The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
3D‐Bioprinted Mini‐Brain: A Glioblastoma Model to Study Cellular Interactions and Therapeutics
Open accessAbstract
Glioblastoma‐associated macrophages (GAMs) play a crucial role in the progression and invasiveness of glioblastoma multiforme (GBM); however, the exact crosstalk between GAMs and glioblastoma cells is not fully understood. Furthermore, there is a lack of relevant in vitro models to mimic their interactions. Here, novel 3D‐bioprinted mini‐brains consisting of glioblastoma cells and macrophages are presented as tool to study the interactions between these two cell types and to test therapeutics that target this interaction. It is demonstrated that in the mini‐brains, glioblastoma cells actively recruit macrophages and polarize them into a GAM‐specific phenotype, showing clinical relevance to transcriptomic and patient survival data. Furthermore, it is shown that macrophages induce glioblastoma cell progression and invasiveness in the mini‐brains. Finally, it is demonstrated how therapeutics can inhibit the interaction between GAMs and tumor cells resulting in reduced tumor growth and more sensitivity to chemotherapy. It is envisioned that this 3D‐bioprinted tumor model is used to improve the understanding of tumor biology and for evaluating novel cancer therapeutics.
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Cites
1 retracted
Effect of CCL2 siRNA on proliferation and apoptosis in the U251 human glioma cell line
Lu, B., Zhou, Y., Su, Z., Yan, A., & Ding, P. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6995 · Cited by 22
RetractedMicroenvironmental regulation of tumor progression and metastasis
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Tumour-associated macrophages as treatment targets in oncology
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A 3D bioprinting system to produce human-scale tissue constructs with structural integrity
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CSF-1R inhibition alters macrophage polarization and blocks glioma progression
Pyonteck, S. M., Akkari, L., Schuhmacher, A. J., Bowman, R. L., Sevenich, L., Quail, D. F., Olson, O. C., Quick, M. L., Huse, J. T., Teijeiro, V., et al. (2013) · Nature Medicine · doi:10.1038/nm.3337 · Cited by 2,463
Modeling physiological events in 2D vs. 3D cell culture
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Direct 3D bioprinting of perfusable vascular constructs using a blend bioink
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Cited by
3D bioprinting for reconstituting the cancer microenvironment
Datta, P., Dey, M., Ataie, Z., Unutmaz, D., & Ozbolat, I. T. (2020) · npj Precision Oncology · doi:10.1038/s41698-020-0121-2 · Cited by 304
Barbosa, M. A. G., Xavier, C. P. R., Pereira, R. F., Petrikaitė, V., & Vasconcelos, M. H. (2021) · Cancers · doi:10.3390/cancers14010190 · Cited by 285
Emerging Technologies in Multi‐Material Bioprinting
Ravanbakhsh, H., Karamzadeh, V., Bao, G., Mongeau, L., Juncker, D., & Zhang, Y. S. (2021) · Advanced Materials · doi:10.1002/adma.202104730 · Cited by 266
Self-citationThree-dimensional in vitro culture models in oncology research
Jubelin, C., Muñoz-Garcia, J., Griscom, L., Cochonneau, D., Ollivier, E., Heymann, M.-F., Vallette, F. M., Oliver, L., & Heymann, D. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00887-3 · Cited by 264
Cell Culture Based in vitro Test Systems for Anticancer Drug Screening
Kitaeva, K. V., Rutland, C. S., Rizvanov, A. A., & Solovyeva, V. V. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00322 · Cited by 142
Metadata
- Authors
- Heinrich, M. A., Bansal, R., Lammers, T., Zhang, Y. S., Michel Schiffelers, R., & Prakash, J.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2019-01-31
- Volume
- 31
- Issue
- 14
- Pages
- e1806590-e1806590
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2911923471
- Cited by
- 317
- References
- 33
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Heinrich, M. A., Bansal, R., Lammers, T., Zhang, Y. S., Michel Schiffelers, R., & Prakash, J. (2019). 3D‐Bioprinted Mini‐Brain: A Glioblastoma Model to Study Cellular Interactions and Therapeutics. Advanced Materials. https://doi.org/10.1002/adma.201806590
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