The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Sleep and Circadian Rhythm Regulation in Early Parkinson Disease
Open accessAbstract
IMPORTANCE: Sleep disturbances are recognized as a common nonmotor complaint in Parkinson disease but their etiology is poorly understood. OBJECTIVE: To define the sleep and circadian phenotype of patients with early-stage Parkinson disease. DESIGN, SETTING, AND PARTICIPANTS: Initial assessment of sleep characteristics in a large population-representative incident Parkinson disease cohort (N=239) at the University of Cambridge, England, followed by further comprehensive case-control sleep assessments in a subgroup of these patients (n=30) and matched controls (n=15). MAIN OUTCOMES AND MEASURES: Sleep diagnoses and sleep architecture based on polysomnography studies, actigraphy assessment, and 24-hour analyses of serum cortisol, melatonin, and peripheral clock gene expression (Bmal1, Per2, and Rev-Erbα). RESULTS: Subjective sleep complaints were present in almost half of newly diagnosed patients and correlated significantly with poorer quality of life. Patients with Parkinson disease exhibited increased sleep latency (P = .04), reduced sleep efficiency (P = .008), and reduced rapid eye movement sleep (P = .02). In addition, there was a sustained elevation of serum cortisol levels, reduced circulating melatonin levels, and altered Bmal1 expression in patients with Parkinson disease compared with controls. CONCLUSIONS AND RELEVANCE: Sleep dysfunction seen in early Parkinson disease may reflect a more fundamental pathology in the molecular clock underlying circadian rhythms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Compared with healthy aged people, individuals with AD or PD show considerably lower melatonin rhythm amplitudes and excessive sleepiness, as well as other sleep–wake cycle disturbances, such as later sleep onsets254–258.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [255]
In the citing paper
“This study shows significantly increased sleep latency, reduced sleep efficiency and reduced REM, along with reduced melatonin levels and a loss of BMAL1 serum expression rhythms, in a cohor of 239 individuals with PD.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [255]
In the citing paper
“A lack of time-dependent variation in Bmal1 expression in PD patients was recently confirmed in another study (Breen et al., 2014).”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Breen et al., 2014
In the citing paper
“However, both studies reported decreased amplitude of melatonin secretion.”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Breen et al., 2014
In the citing paper
“Two other recent studies did not show alterations in the circadian phase of melatonin secretion (Breen et al., 2014, Videnovic et al., 2014a, Videnovic et al., 2014b).”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Breen et al., 2014
In the citing paper
“PD patients had elevated cortisol levels and reduced melatonin levels.”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Breen et al., 2014
In the citing paper
“While PD patients exhibit a preserved circadian rhythm of cortisol, the amount of cortsiol secreted is elevated in early PD (Breen et al., 2014).”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Breen et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(2007) · Cited by 6,530
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421
Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment
Chaudhuri, К. R., & Schapira, A. H. V. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70068-7 · Cited by 1,818
Barone, P., Antonini, A., Colosimo, C., Marconi, R., Morgante, L., Avarello, T. P., Bottacchi, E., Cannas, A., Ceravolo, G., Ceravolo, R., et al. (2009) · Movement Disorders · doi:10.1002/mds.22643 · Cited by 1,445
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,223
Self-citationSchenck, C. H., Boeve, B. F., & Mahowald, M. W. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2012.10.009 · Cited by 814
The circadian clock and pathology of the ageing brain
Kondratova, A. A., & Kondratov, R. V. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3208 · Cited by 482
Age-Related Decline in Circadian Output
Nakamura, T. J., Nakamura, W., Yamazaki, S., Kudo, T., Cutler, T., Colwell, C. S., & Block, G. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0451-11.2011 · Cited by 386
The human pineal gland and melatonin in aging and Alzheimer's disease
Wu, Y., & Swaab, D. F. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00196.x · Cited by 371
Flagged first, then by citations
Cited by
Sorted by citations
Sleep and mental disorders: a meta-analysis of polysomnographic research
