E. J., & Levy, D. (1994) · Circulation · doi:10.1161/01.cir.89.2.724 · Cited by 1,073 · see citing works
KCNQ1 Gain-of-Function Mutation in Familial Atrial Fibrillation
Chen, Y.-H., Xu, S.-J., Bendahhou, S., Wang, X.-L., Wang, Y., Xu, W.-Y., Jin, H., Sun, H., Su, X.-Y., Zhuang, Q.-N., et al. (2003) · Science · doi:10.1126/science.1077771 · Cited by 989 · see citing works
D'Agostino, R. B., Lee, M., Belanger, A. J., Cupples, L. A., Anderson, K., & Kannel, W. B. (1990) · Statistics in Medicine · doi:10.1002/sim.4780091214 · Cited by 798 · see citing works
Impact of Atrial Fibrillation on Mortality, Stroke, and Medical Costs
Wolf, P. A., Mitchell, J. B., Baker, C. S., Kannel, W. B., & D’Agostino, R. B. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.3.229 · Cited by 683 · see citing works
Evidence for a Gene Influencing Blood Pressure on Chromosome 17
Levy, D. A., DeStefano, A. L., Larson, M. G., O’Donnell, C. J., Lifton, R. P., Gavras, H. P., Cupples, L. A., & Myers, R. H. (2000) · Hypertension · doi:10.1161/01.hyp.36.4.477 · Cited by 594 · see citing works
AN APPROACH TO LONGITUDINAL STUDIES IN A COMMUNITY: THE FRAMINGHAM STUDY
Dawber, T. R., Kannel, W. B., & Lyell, L. P. (1963) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1963.tb13299.x · Cited by 561 · see citing works
Identification of a Genetic Locus for Familial Atrial Fibrillation
Brugada, R., Tapscott, T., Czernuszewicz, G. Z., Marian, A. J., Iglesias, A., Mont, L., Brugada, J., Girona, J. M., Domingo, A., Bachinski, L. L., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199703273361302 · Cited by 554 · see citing works
A comprehensive linkage analysis for myocardial infarction and its related risk factors
Broeckel, U., Hengstenberg, C., Mayer, B., Holmer, S., Martin, L. J., Comuzzie, A., Blangero, J., Nürnberg, P., Reis, A., Riegger, G., et al. (2002) · Nature Genetics · doi:10.1038/ng827 · Cited by 359 · see citing works
Renin-Angiotensin System Gene Polymorphisms and Atrial Fibrillation
Tsai, C., Lai, L., Lin, J.-L., Chiang, F., Hwang, J., Ritchie, M. D., Moore, J. H., Hsu, K.-L., Tseng, C.-D., Liau, C., et al. (2004) · Circulation · doi:10.1161/01.cir.0000124487.36586.26 · Cited by 345 · see citing works
Familial atrial fibrillation is a genetically heterogeneous disorder
Darbar, D., Herron, K. J., Ballew, J. D., Jahangir, A., Gersh, B. J., Shen, W.-K., Hammill, S. C., Packer, D. L., & Olson, T. M. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00465-0 · Cited by 330 · see citing works
IDENTIFICATION OF A GENETIC LOCUS FOR FAMILIAL ATRIAL FIBRILLATION
Rugada, R. A. B., Apscott, T. E. T., Zernuszewicz, Z. C., Glesias, A. N. I., Ont, L. L. M., Rugada, J. O. B., Irona, J. O. G., Nna, A., Achinski, L. I. L. B., & Oberts, R. O. R. (1997) · Cited by 282 · see citing works
Locus for Atrial Fibrillation Maps to Chromosome 6q14–16
Ellinor, P. T., Shin, J. T., Moore, R. K., Yoerger, D. M., & MacRae, C. A. (2003) · Circulation · doi:10.1161/01.cir.0000077910.80718.49 · Cited by 222 · see citing works
Genomewide Search for Type 2 Diabetes Susceptibility Genes in Four American Populations
Ehm, M. G., Karnoub, M., Sakul, H., Gottschalk, K., Holt, D. C., Weber, J. L., Vaske, D. A., Briley, J. D., Briley, L. P., Kopf, J., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/302950 · Cited by 194 · see citing works
Lai, L., Su, M., Yeh, H., Lin, J.-L., Chiang, F., Hwang, J., Hsu, K.-L., Tseng, C.-D., Lien, W.-P., Tseng, Y.-Z., et al. (2002) · American Heart Journal · doi:10.1067/mhj.2002.123573 · Cited by 160 · see citing works
Atrial Fibrillation and the Prothrombotic State in the Elderly
Conway, D., Heeringa, J., van der Kuip, D. A. M., Chin, B., Albert Hofman, D., Witteman, J. C. M., & Lip, G. Y. H. (2003) · Stroke · doi:10.1161/01.str.0000051728.85133.32 · Cited by 93 · see citing works
