Aggregation‐Induced Emission (AIE) Nanoparticles‐Assisted NIR‐II Fluorescence Imaging‐Guided Diagnosis and Surgery for Inflammatory Bowel Disease (IBD)

Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole

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Aggregation-Induced Emission: Together We Shine, United We Soar!

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A small-molecule dye for NIR-II imaging

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Chemically induced mouse models of acute and chronic intestinal inflammation

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Pathophysiology of Inflammatory Bowel Diseases

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First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows

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Multifunctional in vivo vascular imaging using near-infrared II fluorescence

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Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels

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Past and Future Burden of Inflammatory Bowel Diseases Based on Modeling of Population-Based Data

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The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

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Safety and Efficacy of Indocyanine Green Tracer-Guided Lymph Node Dissection During Laparoscopic Radical Gastrectomy in Patients With Gastric Cancer

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Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting

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Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy

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Approach to the Management of Recently Diagnosed Inflammatory Bowel Disease Patients: A User’s Guide for Adult and Pediatric Gastroenterologists

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Novel near-infrared II aggregation-induced emission dots for in vivo bioimaging

Lin, J., Zeng, X., Xiao, Y., Tang, L., Nong, J., Liu, Y., Zhou, H., Ding, B., Xu, F., Tong, H., et al. (2018) · Chemical Science · doi:10.1039/c8sc04363a · Cited by 242 · see citing works

Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy

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Precise Deciphering of Brain Vasculatures and Microscopic Tumors with Dual NIR‐II Fluorescence and Photoacoustic Imaging

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Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm

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5-Aminosalicylic acid enemas: Effective agent in maintaining remission in left-sided ulcerative colitis

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Leukocyte-mediated Delivery of Nanotherapeutics in Inflammatory and Tumor Sites

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Postoperative Outcomes in Vedolizumab-Treated Patients Undergoing Abdominal Operations for Inflammatory Bowel Disease

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NIR-II fluorescence microscopic imaging of cortical vasculature in non-human primates

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Clinical Practice Guideline for the Surgical Management of Crohn’s Disease

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Biologically Excretable Aggregation‐Induced Emission Dots for Visualizing Through the Marmosets Intravitally: Horizons in Future Clinical Nanomedicine

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Surgery in Ulcerative Colitis: Indication and Timing

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In-Situ Imaging of Azoreductase Activity in the Acute and Chronic Ulcerative Colitis Mice by a Near-Infrared Fluorescent Probe

Tian, Y., Li, Y., Jiang, W., Zhou, D.-Y., Fei, J., & Li, C. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b02857 · Cited by 91 · see citing works

Nanoprobes‐Assisted Multichannel NIR‐II Fluorescence Imaging‐Guided Resection and Photothermal Ablation of Lymph Nodes

Fan, X., Li, Y., Feng, Z., Chen, G., Zhou, J., He, M., Wu, L., Li, S., Qian, J., & Lin, H. M. (2021) · Advanced Science · doi:10.1002/advs.202003972 · Cited by 87 · see citing works

Advances in Use of Endoscopy, Radiology, and Biomarkers to Monitor Inflammatory Bowel Diseases

Panés, J., Jairath, V., & Levesque, B. G. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.10.005 · Cited by 84 · see citing works

Fluorescence Imaging of Nerves During Surgery

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All-in-one mitochondria-targeted NIR-II fluorophores for cancer therapy and imaging

Zheng, Y., Li, Q., Wu, J., Luo, Z., Zhou, W., Li, A., Chen, Y., Rouzi, T., Tian, T., Zhou, H., et al. (2020) · Chemical Science · doi:10.1039/d0sc04727a · Cited by 79 · see citing works

Endoscopic evaluation of surgically altered bowel in inflammatory bowel disease: a consensus guideline from the Global Interventional Inflammatory Bowel Disease Group

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High Disease Burden Drives Indirect Costs in Employed Inflammatory Bowel Disease Patients: The WORK-IBD Study

van Gennep, S., Evers, S. W., Rietdijk, S. T., Gielen, M. E., de Boer, N. K. H., Gecse, K. B., Ponsioen, C. Y., Duijvestein, M., D’Haens, G., de Boer, A. G. E. M., et al. (2020) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa082 · Cited by 61 · see citing works

Detecting Basal Myeloperoxidase Activity in Living Systems with a Near-Infrared Emissive “Turn-On” Probe

Liu, L., Wei, P., Yuan, W., Liu, Z., Xue, F., Zhang, X., & Yi, T. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04601 · Cited by 56 · see citing works

