Cited by 112Schizophrenia research and treatmentTryptophan and brain disordersTreatment of Major Depression

Growth factors as clinical biomarkers of prognosis and diagnosis in psychiatric disorders

Galvez-Contreras, Alma Y., Campos-Ordonez, Tania, Lopez-Virgen, Veronica, Gomez-Plascencia, Jesus, Ramos-Zuniga, Rodrigo, Gonzalez-Perez, Oscar·2016·Cytokine & Growth Factor Reviews

Abstract

The psychiatric disorders are one of the most disabling illnesses in the world and represent a major problem for public health. These disorders are characterized by neuroanatomical or biochemical changes and it has been suggested that such changes may be due to inadequate neurodevelopment. Diverse alterations in the gene expression and/or serum level of specific growth factors have been implicated in the etiology, symptoms and progression of some psychiatric disorders. Herein, we summarize the latest information regarding the role of brain-derived neurotrophic factor (BDNF), epidermal growth factor (EGF), fibroblast growth factor (FGF), Insulin-like growth factor (IGF-1), neuroregulin-1 (NGR-1), erythropoietin (EPO), vascular growth factor (VEGF), transforming growth factor beta (TGF-β), nerve growth factor (NGF) and others cytokines in the pathogenesis of schizophrenia, depression, bipolar and anxiety disorders. Focusing on the role of these growth factors and their relationship with the main impairments (cognitive, emotional and social) of these pathologies. Some of these signaling molecules may be suitable biological markers for diagnosis and prognosis in cognitive, mood and social disabilities across different mental disorders.

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Crossref · 10.1016/j.cytogfr.2016.08.004

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Authors
Galvez-Contreras, A. Y., Campos-Ordonez, T., Lopez-Virgen, V., Gomez-Plascencia, J., Ramos-Zuniga, R., & Gonzalez-Perez, O.
Affiliations
Universidad de Guadalajara (MX)
Venue
Cytokine & Growth Factor Reviews
Publisher
Elsevier BV
Published
2016-12
Volume
32
Pages
85-96
ISSN
1359-6101 (ISSN-L)
OpenAlex
W2512586741
Cited by
112
References
142
Citations by year
2026: 7 · 2025: 13 · 2024: 15 · 2023: 20 · 2022: 10 · 2021: 8 · 2020: 13 · 2019: 8 · 2018: 10 · 2017: 8
FWCI
1.24
Type
journal article
Language
en
Open access
closed
Locations
  • Cytokine & Growth Factor Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Consejo Nacional de Ciencia y Tecnologia (268062, 660523, 736339)
  • Red Temática Células Troncales y Medicina Regenerativa (271609)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
growth factors, clinical biomarkers, mental illness, schizophrenia, depression, bipolar disorder, anxiety disorders, brain-derived neurotrophic factor, epidermal growth factor, fibroblast growth factor, insulin-like growth factor I, erythropoietin, vascular endothelial growth factor, TGF-beta, nerve growth factor, cytokines, brain development, cognitive impairment, social dysfunction, diagnosis and prognosis
MeSH terms
Animals, Mental Disorders, Humans, Prognosis, Biomarkers, Intercellular Signaling Peptides and Proteins

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