Baglioni, C., Nanovska, S., Regen, W., Spiegelhalder, K., Feige, B., Nissen, C., Reynolds, C. F., & Riemann, D. (2016) · Psychological Bulletin · doi:10.1037/bul0000053 · Cited by 1,074
Mechanisms linking circadian clocks, sleep, and neurodegeneration
Musiek, E. S., & Holtzman, D. M. (2016) · Science · doi:10.1126/science.aah4968 · Cited by 878
Rhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713
Association between circadian rhythms and neurodegenerative diseases
Leng, Y., Musiek, E. S., Hu, K., Cappuccio, F. P., & Yaffe, K. S. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30461-7 · Cited by 677
The aging clock: circadian rhythms and later life
Hood, S., & Amir, S. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90328 · Cited by 645
'The clocks that time us'—circadian rhythms in neurodegenerative disorders
Videnović, A., Lázár, A. S., Barker, R. A., & Overeem, S. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.206 · Cited by 381
Self-citationCircadian Rhythms, Sleep, and Disorders of Aging
Mattis, J., & Sehgal, A. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.02.003 · Cited by 369
Chahine, L., Amara, A., & Videnovic, A. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.08.001 · Cited by 306
Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's
Liu, G., Boot, B. P., Locascio, J. J., Jansen, I. E., Winder‐Rhodes, S., Eberly, S. W., Elbaz, A., Brice, A., Ravina, B. M., van Hilten, J. J., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24781 · Cited by 266
Self-citationCircadian rhythms in neurodegenerative disorders
Nassan, M. M., & Videnović, A. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00577-7 · Cited by 266
Subcortical evidence for a contribution of arousal to fMRI studies of brain activity
Liu, X., de Zwart, J. A., Schölvinck, M. L., Chang, C., Ye, F. Q., Leopold, D. A., & Duyn, J. H. (2018) · Nature Communications · doi:10.1038/s41467-017-02815-3 · Cited by 243
Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson’s Disease: Past, Present, and Future
Tan, Y., Jenner, P. G., & Chen, S. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-212976 · Cited by 247
Du, X., & Pang, T. Y. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00032 · Cited by 221
Melatonin receptors: distribution in mammalian brain and their respective putative functions
Ng, K. Y., Leong, M. K., Liang, H., & Paxinos, G. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1439-6 · Cited by 183
Circadian disruption and sleep disorders in neurodegeneration
Shen, Y., Lv, Q.-K., Xie, W.-Y., Gong, S.-Y., Zhuang, S., Liu, J.-Y., Mao, C.-J., & Liu, C.-F. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00340-6 · Cited by 171
Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1
Lananna, B. V., Nadarajah, C. J., Izumo, M., Cedeño, M. R., Xiong, D. D., Dimitry, J. M., Tso, C. F., McKee, C. A., Griffin, P. Y., Sheehan, P. W., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.015 · Cited by 173
Sundaram, S., Hughes, R. L., Peterson, E., Müller-Oehring, E. M., Brontë-Stewart, H. M., Poston, K. L., Faerman, A., Bhowmick, C., & Schulte, T. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.016 · Cited by 152
Neurodegeneration and the Circadian Clock
Hood, S., & Amir, S. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00170 · Cited by 152
Sleep in Parkinson's disease: A systematic review and meta-analysis of polysomnographic findings
Zhang, Y., Ren, R., Sanford, L. D., Yang, L., Zhou, J., Tan, L., Li, T., Zhang, J., Wing, Y. K., Shi, J., et al. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101281 · Cited by 151
Lananna, B. V., & Musiek, E. S. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104832 · Cited by 147
Sleep Disturbance as Potential Risk and Progression Factor for Parkinson’s Disease
Bohnen, N. I., & Hu, M. T. M. (2019) · Journal of Parkinson s Disease · doi:10.3233/jpd-191627 · Cited by 146
Leng, Y., Blackwell, T., Cawthon, P. M., Ancoli‐Israel, S., Stone, K. L., & Yaffe, K. S. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.1623 · Cited by 140
The Treatment of Sleep Disorders in Parkinson’s Disease: From Research to Clinical Practice
Loddo, G., Buonaura, G. C., Sambati, L., Giannini, G., Cecere, A., Cortelli, P., & Provini, F. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00042 · Cited by 143
Neurodegenerative Disorders and Sleep
Malhotra, R. K. (2018) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2017.09.006 · Cited by 127
Chronic sleep disturbance and neural injury: links to neurodegenerative disease
Videnović, A., & Abbott, S. M. (2016) · Nature and Science of Sleep · doi:10.2147/nss.s78947 · Cited by 133
Circadian clock disruption in neurodegenerative diseases: cause and effect?