Surgical Outcomes in Vedolizumab-Treated Patients with Ulcerative Colitis

Lightner, A. L., McKenna, N. P., Moncrief, S. B., Pembérton, J. H., Raffals, L. E., & Mathis, K. L. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001248 · Cited by 53 · see citing works

Polydopamine-coated downconversion nanoparticle as an efficient dual-modal near-infrared-II fluorescence and photoacoustic contrast agent for non-invasive visualization of gastrointestinal tract in vivo

Ma, L., Huang, S., He, S., Wang, Z., & Cheng, Z. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.112000 · Cited by 44 · see citing works

Validation of the Red Flags Index for Early Diagnosis of Crohn’s Disease: A Prospective Observational IG-IBD Study Among General Practitioners

Fiorino, G., Bonovas, S., Gilardi, D., Sabatino, A. D., Allocca, M., Furfaro, F., Roda, G., Lenti, M. V., Aronico, N., Mengoli, C., et al. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa111 · Cited by 41 · see citing works

Organic Dots with Large π-Conjugated Planar for Cholangiography beyond 1500 nm in Rabbits: A Non-Radioactive Strategy

Wu, D., Liu, S., Zhou, J., Chen, R., Wang, Y., Feng, Z., Lin, H. M., Qian, J., Tang, B. Z., & Cai, X. (2021) · ACS Nano · doi:10.1021/acsnano.0c09981 · Cited by 39 · see citing works

Up-to-date surgery for ulcerative colitis in the era of biologics

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Near infrared readouts offer sensitive and rapid assessments of intestinal permeability and disease severity in inflammatory bowel disease models

Zhang, L., Wallace, C. D., Erickson, J. E., Nelson, C. M., Gaudette, S. M., Pohl, C. S., Karsen, S. D., Simler, G. H., Peng, R., Stedman, C., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-61756-y · Cited by 12 · see citing works

In vivo NIR-II fluorescence imaging for biology and medicine

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Aggregation-Induced Emission (AIE), Life and Health

Wang, H., Li, Q., Alam, P., Bai, H., Bhalla, V., Bryce, M. R., Cao, M., Chen, C., Chen, S., Chen, X., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c03925 · Cited by 398 · see citing works

Molecular Gold Nanoclusters for Advanced NIR-II Bioimaging and Therapy

Baghdasaryan, A., & Dai, H. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00835 · Cited by 131 · see citing works

Recent advances in NIR-II fluorescence/photoacoustic dual-modality imaging probes

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Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine

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Stimuli-Responsive Nanomedicines for the Treatment of Non-cancer Related Inflammatory Diseases

Yang, J., Rieux, A. D., & Malfanti, A. (2025) · ACS Nano · doi:10.1021/acsnano.5c00700 · Cited by 114 · see citing works

Noncancerous disease-targeting AIEgens

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From single molecule to molecular aggregation science

Gu, J., Li, Z., & Li, Q. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214872 · Cited by 106 · see citing works

Molecular Programming of NIR‐IIb‐Emissive Semiconducting Small Molecules for In Vivo High‐Contrast Bioimaging Beyond 1500 nm

Yuan, Y., Feng, Z., Li, S., Huang, Z., Wan, Y., Cao, C., Lin, S., Wu, L., Zhou, J., Liao, L., et al. (2022) · Advanced Materials · doi:10.1002/adma.202201263 · Cited by 99 · see citing works

D–A Type NIR‐II Organic Molecules: Strategies for the Enhancement Fluorescence Brightness and Applications in NIR‐II Fluorescence Imaging‐Navigated Photothermal Therapy

Chen, Y., Chen, S., Yu, H., Wang, Y., Cui, M., Wang, P., Sun, P., & Ji, M. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201158 · Cited by 95 · see citing works

A historical review of aggregation‐induced emission from 2001 to 2020: A bibliometric analysis

Xia, Q., Zhang, Y., Li, Y., Li, Y., Li, Y., Feng, Z., Fan, X., Qian, J., & Lin, H. M. (2022) · Aggregate · doi:10.1002/agt2.152 · Cited by 92 · see citing works

Aggregation-induced emission luminogens for assisted cancer surgery

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An AIEgen-based oral-administration nanosystem for detection and therapy of ulcerative colitis via 3D-MSOT/NIR-II fluorescent imaging and inhibiting NLRP3 inflammasome

Sun, L., Ouyang, J., Zeng, F., & Wu, S. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121468 · Cited by 84 · see citing works

Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

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Aggregation-induced emission fluorophores towards the second near-infrared optical windows with suppressed imaging background

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Near‐infrared aggregation‐induced emission materials: Bibliometric analysis and their application in biomedical field

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Biomimetic Aggregation‐Induced Emission Nanodots with Hitchhiking Function for T Cell‐Mediated Cancer Targeting and NIR‐II Fluorescence‐Guided Mild‐Temperature Photothermal Therapy

Yang, X. W., Yang, T., Liu, Q., Zhang, X., Yu, X., Kwok, R. T. K., Hai, L., Zhang, P., Tang, B. Z., Cai, L., et al. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202206346 · Cited by 60 · see citing works

Recent Progresses in NIR-I/II Fluorescence Imaging for Surgical Navigation

Li, S., Cheng, D., He, L., & Yuan, L. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.768698 · Cited by 56 · see citing works

Aggregation-induced emission-based phototheranostics to combat bacterial infection at wound sites: A review

Fang, Z., Zhang, S., Wang, W., Xu, Y., Xu, Y., Qian, Y., Xiao, X., Li, Y., Tang, B. Z., & Zhang, M. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122950 · Cited by 56 · see citing works

Recent advances of aggregation-induced emission materials for fluorescence image-guided surgery

He, W., Zhang, Z., Luo, Y., Kwok, R. T. K., Zhao, Z., & Tang, B. Z. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121709 · Cited by 51 · see citing works

Recent advances on emerging nanomaterials for diagnosis and treatment of inflammatory bowel disease

Fu, W., Xu, L., Chen, Z., Kan, L., Ma, Y., Qian, H., & Wang, W. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.09.033 · Cited by 51 · see citing works

Metabolic Nanoregulator Remodels Gut Microenvironment for Treatment of Inflammatory Bowel Disease

Xu, T., Ning, X., Wu, J., Wang, Q., Wang, Z., Chen, Z., Tang, X., Bai, P., Pu, K., Li, L., et al. (2024) · ACS Nano · doi:10.1021/acsnano.3c11496 · Cited by 50 · see citing works

NIR-II Fluorescent Probes for Fluorescence-Imaging-Guided Tumor Surgery

Ullah, Z., Roy, S., Gu, J., Soe, S. K., Jin, J. G., & Guo, B. (2024) · Biosensors · doi:10.3390/bios14060282 · Cited by 50 · see citing works

Molecular Crystal Engineering of Organic Chromophores for NIR-II Fluorescence Quantification of Cerebrovascular Function

Li, Y., Fan, X., Liu, S., Liu, S., Chuah, C., Tang, Y., Kwok, R. T. K., Lam, J. W. Y., Lu, X., Qian, J., et al. (2022) · ACS Nano · doi:10.1021/acsnano.1c11424 · Cited by 38 · see citing works

A Biomarker‐Responsive Nanosystem with Colon‐Targeted Delivery for Ulcerative Colitis's Detection and Treatment with Optoacoustic/NIR‐II Fluorescence Imaging

Zeng, Z., Ouyang, J., Sun, L., Zeng, F., & Wu, S. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201544 · Cited by 40 · see citing works

A ratiometric near-infrared fluorescence/photoacoustic dual-modal probe with strong donor dithienopyrrole for in vivo nitric oxide detection

Xiao, P., Liang, M., Yang, S., Sun, Y., Li, J., Gu, Z., Zhang, L., Fan, Q., Jiang, X., & Wu, W. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.121993 · Cited by 36 · see citing works

Thiadiazoloquinoxaline derivative-based NIR-II organic molecules for NIR-II fluorescence imaging and photothermal therapy

Chen, Y., Yu, H., Wang, Y., Sun, P., Fan, Q., & Ji, M. (2022) · Biomaterials Science · doi:10.1039/d2bm00283c · Cited by 34 · see citing works

Aggregation-induced emission (AIE)-Based nanocomposites for intracellular biological process monitoring and photodynamic therapy

Lin, X., Li, W., Wen, Y., Su, L., & Zhang, X. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121603 · Cited by 33 · see citing works

Noninvasive Gastrointestinal Tract Imaging Using BSA-Ag2Te Quantum Dots as a CT/NIR-II Fluorescence Dual-Modal Imaging Probe in Vivo

Li, B., Wang, G., Tong, Y., Zhang, Y., Sun, S., & Yu, C. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00886 · Cited by 32 · see citing works

Progress of NIR-II fluorescence imaging technology applied to disease diagnosis and treatment