Heath, A. C., Madden, P. A. F., Bucholz, K. K., Bierut, L. J., Whitfield, J. B., Dinwiddie, S. H., Slutske, W. S., Statham, D. J., & Martin, N. G. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.178.40.s33 · Cited by 79 · see citing works
Transgenic and knockout mouse models of atrial arrhythmias
Olgin, J. E. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00225-0 · Cited by 34 · see citing works
Mattioli, A. V., Bonatti, S., Bonetti, L., Borella, P., & Mattioli, G. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00404-1 · Cited by 16 · see citing works
Renin-angiotensin system gene polymorphisms and atrial fibrillation
Tsai, C., Lai, L., & Lin, J. (2004) · ACC Current Journal Review · doi:10.1016/j.accreview.2004.06.040 · Cited by 13 · see citing works
Heritability of left atrial size in the Tecumseh population
Palatini, P., Amerena, J. V., Nesbitt, S. D., Valentini, M., Majahalme, S. K., Krause, L. C., Tikhonoff, V., & Julius, S. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.01009.x · Cited by 11 · see citing works
HANSEN, B. C. (1995) · Diabetes Care · doi:10.2337/diacare.18.6.a1 · Cited by 8 · see citing works
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Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591 · see citing works
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström‐Lundqvist, C., Boriani, G., Castella, M., Dan, G.-A., Dilaveris, P., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa612 · Cited by 10,225 · see citing works
Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Delling, F. N., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000757 · Cited by 9,175 · see citing works
Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036 · see citing works
Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146 · see citing works
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333 · see citing works
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H. G., Cigarroa, J. E., Cleveland, J. C., CONTI, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000041 · Cited by 7,119 · see citing works
Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
Guidelines for the management of atrial fibrillation
Authors/Task Force Members, Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq278 · Cited by 5,875 · see citing works
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797 · see citing works
Heart Disease and Stroke Statistics—2014 Update
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Blaha, M. J., Dai, S., Ford, E. S., Fox, C. S., Franco, S., et al. (2013) · Circulation · doi:10.1161/01.cir.0000441139.02102.80 · Cited by 5,207 · see citing works
Heart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31828124ad · Cited by 5,292 · see citing works
Gelder, I. C. V., Rienstra, M., Bunting, K. V., Casado-Arroyo, R., Caso, V., Crijns, H. J. G. M., Potter, T. J. R. D., Dwight, J., Guasti, L., Hanke, T., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae176 · Cited by 3,338 · see citing works
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H., Cigarroa, J. E., Cleveland, J. C., Conti, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.022 · Cited by 2,955 · see citing works
Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Le Heuzey, J.-Y., Kay, G. N., Lowe, J. E., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.177292 · Cited by 2,805 · see citing works
Calkins, H. G., Hindricks, G., Cappato, R., Kim, Y., Saad, E., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, A. J., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.05.012 · Cited by 2,770 · see citing works
Calkins, H., Kuck, K. H., Cappato, R., Brugada, J., Camm, A. J., Chen, S.-A., Crijns, H. J. G., Damiano, R. J., Davies, D. W., DiMarco, J., et al. (2012) · Europace · doi:10.1093/europace/eus027 · Cited by 2,722 · see citing works
Guidelines for the management of atrial fibrillation
Authors/Task Force Members, Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., et al. (2010) · EP Europace · doi:10.1093/europace/euq350 · Cited by 1,749 · see citing works
