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Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore
Open accessAbstract
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, and biocompatible near-infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR-II fluorophores can provide noninvasive assessment of TBI.
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Metadata
- Authors
- Zhang, X., Wang, H., Antaris, A. L., Li, L., Diao, S., Ma, R., Nguyen, A., Hong, G., Ma, Z., Wang, J., Zhu, S., Castellano, J. M., Wyss‐Coray, T., Liang, Y., Luo, J., & Dai, H.
- Affiliations
- Department of Chemistry Stanford University Stanford CA 94305 USA
- Southern University of Science and Technology (CN)
- Stanford University (US)
- VA Palo Alto Health Care System (US)
- Stanford Medicine (US)
- Corresponding author
- Liang, Yongye
- Luo, Jian
- Dai, Hongjie
- ORCID
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2016-06-02
- Volume
- 28
- Issue
- 32
- Pages
- 6872-6879
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- PMC
- PMC5293734
- OpenAlex
- W2416606193
- Cited by
- 386
- References
- 61
- Citations by year
- 2026: 13 · 2025: 32 · 2024: 35 · 2023: 37 · 2022: 47 · 2021: 50 · 2020: 52 · 2019: 44 · 2018: 45 · 2017: 28 · 2016: 2
- FWCI
- 34.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Natural Science Foundation of China (81471786)
- National Institutes of Health (NS092868)
- South University of Science and Technology of China (FRG‐SUSTC1501A‐62)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- traumatic brain injury, molecular fluorophores, renal excretion, cerebral hypoperfusion, in vivo imaging, non-invasive diagnosis
- MeSH terms
- Brain Injuries, Traumatic, Animals, Disease Models, Animal, Fluorescent Dyes, Mice
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