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Telomere Length Shortening and Alzheimer Disease—A Mendelian Randomization Study
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“Supporting this idea, genetic variations in genes involved in telomere maintenance have been shown to correlate with AD susceptibility [121].”
From Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology (2023) · cites this paper as [121]
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Cites
Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
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Self-citationThe Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis
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Self-citationAssociation of Shorter Leukocyte Telomere Repeat Length With Dementia and Mortality
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“Likewise, in ADpatients, telomere lengths have been shown to be shorter, both in observational (Forero et al., 2016a) and causal Mendelian Randomization (Zhan et al., 2015) studies.”
BackgroundSelf-citationTelomere Length and All-Cause Mortality: A Meta-analysis
Wang, Q., Zhan, Y., Pedersen, N. L., Fang, F., & Hägg, S. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.09.002 · Cited by 333
Self-citationMeta-analysis of Telomere Length in Alzheimer’s Disease
Forero, D. A., González-Giraldo, Y., López-Quintero, C., Castro-Vega, L. J., Barreto, G. E., & Perry, G. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw053 · Cited by 229
“Future studies using high-throughput approaches, such as nextgeneration sequencing, could identify novel genetic and epigenetic factors (39) that influence TL in AD patients and in its presymptomatic stages (40).”
BackgroundPuterman, E., Gemmill, A., Karasek, D., Weir, D., Adler, N. E., Prather, A. A., & Epel, E. S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525602113 · Cited by 165
“They showed that common sequence variants of seven genes that directly regulate telomere maintenance, summed as a genetic risk score, significantly increase risks for cardiovascular, pulmonary (23), and Alzheimer’s diseases (24).”
BackgroundGenome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length
Li, C., Stoma, S., Lotta, L. A., Warner, S. C., Albrecht, E., Allione, A., Arp, P., Broer, L., Buxton, J. L., Alves, A. C., et al. (2020) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2020.02.006 · Cited by 163
Self-citationStress, telomeres, and psychopathology: toward a deeper understanding of a triad of early aging
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Nutrition and the ageing brain: Moving towards clinical applications
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“, 2016) and a causal link has been suggested through a Mendelian randomization approach (Zhan et al., 2015).”
Wu, Z., Qu, J., & Liu, G.-H. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00775-3 · Cited by 118
“…such as dyskeratosis congenita 188 , telomere dysregulation is also a common feature in various age-related diseases such as Alzheimer disease 189 , pulmonary fibrosis 190 , Duchenne muscular dystrophy 97 , metabolic diseases 191 , osteoarthritis 91 and cancers 192 (Table 1 and Supplementary…”
Xu, X., Chen, X., Zhang, X., Liu, Y., Wang, Z., Wang, P., Du, Y., Qin, Y., & Chen, Z.-J. (2016) · Human Reproduction · doi:10.1093/humrep/dew283 · Cited by 109
“Telomere attrition has been considered to be involved in age-related disorders, such as cardiovascular diseases (Brouilette et al., 2003, 2007; Morgan et al., 2014), neurological diseases (Tedone et al., 2015; Zhan et al., 2015) and cancers (Hahn, 2003; Willeit et al., 2010).”
BackgroundKuo, C., Pilling, L. C., Kuchel, G. A., Ferrucci, L., & Melzer, D. R. (2019) · Aging Cell · doi:10.1111/acel.13017 · Cited by 112
“These variants have been used to perform MR, but the focus was on dis‐ eases (Haycock et al., 2017; Zhan et al., 2015).”
MethodRivero-Segura, N. A., Bello‐Chavolla, O. Y., Barrera-Vázquez, O. S., Gutiérrez‐Robledo, L. M., & Gómez-Verján, J. C. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101164 · Cited by 99
The relationship between childhood psychosocial stressor level and telomere length: a meta-analysis
M. Hanssen, L., S. Schutte, N., M. Malouff, J., & S. Epel, E. (2017) · Health Psychology Research · doi:10.4081/hpr.2017.6378 · Cited by 93
“Telomere length appears to be one of the causal factors, as recent mendelian genetic studies of telomere length have shown direct prediction of earlier onset of certain diseases of aging (Codd et al., 2013; Zhan et al., 2015).”