Calkins, H. G., Kück, K., Cappato, R., Brugada, J., Camm, A. J., Chen, S., Crijns, H. J. G. M., Damiano, R. J., Davies, D. W., Dimarco, J., et al. (2012) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-012-9672-7 · Cited by 1,677 · see citing works
Calkins, H., Kuck, K. H., Cappato, R., Brugada, J., Camm, A. J., Chen, S.-A., Crijns, H. J. G., Damiano, R. J., Davies, D. W., DiMarco, J., et al. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2011.12.016 · Cited by 1,456 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works
Obesity and the risk of new-onset atrial fibrillation
Wang, T. J. (2004) · JAMA · doi:10.1001/jama.292.20.2471 · Cited by 1,427 · see citing works
Stærk, L., Sherer, J. A., Ko, D., Benjamin, E. J., & Helm, R. H. (2017) · Circulation Research · doi:10.1161/circresaha.117.309732 · Cited by 1,224 · see citing works
The Clinical Profile and Pathophysiology of Atrial Fibrillation
Andrade, J. G., Khairy, P., Dobrev, D., & Nattel, S. (2014) · Circulation Research · doi:10.1161/circresaha.114.303211 · Cited by 1,206 · see citing works
Calkins, H. G., Hindricks, G., Cappato, R., Kim, Y., Saad, E., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, A. J., et al. (2017) · EP Europace · doi:10.1093/europace/eux274 · Cited by 1,191 · see citing works
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.009 · Cited by 1,157 · see citing works
Variants conferring risk of atrial fibrillation on chromosome 4q25
Gudbjartsson, D. F., Arnar, D. O., Helgadottir, A., Gretarsdottir, S., Holm, H., Sigurdsson, A., Jonasdottir, A., Baker, A., Thorleifsson, G., Kristjansson, K., et al. (2007) · Nature · doi:10.1038/nature06007 · Cited by 955 · see citing works
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Kay, G. N., Huezey, J.-Y. L., Lowe, J. E., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.013 · Cited by 921 · see citing works
Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Kay, G. N., Le Huezey, J.-Y., Lowe, J. E., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318214876d · Cited by 859 · see citing works
Global epidemiology of atrial fibrillation
Rahman, F., Kwan, G. F., & Benjamin, E. J. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.118 · Cited by 731 · see citing works
Heijman, J., Voigt, N., Nattel, S., & Dobrev, D. (2014) · Circulation Research · doi:10.1161/circresaha.114.302226 · Cited by 681 · see citing works
ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · EP Europace · doi:10.1093/europace/eul097 · Cited by 663 · see citing works
Authors Task Force Members, Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl176 · Cited by 645 · see citing works
Atrial fibrillation: Profile and burden of an evolving epidemic in the 21st century
Ball, J., Carrington, M. J., McMurray, J. J. V., & Stewart, S. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.12.093 · Cited by 632 · see citing works
Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation
Olson, T. M., Alekseev, A. E., Liu, X., Park, S., Zingman, L. V., Bienengraeber, M., Sattiraju, S., Ballew, J. D., Jahangir, A., & Terzic, A. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl143 · Cited by 491 · see citing works
Common variants in KCNN3 are associated with lone atrial fibrillation
Ellinor, P. T., Lunetta, K. L., Glazer, N. L., Pfeufer, A., Alonso, A., Chung, M. K., Sinner, M. F., de Bakker, P. I. W., Mueller, M., Lubitz, S. A., et al. (2010) · Nature Genetics · doi:10.1038/ng.537 · Cited by 485 · see citing works
Clinical and genetic issues in familial dilated cardiomyopathy
Burkett, E., & Hershberger, R. E. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.11.066 · Cited by 472 · see citing works
Prevention of Atrial Fibrillation