Musiek, E. S. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00029 · Cited by 125
Plasma melatonin is reduced in Huntington's disease
Kalliolia, E., Silajdžić, E., Nambron, R., Hill, N. R., Doshi, A., Frost, C. D., Watt, H., Hindmarsh, P. C., Björkqvist, M., & Warner, T. T. (2014) · Movement Disorders · doi:10.1002/mds.26003 · Cited by 118
Steele, T. A., Louis, E. K. S., Videnović, A., & Auger, R. R. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01031-8 · Cited by 128
Circadian system — A novel diagnostic and therapeutic target in Parkinson's disease?
Videnović, A., & Willis, G. L. (2016) · Movement Disorders · doi:10.1002/mds.26509 · Cited by 115
Retinal Ganglion Cells and Circadian Rhythms in Alzheimer’s Disease, Parkinson’s Disease, and Beyond
Morgia, C. L., Ross‐Cisneros, F. N., Sadun, A. A., & Carelli, V. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00162 · Cited by 116
Kang, H., Zhang, W., Jing, J., Huang, D., Zhang, L., Wang, J., Lin, H., Liu, Z., Wang, Z., & Gao, A. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131949 · Cited by 113
Kou, L., Chi, X., Sun, Y., Han, C., Wan, F., Hu, J., Yin, S., Wu, J., Li, Y., Zhou, Q., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02494-y · Cited by 109
Sleep and circadian rhythms in Parkinson’s disease and preclinical models
Hunt, J., Coulson, E. J., Rajnarayanan, R. V., Oster, H., Videnović, A., & Rawashdeh, O. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00504-w · Cited by 118
Sleep and risk of parkinsonism and Parkinson’s disease: a population-based study
Lysen, T. S., Darweesh, S. K. L., Ikram, M. K., Luik, A. I., & Ikram, M. A. (2019) · Brain · doi:10.1093/brain/awz113 · Cited by 108
Liu, W., Wei, S., Huang, G., Liu, L.-B., Gu, C., Shen, Y., Wang, X., Xia, S., Xie, A., Hu, L., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201901565rr · Cited by 107
Sleep Issues in Parkinson's Disease and Their Management
Zuzuárregui, J. R. P., & During, E. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00938-y · Cited by 117
Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese
Gu, Z., Wang, B., Zhang, Y., Ding, H., Zhang, Y., Yu, J. M., Gu, M., Chan, P., & Cai, Y. (2015) · Scientific Reports · doi:10.1038/srep15891 · Cited by 106
Implications of DNA Methylation in Parkinson’s Disease
Miranda-Morales, E. G., Meier, K., Sandoval-Carrillo, A. A., Salas-Pacheco, J. M., Vázquez-Cárdenas, P., & Arias-Carrión, Ó. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00225 · Cited by 108
Lecarpentier, Y., CLAES, V. A., Duthoit, G., & Hébert, J. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00429 · Cited by 98
Molecular mechanisms of the circadian clockwork in mammals
Robinson, I., & Reddy, A. B. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.06.005 · Cited by 108
Self-citationMassey, A., Boag, M. K., Magnier, A., Bispo, D. P. C. F., Khoo, T. K., & Pountney, D. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112928 · Cited by 103
Sleep in Neurodegenerative Diseases
Iranzo, Á. (2016) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.10.011 · Cited by 100
An overview of sleep and circadian dysfunction in Parkinson's disease
Mantovani, S., Smith, S. S., Gordon, R., & O’Sullivan, J. D. (2018) · Journal of Sleep Research · doi:10.1111/jsr.12673 · Cited by 105
Dong, X., Liao, Z., Gritsch, D., Hadzhiev, Y., Bai, Y., Locascio, J. J., Guennewig, B., Liu, G., Blauwendraat, C., Wang, T., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0223-0 · Cited by 97
Clinical trials in REM sleep behavioural disorder: challenges and opportunities
Videnović, A., Ju, Y. S., Arnulf, I., Cock, V. C. D., Högl, B., Kunz, D., Provini, F., Ratti, P., Schiess, M. C., Schenck, C. H., et al. (2020) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-322875 · Cited by 97
Defining circadian disruption in neurodegenerative disorders
Colwell, C. S. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148288 · Cited by 90
Sleep disorders in Parkinson’s disease, an early and multiple problem
Dodet, P., Houot, M., Leu‐Semenescu, S., Corvol, J., Lehéricy, S., Mangone, G., Vidailhet, M., Roze, E. F., & Arnulf, I. (2024) · npj Parkinson s Disease · doi:10.1038/s41531-024-00642-0 · Cited by 99
Kakhaki, R. D., Ostadmohammadi, V., Kouchaki, E., Aghadavod, E., Bahmani, F., Tamtaji, O. R., Reiter, R. J., Mansournia, M. A., & Asemi, Z. (2020) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2020.105878 · Cited by 87