BackgroundEpigenetic Mechanisms Impacting Aging: A Focus on Histone Levels and Telomeres
Song, S., & Johnson, F. B. (2018) · Genes · doi:10.3390/genes9040201 · Cited by 95
Farahzadi, R., Fathi, E., & Vietor, I. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00052 · Cited by 92
Short telomere length is associated with impaired cognitive performance in European ancestry cohorts
Hägg, S., Zhan, Y., Karlsson, R., Gerritsen, L., Ploner, A., van der Lee, S. J., Broer, L., Deelen, J., Marioni, R. E., Wong, A., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.73 · Cited by 91
“5,16,27 Moreover, other studies suggest telomeres might even elongate in somatic cells to maintain cellular stability, 21,28,29 although this phenomenon could be partly explained by leukocyte turnover or imprecise measurements.”
Self-citationWei, Z., Chen, X.-C., Song, Y., Pan, X.-D., Dai, X.-M., Zhang, J., Cui, X.-L., Wu, X.-L., & Zhu, Y.-G. (2016) · Chinese Medical Journal · doi:10.4103/0366-6999.186646 · Cited by 89
“[7,8] Besides telomere shortening,[9] cell”
Innes, K. E., & Sambamoorthi, U. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200960 · Cited by 87
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Biological Hallmarks of Cancer in Alzheimer’s Disease
Nudelman, K. N. H., McDonald, B. C., Lahiri, D. K., & Saykin, A. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1591-5 · Cited by 73
“that AD patients have shorter telomeres, and that shorter telomere length is a risk factor for AD [88, 89].”
Telomere Length and the Risk of Alzheimer’s Disease: The Rotterdam Study
Fani, L., Hilal, S., Sedaghat, S., Broer, L., Licher, S., Arp, P., van Meurs, J. B. J., Ikram, M. K., & Ikram, M. A. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190759 · Cited by 72
Telomere length and brain aging: A systematic review and meta-analysis
Gampawar, P. G., Schmidt, R., & Schmidt, H. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101679 · Cited by 73
“In addition, Mendelian randomization studies provided evidence for a causal relationship between telomere length and Alzheimer‘s disease (Zhan et al., 2015) and cardiovascular”
BackgroundMachiela, M. J., Lan, Q., Slager, S. L., Vermeulen, R. C. H., Teras, L. R., Camp, N. J., Cerhan, J. R., Spinelli, J. J., Wang, S. S., Nieters, A., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw027 · Cited by 58
“While the total variance in telomere length explained by these variants is limited (∼1%), recent studies suggest that genetic risk scores (GRSs) of these variants have utility as surrogatemeasures of peripheral leukocyte telomere length in deciphering associations with coronary artery disease (9), Alzheimer’s disease…”
BackgroundDevelopments in molecular epidemiology of aging
Hägg, S., Belsky, D. W., & Cohen, A. A. (2019) · Emerging Topics in Life Sciences · doi:10.1042/etls20180173 · Cited by 58
Self-citationKuźma, E., Hannon, E. J., Zhou, A., Lourida, I., Bethel, A. C., Levine, D. A., Lunnon, K., Coon, J. T., Hyppönen, E., & Llewellyn, D. J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180013 · Cited by 63
“rs9420907) providing evidence for a causal association with AD when used as single SNP IVs [25].”
BackgroundMethodResultInfluentialMadrid, A. S., Rasmussen, K. L., Rode, L., Frikke‐Schmidt, R., Nordestgaard, B. G., & Bojesen, S. E. (2019) · European Journal of Epidemiology · doi:10.1007/s10654-019-00563-w · Cited by 55
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Stress and Alzheimer’s disease: A senescence link?
