Cardiorespiratory fitness and brain atrophy in early Alzheimer disease.

Burns, J. M.; Cronk, B. B.; Anderson, H. S.; Donnelly, J. E.; Thomas, G. P.; Harsha, A.; Brooks, W. M.; Swerdlow, R. H.

doi:10.1212/01.wnl.0000317094.86209.cb

Cited by 363Dementia and Cognitive Impairment ResearchPhysical Activity and HealthCardiovascular and exercise physiology

Cardiorespiratory fitness and brain atrophy in early Alzheimer disease.

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Burns, J. M., Cronk, B. B., Anderson, H. S., Donnelly, J. E., Thomas, G. P., Harsha, A., Brooks, W. M., Swerdlow, R. H.·2008·Neurology

DOI 10.1212/01.wnl.0000317094.86209.cbPMC PMC2657657

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Abstract

OBJECTIVE: To examine the correlation of cardiorespiratory fitness with brain atrophy and cognition in early-stage Alzheimer disease (AD). BACKGROUND: In normal aging physical fitness appears to mitigate functional and structural age-related brain changes. Whether this is observed in AD is not known. METHODS: Subjects without dementia (n = 64) and subjects with early-stage AD (n = 57) had MRI and standard clinical and psychometric evaluations. Peak oxygen consumption (VO(2)(peak)), the standard measure of cardiorespiratory fitness, was assessed during a graded treadmill test. Normalized whole brain volume, a brain atrophy estimate, was determined by MRI. Pearson correlation and linear regression were used to assess fitness in relation to brain volume and cognitive performance. RESULTS: Cardiorespiratory fitness (VO(2)(peak)) was modestly reduced in subjects with AD (34.7 [5.0] mL/kg/min) vs subjects without dementia (38.1 [6.3] mL/kg/min, p = 0.002). In early AD, VO(2)(peak) was associated with whole brain volume (beta = 0.35, p = 0.02) and white matter volume (beta = 0.35, p = 0.04) after controlling for age. Controlling for additional covariates of sex, dementia severity, physical activity, and physical frailty did not attenuate the relationships. VO(2)(peak) was associated with performance on delayed memory and digit symbol in early AD but not after controlling for age. In participants with no dementia, there was no relationship between fitness and brain atrophy. Fitness in participants with no dementia was associated with better global cognitive performance (r = 0.30, p = 0.02) and performance on Trailmaking A and B, Stroop, and delayed logical memory but not after controlling for age. CONCLUSIONS: Increased cardiorespiratory fitness is associated with reduced brain atrophy in Alzheimer disease (AD). Cardiorespiratory fitness may moderate AD-related brain atrophy or a common underlying AD-related process may impact both brain atrophy and cardiorespiratory fitness.

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A higher level of cardiorespiratory fitness is associated with favorable structural brain changes in older adults and individuals with Alzheimer's disease.
“(iii) favorable structural brain changes in older adults (Colcombe et al., 2003; Erickson et al., 2009; Szabo et al., 2011; Bugg et al., 2012) and individuals with Alzheimer’s disease (Burns et al., 2008; Honea et al., 2009; Vidoni et al., 2012).”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Burns et al., 2008

