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Local opinion leaders: effects on professional practice and health care outcomes
Open accessAbstract
BACKGROUND: Clinical practice is not always evidence-based and, therefore, may not optimise patient outcomes. Opinion leaders disseminating and implementing 'best evidence' is one method that holds promise as a strategy to bridge evidence-practice gaps. OBJECTIVES: To assess the effectiveness of the use of local opinion leaders in improving professional practice and patient outcomes. SEARCH STRATEGY: We searched Cochrane EPOC Group Trials Register, the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, HMIC, Science Citation Index, Social Science Citation Index, ISI Conference Proceedings and World Cat Dissertations up to 5 May 2009. In addition, we searched reference lists of included articles. SELECTION CRITERIA: Studies eligible for inclusion were randomised controlled trials investigating the effectiveness of using opinion leaders to disseminate evidence-based practice and reporting objective measures of professional performance and/or health outcomes. DATA COLLECTION AND ANALYSIS: Two review authors independently extracted data from each study and assessed its risk of bias. For each trial, we calculated the median risk difference (RD) for compliance with desired practice, adjusting for baseline where data were available. We reported the median adjusted RD for each of the main comparisons. MAIN RESULTS: We included 18 studies involving more than 296 hospitals and 318 PCPs. Fifteen studies (18 comparisons) contributed to the calculations of the median adjusted RD for the main comparisons. The effects of interventions varied across the 63 outcomes from 15% decrease in compliance to 72% increase in compliance with desired practice. The median adjusted RD for the main comparisons were: i) Opinion leaders compared to no intervention, +0.09; ii) Opinion leaders alone compared to a single intervention, +0.14; iii) Opinion leaders with one or more additional intervention(s) compared to the one or more additional intervention(s), +0.10; iv) Opinion leaders as part of multiple interventions compared to no intervention, +0.10. Overall, across all 18 studies the median adjusted RD was +0.12 representing a 12% absolute increase in compliance in the intervention group. AUTHORS' CONCLUSIONS: Opinion leaders alone or in combination with other interventions may successfully promote evidence-based practice, but effectiveness varies both within and between studies. These results are based on heterogeneous studies differing in terms of type of intervention, setting, and outcomes measured. In most of the studies the role of the opinion leader was not clearly described, and it is therefore not possible to say what the best way is to optimise the effectiveness of opinion leaders.
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“This extension enables the i-PARIHS framework to consider the impact individuals and teams have in supporting or resisting an innovation.”
From PARIHS revisited: from heuristic to integrated framework for the successful implementation of knowledge into practice (2015) · cites this paper as [37]
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“Systematic reviews of KT interventions to change HCPs’ practice consistently indicate that interventions are haphazardly designed and poorly specified, limiting our ability for replication, understanding, and generalizability [5, 6].”
From Methods for designing interventions to change healthcare professionals’ behaviour: a systematic review (2017) · cites this paper as [5]
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“’ In a systematic review, opinion leaders may have a positive effect on evidence-based practice uptake when tested in randomized controlled trials [77].”