Benjamin, E. J., Chen, P., Bild, D. E., Mascette, A. M., Albert, C. M., Alonso, Á., Calkins, H. G., Connolly, S. J., Curtis, A. B., Darbar, D., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.825380 · Cited by 471 · see citing works
ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.018 · Cited by 465 · see citing works
Genome-wide association study of PR interval
Pfeufer, A., van Noord, C., Marciante, K., Arking, D., Larson, M., Smith, A., Tarasov, K., Müller, M., Sotoodehnia, N., Sinner, M. F., et al. (2010) · Nature Genetics · doi:10.1038/ng.517 · Cited by 470 · see citing works
Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2013)
JCS Joint Working Group (2014) · Circulation Journal · doi:10.1253/circj.cj-66-0092 · Cited by 428 · see citing works
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
Benjamin, E. J., Rice, K. M., Arking, D. E., Pfeufer, A., van Noord, C., Smith, A. V., Schnabel, R. B., Bis, J. C., Boerwinkle, E., Sinner, M. F., et al. (2009) · Nature Genetics · doi:10.1038/ng.416 · Cited by 390 · see citing works
Status of the Epidemiology of Atrial Fibrillation
Kannel, W. B., & Benjamin, E. J. (2007) · Medical Clinics of North America · doi:10.1016/j.mcna.2007.09.002 · Cited by 359 · see citing works
Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis
Ko, D., Rahman, F., Schnabel, R. B., Yin, X., Benjamin, E. J., & Christophersen, I. E. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.45 · Cited by 353 · see citing works
Atrial Natriuretic Peptide Frameshift Mutation in Familial Atrial Fibrillation
Hodgson‐Zingman, D., Karst, M. L., Zingman, L. V., Heublein, D. M., Darbar, D., Herron, K. J., Ballew, J. D., de Andrade, M., Burnett, J. C. J., & Olson, T. M. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706300 · Cited by 343 · see citing works
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.177031 · Cited by 341 · see citing works
Lip, G. Y. H., Tse, H., & Lane, D. A. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61514-6 · Cited by 341 · see citing works
Cardiac Sodium Channel ( <i>SCN5A</i> ) Variants Associated with Atrial Fibrillation
Darbar, D., Kannankeril, P. J., Donahue, B. S., Kucera, G., Stubblefield, T., Haines, J. L., George, A. L., & Roden, D. M. (2008) · Circulation · doi:10.1161/circulationaha.107.757955 · Cited by 334 · see citing works
Association Between Familial Atrial Fibrillation and Risk of New-Onset Atrial Fibrillation
Lubitz, S. A., Yin, X., Fontes, J. D., Magnani, J. W., Rienstra, M., Pai, M., Villalon, M. L., Vasan, R. S., Pencina, M. J., Levy, D., et al. (2010) · JAMA · doi:10.1001/jama.2010.1690 · Cited by 313 · see citing works
Familial aggregation of atrial fibrillation in Iceland
Arnar, D. O., Thorvaldsson, S., Manolio, T. A., Thorgeirsson, G., Kristjansson, K., Hakonarson, H., & Stefansson, K. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi727 · Cited by 305 · see citing works
70-year legacy of the Framingham Heart Study
Andersson, C., Johnson, A. D., Benjamin, E. J., Levy, D., & Vasan, R. S. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0202-5 · Cited by 305 · see citing works
Pharmacogenomics: Challenges and Opportunities
Roden, D. M., Altman, R. B., Benowitz, N. L., Flockhart, D. A., Giacomini, K. M., Johnson, J. A., Krauss, R. M., McLeod, H. L., Ratain, M. J., Relling, M. V., et al. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-10-200611210-00007 · Cited by 289 · see citing works
Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2013):– Digest Version –
JCSJointWorkingGroup (2014) · Circulation · Cited by 261 · see citing works
Familial aggregation in lone atrial fibrillation
Ellinor, P. T., Yoerger, D. M., Ruskin, J. N., & MacRae, C. A. (2005) · Human Genetics · doi:10.1007/s00439-005-0034-8 · Cited by 260 · see citing works
Genetics of acquired long QT syndrome
Roden, D. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25539 · Cited by 258 · see citing works
European Ancestry as a Risk Factor for Atrial Fibrillation in African Americans