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“These findings are particularly relevant in the context of human literature demonstrating that shorter telomeres increases risk for AD (Zhan et al., 2015).”
BackgroundPolygenic analysis of inflammatory disease variants and effects on microglia in the aging brain
Felsky, D., Patrick, E., Schneider, J. A., Mostafavi, S., Gaiteri, C., Patsopoulos, N. A., Bennett, D. A., & Jager, P. L. D. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0272-6 · Cited by 44
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“Mean telomere length (MTL) has significantly relationship with different age-related diseases, such as heart failure (8), diabetes mellitus (9), osteoporosis (10), atherosclerosis (11) and dementia (12).”
BackgroundZhou, X., Lian, P., Liu, H., Wang, Y., Zhou, M., & Feng, Z. (2023) · Nutrients · doi:10.3390/nu15204445 · Cited by 40
“In such cases, an alternative MR method was employed to report the findings [69,92].”
MethodZhan, Y., Clements, M., Roberts, R. O., Vassilaki, M. E., Druliner, B. R., Boardman, L. A., Petersen, R. C., Reynolds, C. A., Pedersen, N. L., & Hägg, S. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.05.004 · Cited by 37
“…for mortality (Bakaysa et al., 2007; Mons et al., 2017), cardiovascular diseases (Hammadah et al., 2017; Zhan et al., 2017), some cancers (Barthel et al., 2017; Telomeres Mendelian Randomization Collaboration et al., 2017), and neurodegenerative disorders (Honig et al., 2012; Zhan et al., 2015).”
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A systematic review on the effects of social discrimination on telomere length
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“So far findings from this design are mixed and include evidence that longer telomeres may increase risk for some cancers (Rode et al., 2015; Zhan et al., 2015; Zhang et al., 2015; Haycock et al., 2017).”
BackgroundCardillo, G. D. M., de Paula, V. D. J. R., Ikenaga, E. H., Costa, L. R., Catanozi, S., Schaeffer, E. L., Gattaz, W. F., Kerr, D. S., & Forlenza, O. V. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170838 · Cited by 35
“In fact, several age-related diseases have been related to altered telomere length (TL), such as cardiovascular diseases [5, 6], age-related diabetes [7, 8] and neurodegenerative disorders [9–11] including Alzheimer’s disease (AD) [12–15].”
Potential roles of telomeres and telomerase in neurodegenerative diseases
Wang, J., Liu, Y., Xia, Q., Xia, Q., Wang, B., Yang, C., Liang, J., & Liu, X. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.046 · Cited by 37
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Rodríguez‐Fernández, B., Vilor‐Tejedor, N., Arenaza‐Urquijo, E. M., Sánchez‐Benavides, G., Suárez‐Calvet, M., Operto, G., Minguillón, C., Fauria, K., Kollmorgen, G., Suridjan, I., et al. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01101-9 · Cited by 31
“Interestingly, some of the genetic variants which were used as instrumental variables to estimate genetically predicted telomere length in the present study were primarily related to the risk of cardiovascular disease [81], and they were later found to be causally associated with AD risk [27].”
BackgroundProgrammed ageing: decline of stem cell renewal, immunosenescence, and Alzheimer's disease
Lathe, R., & Clair, D. S. (2023) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12959 · Cited by 37
An introduction to Mendelian randomization with applications in neurology
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“In addition, it was reported that lower general cognitive ability level was associated with shorter TL [39], and shorter TL was causally related to a higher risk of suffering from Alzheimer’s disease [40].”
Gampawar, P. G., Schmidt, R., & Schmidt, H. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00100 · Cited by 31
“Mendelian randomization studies suggested a causal role for telomeres for Alzheimer's Disease (22, 23).”