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“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Studies of interference in serial verbal reactions
Stroop, J. R. (1935) · Journal of Experimental Psychology · doi:10.1037/h0054651 · Cited by 18,622 · see citing works
Psychophysical bases of perceived exertion
BORG, G. A. V. (1982) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198205000-00012 · Cited by 16,580 · see citing works
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
Manual for the Wechsler Adult Intelligence Scale.
Wechsler, D. (1955) · Psychological Corp. eBooks · Cited by 4,941 · see citing works
Exercise: a behavioral intervention to enhance brain health and plasticity
Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739 · see citing works
ACC/AHA 2002 Guideline Update for Exercise Testing: Summary Article
Gibbons, R. J., Balady, G. J., Bricker, J. T., CHAITMAN, B. R., Fletcher, G. F., Froelicher, V. F., Mark, D. B., McCallister, B. D., Mooss, A. N., O’Reilly, M. G., et al. (2002) · Circulation · doi:10.1161/01.cir.0000034670.06526.15 · Cited by 2,606 · see citing works
Exercise enhances learning and hippocampal neurogenesis in aged mice
van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078 · see citing works
Leisure Activities and the Risk of Dementia in the Elderly
Verghese, J., Lipton, R. B., Katz, M. J., Hall, C. B., Derby, C. A., Kuslansky, G., Ambrose, A. F., Sliwinski, M., & Buschke, H. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022252 · Cited by 1,961 · see citing works
Mild Cognitive Impairment Represents Early-Stage Alzheimer Disease
Morris, J. C., Storandt, M., Miller, J. P., McKeel, D. W., Price, J. L., Rubin, E. H., & Berg, L. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.397 · Cited by 1,833 · see citing works
Cardiovascular fitness, cortical plasticity, and aging
Colcombe, S. J., Kramer, A. F., Erickson, K. I., Scalf, P., McAuley, E., Cohen, N. J., Webb, A., Jerome, G. J., Marquez, D. X., & Elavsky, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400266101 · Cited by 1,648 · see citing works
The effects of exercise training on elderly persons with cognitive impairment and dementia: A meta-analysis11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.
Heyn, P., Abreu, B. C., & Ottenbacher, K. J. (2004) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2004.03.019 · Cited by 1,223 · see citing works
Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats.
Black, J. E., Isaacs, K. R., Anderson, B. J., Alcantara, A. A., & Greenough, W. T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5568 · Cited by 1,161 · see citing works
Dynamics of Gray Matter Loss in Alzheimer's Disease
Thompson, P. M., Hayashi, K. M., de Zubicaray, G., Janke, A. L., Rose, S. E., Semple, J., Herman, D., Hong, M. S., Dittmer, S. S., Doddrell, D. M., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00994.2003 · Cited by 1,132 · see citing works
Is physical activity or physical fitness more important in defining health benefits?
Blair, S. N., Cheng, Y. J., & HOLDER, J. S. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200106001-00007 · Cited by 1,113 · see citing works
ACC/AHA Guidelines for Exercise Testing: Executive Summary: A Report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Committee on Exercise Testing)
Gibbons, R. J., Balady, G. J., Beasley, J. W., FAAFP, Bricker, J. T., Duvernoy, W. F. C., Froelicher, V. F., Mark, D. B., Marwick, T. H., McCallister, B. D., et al. (1997) · Circulation · doi:10.1161/01.cir.96.1.345 · Cited by 1,094 · see citing works
Exercise and brain neurotrophins
Neeper, S. A., Góauctemez-Pinilla, F., Choi, J., & Cotman, C. (1995) · Nature · doi:10.1038/373109a0 · Cited by 1,066 · see citing works
Aerobic fitness reduces brain tissue loss in aging humans.
Colcombe, S. J., Erickson, K. I., Raz, N., Webb, A. G., Cohen, N. J., McAuley, E., & Kramer, A. F. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.2.m176 · Cited by 1,017 · see citing works
The Physical Activity Scale for the Elderly (PASE)
Washburn, R. A., McAuley, E., Katula, J. A., Mihalko, S. L., & Boileau, R. A. (1999) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(99)00049-9 · Cited by 999 · see citing works
Accelerated longitudinal decline of aerobic capacity in healthy older adults
Fleg, J. L., Morrell, C. H., Bos, A. G., Brant, L. J., Talbot, L. A., Wright, J. G., & Lakatta, E. G. (2005) · Circulation · doi:10.1161/circulationaha.105.545459 · Cited by 970 · see citing works
Screening for dementia by memory testing
Grober, E. H., Herman Buschke, L., Crystal, H., Bang, S., & Dresner, R. (1988) · Neurology · doi:10.1212/wnl.38.6.900 · Cited by 956 · see citing works
Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: The Hisayama Study
Yoshitake, T., Kiyohara, Y., Kato, I., Ohmura, T., Iwamoto, H., Nakayama, K., Ohmori, S., Nomiyama, K., Kawano, H., Ueda, K., et al. (1995) · Neurology · doi:10.1212/wnl.45.6.1161 · Cited by 829 · see citing works
Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease
Adlard, P. A., Perreau, V. M., Pop, V., & Cotman, C. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0496-05.2005 · Cited by 806 · see citing works
Clinicopathologic Studies in Cognitively Healthy Aging and Alzheimer Disease: Relation of Histologic Markers to Dementia Severity, Age, Sex, and Apolipoprotein E Genotype