Marcus, G. M., Alonso, A., Peralta, C. A., Lettre, G., Vittinghoff, E., Lubitz, S. A., Fox, E. R., Levitzky, Y. S., Mehra, R., Kerr, K. F., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.958306 · Cited by 255 · see citing works
Magnani, J. W., Rienstra, M., Lin, H., Sinner, M. F., Lubitz, S. A., McManus, D. D., Dupuis, J., Ellinor, P. T., & Benjamin, E. J. (2011) · Circulation · doi:10.1161/circulationaha.111.039677 · Cited by 247 · see citing works
Kirchhof, P. F., Lip, G. Y. H., Gelder, I. C. V., Bax, J. J., Hylek, E. M., Kääb, S., Schotten, U., Wegscheider, K., Boriani, G., Brandes, A., et al. (2011) · EP Europace · doi:10.1093/europace/eur241 · Cited by 242 · see citing works
The role of obesity in atrial fibrillation
Nalliah, C. J., Sanders, P., Kottkamp, H., & Kalman, J. M. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv486 · Cited by 240 · see citing works
Zuo, K., Li, J., Li, K., Hu, C., Gao, Y., Chen, M., Hu, R., Liu, Y., Chi, H., Wang, H., et al. (2019) · GigaScience · doi:10.1093/gigascience/giz058 · Cited by 235 · see citing works
Kääb, S., Darbar, D., van Noord, C., Dupuis, J., Pfeufer, A., Newton‐Cheh, C., Schnabel, R. B., Makino, S., Sinner, M. F., Kannankeril, P. J., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn578 · Cited by 217 · see citing works
Cupples, L. A., Arruda, H. T., Benjamin, E. J., D’Agostino, R. B., Demissie, S., DeStefano, A. L., Dupuis, J., Falls, K. M., Fox, C. S., Gottlieb, D. J., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s1 · Cited by 212 · see citing works
Wyse, D. G., Gelder, I. C. V., Ellinor, P. T., Go, A. S., Kalman, J. M., Narayan, S. M., Nattel, S., Schotten, U., & Rienstra, M. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.01.023 · Cited by 214 · see citing works
Familial Aggregation of Atrial Fibrillation: A Study in Danish Twins
Christophersen, I. E., Ravn, L. S., Budtz-Joergensen, E., Skytthe, A., Haunsoe, S., Svendsen, J. H., & Christensen, K. (2009) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.108.786665 · Cited by 209 · see citing works
Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
Larson, M. G., Atwood, L. D., Benjamin, E. J., Cupples, L. A., D’Agostino, R. B., Fox, C. S., Govindaraju, D. R., Guo, C., Heard‐Costa, N. L., Hwang, S., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s5 · Cited by 190 · see citing works
Cardiac sodium channel mutation in atrial fibrillation
Ellinor, P. T., Nam, E. G., Shea, M. A., Milan, D. J., Ruskin, J. N., & MacRae, C. A. (2007) · Heart Rhythm · doi:10.1016/j.hrthm.2007.09.015 · Cited by 180 · see citing works
Predictors for atrial fibrillation detection after cryptogenic stroke: Results from CRYSTAL AF
Thijs, V. N., Brachmann, J., Morillo, C. A., Passman, R. S., Sanna, T., Bernstein, R. A., Diener, H.-C., Di Lazzaro, V., Rymer, M. M., Hogge, L., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002282 · Cited by 170 · see citing works
Magnani, J. W., Johnson, V. M., SULLIVAN, L. M., Gorodeski, E. Z., Schnabel, R. B., Lubitz, S. A., Levy, D. A., Ellinor, P. T., & Benjamin, E. J. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.10.075 · Cited by 167 · see citing works
Current concepts in the pathogenesis of atrial fibrillation
Kourliouros, A., Savelieva, I., Kiotsekoglou, A., Jahangiri, M., & Camm, A. J. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.10.009 · Cited by 166 · see citing works
Low, S., Takahashi, A., Ebana, Y., Ozaki, K., Christophersen, I. E., Ellinor, P. T., Ogishima, S., Yamamoto, M. P., Satoh, M., Sasaki, M., et al. (2017) · Nature Genetics · doi:10.1038/ng.3842 · Cited by 166 · see citing works
Christophersen, I. E., OLESEN, M. S., Liang, B., Andersen, M. N., Larsen, A. P., Nielsen, J. B., Haunsø, S., Olesen, S., Tveit, A., Svendsen, J. H., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs442 · Cited by 161 · see citing works
