Cognitive Performance in Older Women Relative to ApoE-ε4 Genotype and Aerobic Fitness
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INTRODUCTION: Apolipoprotein E (ApoE) genotype and aerobic fitness are each associated with cognitive performance in older adults. However, their potentially interactive effects on cognitive performance have not been examined. PURPOSE: The primary purpose of this study was to determine whether ApoE genotype and aerobic fitness interact to uniquely impact memory performance and executive functioning. A secondary purpose was to examine the interactive effects on other measures of cognition to provide a more comprehensive assessment of cognitive abilities across a broad range of functions. METHODS: Community-dwelling, cognitively normal older women (N = 90) provided blood samples to allow for assessment of ApoE genotype, completed cognitive tests, and performed a maximal aerobic fitness test. Primary outcome variables were the auditory verbal learning test (AVLT), the complex figures test (CFT), and the Wisconsin card-sorting task (WCST). Secondary outcome variables were the block design test and the paced auditory serial addition task (PASAT). RESULTS: Regression analyses indicated that aerobic fitness was associated with significantly better performance on measures of the AVLT, the CFT, and the PASAT for the ApoE-epsilon4 homozygotes. CONCLUSION: The preliminary findings from this study support the possibility that aerobic fitness is positively associated with the memory performance of those individuals at most genetic risk for Alzheimer disease.
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Self-citation
- Authors
- ETNIER, J. L., CASELLI, R. J., REIMAN, E. M., ALEXANDER, G. E., SIBLEY, B. A., TESSIER, D., & MCLEMORE, E. C.
- Affiliations
- University of North Carolina at Greensboro (US)
- Mayo Clinic (US)
- Banner Health (US)
- Arizona State University (US)
- Miami University (US)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2007-01
- Volume
- 39
- Issue
- 1
- Pages
- 199-207
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2077568856
- Cited by
- 124
- References
- 41
- Citations by year
- 2026: 2 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 13 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 9 · 2014: 13 · 2013: 9 · 2012: 11
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- green
- libres.uncg.edu
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- NC Digital Online Collection of Knowledge and Scholarship (The University of North Carolina at Greensboro) (submittedVersion)
- Funders
- National Institute on Aging (P30-AG-19610, R03AG022621, R03 AG 22621-01, P30AG019610)
- National Institute of Mental Health (R01MH057899)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- apolipoprotein E, APOE ε4 genotype, cardiorespiratory fitness, cognitive performance, older women, memory, executive function, Alzheimer's disease risk, gene-environment interaction, auditory verbal learning, Wisconsin Card Sorting Test, Paced Auditory Serial Addition Test
- MeSH terms
- Aged, Arizona, Cognition, Female, Humans, Middle Aged, Physical Fitness, Task Performance and Analysis, Apolipoprotein E4
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