Berg, L., McKeel, D. W., Miller, J. P., Storandt, M., Rubin, E. H., Morris, J. C., Baty, J., Coats, M., Norton, J., Goate, A. M., et al. (1998) · Archives of Neurology · doi:10.1001/archneur.55.3.326 · Cited by 657 · see citing works
A Longitudinal Study of Cardiorespiratory Fitness and Cognitive Function in Healthy Older Adults
Barnes, D. E., Yaffe, K., Satariano, W. A., & Tager, I. B. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51153.x · Cited by 608 · see citing works
Circulating Insulin-Like Growth Factor I Mediates the Protective Effects of Physical Exercise against Brain Insults of Different Etiology and Anatomy
Carro, E., Trejo, J. L., Busiguina, S., & Torres-Aleman, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05678.2001 · Cited by 601 · see citing works
Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD
Fotenos, A. F., Snyder, A. Z., Girton, L. E., Morris, J. C., & Buckner, R. L. (2005) · Neurology · doi:10.1212/01.wnl.0000154530.72969.11 · Cited by 579 · see citing works
An analysis of certain psychological tests used for the evaluation of brain injury.
Armitage, S. G. (1946) · The Psychological Monographs · doi:10.1037/h0093567 · Cited by 518 · see citing works
Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI
Storandt, M., Grant, E., Miller, J. P., & Morris, J. C. (2006) · Neurology · doi:10.1212/01.wnl.0000228231.26111.6e · Cited by 285 · see citing works
The Fitness, Obesity, and Health Equation
Blair, S. N., & Church, T. (2004) · JAMA · doi:10.1001/jama.292.10.1232 · Cited by 264 · see citing works
Reduced mortality and brain damage after locomotor activity in gerbil forebrain ischemia.
Stummer, W., Weber, K., Tranmer, B. I., Baethmann, A. J., & Kempski, O. S. (1994) · Stroke · doi:10.1161/01.str.25.9.1862 · Cited by 205 · see citing works
Health habits and risk of cognitive impairment and dementia in old age: A prospective study on the effects of exercise, smoking and alcohol consumption
Broe, G. A., Creasey, H., Jorm, A. F., Bennett, H. P., Casey, B., Waite, L. M., Grayson, D. A., & Cullen, J. (1998) · Australian and New Zealand Journal of Public Health · doi:10.1111/j.1467-842x.1998.tb01449.x · Cited by 169 · see citing works
Relating imaging indices of white matter integrity and volume in healthy older adults
Hugenschmidt, C. E., Peiffer, A. M., Kraft, R. A., Casanova, R., Deibler, A. R., Burdette, J. H., Maldjian, J. A., & Laurienti, P. J. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm080 · Cited by 166 · see citing works
White matter lesions are prevalent but differentially related with cognition in aging and early Alzheimer disease
Burns, J. M., Church, J. A., Johnson, D. K., Xiong, C., Marcus, D., Fotenos, A. F., Snyder, A. Z., Morris, J. C., & Buckner, R. L. (2005) · Archives of Neurology · doi:10.1001/archneur.62.12.1870 · Cited by 155 · see citing works
A three‐year follow‐up study of age‐related dementia in an urban area of Beijing
Li, G., Shen, Y., Chen, C. H., Zhau, Y. W., Li, S. R., & Lü, M. (1991) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1991.tb07373.x · Cited by 143 · see citing works
Mitochondria in Alzheimer's disease
Swerdlow, R. H., & Kish, S. J. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)53013-0 · Cited by 126 · see citing works
Self-citation
Treadmill Exercise Testing in an Epidemiologic Study of Elderly Subjects
Hollenberg, M., Ngo, L. H., Turner, D., & Tager, I. B. (1998) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/53a.4.b259 · Cited by 97 · see citing works
The Assessment of Aphasia & Related Disorders. Second Edition. Edited by H. Goodglass and E. Kaplan. Published by Lea & Febiger. 102 pages. Additional materials: A Boston Diagnostic Aphasia Examination booklet, copy bound in the book (32 pages); test stimulus cards (16); the Boston Naming Test (64 pages); Boston Naming Test scoring booklet (8 pages). $34.50 Canadian.
KERTESZ, A. E. (1984) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100045868 · Cited by 67 · see citing works
Cardiorespiratory Fitness in Early-stage Alzheimer Disease
Burns, J. M., Mayo, M. S., Anderson, H. S., Smith, H. J., & Donnelly, J. E. (2008) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31815a9ddc · Cited by 65 · see citing works
Self-citation
Reduced protein kinase C activity in sporadic Alzheimer's disease fibroblasts
Bruel, A., Cherqui, G., Columelli, S., Margelin, D., Roudier, M., Sinet, P., Prieur, M., Pérignon, J., & Delabar, J. M. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90064-z · Cited by 37 · see citing works
Variables Associated with Cognitive Function in Elderly California Seventh day Adventists
Fraser, G. E., Singh, P. N., & Bennett, H. P. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008705 · Cited by 37 · see citing works
Impaired Physical Performance and the Assessment of Dementia of the Alzheimer Type
Shah, K. R., Carr, D. B., Roe, C. M., Miller, J. P., Coats, M. A., & Morris, J. C. (2004) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000127441.77570.f3 · Cited by 28 · see citing works
Alteraciones de canales iónicos y segundos mensajeros en la enfermedad de Alzheimer. Relevancia de estudios en células extraneurales
Etcheberrigaray, R., & Ibarreta, D. (2001) · Revista de Neurología · doi:10.33588/rn.3308.2001342 · Cited by 11 · see citing works