BackgroundHautekiet, P., Nawrot, T. S., Janssen, B. G., Martens, D. S., Clercq, E. M. D., Dadvand, P., Plusquin, M., Bijnens, E. M., & Saenen, N. D. (2020) · Environment International · doi:10.1016/j.envint.2020.106332 · Cited by 32
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“…et al. 2012; Honig et al. 2012; Lukens et al. 2009; Movérare-Skrtic et al. 2012; Panossian et al. 2003; Takata et al. 2012; Leukocyte telomere length is linked to vascular risk factors not to Alzheimer’s disease in… 815 Tedone et al. 2015; Thomas et al. 2008; Zekry et al. 2010; Zhan et al. 2015).”
BackgroundResultInfluentialGao, K., Chen, W., Zhu, J. L., Wang, X., Chen, G., Luo, Y., Zhang, D., Yue, W., & Yu, H. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00843 · Cited by 29
“Two MR studies have suggested that SNPs associated with telomerase length shortening as causative for AD (20, 21), however, the selected number of risk SNPs for telomerase length is only seven.”
BackgroundLi, Z., Liu, H., Qian, Y., Li, X., Guo, C., Wang, Z., & Wei, Y. (2020) · Environment International · doi:10.1016/j.envint.2020.105769 · Cited by 29
Rodríguez‐Fernández, B., Gispert, J. D., Guigó, R., Navarro, A., Vilor‐Tejedor, N., & Crous‐Bou, M. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.08.006 · Cited by 30
Leukocyte Telomere Length Shortening and Alzheimer’s Disease Etiology
Guo, Y., & Yu, H. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190134 · Cited by 27
“Thepresentstudywillupdateapreviousstudy usingthenewADGWASdataandasimilarapproach [4].”
de Baca, T. C., Prather, A. A., Lin, J., Sternfeld, B., Adler, N. E., Epel, E. S., & Puterman, E. M. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0482-5 · Cited by 26
“Other Mendelian randomization studies associate the telomere-regulating common sequence variants with pulmonary [16] and Alzheimer’s diseases [17].”
BackgroundZhan, Y., Liu, X., Reynolds, C. A., Pedersen, N. L., Hägg, S., & Clements, M. (2018) · American Journal of Epidemiology · doi:10.1093/aje/kwy128 · Cited by 25
Self-citationTelomere Shortening in the Alzheimer’s Disease Neuroimaging Initiative Cohort
Nudelman, K. N. H., Lin, J., Lane, K. A., Nho, K. T., Kim, S., Faber, K. M., Risacher, S. L., Foroud, T., Gao, S., Davis, J. W., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190010 · Cited by 23
“Studies using Mendelian randomization provide support for a causal relationship between shorter telomeres and AD [31, 32].”
Rosero‐Bixby, L., Rehkopf, D. H., Dow, W. H., Lin, J., Epel, E. S., Azofeifa, J., & Leal, A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223766 · Cited by 24
“Some genetic studies have found associations of telomere length and cardiovascular disease risk [7] and Alzheimer’s dementia [8].”
BackgroundAssociation Between Weight Change and Leukocyte Telomere Length in U.S. Adults
Zhang, Y., Xu, Z., Yang, Y., Cao, S., Lyu, S., & Duan, W. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.650988 · Cited by 26
“For decades, a large number of experimental and observational studies have revealed that telomere length (TL) is associated with age-related diseases (6, 7), and even cancer risks (8–10).”