BackgroundEficacia de las sesiones educativas para modificar la prescripción de fármacos nuevos
Molina-López, T., Camacho, J. C. D., Santos‐Lozano, J. M., Carrillo, A., Acevedo, J. S., & León, M. L. P. (2005) · Atención Primaria · doi:10.1157/13080299 · Cited by 5
Nonmedical factors in treatment selection
Brawley, O. W. (2003) · Urologic Clinics of North America · doi:10.1016/s0094-0143(02)00186-6 · Cited by 5
Simms, A. M., LI, L. C., Geddes, L. E., Brooks, D., Hoens, A. M., & Reid, D. W. (2012) · Journal of Continuing Education in the Health Professions · doi:10.1002/chp.21134 · Cited by 5
Overcoming Barriers to the Implementation of an Enhanced Recovery After Surgery Program
Pearsall, E. A., & Okrainec, A. (2015) · Springer eBooks · doi:10.1007/978-3-319-20364-5_17 · Cited by 5
Canares, G., & Dhar, V. K. (2019) · Journal of Dental Education · doi:10.21815/jde.019.151 · Cited by 5
Local consensus processes: effects on professional practice and health care outcomes
Nasser, M., Oxman, A. D., Paulsen, E., & Fedorowicz, Z. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003165.pub3 · Cited by 5
RetractedUnderstanding variations in the use of tranexamic acid in surgery: A qualitative interview study
Strickland, L. H. H., Evans, H. G., Palmer, A. J. R., Warnakulasuriya, S. R., Murphy, M. F., Stanworth, S. J., Foy, R., & collaborators, N. B. I. D. D. T. P. (2025) · British Journal of Haematology · doi:10.1111/bjh.20008 · Cited by 4
Naar, S., Fernandez, M. I., Todd, L., Green, S. K. S., Henna Budhwani, P., Carcone, A. I., Coyle, K. K., Aarons, G. A., MacDonell, K. K., & Harper, G. W. (2023) · Implementation Research and Practice · doi:10.1177/26334895231164585 · Cited by 4
Who will guard the guards? Medical leadership and conflict of interest in South African healthcare
Parrish, A., & Blockman, M. (2014) · South African Medical Journal · doi:10.7196/samj.8546 · Cited by 4
Developing clinical guidelines for end-of-life care: blending evidence and consensus
Dunning, T. L., Savage, S., Duggan, N. M., & Martin, P. (2012) · International Journal of Palliative Nursing · doi:10.12968/ijpn.2012.18.8.397 · Cited by 4
Sidhu, S., Gorman, S. K., Slavik, R. S., Ramsey, T., Bruchet, N., & Murray, S. (2017) · Journal of Continuing Education in the Health Professions · doi:10.1097/ceh.0000000000000166 · Cited by 4
Ayorinde, A., Williams, I., Mannion, R., Song, F., Skrybant, M., Lilford, R. J., & Chen, Y. (2020) · Health Services and Delivery Research · doi:10.3310/hsdr08330 · Cited by 4
Tinker, M., Roach, V., & Elliott, R. M. (2020) · Wound Practice and Research · doi:10.33235/wpr.28.3.106-114 · Cited by 4
Gray, S. L., Elsisi, Z., Phelan, E. A., & Hanlon, J. T. (2021) · Drugs & Aging · doi:10.1007/s40266-021-00835-9 · Cited by 4
Dray, J., Licata, M., Doherty, E. L., Tully, B., Williams, B., Curtin, S., White, D., Lecathelinais, C., Ward, S. L., Hasson, S., et al. (2022) · BMC Health Services Research · doi:10.1186/s12913-022-07717-9 · Cited by 4
“Varied facilitators (peers and experts) • Include sessions conducted by a peer • Include session(s) conducted by an expert • Slightly improved level of change when educational sessions are conducted by a peer compared to a non-peer [16] • Some support for the use of a local opinion leader/expert opinion in practice ch…”
BackgroundThe 2021 AHA/ACC/SCAI Coronary Artery Revascularization Recommendations
Cardoso, R. N., Abovich, A., Boden, W. E., Arbab‐Zadeh, A., Blankstein, R., & Blumenthal, R. S. (2022) · JACC Advances · doi:10.1016/j.jacadv.2022.100006 · Cited by 4
Patient-mediated interventions to improve professional practice
Fønhus, M. S., Dalsbø, T. K., Johansen, M., Fretheim, A., Skirbekk, H., & Flottorp, S. A. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012472 · Cited by 4
Tsang, T. W., Kingsland, M., Doherty, E. L., Wiggers, J. H., Attia, J., Wolfenden, L., Dunlop, A. J., Tully, B., Symonds, I., Rissel, C. E., et al. (2022) · Substance Abuse Treatment Prevention and Policy · doi:10.1186/s13011-022-00490-2 · Cited by 5
Use of Theory in Quality Innovations
Cronn, S. E., Trevino, C. M., & Jansen, K. (2022) · Journal of Nursing Care Quality · doi:10.1097/ncq.0000000000000647 · Cited by 4
Belot, M., Hoens, A. M., Kennedy, C., & LI, L. C. (2017) · Physiotherapy Canada · doi:10.3138/ptc.2016-32 · Cited by 4
Hygiene and Health: Who Do Mothers in Vanuatu Communicate with about Health?
