Lifespan adversity and later adulthood telomere length in the nationally representative US Health and Retirement Study

Puterman, Eli; Gemmill, Alison; Karasek, Deborah; Weir, David; Adler, Nancy E.; Prather, Aric A.; Epel, Elissa S.

doi:10.1073/pnas.1525602113

Cited by 165Telomeres, Telomerase, and SenescenceChild Abuse and TraumaHealth disparities and outcomes

Lifespan adversity and later adulthood telomere length in the nationally representative US Health and Retirement Study

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Puterman, Eli, Gemmill, Alison, Karasek, Deborah, Weir, David, Adler, Nancy E., Prather, Aric A., Epel, Elissa S.·2016·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1525602113PMC PMC5081642

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Abstract

Stress over the lifespan is thought to promote accelerated aging and early disease. Telomere length is a marker of cell aging that appears to be one mediator of this relationship. Telomere length is associated with early adversity and with chronic stressors in adulthood in many studies. Although cumulative lifespan adversity should have bigger impacts than single events, it is also possible that adversity in childhood has larger effects on later life health than adult stressors, as suggested by models of biological embedding in early life. No studies have examined the individual vs. cumulative effects of childhood and adulthood adversities on adult telomere length. Here, we examined the relationship between cumulative childhood and adulthood adversity, adding up a range of severe financial, traumatic, and social exposures, as well as comparing them to each other, in relation to salivary telomere length. We examined 4,598 men and women from the US Health and Retirement Study. Single adversities tended to have nonsignificant relations with telomere length. In adjusted models, lifetime cumulative adversity predicted 6% greater odds of shorter telomere length. This result was mainly due to childhood adversity. In adjusted models for cumulative childhood adversity, the occurrence of each additional childhood event predicted 11% increased odds of having short telomeres. This result appeared mainly because of social/traumatic exposures rather than financial exposures. This study suggests that the shadow of childhood adversity may reach far into later adulthood in part through cellular aging.

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In the Health and Retirement Study, childhood adversity had a significant effect on telomere length.
“When broken down by life period, childhood adversity had a significant effect on proinflammatory gene expression (Levine et al., 2015), as well as telomere length (Puterman et al., 2016), both potential mechanisms of disease development.”
From More than a feeling: A unified view of stress measurement for population science (2018) · cites this paper as Puterman et al., 2016

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More than a feeling: A unified view of stress measurement for population science
Epel, E. S., Crosswell, A. D., Mayer, S. E., Prather, A. A., Slavich, G. M., Puterman, E., & Mendes, W. B. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.03.001 · Cited by 1,077 · see citing works
“, 2015), as well as telomere length (Puterman et al., 2016), both potential mechanisms of disease development.”
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Measuring biological aging in humans: a quest
Ferrucci, L., Gonzalez‐Freire, M., Fabbri, E., Simonsick, E., Tanaka, T., Moore, Z., Salimi, S., Sierra, F., & de Cabo, R. (2020) · Aging Cell · doi:10.1111/acel.13080 · Cited by 781 · see citing works
Psychological Stress and Mitochondria: A Conceptual Framework
Picard, M. A., & McEwen, B. S. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000544 · Cited by 318 · see citing works
The effects of early life adversity on the immune system
Elwenspoek, M. M. C., Kuehn, A., Muller, C. P., & Turner, J. D. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.05.012 · Cited by 180 · see citing works