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Ross, R., Blair, S. N., Arena, R., Church, T. S., Després, J.-P., Franklin, B. A., Haskell, W. L., Kaminsky, L. A., Levine, B. D., Lavie, C. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000461 · Cited by 2,486 · see citing works
Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis
Northey, J. M., Cherbuin, N., Pumpa, K. L., Smee, D. J., & Rattray, B. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-096587 · Cited by 1,380 · see citing works
Effects of Aerobic Exercise on Mild Cognitive Impairment: A Controlled Trial
Baker, L. D., Frank, L. L., Foster-Schubert, K., Green, P. S., Wilkinson, C. W., McTiernan, A., Plymate, S. R., Fishel, M. A., Watson, G. S., Cholerton, B. A., et al. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.307 · Cited by 1,171 · see citing works
A Meta-Analysis of Cytokines in Alzheimer's Disease
Swardfager, W., Lanctôt, K., Rothenburg, L., Wong, A., Cappell, J., & Herrmann, N. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.012 · Cited by 1,108 · see citing works
Aerobic fitness is associated with hippocampal volume in elderly humans
Erickson, K. I., Prakash, R. S., Voss, M. W., Chaddock, L., Hu, L., Morris, K. S., White, S. M., Wójcicki, T. R., McAuley, E., & Kramer, A. F. (2009) · Hippocampus · doi:10.1002/hipo.20547 · Cited by 1,007 · see citing works
A Review of the Effects of Physical Activity and Exercise on Cognitive and Brain Functions in Older Adults
Bherer, L., Erickson, K. I., & Liu-Ambrose, T. (2013) · Journal of Aging Research · doi:10.1155/2013/657508 · Cited by 899 · see citing works
Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging
Ahlskog, J. E., Geda, Y. E., Graff-Radford, N. R., & Petersen, R. C. (2011) · Mayo Clinic Proceedings · doi:10.4065/mcp.2011.0252 · Cited by 885 · see citing works
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Erickson, K. I., Leckie, R. L., & Weinstein, A. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.034 · Cited by 630 · see citing works
The Alzheimer’s Disease Mitochondrial Cascade Hypothesis
Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100339 · Cited by 562 · see citing works
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Erickson, K. I., Raji, C. A., Lopez, O. L., Becker, J. T., Rosano, C., Newman, A. B., Gach, H. M., Thompson, P. M., Ho, A. J., & Kuller, L. H. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f88359 · Cited by 508 · see citing works
Measures of frailty in population-based studies: an overview
Bouillon, K., Mika Kivimaki, B., Hamer, M., Sabia, S., Fransson, E. I., Singh‐Manoux, A., Galé, C. R., & Batty, G. D. (2013) · BMC Geriatrics · doi:10.1186/1471-2318-13-64 · Cited by 466 · see citing works
Physical exercise and cognitive performance in the elderly: Current perspectives.
Kirk-Sanchez, N., & McGough, E. (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s39506 · Cited by 465 · see citing works
Does vigorous exercise have a neuroprotective effect in Parkinson disease?
Ahlskog, J. E. (2011) · Neurology · doi:10.1212/wnl.0b013e318225ab66 · Cited by 463 · see citing works
Aerobic exercise effects on cognitive and neural plasticity in older adults
Erickson, K. I., & Kramer, A. F. (2008) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.052498 · Cited by 456 · see citing works
The neuropathology of sport
McKee, A. C., Daneshvar, D. H., Alvarez, V. E., & Stein, T. D. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1230-6 · Cited by 422 · see citing works
Reduced Lean Mass in Early Alzheimer Disease and Its Association With Brain Atrophy
