The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Constitutional Isomerization Enables Bright NIR‐II AIEgen for Brain‐Inflammation Imaging
Open accessAbstract
The shortage of high quantum yield (QY) organic fluorophores in the second near‐infrared window (NIR‐II) has become a bottleneck in bioimaging field. Now, a simple strategy is proposed to address this: constitutional isomerization on the basis of the molecular design philosophy of aggregation‐induced emission. With the combination of backbone distortion and rotor twisting, the resultant NIR‐II fluorophore 2TT‐ o C6B displays an emission peak at 1030 nm and a QY of 11% in nanoparticles, one of the highest reported so far. Control molecules confirm that the distorted backbone and twisted rotors play equally important roles in determining the fluorescence properties of the NIR‐II fluorophores. To allow for the targeting ability to reach deeply located diseases, neutrophils (NEs) are used to penetrate the brain tissues and accumulate in the inflammation site. Herein, it is shown that NEs carrying 2TT‐ o C6B nanoparticles can penetrate the blood‐brain‐barrier and visualize the deeply located inflammation through an intact scalp and skull. Notably, the bright 2TT‐ o C6B contributes to a significantly enhanced signal‐to‐background ratio of 30.6 in the brain inflammation site.
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Self-citationOrigin and physiological roles of inflammation
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Self-citationA small-molecule dye for NIR-II imaging
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Cited by
Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications
Li, C., Chen, G., Zhang, Y., Wu, F., & Wang, Q. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07022 · Cited by 1,037
Aggregation‐enhanced theranostics: AIE sparkles in biomedical field
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Self-citationLi, Y., Cai, Z., Liu, S., Zhang, H., Wong, S. T. H., Lam, J. W. Y., Kwok, R. T. K., Qian, J., & Tang, B. Z. (2020) · Nature Communications · doi:10.1038/s41467-020-15095-1 · Cited by 464
Self-citationPerfecting and extending the near-infrared imaging window
Feng, Z., Tang, T., Wu, T., Yu, X., Zhang, Y., Wang, M., Zheng, J., Ying, Y., Chen, S., Zhou, J., et al. (2021) · Light: Science & Applications · doi:10.1038/s41377-021-00628-0 · Cited by 394
J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging
Li, K., Duan, X., Jiang, Z., Ding, D., Chen, Y., Zhang, G.-Q., & Liu, Z. (2021) · Nature Communications · doi:10.1038/s41467-021-22686-z · Cited by 301
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Metadata
- Authors
- Liu, S., Chen, C., Li, Y., Zhang, H., Liu, J., Wang, R., Wong, S. T. H., Lam, J. W. Y., Ding, D., & Tang, B. Z.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2019-12-18
- Volume
- 30
- Issue
- 7
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2996334262
- Cited by
- 267
- References
- 77
- FWCI
- 12.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Liu, S., Chen, C., Li, Y., Zhang, H., Liu, J., Wang, R., Wong, S. T. H., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2020). Constitutional Isomerization Enables Bright NIR‐II AIEgen for Brain‐Inflammation Imaging. Advanced Functional Materials. https://doi.org/10.1002/adfm.201908125
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