The energetic cost of allostasis and allostatic load
Bobba‐Alves, N., Juster, R., & Picard, M. A. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105951 · Cited by 155 · see citing works
Stress, telomeres, and psychopathology: toward a deeper understanding of a triad of early aging
Epel, E. S., & Prather, A. A. (2018) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032816-045054 · Cited by 153 · see citing works
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Association of Unhealthy Lifestyle and Childhood Adversity With Acceleration of Aging Among UK Biobank Participants
Yang, G., Cao, X., Li, X., Zhang, J., Ma, C., Zhang, N., Lu, Q., Crimmins, E. M., Gill, T. M., Chen, X., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.30690 · Cited by 143 · see citing works
Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children
Marini, S., Davis, K. A., Soare, T. W., Zhu, Y., Suderman, M. J., Simpkin, A. J., Smith, A. D. A. C., Wolf, E. J., Relton, C. L., & Dunn, E. C. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104484 · Cited by 140 · see citing works
Psychosocial stressors and telomere length: A current review of the science
Rentscher, K. E., Carroll, J. E., & Mitchell, C. (2020) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-040119-094239 · Cited by 138 · see citing works
Social hallmarks of aging: Suggestions for geroscience research
Crimmins, E. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101136 · Cited by 120 · see citing works
Adverse Childhood Experiences Run Deep: Toxic Early Life Stress, Telomeres, and Mitochondrial DNA Copy Number, the Biological Markers of Cumulative Stress
Ridout, K. K., Khan, M. B., & Ridout, S. J. (2018) · BioEssays · doi:10.1002/bies.201800077 · Cited by 118 · see citing works
The Trauma Resiliency Model: A “Bottom-Up” Intervention for Trauma Psychotherapy
Grabbe, L., & Miller-Karas, E. (2018) · Journal of the American Psychiatric Nurses Association · doi:10.1177/1078390317745133 · Cited by 107 · see citing works
Accelerating research on biological aging and mental health: Current challenges and future directions.
Han, L. K. M., Verhoeven, J. E., Tyrka, A. R., Penninx, B. W. J. H., Wolkowitz, O. M., Månsson, K. N. T., Lindqvist, D., Boks, M. P., Révész, D., Mellon, S. H., et al. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.004 · Cited by 104 · see citing works
Predicting mortality from 57 economic, behavioral, social, and psychological factors
Puterman, E. M., Weiss, J., Hives, B. A., Gemmill, A., Karasek, D. A., Mendes, W. B., & Rehkopf, D. H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918455117 · Cited by 103 · see citing works
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Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging
Ariffin, H., Azanan, M. S., Abd Ghafar, S. S., Oh, L., Lau, K. H., Thirunavakarasu, T., Sedan, A., Ibrahim, K., Chan, A., Chin, T. F., et al. (2017) · Cancer · doi:10.1002/cncr.30857 · Cited by 99 · see citing works
Early-life adversity and long-term neurobehavioral outcomes: epigenome as a bridge?
Vaiserman, A. M., & Koliada, A. K. (2017) · Human Genomics · doi:10.1186/s40246-017-0129-z · Cited by 96 · see citing works
Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study
Liu, Z., Chen, X., Gill, T. M., Ma, C., Crimmins, E. M., & Levine, M. E. (2019) · PLoS Medicine · doi:10.1371/journal.pmed.1002827 · Cited by 88 · see citing works
Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan
Chen, M. A., LeRoy, A. S., Majd, M., Chen, J. Y., Brown, R. L., Christian, L. M., & Fagundes, C. P. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.788351 · Cited by 85 · see citing works
Association between childhood trauma and accelerated telomere erosion in adulthood: a meta-analytic study
Li, Z., He, Y., Wang, D., Tang, J., & Chen, X. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.06.002 · Cited by 84 · see citing works
The role of epigenetic aging in education and racial/ethnic mortality disparities among older U.S. Women
