Association of Resting Heart Rate and Blood Pressure in Late Adolescence With Subsequent Mental Disorders: A Longitudinal Population Study of More Than 1 Million Men in Sweden
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IMPORTANCE: Differences in cardiovascular autonomic activity between individuals with psychiatric disorders and healthy controls have been observed, but whether cardiovascular autonomic abnormalities are associated with subsequent psychiatric disorders is unknown. OBJECTIVE: To investigate whether differences in cardiac autonomic function as indexed by resting heart rate and blood pressure are associated with psychiatric disorders during the lifetime of men in Sweden. DESIGN, SETTING, AND PARTICIPANTS: We conducted a longitudinal register-based study of Swedish men whose resting heart rate (n = 1 039 443) and blood pressure (n = 1 555 979) were measured at military conscription at a mean (SD) age of 18.3 (0.6) years during the period from 1969 to 2010, with register-based follow-up data available until the end of 2013. Analyses were performed from November 18, 2015, to June 9, 2016. MAIN OUTCOMES AND MEASURES: Dates of inpatient/outpatient diagnoses of anxiety disorders, obsessive-compulsive disorder, posttraumatic stress disorder, depressive disorders, bipolar disorder, schizophrenia, and substance use disorders and convictions for violent crimes, between 1973 and 2013, were obtained from nationwide registers. Adjustments were made for height, weight, body mass index, cardiorespiratory fitness, cognitive ability, and socioeconomic covariates. RESULTS: After adjustment for covariates, Cox regression models with up to 45 years of follow-up data showed that men (mean [SD] age of 18.3 [0.6] years at conscription) with resting heart rates above 82 beats per minute had a 69% (95% CI, 46%-94%) increased risk for obsessive-compulsive disorder, a 21% (95% CI, 11%-33%) increased risk for schizophrenia, and an 18% (95% CI, 13%-22%) increased risk for anxiety disorders compared with men with resting heart rates below 62 beats per minute. Similar associations were observed with systolic/diastolic blood pressure. In contrast, lower resting heart rate and lower systolic blood pressure were associated with substance use disorders and violent criminality. CONCLUSIONS AND RELEVANCE: Our results suggest that for men, differences in heart rate and blood pressure in late adolescence are associated with lifetime major psychiatric disorders, with higher levels associated with obsessive-compulsive disorder, schizophrenia, and anxiety disorders and lower levels associated with substance use disorders and violent behavior. Differences in autonomic nervous system functioning may predate or represent an early marker of psychiatric disorders.
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Higher resting heart rate predicts subsequent psychological symptoms in a large longitudinal cohort study.
“Differences in cardiovascular autonomic activity (eg, heart rate) between individuals with and without psychiatric conditions have been observed, where higher resting heart rate predicts subsequent psychological symptoms in a large longitudinal cohort study.18 19”
From Variant connective tissue (joint hypermobility) and its relevance to depression and anxiety in adolescents: a cohort-based case–control study (2022) · cites this paper as [19]
The Discussion reports that, in a large longitudinal cohort of men, higher resting heart rate in late adolescence was associated with later OCD, schizophrenia, and anxiety disorder diagnoses. The claim broadens those specific diagnoses to “psychological symptoms,” which the study did not measure as stated; it also omits the finding that lower heart rate was associated with some other psychiatric outcomes. (LLM, conf=0.84)
Experimental — accuracy not yet measuredA Swedish cohort study demonstrated that adolescent males with higher basal heart rate are more likely to develop subsequent psychopathology, notably anxiety disorders.
“Interestingly, a Swedish cohort study also demonstrated that adolescent males with higher basal heart rate are more likely to develop subsequent psychopathology, notably anxiety disorders.19”
From Variant connective tissue (joint hypermobility) and its relevance to depression and anxiety in adolescents: a cohort-based case–control study (2022) · cites this paper as [19]
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- Authors
- Latvala, A., Kuja-Halkola, R., Rück, C., D’Onofrio, B. M., Jernberg, T., Almqvist, C., Mataix-Cols, D., Larsson, H., & Lichtenstein, P.
- Affiliations
- University of Helsinki (FI)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- Karolinska Institutet (SE)
- Department of Psychological and Brain Sciences, Indiana University, Bloomington
- Karolinska University Hospital (SE)
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
- Örebro University (SE)
- Corresponding author
- Latvala, Antti
- ORCID
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2016-12-01
- Volume
- 73
- Issue
- 12
- Pages
- 1268
- ISSN
- 2168-622X (ISSN-L)
- OpenAlex
- W2541829595
- Cited by
- 82
- References
- 50
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 13 · 2023: 7 · 2022: 13 · 2021: 14 · 2020: 10 · 2019: 6 · 2018: 7 · 2017: 3
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- resting heart rate, blood pressure, cardiac autonomic function, mental illness, obsessive-compulsive disorder, schizophrenia, anxiety disorders, substance use disorders, late adolescence, conscription, men
- MeSH terms
- Adolescent, Adult, Autonomic Nervous System, Mental Disorders, Blood Pressure, Heart Rate, Humans, Longitudinal Studies, Male, Military Personnel, Statistics as Topic, Sweden, Biomarkers, Young Adult, Prodromal Symptoms
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