BackgroundFares, D. A., Schalekamp–Timmermans, S., Nawrot, T. S., & Steegers‐Theunissen, R. P. M. (2020) · Birth Defects Research · doi:10.1002/bdr2.1682 · Cited by 23
Genetically Predicted Telomere Length and Its Relationship With Alzheimer’s Disease
Yu, G., Lu, L., Ma, Z., & Wu, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.595864 · Cited by 21
Stefler, D., Malyutina, S. K., Maximov, V. N., Orlov, P. S., Иванощук, Д. Е., Nikitin, Y., Гафаров, В. В., Ryabikov, A. N., Voevoda, M. I., Bobák, M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-35122-y · Cited by 22
Dietary Copper Intake and Its Association With Telomere Length: A Population Based Study
Lin, Z., Gao, H., Wang, B., & Wang, Y. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00404 · Cited by 21
Genetically Determined Serum Uric Acid and Alzheimer’s Disease Risk
Yuan, H., & Yang, W. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180538 · Cited by 19
Inflammation and Vascular Ageing: From Telomeres to Novel Emerging Mechanisms
Chiriacò, M., Georgiopoulos, G. A., Duranti, E., Antonioli, L., Puxeddu, I., Nannipieri, M., Rosada, J., Blandizzi, C., Taddei, S., Virdis, A., et al. (2019) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-019-00331-7 · Cited by 20
Using Mendelian randomization to understand and develop treatments for neurodegenerative disease
Storm, C. S., Kia, D. A., Almramhi, M. M., & Wood, N. W. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa031 · Cited by 19
“These SNPs are associated with telomere length in leukocytes, which are correlated with that in neurons (Zhan et al., 2015; Aziz and Weydt, 2018).”
BackgroundMahady, L. J., He, B., Malek‐Ahmadi, M. H., & Mufson, E. J. (2020) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12672 · Cited by 18
Crocco, P., Rango, F. D., Dato, S., Grotta, R. L., Maletta, R., Bruni, A. C., Passarino, G., & Rose, G. (2023) · Biology · doi:10.3390/biology12101286 · Cited by 15
Whither the genotype‐phenotype relationship? An historical and methodological appraisal
Fisch, G. S. (2017) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31571 · Cited by 18
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“Mendelian randomization studies have shown that robust genetic predictors of shorter TL are associated with higher odds of Alzheimer’s disease (Zhan et al., 2015) and coronary artery disease (Codd et al.”
BackgroundIncident hand OA is strongly associated with reduced peripheral blood leukocyte telomere length
McAlindon, T. E., Roberts, M. B., Driban, J. B., Schaefer, L. F., Haugen, I. K., Smith, S. E., Duryea, J., Cunha, D., Blanco, F. J., Fernández-García, J., et al. (2018) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2018.08.010 · Cited by 15
Fat metabolism is associated with telomere length in six population-based studies
van der Spek, A., Karamujić‐Čomić, H., Pool, R., Bot, M., Beekman, M., Garmaeva, S., Arp, P., Henkelman, S., Liu, J., Alves, A. C., et al. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab281 · Cited by 16
“One of the most intriguing findings in studies investigating genetic determinants of LTL is that the identified genetic variants underscore the association between LTL and cardiovascular and metabolic diseases (18,43), Alzheimer’s disease (46)”
Zhang, R., Zhao, J., Xu, J., & Liu, F. (2016) · Oncotarget · doi:10.18632/oncotarget.9536 · Cited by 15
“Epidemiological studies have also shown that peripheral leukocytes telomere length (LTL) correlates with the incidence of major chronic diseases [14, 22–26].”
BackgroundTelomere length is independently associated with all-cause mortality in chronic heart failure
Romaine, S. P. R., Denniff, M. J., Codd, V., Nath, M., Koekemoer, A. L., Anker, S. D., Cleland, J. G. F., Filippatos, G. S., Levin, D., Metra, M., et al. (2021) · Heart · doi:10.1136/heartjnl-2020-318654 · Cited by 12
Aziz, N. A., & Weydt, P. (2018) · Journal of Neurology · doi:10.1007/s00415-018-8972-y · Cited by 11
Zhan, Y., & Hägg, S. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7704-8_20 · Cited by 10
Self-citationDai, J., Xu, Y., Wang, T., & Zeng, P. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110700 · Cited by 10
Uppuluri, L., Varapula, D. T., Young, E., Riethman, H. C., & Xiao, M. (2020) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2020.103562 · Cited by 12
“Telomere and disease In the last two decades, numerous studies associating shortening of telomere length to conditions like type 2 diabetes (Zhao et al., 2013), cancers (bladder, esophageal, gastric, head, breast, neck, ovarian, renal) (Blackburn et al., 2015; Wentzensen et al., 2011), Alzheimer’s (Zhan et al., 2015)…”
BackgroundInfluentialLin, A., Arnold, B. F., Mertens, A., Lin, J., Benjamin‐Chung, J., Ali, S., Hubbard, A., Stewart, C. P., Shoab, A. K., Rahman, M. Z., et al. (2017) · eLife · doi:10.7554/elife.29365 · Cited by 7
“It remains an open debate whether TL serves as a ‘molecular clock’ that gauges cumulative stress exposures over a lifespan or plays a role in the etiology of various diseases (Blackburn et al., 2015; Hamad et al., 2016; Zhan et al., 2015).”