Li, N., Wang, M., Zhou, J., Wang, Z., Cao, L., Ye, J., & Sun, G. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116173 · Cited by 31 · see citing works

High-Luminescence Efficiency NIR-II Nanocrystals via Hierarchical Confinements for Imaging-Guided Surgery of Acute Intestinal Ischemia

Ma, F., Zhang, R., Wang, B., Liang, Z., Zhang, S., Jiang, J., Tan, H., Xing, G., Kwok, R. T. K., Lam, J. W. Y., et al. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c05981 · Cited by 29 · see citing works

Water-Dispersible Activatable Nanoprobe for Detecting Cadmium-Ion-Induced Oxidative Stress in Edible Crops via Near-Infrared Second-Window Fluorescence Imaging

Zeng, C., Long, Y., Tan, Y., Zeng, F., & Wu, S. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c03404 · Cited by 26 · see citing works

Asymmetric D–A–D′ Ratiometric Molecule for Highly Specific Hypochlorous Acid Detection

Che, J., Gong, H., Yang, A., Gao, Y., Zhong, C. M., Chen, D., Lou, X., Xia, F., & Dai, J. Y. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c00070 · Cited by 26 · see citing works

Recent progress of second near-infrared (NIR-II) fluorescence microscopy in bioimaging

Wang, T., Chen, Y., Wang, B., & Wu, M. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1126805 · Cited by 25 · see citing works

Organic Fluorophores for 1064 nm Excited NIR-II Fluorescence Imaging

Wang, W., He, X., Du, M., Xie, C., Zhou, W. J., Huang, W., & Fan, Q. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.769655 · Cited by 21 · see citing works

Activatable dual-functional molecular agents for imaging-guided cancer therapy

Zhang, P., Zhu, Y., Xiao, C., & Chen, X. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114725 · Cited by 21 · see citing works

Emerging advances in fluorescence imaging and phototherapy of arthritis

Wang, X., Dai, J., Shao, C., Goto, T., & Dai, H. (2023) · Interdisciplinary materials · doi:10.1002/idm2.12130 · Cited by 21 · see citing works

Quantum dots assisted in vivo two-photon microscopy with NIR-II emission

Ni, H., Wang, Y., Tang, T., Yu, W., Li, D., He, M., Chen, R., Zhang, M., & Qian, J. (2021) · Photonics Research · doi:10.1364/prj.441471 · Cited by 19 · see citing works

Recent advances of versatile fluorophores for multifunctional biomedical imaging in the NIR-II region

Ma, K. L., Jiang, Q., Yang, Y., & Zhang, F. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb01957a · Cited by 18 · see citing works

NIR-II and visible fluorescence hybrid imaging-guided surgery via aggregation-induced emission fluorophores cocktails

Fan, X., Xia, Q., Liu, S., Zheng, Z., Zhang, Y., Wu, T., Li, Y., Tang, G., Tang, B. Z., Qian, J., et al. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100399 · Cited by 18 · see citing works

D–A–D organic fluorescent probes for NIR-II fluorescence imaging and efficient photothermal therapy of breast cancer

Gao, J., Yuan, L., Min, Y. L., Yu, B., Cong, H., & Shen, Y. (2024) · Biomaterials Science · doi:10.1039/d3bm01604h · Cited by 18 · see citing works

Organic small-molecule NIR-II fluorophores for tumor phototheranostics

Xiang, D., Wang, Z., Zheng, H., Tang, Y., & Li, Q. (2026) · Light: Science & Applications · doi:10.1038/s41377-026-02212-w · Cited by 22 · see citing works

Harnessing the power of aggregation-induced emission luminogens: From bright probes to theranostic platforms in biomedicine

Wang, W., Liu, Y., Xu, J., Deng, Y., Chen, W., Lin, Y., Tang, B. Z., & Zhang, M. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.217553 · Cited by 16 · see citing works

Repurposing organic semiconducting nanomaterials to accelerate clinical translation of NIR-II fluorescence imaging

Hu, X., Sun, F., Zhu, C., Yáng, Z., & Huang, W. (2022) · Nano Research · doi:10.1007/s12274-022-5145-1 · Cited by 17 · see citing works

Ultrabright NIR‐II Nanoparticles for High‐Resolution In Vivo Imaging: From Systemic Vasculature Visualization to Pathological Microenvironment Monitoring

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Luminescence Fingerprint of Intracellular NIR-II Gold Nanocluster Transformation: Implications for Sensing and Imaging

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