Liu, Z., Chen, B. H., Assimes, T. L., Ferrucci, L., Horvath, S., & Levine, M. E. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.01.028 · Cited by 79 · see citing works
Cumulative lifetime stress exposure and leukocyte telomere length attrition: The unique role of stressor duration and exposure timing
Mayer, S. E., Prather, A. A., Puterman, E. M., Lin, J., Arenander, J., Coccia, M., Shields, G. S., Slavich, G. M., & Epel, E. S. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.002 · Cited by 75 · see citing works
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The Roadmap for Resilience: The California Surgeon General's Report on Adverse Childhood Experiences, Toxic Stress, and Health
Bhushan, D., Kotz, K. J., McCall, J., Wirtz, S., Gilgoff, R., Dube, S. R., Powers, C., Olson-Morgan, J., Galeste, M., Patterson, K., et al. (2020) · doi:10.48019/peam8812 · Cited by 71 · see citing works
Processes Linking Religious Involvement and Telomere Length
Hill, T. D., Vaghela, P., Ellison, C. G., & Rote, S. M. (2017) · Biodemography and Social Biology · doi:10.1080/19485565.2017.1311204 · Cited by 69 · see citing works
Quantitative mapping of human hair greying and reversal in relation to life stress
Rosenberg, A. M., Rausser, S., Ren, J., Mosharov, E. V., Sturm, G., Ogden, R. T., Patel, P. R., Soni, R. K., Lacefield, C., Tobin, D. J., et al. (2021) · eLife · doi:10.7554/elife.67437 · Cited by 68 · see citing works
A stable and replicable neural signature of lifespan adversity in the adult brain
Holz, N. E., Zabihi, M., Kia, S. M., Monninger, M., Aggensteiner, P.-M., Siehl, S., Floris, D. L., Bokde, A. L. W., Desrivières, S., Flor, H., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01410-8 · Cited by 66 · see citing works
There are only four basic modes of cell death, although there are many ad-hoc variants adapted to different situations
Liu, X., Yang, W., Guan, Z.-Z., Yu, W., Fan, B., Xu, N., & Liao, D. J. (2018) · Cell & Bioscience · doi:10.1186/s13578-018-0206-6 · Cited by 64 · see citing works
Proinflammatory T Cell Status Associated with Early Life Adversity
Elwenspoek, M. M. C., Hengesch, X., Leenen, F. A. D., Schritz, A., Sias, K., Schaan, V., Mériaux, S. B., Schmitz, S., Bonnemberger, F., Schächinger, H., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1701082 · Cited by 63 · see citing works
Gender-based violence and trauma in marginalized populations of women: Role of biological embedding and toxic stress
Sabri, B., & Granger, D. A. (2018) · Health Care for Women International · doi:10.1080/07399332.2018.1491046 · Cited by 60 · see citing works
Contribution of life course circumstances to the acceleration of phenotypic and functional aging: A retrospective study
Cao, X., Ma, C., Zheng, Z., Liu, H., Hao, M., Chen, X., Crimmins, E. M., Gill, T. M., Levine, M. E., & Liu, Z. (2022) · EClinicalMedicine · doi:10.1016/j.eclinm.2022.101548 · Cited by 58 · see citing works
Basal cortisol, cortisol reactivity, and telomere length: A systematic review and meta-analysis
Jiang, Y., Da, W., Qiao, S., Zhang, Q., Li, X., Ivey, G., & Zilioli, S. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.01.022 · Cited by 58 · see citing works
Lifetime trauma, perceived control, and all-cause mortality: Results from the Midlife in the United States Study.
Elliot, A. J., Turiano, N. A., Infurna, F. J., Lachman, M. E., & Chapman, B. P. (2018) · Health Psychology · doi:10.1037/hea0000585 · Cited by 54 · see citing works
Associations between early life parent-child separation and shortened telomere length and psychopathological outcomes during adolescence
Chen, X., Zeng, C., Gong, C., Zhang, L., Wan, Y., Tao, F., & Sun, Y. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.01.021 · Cited by 51 · see citing works
Adverse Childhood Experiences and Telomere Length a Look Into the Heterogeneity of Findings—A Narrative Review
Bürgin, D., O’Donovan, A., d’Huart, D., Gallo, A. D., Eckert, A., Fegert, J. M., Schmeck, K., Schmid, M., & Boonmann, C. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00490 · Cited by 49 · see citing works