BackgroundHaferkamp, U., Hartmann, C., Abid, C. L., Brachner, A., Höchner, A., Gerhartl, A., Harwardt, B., Leckzik, S., Leu, J., Metzger, M., et al. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00471-y · Cited by 12
“Moderately increasing shortening of telomeres is associated with aging while increased shortening of telomeres beyond physiological levels is associated with the onset of LOAD [36].”
BackgroundEarly adversity and the comorbidity between metabolic disease and psychopathology
Gómez‐Ilescas, A., & Silveira, P. P. (2025) · The Journal of Physiology · doi:10.1113/jp285927 · Cited by 9
“A mendelian randomization study has provided evidence for a causal relationship between telomer length and Alzheimer’s disease (Zhan et al., 2015).”
Lin, Z., Gao, H., Wang, B., & Wang, Y. (2021) · Mediators of Inflammation · doi:10.1155/2021/6675353 · Cited by 8
Gao, Y., Wang, T., Yu, X., Ferrari, R., Hernandez, D. G., Nalls, M. A., Rohrer, J. D., Ramasamy, A., Kwok, J. B., Dobson‐Stone, C., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-68848-9 · Cited by 7
Guo, X., Li, J., Qi, Y., Chen, J., Jiang, M., Zhu, L., Liu, Z., Wang, H., Wang, G.-W., & Wang, X. (2024) · Aging Cell · doi:10.1111/acel.14121 · Cited by 6
“The Mendelian randomization study has provided evidence for a causal role of TL shortening in AD (Scheller Madrid et al., 2020; Zhan et al., 2015).”
BackgroundPalomares, D., Vanparys, A., Jorgji, J., Paître, E., Kienlen‐Campard, P., & Suelves, N. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02118-5 · Cited by 7
“Additionally, increasing evidence suggests a direct correlation between shorter telomere length and increased AD risk [20-23].”
Li, W., Han, Y., Wang, P., & Qiao, S. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70803 · Cited by 6
Meng, X., Li, X., Cao, M., Dong, J., Wang, H., Cao, W., Liu, D., & Wang, Y. (2025) · Systematic Reviews · doi:10.1186/s13643-025-02792-5 · Cited by 6
Longer Telomere Length and its Association with Lower Levels of C-Peptide
Yang, M. J., Jiang, P. X., Jin, C., & Wang, J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00244 · Cited by 5
“TL declines with increasing age in human beings and has been associated with type 2 diabetes (2, 3), cardiovascular disease (4, 5), obesity (6), insulin resistance (4, 7), and other chronic conditions (5, 8, 9).”
BackgroundLiang, Y., & Huang, P. (2023) · Aging Clinical and Experimental Research · doi:10.1007/s40520-023-02607-4 · Cited by 4
“Short-ened telomere has been correlated with an increased susceptibility to common age-related illnesses and higher mortality rates, including cardiovascular diseases (CVDs) [14], Alzheimer’s disease [15] and type 2 diabetes [16].”