Independent Susceptibility Markers for Atrial Fibrillation on Chromosome 4q25
Lubitz, S. A., Sinner, M. F., Lunetta, K. L., Makino, S., Pfeufer, A., Rahman, R., Veltman, C. E., Barnard, J., Bis, J. C., Danik, S. P., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.886440 · Cited by 156 · see citing works
Stretch-Sensitive KCNQ1Mutation
Otway, R., Vandenberg, J. I., Guo, G., Varghese, A., Castro, M. L., Liu, J., Zhao, J., Bursill, J. A., Wyse, K. R., Crotty, H., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.09.044 · Cited by 154 · see citing works
A Common Polymorphism in SCN5A is Associated with Lone Atrial Fibrillation
Chen, L. Y., Ballew, J. D., Herron, K. J., Rodeheffer, R. J., & Olson, T. M. (2006) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100016 · Cited by 151 · see citing works
Atrial Fibrillation in Congestive Heart Failure
Lubitz, S. A., Benjamin, E. J., & Ellinor, P. T. (2010) · Heart Failure Clinics · doi:10.1016/j.hfc.2009.11.001 · Cited by 149 · see citing works
Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese
Lubitz, S. A., Lunetta, K. L., Lin, H., Arking, D. E., Trompet, S., Li, G., Krijthe, B. P., Chasman, D. I., Barnard, J., Kleber, M. E., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.12.015 · Cited by 148 · see citing works
Epidemiology of Atrial Fibrillation
Zhang, J., Johnsen, S. P., Guo, Y., & Lip, G. Y. H. (2021) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2020.10.010 · Cited by 144 · see citing works
Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation
Yang, Y., Li, J., Lin, X., Yang, Y., Hong, K., Wang, L., Liu, J., Li, L., Yan, D., Liang, D., et al. (2009) · Journal of Human Genetics · doi:10.1038/jhg.2009.26 · Cited by 137 · see citing works
OLESEN, M. S., Yuan, L., Liang, B., Holst, A. G., Nielsen, N., Nielsen, J. B., Hedley, P. L., Christiansen, M., Olesen, S., Haunsø, S., et al. (2012) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.111.962597 · Cited by 138 · see citing works
Epidemiology of atrial fibrillation: A current perspective
Chen, L. Y., & Shen, W.-K. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.12.018 · Cited by 140 · see citing works
Current Perceptions of the Epidemiology of Atrial Fibrillation
Kannel, W. B., & Benjamin, E. J. (2008) · Cardiology Clinics · doi:10.1016/j.ccl.2008.09.015 · Cited by 138 · see citing works
Frequency of elevation of C-reactive protein in atrial fibrillation
Anderson, J. L., Maycock, C. A. A., LAPPE, D. L., Crandall, B. G., Horne, B. D., Bair, T. L., Morris, S. R., Li, Q., & Muhlestein, J. B. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.07.108 · Cited by 137 · see citing works
The role of connexin40 in atrial fibrillation
Chaldoupi, S., Loh, P. K. K., Hauer, R. N. W., de Bakker, J. M. T., & van Rijen, H. V. M. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp203 · Cited by 136 · see citing works
Menezes, A. R., Lavie, C. J., DiNicolantonio, J. J., O’Keefe, J. H., Morin, D. P., Khatib, S., & Milani, R. V. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.01.022 · Cited by 136 · see citing works
Emerging Directions in the Genetics of Atrial Fibrillation
Tucker, N. R., & Ellinor, P. T. (2014) · Circulation Research · doi:10.1161/circresaha.114.302225 · Cited by 130 · see citing works
Gain of function in IKs secondary to a mutation in KCNE5 associated with atrial fibrillation
Ravn, L. S., Aizawa, Y., Pollevick, G. D., Hofman-Bang, J., Cordeiro, J. M., Dixen, U., Jensen, G. B., Wu, Y., Burashnikov, E., Haunsø, S., et al. (2008) · Heart Rhythm · doi:10.1016/j.hrthm.2007.12.019 · Cited by 130 · see citing works
Görenek, B., Pelliccia, A., Benjamin, E. J., Boriani, G., Crijns, H. J. G. M., Fogel, R. I., Gelder, I. C. V., Halle, M., Kudaiberdieva, G., Lane, D. A., et al. (2016) · EP Europace · doi:10.1093/europace/euw242 · Cited by 128 · see citing works
Racial differences in the prevalence of atrial fibrillation among males.