Childhood/Adolescent stressors and allostatic load in adulthood: Support for a calibration model
Berg, M. T., Simons, R. L., Barr, A. B., Beach, S. R. H., & Philibert, R. A. (2017) · Social Science & Medicine · doi:10.1016/j.socscimed.2017.09.028 · Cited by 47 · see citing works
Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking
Faraji, J., Karimi, M., Soltanpour, N., Moharrerie, A., Rouhzadeh, Z., Lotfi, H., Hosseini, S. A., Jafari, S. Y., Roudaki, S., Moeeini, R., et al. (2018) · eLife · doi:10.7554/elife.40262 · Cited by 45 · see citing works
Advancing Research on Psychosocial Stress and Aging with the Health and Retirement Study: Looking Back to Launch the Field Forward
Crosswell, A. D., Suresh, M., Puterman, E. M., Gruenewald, T. L., Lee, J., & Epel, E. S. (2018) · The Journals of Gerontology Series B · doi:10.1093/geronb/gby106 · Cited by 41 · see citing works
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A scoping systematic review of social stressors and various measures of telomere length across the life course
Willis, M. M., Reid, S., Calvo, E., Staudinger, U. M., & Factor-Litvak, P. R. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.006 · Cited by 39 · see citing works
Does Telomere Length Indicate Biological, Physical, and Cognitive Health Among Older Adults? Evidence from the Health and Retirement Study
Brown, L. L., Zhang, Y. S., Mitchell, C. M., & Ailshire, J. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly001 · Cited by 38 · see citing works
Stress and immunological aging
Reed, R. G. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.01.012 · Cited by 36 · see citing works
Adverse childhood or adult experiences and risk of bilateral oophorectomy: a population-based case–control study
Rocca, L. G., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Stewart, E. A., & Rocca, W. A. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-016045 · Cited by 35 · see citing works
Cellular response to chronic psychosocial stress: Ten-year longitudinal changes in telomere length in the Multi-Ethnic Study of Atherosclerosis
Meier, H. C. S., Hussein, M., Needham, B. L., Barber, S., Lin, J., Seeman, T. E., & Roux, A. V. D. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.018 · Cited by 33 · see citing works
The Community Resiliency Model®: a Pilot of an Interoception Intervention to Increase the Emotional Self-Regulation of Women in Addiction Treatment
Grabbe, L., Higgins, M. K., Jordan, D., Noxsel, L., Gibson, B., & Murphy, J. (2020) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-019-00189-9 · Cited by 33 · see citing works
Childhood Adversity and Adult Health: The Role of Developmental Timing and Associations With Accelerated Aging
Riem, M. M. E., & Karreman, A. (2018) · Child Maltreatment · doi:10.1177/1077559518795058 · Cited by 33 · see citing works
Compounding Stress: Childhood Adversity as a Risk Factor for Adulthood Trauma Exposure in the Health and Retirement Study
Bürgin, D., Boonmann, C., Schmeck, K., Schmid, M., Tripp, P., Nishimi, K. M., & O’Donovan, A. (2020) · Journal of Traumatic Stress · doi:10.1002/jts.22617 · Cited by 30 · see citing works
The associations of socioeconomic status with incident dementia and Alzheimer’s disease are modified by leucocyte telomere length: a population-based cohort study
Lai, K. Y., Webster, C. J., Kumari, S., Gallacher, J., & Sarkar, C. (2023) · Scientific Reports · doi:10.1038/s41598-023-32974-x · Cited by 30 · see citing works
Interpersonal-level discrimination indices, sociodemographic factors, and telomere length in African-Americans and Whites
Moody, D. L. B., Leibel, D. K., Darden, T. M., Ashe, J. J., Waldstein, S. R., Katzel, L. I., Liu, H. B., Weng, N., Evans, M. K., & Zonderman, A. B. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2018.12.004 · Cited by 30 · see citing works
Lifecourse Adversity and Telomere Length in Older Women from Northeast Brazil
Oliveira, B. S., Zunzunegui, M. V., Quinlan, J., de Medeiros, S. R. B., Thomasini, R. L., & Guerra, R. O. (2017) · Rejuvenation Research · doi:10.1089/rej.2017.1937 · Cited by 29 · see citing works