Bayón, A. R., & Sampedro, F. G. (2018) · Neurología (English Edition) · doi:10.1016/j.nrleng.2017.01.011 · Cited by 4
Fernández‐Eulate, G., Alberro, A., Muñoz‐Culla, M., Zulaica, M., Zufiría, M., Barandiarán, M., Etxeberría, I., Yanguas, J. J., Gallardo, M. M., Soberón, N. E., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00380 · Cited by 4
Wang, Y., Liu, Q., Liang, S., Yao, M., Zheng, H., Hu, D., & Wang, Y. (2024) · Aging · doi:10.18632/aging.205583 · Cited by 5
The relationship between naevus count, memory function and telomere length in the Twins UK cohort
Masi, S., Georgiopoulos, G. A., Ribero, S., Taddei, S., Bataille, V. A., & Steves, C. J. (2018) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12722 · Cited by 2
Combining Mendelian randomization with the sibling comparison design
Sjölander, A., Frisell, T., Öberg, A. S., Wang, Y., & Hägg, S. (2023) · Statistics in Medicine · doi:10.1002/sim.9983 · Cited by 2
Self-citationBarbé‐Tuana, F. M., Grün, L. K., Pierdoná, V., de Oliveira, B. C. D., de Paiva, S. C., Shiburah, M. E., da Silva, V. L., Morea, E. G. O., Fontes, V. S., & Cano, M. I. N. (2021) · Springer eBooks · doi:10.1007/978-3-030-73151-9_7 · Cited by 2
Longueur des télomères : de la sénescence cellulaire aux trajectoires du vieillissement humain
Benetos, A. (2022) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/j.banm.2022.02.018 · Cited by 3
Editorial: Genetics of Age-Related Diseases and Their Risk and Protective Factors
Karlsson, I., Arpawong, T. E., Zhan, Y., & Lehto, K. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.771109 · Cited by 2
Self-citationTelomere Dynamics and Aging Related Diseases
Toupance, S., & Bénétos, A. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316677018.007 · Cited by 1
Association of Telomere Length, a Cellular Aging Marker, with Depression, PTSD and Hostility
Zhang, L., Hu, X., Li, X., Dohl, J., Yu, T., & Ursano, R. J. (2019) · OBM Geriatrics · doi:10.21926/obm.geriatr.1901041 · Cited by 1
Campos-Sánchez, I., Navarrete‐Muñoz, E. M., Martens, D. S., Galán, I. R., Lertxundi, A., Llop, S., Guxens, M., Rodríguez-Dehli, C., Lertxundi, N., Soler-Blasco, R., et al. (2025) · Journal of Attention Disorders · doi:10.1177/10870547251314923 · Cited by 1
“Studies in the adult population have shown that shorter telomeres are related to chronic pathologies such as cardiovascular diseases (De Meyer et al., 2018), cancer (Wentzensen et al., 2011), Alzheimer’s disease (Zhan et al., 2015), and psychiatric pathologies (Darrow et al., 2016).”
The telomere-telomerase system and mental processes in aging, norm and pathology (Literature review)
Pavlov, K. I., Mukhin, V. N., Клименко, В. М., & Anisimov, V. N. (2017) · Advances in Gerontology · doi:10.1134/s2079057017020114 · Cited by 14
Metadata
- Authors
- Zhan, Y., Song, C., Karlsson, R., Tillander, A., Reynolds, C. A., Pedersen, N. L., & Hägg, S.
- Affiliations
- Karolinska Institutet (SE)
- University of California, Riverside (US)
- Corresponding author
- Hägg, Sara
- ORCID
- Venue
- JAMA Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2015-10-01
- Volume
- 72
- Issue
- 10
- Pages
- 1202
- ISSN
- 2168-6149 (ISSN-L)
- OpenAlex
- W2122450728
- Cited by
- 111
- References
- 6
- Citations by year
- 2025: 7 · 2024: 4 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 18 · 2019: 18 · 2018: 23 · 2017: 10 · 2016: 7 · 2015: 1
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- telomere length, telomere shortening, Alzheimer's disease, genetic variants, causal inference
- MeSH terms
- Alzheimer Disease, Genetic Testing, Humans, Risk, Telomere, Polymorphism, Single Nucleotide, Mendelian Randomization Analysis
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