Troili, F., Cipollini, V., Moci, M., Morena, E., Palotai, M., Rinaldi, V., Romano, C., Ristori, G., Giubilei, F., Salvetti, M., et al. (2020) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2020.00017 · Cited by 91
A New Perspective for Parkinson’s Disease: Circadian Rhythm
Li, S., Wang, Y., Wang, F., Hu, L., & Liu, C. (2016) · Neuroscience Bulletin · doi:10.1007/s12264-016-0089-7 · Cited by 86
Neuroendocrine abnormalities in Parkinson's disease
Pablo‐Fernández, E. D., Breen, D. P., Bouloux, P. M., Barker, R. A., Foltynie, T., & Warner, T. T. (2016) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-314601 · Cited by 89
Self-citationPablo‐Fernández, E. D., Courtney, R. J., Warner, T. T., & Holton, J. L. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.0640 · Cited by 88
Ortuño‐Lizarán, I., Esquiva, G., Beach, T. G., Serrano, G. E., Adler, C. H., Lax, P., & Cuenca, N. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0596-z · Cited by 87
Bassani, T. B., Gradowski, R. W., Zaminelli, T., Barbiero, J. K., Santiago, R. M., Boschen, S. L., Cunha, C. D., Lima, M. M. S., Andreatini, R., & Vital, M. A. B. F. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.068 · Cited by 83
Julienne, H., Buhl, E., Leslie, D. S., & Hodge, J. J. L. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.04.014 · Cited by 90
Review: The spectrum of clinical features seen with alpha synuclein pathology
Barker, R., & Williams‐Gray, C. H. (2016) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12303 · Cited by 85
Self-citationMack, J. M., Schamne, M. G., Sampaio, T. B., Pértile, R. A. N., Fernandes, P. A. C. M., Markus, R. P., & Prediger, R. D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3472032 · Cited by 81
Delgado-Lara, D. L. C., González-Enríquez, G. V., Torres-Mendoza, B. M., González-Usigli, H., Cárdenas-Bedoya, J., Macías-Islas, M. Á., de la Rosa, A. C., Jiménez-Delgado, A., Pacheco-Moisés, F. P., Serrano, J. A. C., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110485 · Cited by 82
Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease
Breen, D. P., Nombela, C., Vuono, R., Jones, P. S., Fisher, K., Burn, D. J., Brooks, D. J., Reddy, A. B., Rowe, J. B., & Barker, R. A. (2016) · Movement Disorders · doi:10.1002/mds.26592 · Cited by 79
Self-citationConsequences of Circadian Disruption on Neurologic Health
Videnović, A., & Zee, P. C. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.08.004 · Cited by 75
Sleep as a Therapeutic Target in the Aging Brain
Bah, T. M., Goodman, J. R., & Iliff, J. J. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00769-6 · Cited by 76
The Neurophysiology of Sleep in Parkinson's Disease
Zahed, H., Zuzuárregui, J. R. P., Gilron, R., Denison, T., Starr, P. A., & Little, S. J. (2021) · Movement Disorders · doi:10.1002/mds.28562 · Cited by 78
Circadian Clock Regulates Inflammation and the Development of Neurodegeneration
Wang, X., & Li, L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.696554 · Cited by 78
Gabryelska, A., Turkiewicz, S., Karuga, F. F., Sochal, M., Strzelecki, D., & Białasiewicz, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020709 · Cited by 74
Zhang, J., Culp, M. L., Craver, J., & Darley-Usmar, V. M. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14308 · Cited by 74
Melatonin and Parkinson Disease: Current Status and Future Perspectives for Molecular Mechanisms
Tamtaji, O. R., Reiter, R. J., Alipoor, R., Dadgostar, E., Kouchaki, E., & Asemi, Z. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00720-5 · Cited by 73
Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update
Fifel, K., & Videnović, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.627330 · Cited by 71
Curtis, W. M., Seeds, W. A., Mattson, M. P., & Bradshaw, P. C. (2022) · Cells · doi:10.3390/cells11152416 · Cited by 72
Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly
Hastings, M. H., Brancaccio, M., Gonzalez-Aponte, M. F., & Herzog, E. D. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-100322-112249 · Cited by 72
Influence of Circadian Rhythm in the Eye: Significance of Melatonin in Glaucoma
Martínez‐Águila, A., Martín‐Gil, A., Carpena‐Torres, C., Pastrana, C., & Carracedo, G. (2021) · Biomolecules · doi:10.3390/biom11030340 · Cited by 72
Physiological links of circadian clock and biological clock of aging
Liu, F., & Chang, H.-C. (2017) · Protein & Cell · doi:10.1007/s13238-016-0366-2 · Cited by 69
Nocturia in Parkinson's Disease: Why Does It Occur and How to Manage?