Harnessing BDNF Signaling to Promote Resilience in Aging
Faraji, J., & Metz, G. A. S. (2024) · Aging and Disease · doi:10.14336/ad.2024.0961 · Cited by 28 · see citing works
In vivo biomarkers of structural and functional brain development and aging in humans
Franke, K., Bublak, P., Hoyer, D., Billiet, T., Christian Gaser, B., Witte, O. W., & Schwab, M. G. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.11.002 · Cited by 28 · see citing works
Adverse childhood experiences (ACEs) and cardiovascular development from childhood to early adulthood: study protocol of the Niagara Longitudinal Heart Study
Wade, T. J., O’Leary, D. D., Dempster, K. S., MacNeil, A. J., Molnar, D. S., McGrath, J. J., & Cairney, J. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-030339 · Cited by 28 · see citing works
Sleep, stress, and immunity
Prather, A. A. (2019) · Sleep and Health · doi:10.1016/b978-0-12-815373-4.00024-1 · Cited by 27 · see citing works
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Impact of Heartfulness meditation practice on anxiety, perceived stress, well-being, and telomere length
Thakur, M. K., Patil, Y., Philip, S. T., Hamdule, T., Thimmapuram, J., Vyas, N., & Thakur, K. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1158760 · Cited by 27 · see citing works
Placing prostate cancer disparities within a psychosocial context: challenges and opportunities for future research
Cuevas, A. G., Trudel‐Fitzgerald, C., Cofie, L. E., Zaitsu, M., Allen, J. D., & Williams, D. R. (2019) · Cancer Causes & Control · doi:10.1007/s10552-019-01159-1 · Cited by 27 · see citing works
A Cross-Sectional Analysis of Telomere Length and Sleep in the Women’s Health Initiative
Grieshober, L., Wactawski‐Wende, J., Blair, R. H., Mu, L., Liu, J., Nie, J., Carty, C. L., Hale, L. E., Kroenke, C. H., LaCroix, A. Z., et al. (2019) · American Journal of Epidemiology · doi:10.1093/aje/kwz134 · Cited by 27 · see citing works
Chronic psychosocial and financial burden accelerates 5-year telomere shortening: findings from the Coronary Artery Risk Development in Young Adults Study
de Baca, T. C., Prather, A. A., Lin, J., Sternfeld, B., Adler, N. E., Epel, E. S., & Puterman, E. M. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0482-5 · Cited by 26 · see citing works
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How does early‐life adversity shape telomere dynamics during adulthood? Problems and paradigms
Marasco, V., Smith, S., & Angelier, F. (2022) · BioEssays · doi:10.1002/bies.202100184 · Cited by 26 · see citing works
Controlling for baseline telomere length biases estimates of the rate of telomere attrition
Melissa Bateson, B., Eisenberg, D. T. A., & Nettle, D. (2019) · Royal Society Open Science · doi:10.1098/rsos.190937 · Cited by 26 · see citing works
Correlates of longitudinal leukocyte telomere length in the Costa Rican Longevity Study of Healthy Aging (CRELES): On the importance of DNA collection and storage procedures
Rosero‐Bixby, L., Rehkopf, D. H., Dow, W. H., Lin, J., Epel, E. S., Azofeifa, J., & Leal, A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223766 · Cited by 24 · see citing works
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Proximity to roads, but not exposure to metal pollution, is associated with accelerated developmental telomere shortening in nestling great tits
Grunst, A. S., Grunst, M. L., Bervoets, L., Pinxten, R., & Eens, M. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113373 · Cited by 23 · see citing works
Moderate to Severe Chronic Pain in Later Life: Risk and Resilience Factors for Recovery
Li, R., Dworkin, R. H., Chapman, B. P., Becerra, A. Z., Yang, L., Mooney, C. J., & Seplaki, C. L. (2021) · Journal of Pain · doi:10.1016/j.jpain.2021.05.007 · Cited by 23 · see citing works
Minimally invasive biomarkers in human and non‐human primate evolutionary biology: Tools for understanding variation and adaptation
Urlacher, S., Kim, E. Y., Luan, T., Young, L. J., & Adjetey, B. (2022) · American Journal of Human Biology · doi:10.1002/ajhb.23811 · Cited by 21 · see citing works
