Growth factors as clinical biomarkers of prognosis and diagnosis in psychiatric disorders
Abstract
The psychiatric disorders are one of the most disabling illnesses in the world and represent a major problem for public health. These disorders are characterized by neuroanatomical or biochemical changes and it has been suggested that such changes may be due to inadequate neurodevelopment. Diverse alterations in the gene expression and/or serum level of specific growth factors have been implicated in the etiology, symptoms and progression of some psychiatric disorders. Herein, we summarize the latest information regarding the role of brain-derived neurotrophic factor (BDNF), epidermal growth factor (EGF), fibroblast growth factor (FGF), Insulin-like growth factor (IGF-1), neuroregulin-1 (NGR-1), erythropoietin (EPO), vascular growth factor (VEGF), transforming growth factor beta (TGF-β), nerve growth factor (NGF) and others cytokines in the pathogenesis of schizophrenia, depression, bipolar and anxiety disorders. Focusing on the role of these growth factors and their relationship with the main impairments (cognitive, emotional and social) of these pathologies. Some of these signaling molecules may be suitable biological markers for diagnosis and prognosis in cognitive, mood and social disabilities across different mental disorders.
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Patients with psychiatric and neurodegenerative disorders often have reduced BDNF concentrations in their blood and brain.
“Patients with psychiatric and neurodegenerative disorders often have reduced BDNF concentrations in their blood and brain.”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [21]
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Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works
BDNF as a Biomarker of Cognition in Schizophrenia/Psychosis: An Updated Review
Nieto, R. R., Carrasco, A., Corral, S., Castillo, R., Gaspar, P. A., Bustamante, M. L., & Silva, H. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.662407 · Cited by 83 · see citing works
Revealing the Potency of Growth Factors in Bovine Colostrum
Yalçıntaş, Y. M., Duman, H., López, J. M. M., Portocarrero, A. C. M., Lombardo, M., Khallouki, F., Koch, W., Bordiga, M., El-Seedi, H., Raposo, A., et al. (2024) · Nutrients · doi:10.3390/nu16142359 · Cited by 31 · see citing works
- Authors
- Galvez-Contreras, A. Y., Campos-Ordonez, T., Lopez-Virgen, V., Gomez-Plascencia, J., Ramos-Zuniga, R., & Gonzalez-Perez, O.
- Affiliations
- Universidad de Guadalajara (MX)
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 32
- Pages
- 85-96
- ISSN
- 1359-6101 (ISSN-L)
- OpenAlex
- W2512586741
- Cited by
- 112
- References
- 142
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 15 · 2023: 20 · 2022: 10 · 2021: 8 · 2020: 13 · 2019: 8 · 2018: 10 · 2017: 8
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine & Growth Factor Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Consejo Nacional de Ciencia y Tecnologia (268062, 660523, 736339)
- Red Temática Células Troncales y Medicina Regenerativa (271609)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- growth factors, clinical biomarkers, mental illness, schizophrenia, depression, bipolar disorder, anxiety disorders, brain-derived neurotrophic factor, epidermal growth factor, fibroblast growth factor, insulin-like growth factor I, erythropoietin, vascular endothelial growth factor, TGF-beta, nerve growth factor, cytokines, brain development, cognitive impairment, social dysfunction, diagnosis and prognosis
- MeSH terms
- Animals, Mental Disorders, Humans, Prognosis, Biomarkers, Intercellular Signaling Peptides and Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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