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Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore
Open accessAbstract
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, and biocompatible near-infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR-II fluorophores can provide noninvasive assessment of TBI.
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Metadata
- Authors
- Zhang, X., Wang, H., Antaris, A. L., Li, L., Diao, S., Ma, R., Nguyen, A., Hong, G., Ma, Z., Wang, J., Zhu, S., Castellano, J. M., Wyss‐Coray, T., Liang, Y., Luo, J., & Dai, H.
- Affiliations
- Department of Chemistry Stanford University Stanford CA 94305 USA
- Southern University of Science and Technology (CN)
- Stanford University (US)
- VA Palo Alto Health Care System (US)
- Stanford Medicine (US)
- Corresponding author
- Liang, Yongye
- Luo, Jian
- Dai, Hongjie
- ORCID
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2016-06-02
- Volume
- 28
- Issue
- 32
- Pages
- 6872-6879
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- PMC
- PMC5293734
- OpenAlex
- W2416606193
- Cited by
- 386
- References
- 61
- Citations by year
- 2026: 13 · 2025: 32 · 2024: 35 · 2023: 37 · 2022: 47 · 2021: 50 · 2020: 52 · 2019: 44 · 2018: 45 · 2017: 28 · 2016: 2
- FWCI
- 34.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Natural Science Foundation of China (81471786)
- National Institutes of Health (NS092868)
- South University of Science and Technology of China (FRG‐SUSTC1501A‐62)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- traumatic brain injury, molecular fluorophores, renal excretion, cerebral hypoperfusion, in vivo imaging, non-invasive diagnosis
- MeSH terms
- Brain Injuries, Traumatic, Animals, Disease Models, Animal, Fluorescent Dyes, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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