Cited by 271Immunotherapy and Immune ResponsesGlioma Diagnosis and TreatmentCancer Immunotherapy and Biomarkers

Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell–driven rejection of high-grade glioma

Garg, Abhishek D., Vandenberk, Lien, Koks, Carolien, Verschuere, Tina, Boon, Louis, Van Gool, Stefaan W., Agostinis, Patrizia·2016·Science Translational Medicine

Abstract

Combining an immunogenic cell death inducer with dendritic cell immunotherapy treats high-grade glioma in a preclinical model.

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Crossref · 10.1126/scitranslmed.aae0105

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83 of 83 references verified0 citation errors · 0 not checkable

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  • ICD can be initiated by viral infection, some FDA-approved chemotherapeutics (e.g., anthracyclines, bortezomib), specific forms of radiation therapy, and hypericin-based photodynamic therapy.

    “ICD can be initiated by a relatively restricted set of stimuli, including viral infection, some FDA-approved chemotherapeutics (e.g., anthracyclines, bortezomib), specific forms of radiation therapy, and hypericin-based photodynamic therapy [854–861].”
  • Cytotoxic therapies such as radiation and chemotherapy can increase the neoantigen load of tumours that have a low baseline neoantigen load, which is a barrier to effective immunotherapy.

    “cytotoxic therapies (radiation and chemotherapy) can be used to increase the neoantigen load of tumours that have a low baseline neoantigen load, which is a barrier to effective immunotherapy121.”

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Authors
Garg, A. D., Vandenberk, L., Koks, C., Verschuere, T., Boon, L., Van Gool, S. W., & Agostinis, P.
Affiliations
  • KU Leuven (BE)
  • EPIRUS Biopharmaceuticals Netherlands BV, 3584 Utrecht, Netherlands.
  • Laboratory of Pediatric Immunology, Department of Microbiology and Immunology, KU Leuven, Leuven 3000, Belgium.
Corresponding author
  • Garg, Abhishek D.
  • Vandenberk, Lien
  • Agostinis, Patrizia
Venue
Science Translational Medicine
Published
2016-03-02
Volume
8
Issue
328
Pages
328ra27-328ra27
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2292411590
Cited by
270
References
83
Citations by year
2026: 9 · 2025: 16 · 2024: 21 · 2023: 36 · 2022: 34 · 2021: 20 · 2020: 34 · 2019: 24 · 2018: 28 · 2017: 33 · 2016: 15
FWCI
20.16
Type
journal article
Language
en
Open access
closed
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Lirias (submittedVersion)
Funders
  • FWO (Fonds Wetenschappelijk Onderzoek)
  • IWT (Innovatie door Wetenschap en Technologie)
  • FWO (G0584.12N, K202313N, GA01111N)
  • KU Leuven (C16/15/073)
  • Olivia Hendrickx Research Fund
  • James E. Kearney Memorial Fund
  • Herman Memorial Research Fund
  • Belgian Brain Tumor Support
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
dendritic cell vaccine, immunogenic cell death, high-grade glioma, glioblastoma, photodynamic therapy, hypericin, damage-associated molecular patterns, reactive oxygen species, MyD88 signaling, CD8+ T cells, temozolomide, tumor immunosuppression, regulatory T cells, cytotoxic T lymphocytes, Th17 cells, prognosis, immunotherapy
MeSH terms
Animals, Anthracenes, Brain Neoplasms, Dendritic Cells, Glioma, Mice, Inbred C57BL, Perylene, Photochemotherapy, T-Lymphocytes, Cytotoxic, Cell Death, Apoptosis, Reactive Oxygen Species, CD8-Positive T-Lymphocytes, Cancer Vaccines, Mice, Adaptive Immunity, Endoplasmic Reticulum Stress, Neoplasm Grading

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