File, K., Valente, T. W., & McLaws, M. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15030443 · Cited by 4
Utilización de la investigación y práctica basada en la evidencia
Orts‐Cortés, M. I. (2014) · Elsevier eBooks · doi:10.1016/b978-84-9022-448-9.00001-6 · Cited by 4
Petosic, A., Småstuen, M. C., Beeckman, D., Flaatten, H. K., Sunde, K., & Wøien, H. (2021) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.13969 · Cited by 5
Talungchit, P., Liabsuetrakul, T., & Lindmark, G. (2013) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2013.08.005 · Cited by 4
“5 (2–10 [1–25]) 10 (4–16 [1–35]) 0.”
ResultThe African Vaccine-Preventable Diseases Network: a vaccine advocacy initiative
Wiysonge, C. S., Armah, G., Madhi, S. A., Were, F., Kitaka, S., Akoua-Koffi, C. G., Grésenguet, G., Gatheru, Z., Maranga, P., Dicko, A., et al. (2011) · Pan African Medical Journal · doi:10.4314/pamj.v8i1.71081 · Cited by 4
“Strategies for improved vaccine advocacy are needed in Africa, based on the knowledge that innovative and sustained activities can bring about change [6-9].”
BackgroundHo, J. J., Japaraj, R. P., Cy, A., Rostenberghe, H. V., As, C., & Sivasangari, S. (2011) · PubMed · Cited by 4
Metadata
- Authors
- Flodgren, G., Parmelli, E., Doumit, G., Gattellari, M., O'Brien, M. A., Grimshaw, J., & Eccles, M. P.
- Affiliations
- University of Oxford (GB)
- University of Modena and Reggio Emilia (IT)
- Cleveland Clinic (US)
- UNSW Sydney (AU)
- McMaster University; School of Rehabilitation Science, Institute for Applied Health Sciences, Faculty of Health Sciences; 1400 Main Street West Room 403 Hamilton Ontario Canada L8S 1C7
- Ottawa Health Research Institute; Clinical Epidemiology Program; 1053 Carling Avenue Ottawa ON Canada K1Y 4E9
- Newcastle University (GB)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2011-08-10
- Volume
- 6
- Issue
- 8
- Pages
- CD000125-CD000125
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- PMC
- PMC4172331
- OpenAlex
- W1656816330
- Cited by
- 1,070
- References
- 117
- Citations by year
- 2026: 4 · 2025: 25 · 2024: 33 · 2023: 57 · 2022: 52 · 2021: 62 · 2020: 59 · 2019: 52 · 2018: 51 · 2017: 57 · 2016: 53 · 2015: 64 · 2014: 71 · 2013: 69 · 2012: 55
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Update notices
- new_version (2019-06-24)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- National Institute for Health and Care Research (10/4001/03)
- Topics
- Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
- Health Sciences › Health Professions › General Health Professions › Health Sciences Research and Education
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Clinical practice guidelines implementation
- Keywords
- opinion leaders, evidence-based practice, knowledge-practice gap, professional practice change, health care outcomes, clinical teaching, primary care, hospital care, patient outcomes, evidence dissemination, health professions education, patient safety, quality of care, health professional confidence
- MeSH terms
- Humans, Leadership, Practice Patterns, Physicians', Policy Making, Professional Practice, Randomized Controlled Trials as Topic, Process Assessment, Health Care, Evidence-Based Medicine, Information Dissemination
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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