Childhood Stressors, Relationship Quality, and Cognitive Health in Later Life
Thomas, P. A., Williams-Farrelly, M. M., Sauerteig-Rolston, M. R., & Ferraro, K. F. (2022) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbac007 · Cited by 22 · see citing works
Traumatic stress and cellular senescence: The role of war-captivity and homecoming stressors in later life telomere length
Stein, J. Y., Levin, Y., Uziel, O., Abumock, H., & Solomon, Z. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.05.037 · Cited by 22 · see citing works
Lifetime chronic stress exposures, stress hormones, and biological aging: Results from the Midlife in the United States (MIDUS) study
Hansen, J. L., Carroll, J., Seeman, T. E., Cole, S. W., & Rentscher, K. E. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.022 · Cited by 21 · see citing works
The association between sleep quality and telomere length: A systematic literature review
Sabot, D., Lovegrove, R. A., & Stapleton, P. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100577 · Cited by 21 · see citing works
Cumulative Stress Across the Life Course and Biological Aging in Adulthood
Suglia, S. F., Clausing, E. S., Shelton, R. C., Conneely, K. N., Prada, D., Vivo, I. D., Factor-Litvak, P. R., Cirillo, P. M., Baccarelli, A., Cohn, B. A., et al. (2024) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001284 · Cited by 21 · see citing works
Sex‐Specific Association Between Childhood Adversity and Accelerated Biological Aging
Yu, J., Pu, F., Yang, G., Hao, M., Zhang, H., Zhang, J., Cao, X., Zhu, L., Wan, Y., Wang, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202309346 · Cited by 21 · see citing works
New Directions in Geroscience: Integrating Social and Behavioral Drivers of Biological Aging
Nielsen, L., Marsland, A. L., Hamlat, E. J., & Epel, E. S. (2024) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001320 · Cited by 20 · see citing works
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Childhood and Adulthood Trauma Associate With Cognitive Aging Among Black and White Older Adults
Zuelsdorff, M. L., Sonnega, A. J., Barnes, L. L., Byrd, D. R., Rose, D., Cox, R. J. A., Norton, D., & Turner, R. (2023) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2023.09.015 · Cited by 20 · see citing works
Unraveling the causal genes and transcriptomic determinants of human telomere length
Chang, Y., Zhou, Y., Zhou, J., Li, W., Cao, J., Jing, Y., Zhang, S., Shen, Y., Lin, Q., Fan, X., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-44355-z · Cited by 20 · see citing works
Psychometric liability to psychosis and childhood adversities are associated with shorter telomere length: A study on schizophrenia patients, unaffected siblings, and non-clinical controls
Çevik, B., Çalışır, Ö. M., Atbaşoğlu, E. C., Saka, M. C., Alptekın, K., Üçok, A., Sırmatel, B., Gülöksüz, S., Tükün, A., van Os, J., et al. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.01.022 · Cited by 20 · see citing works
A life course approach to total tooth loss: Testing the sensitive period, accumulation, and social mobility models in the Health and Retirement Study
Lee, H. (2019) · Community Dentistry And Oral Epidemiology · doi:10.1111/cdoe.12463 · Cited by 20 · see citing works
Sex differences in the association between salivary telomere length and multimorbidity within the US Health & Retirement Study
Niedzwiedz, C. L., Katikireddi, S. V., Pell, J. P., & Smıth, D. J. (2019) · Age and Ageing · doi:10.1093/ageing/afz071 · Cited by 18 · see citing works
CEO Stress, Aging, and Death
Borgschulte, M., Guenzel, M., Liu, C., & Malmendier, U. M. (2021) · National Bureau of Economic Research · doi:10.3386/w28550 · Cited by 18 · see citing works
Somatic symptoms in children who have a parent with cancer: A systematic review
Graungaard, A. H., Bendixen, C. R., Haavet, O. R., Smith‐Sivertsen, T., & Mākelä, M. (2019) · Child Care Health and Development · doi:10.1111/cch.12647 · Cited by 17 · see citing works
Are Biological Consequences of Childhood Exposures Detectable in Telomere Length Decades Later?