Batla, A., Phé, V., Min, L. D., & Panicker, J. N. (2016) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12374 · Cited by 68
Cheng, W., Ho, J. Y. S., & Chang, R. C. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101620 · Cited by 71
Imaging the Limbic System in Parkinson’s Disease—A Review of Limbic Pathology and Clinical Symptoms
Banwinkler, M., Theis, H., Prange, S., & van Eimeren, T. (2022) · Brain Sciences · doi:10.3390/brainsci12091248 · Cited by 70
Roles of clock genes in the pathogenesis of Parkinson's disease
Shkodina, A. D., Tan, S. C., Hasan, M. M., Abdelgawad, M., Chopra, H., Bilal, M., Boiko, D. I., Tarianyk, K. А., & Alexiou, A. T. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101554 · Cited by 67
Melatonin as a Chronobiotic and Cytoprotective Agent in Parkinson’s Disease
Perez‐Lloret, S., & Cardinali, D. P. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.650597 · Cited by 66
The Influence of Environmental Factors on Sleep Quality in Hospitalized Medical Patients
Bano, M., Chiaromanni, F., Corrias, M., Turco, M., Rui, M. D., Amodio, P., Merkel, C., Gatta, A., Mazzotta, G. M., Costa, R., et al. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00267 · Cited by 67
Circadian dysregulation in Parkinson's disease
Videnovic, A., & Golombek, D. (2017) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2016.11.001 · Cited by 63
Fan, R., Peng, X., Xie, L., Dong, K., Ma, D., Xu, W., Shi, X., Zhang, S., Chen, J., Yu, X., et al. (2022) · Aging Cell · doi:10.1111/acel.13704 · Cited by 60
French, I. T., & Muthusamy, K. A. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00114 · Cited by 69
Soares, N. M., Pereira, G. M., Altmann, V., de Almeida, R. M. M., & Rieder, C. R. D. M. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1947-4 · Cited by 68
Masini, D., Plewnia, C., Bertho, M., Scalbert, N., Caggiano, V., & Fisone, G. (2021) · Biomedicines · doi:10.3390/biomedicines9060598 · Cited by 67
Sleep Dysfunction and EEG Alterations in Mice Overexpressing Alpha-Synuclein
McDowell, K. A., Shin, D., Roos, K. P., & Chesselet, M. (2018) · Journal of Parkinson s Disease · doi:10.3233/jpd-140374 · Cited by 62
A lterations of the circadian system in P arkinson's disease patients
Fifel, K. (2016) · Movement Disorders · doi:10.1002/mds.26865 · Cited by 63
Neurobiological Functions of the Period Circadian Clock 2 Gene, Per2
Kim, M., de la Peña, J. B., Cheong, J. H., & Kim, H. J. (2017) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2017.131 · Cited by 67
Phillipson, O. T. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.006 · Cited by 60
Multidimensional Circadian Monitoring by Wearable Biosensors in Parkinson’s Disease
Madrid-Navarro, C. J., Sevilla, F. E., Mínguez‐Castellanos, A., Campos, M., Abellán, F. R., Madrid, J. A., & Rol, M. A. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00157 · Cited by 59
Weissová, K., Škrabalová, J., Skálová, K., Červená, K., Bendová, Z., Miletínová, E., Kopřivová, J., Šonka, K., Dudysová, D., Bartoš, A., et al. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2018.07.019 · Cited by 58
Chronotherapies for Parkinson’s disease
Fifel, K., & Videnović, A. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.002 · Cited by 58
Therapy With Mesenchymal Stem Cells in Parkinson Disease
Filho, D. M., Ribeiro, P. D. C., de Oliveira, L. F., de Paula, D. R. M., Capuano, V., Farnesi-de-Assunção, T. S., & da Silva, V. J. D. (2018) · The Neurologist · doi:10.1097/nrl.0000000000000188 · Cited by 55