Borzecki, A., Bridgers, D., Liebschutz, J., Kader, B., Kazis, L., & Berlowitz, D. (2008) · Journal of the National Medical Association · doi:10.1016/s0027-9684(15)31212-8 · Cited by 135 · see citing works
Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation
OLESEN, M. S., Jespersen, T., Nielsen, J. B., Liang, B., Møller, D. V., Hedley, P. L., Christiansen, M., Varró, A., Olesen, S., Haunsø, S., et al. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq348 · Cited by 128 · see citing works
OLESEN, M. S., Refsgaard, L., Holst, A. G., Larsen, A. P., Grubb, S., Haunsø, S., Svendsen, J. H., Olesen, S., Schmitt, N., & Calløe, K. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt028 · Cited by 122 · see citing works
Predisposing factors for atrial fibrillation in the elderly.
Wasmer, K., Eckardt, L., & BREITHARDT, G. E. (2017) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2017.03.010 · Cited by 125 · see citing works
Body, S. C., Collard, C. D., Shernan, S. K., Fox, A. A., Liu, K.-Y., Ritchie, M. D., Perry, T. E., Muehlschlegel, J. D., Aranki, S. F., Donahue, B. S., et al. (2009) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.109.849075 · Cited by 117 · see citing works
Molecular Genetics of Atrial Fibrillation
Tsai, C., Lai, L., Hwang, J., Lin, J.-L., & Chiang, F. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.072 · Cited by 119 · see citing works
Atrial fibrillation: the role of common and rare genetic variants
Olesen, M. S., Nielsen, M. W., Haunsø, S., & Svendsen, J. H. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2013.139 · Cited by 112 · see citing works
Atrial fibrillation from the pathologist’s perspective
Corradi, D. (2013) · Cardiovascular Pathology · doi:10.1016/j.carpath.2013.12.001 · Cited by 113 · see citing works
Tada, H., Shiffman, D., Smith, J. G., Sjögren, M., Lubitz, S. A., Ellinor, P. T., Louie, J. Z., Catanese, J. J., Engström, G., Devlin, J. J., et al. (2014) · Stroke · doi:10.1161/strokeaha.114.006072 · Cited by 110 · see citing works
Sinner, M. F., Pfeufer, A., Akyol, M., Beckmann, B.-M., Hinterseer, M., Wacker, A., Perz, S., Sauter, W., Illig, T., Näbauer, M., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehm619 · Cited by 107 · see citing works
Atrial Fibrillation: Basic Mechanisms, Remodeling and Triggers
Shiroshita-Takeshita, A., Brundel, B. J. J. M., & Nattel, S. (2005) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-005-2362-y · Cited by 107 · see citing works
- Authors
- Fox, C. S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Fox, Caroline S.
- ORCID
- Fox, Caroline S.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2004-06-16
- Volume
- 291
- Issue
- 23
- Pages
- 2851
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2065958606
- Cited by
- 600
- References
- 29
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 10 · 2023: 7 · 2022: 17 · 2021: 27 · 2020: 34 · 2019: 31 · 2018: 24 · 2017: 35 · 2016: 37 · 2015: 26 · 2014: 44 · 2013: 36 · 2012: 47
- FWCI
- 14.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k23hl074077-03, n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (K23 HL074077-01, K23 HL04253, K-24-HL-04334, N01‐HC25195, K24HL004334, K23HL004253)
- National Institute of Neurological Disorders and Stroke (5-R01-NS-17950, R01NS017950)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- atrial fibrillation, familial atrial fibrillation, offspring risk, heritability, genetic susceptibility, new-onset atrial fibrillation, Framingham Heart Study
- MeSH terms
- Adult, Aged, Atrial Fibrillation, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Adult Children
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