Kemp, B. R., & Ferraro, K. F. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa019 · Cited by 17 · see citing works
Telomere length: biological marker of cellular vitality, aging, and health-disease process
Teixeira, M. Z. (2021) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.67.02.20200655 · Cited by 16 · see citing works
Genomic Instability Evolutionary Footprints on Human Health: Driving Forces or Side Effects?
Veschetti, L., Treccani, M., Tomi, E. D., & Malerba, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411437 · Cited by 15 · see citing works
Lifetime adversity predicts depression, anxiety, and cognitive impairment in a nationally representative sample of older adults in the United States
Ahn, S., Kim, S., Zhang, H., Dobalian, A., & Slavich, G. M. (2024) · Journal of Clinical Psychology · doi:10.1002/jclp.23642 · Cited by 15 · see citing works
Are There Modifiable Environmental Factors Related to Amyotrophic Lateral Sclerosis?
Kuraszkiewicz, B., Podsiadły-Marczykowska, T., Goszczyńska, H., & Piotrkiewicz, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00220 · Cited by 15 · see citing works
Incident hand OA is strongly associated with reduced peripheral blood leukocyte telomere length
McAlindon, T. E., Roberts, M. B., Driban, J. B., Schaefer, L. F., Haugen, I. K., Smith, S. E., Duryea, J., Cunha, D., Blanco, F. J., Fernández-García, J., et al. (2018) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2018.08.010 · Cited by 15 · see citing works
Psychological resilience to lifetime trauma and risk for cardiometabolic disease and mortality in older adults: A longitudinal cohort study
Nishimi, K. M., Bürgin, D., & O’Donovan, A. (2023) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2023.111539 · Cited by 14 · see citing works
Coming up short: Comparing venous blood, dried blood spots & saliva samples for measuring telomere length in health equity research
Geronimus, A. T., Bound, J., Mitchell, C. M., Martinez-Cardoso, A., Evans, L. A., Hughes, L. D., Schneper, L. M., & Notterman, D. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255237 · Cited by 14 · see citing works
The interaction of socioeconomic stress and race on telomere length in children: A systematic review and meta-analysis
Francis, M., Lindrose, A. R., O’Connell, S. S., Tristano, R. I., McGarvey, C., & Drury, S. S. (2023) · SSM - Population Health · doi:10.1016/j.ssmph.2023.101380 · Cited by 14 · see citing works
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Authors: Puterman, E., Gemmill, A., Karasek, D., Weir, D., Adler, N. E., Prather, A. A., & Epel, E. S.
Affiliations: University of British Columbia (CA)
University of California, Berkeley (US)
University of Michigan (US)
University of California, San Francisco (US)
ORCID: Puterman, Eli
Gemmill, Alison
Karasek, Deborah
Weir, David
Adler, Nancy E.
Prather, Aric A.
Epel, Elissa S.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2016-10-03
Volume: 113
Issue: 42
Pages: E6335-E6342
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1525602113
PMC: PMC5081642
OpenAlex: W2529798465
Cited by: 165
References: 77
Citations by year: 2026: 6 · 2025: 11 · 2024: 11 · 2023: 18 · 2022: 19 · 2021: 13 · 2020: 15 · 2019: 34 · 2018: 25 · 2017: 13
FWCI: 19.17
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: HHS | NIH | National Heart, Lung, and Blood Institute (R00 HL 109247, K08 HL 112961)
Canada Research Chairs (950-230617)
HHS | NIH | National Institute on Aging (T32-AG000246)
Topics: Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Social Sciences › Health › Health disparities and outcomes
Keywords: telomere length, cumulative adversity, childhood adversity, biological embedding, cellular aging, accelerated aging, salivary biomarkers, financial hardship, traumatic events, social adversity
MeSH terms: Aged, Aged, 80 and over, Female, Humans, Longevity, Male, Middle Aged, Risk Factors, Stress, Psychological, United States, Multivariate Analysis, Odds Ratio, Telomere, Cellular Senescence, Telomere Shortening, Public Health Surveillance

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Lifespan adversity and later adulthood telomere length in the nationally representative US Health and Retirement Study

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