Sleep disturbance in movement disorders: insights, treatments and challenges
Bailey, G. A., Hubbard, E., Fasano, A. A., Tijssen, M. A. J., Lynch, T., Anderson, K. N., & Peall, K. J. (2021) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-325546 · Cited by 58
The prevalence of sleep loss and sleep disorders in young and old adults
Jha, V. M. (2022) · Aging Brain · doi:10.1016/j.nbas.2022.100057 · Cited by 67
Endo, T., Matsumura, R., Tokuda, I. T., Yoshikawa, T., Shigeyoshi, Y., Node, K., Sakoda, S., & Akashi, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-64645-6 · Cited by 56
Excessive daytime sleepiness, objective napping and 11-year risk of Parkinson’s disease in older men
Leng, Y., Goldman, S. M., Cawthon, P. M., Stone, K. L., Ancoli‐Israel, S., & Yaffe, K. S. (2018) · International Journal of Epidemiology · doi:10.1093/ije/dyy098 · Cited by 55
Madrid-Navarro, C. J., Puertas, F. J., Sevilla, F. E., Campos, M., Abellán, F. R., Rol, M. A., & Madrid, J. A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00356 · Cited by 55
Circadian rhythms, Neuroinflammation and Oxidative Stress in the Story of Parkinson’s Disease
Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2020) · Cells · doi:10.3390/cells9020314 · Cited by 55
Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8486-x · Cited by 54
Neurological Insights into Sleep Disorders in Parkinson’s Disease
Thangaleela, S., Sivamaruthi, B. S., Kesika, P., Mariappan, S., Rashmi, S., Choeisoongnern, T., Sittiprapaporn, P., & Chaiyasut, C. (2023) · Brain Sciences · doi:10.3390/brainsci13081202 · Cited by 55
Wu, J. Q., Li, P., Stavitsky, K., Hu, K., & Cronin‐Golomb, A. (2018) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12692 · Cited by 51
Mammalian circadian networks mediated by the suprachiasmatic nucleus
Lu, Q., & Kim, J. Y. (2021) · FEBS Journal · doi:10.1111/febs.16233 · Cited by 50
Metadata
- Authors
- Breen, D. P., Vuono, R., Nawarathna, U., Fisher, K., Shneerson, J. M., Reddy, A. B., & Barker, R. A.
- Affiliations
- University of Cambridge (GB)
- Royal Papworth Hospital (GB)
- Corresponding author
- Breen, David P.
- Venue
- JAMA Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2014-05-01
- Volume
- 71
- Issue
- 5
- Pages
- 589
- ISSN
- 2168-6149 (ISSN-L)
- PMC
- PMC4119609
- OpenAlex
- W1996955271
- Cited by
- 440
- References
- 35
- Citations by year
- 2026: 31 · 2025: 37 · 2024: 42 · 2023: 42 · 2022: 44 · 2021: 47 · 2020: 36 · 2019: 31 · 2018: 35 · 2017: 36 · 2016: 35 · 2015: 11 · 2014: 12
- FWCI
- 15.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Neurology (publishedVersion)
- PubMed (publishedVersion)
- Kent Academic Repository (University of Kent) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Wellcome Trust (100574, 100333/Z/12/Z, 100333)
- Parkinson's UK (J-0801)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- Parkinson's disease, sleep disorders, circadian rhythm, early-stage Parkinson's disease, sleep architecture, sleep latency, REM sleep, serum cortisol, melatonin, clock genes, Bmal1, Per2, NR1D1, non-motor symptoms, quality of life
- MeSH terms
- Aged, Circadian Rhythm, Female, Humans, Male, Middle Aged, Parkinson Disease, Sleep, Cohort Studies, Case-Control Studies, Sleep Disorders, Circadian Rhythm, Early Diagnosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