Burns, J. M., Johnson, D. K., Watts, A. S., Swerdlow, R. H., & Brooks, W. M. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.38 · Cited by 400 · see citing works
Self-citation
Exercise and Alzheimer’s disease biomarkers in cognitively normal older adults
Liang, K. Y., Mintun, M. A., Fagan, A. M., Goate, A. M., Bugg, J. M., Holtzman, D. M., Morris, J. C., & Head, D. (2010) · Annals of Neurology · doi:10.1002/ana.22096 · Cited by 340 · see citing works
Exercise benefits on Alzheimer’s disease: State-of-the-science
Valenzuela, P. L., Castillo-García, A., Morales, J. S., de la Villa, P., Hampel, H., Emanuele, E., Lista, S., & Lucia, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101108 · Cited by 337 · see citing works
Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial
Morris, J. K., Vidoni, E. D., Johnson, D. K., Sciver, A. R. V., Mahnken, J. D., Honea, R. A., Wilkins, H., Brooks, W. M., Billinger, S. A., Swerdlow, R. H., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170547 · Cited by 331 · see citing works
Self-citation
Vascular basis for brain degeneration: faltering controls and risk factors for dementia
Kalaria, R. N. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00352.x · Cited by 291 · see citing works
Physical Activity, Brain Plasticity, and Alzheimer's Disease
Erickson, K. I., Weinstein, A. M., & Lopez, O. L. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.09.008 · Cited by 288 · see citing works
Exercise counteracts declining hippocampal function in aging and Alzheimer's disease
Intlekofer, K. A., & Cotman, C. W. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.06.011 · Cited by 286 · see citing works
Physical activity and brain plasticity in late adulthood
Erickson, K. I., Gildengers, A. G., & Butters, M. A. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.1/kerickson · Cited by 288 · see citing works
A Long Journey into Aging, Brain Aging, and Alzheimer’s Disease Following the Oxidative Stress Tracks
Mecocci, P., Boccardi, V., Cecchetti, R., Bastiani, P., Scamosci, M., Ruggiero, C., & Baroni, M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170732 · Cited by 255 · see citing works
A systematic review of MRI studies examining the relationship between physical fitness and activity and the white matter of the ageing brain
Sexton, C. E., Betts, J. F., Demnitz, N., Dawes, H., Ebmeier, K. P., & Johansen‐Berg, H. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.09.071 · Cited by 256 · see citing works
Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease
Yuede, C. M., Zimmerman, S., Dong, H., Kling, M. J., Bero, A. W., Holtzman, D. M., Timson, B. F., & Csernansky, J. G. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.002 · Cited by 250 · see citing works
Exercise moderates age-related atrophy of the medial temporal lobe
Bugg, J. M., & Head, D. M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.008 · Cited by 236 · see citing works
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Brown, A. D., McMorris, C. A., Longman, R. S., Leigh, R., Hill, M. D., Friedenreich, C. M., & Poulin, M. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.11.002 · Cited by 236 · see citing works
Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing
Brown, B. M., Peiffer, J. J., Taddei, K., Lui, J. K., Laws, S. M., Gupta, V. B., Taddei, T., Ward, V. K., Rodrigues, M. A., Burnham, S., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.107 · Cited by 235 · see citing works
Aerobic Exercise Intervention, Cognitive Performance, and Brain Structure: Results from the Physical Influences on Brain in Aging (PHIBRA) Study
Jonasson, L. S., Nyberg, L. H., Kramer, A. F., Lundquist, A., Riklund, K., & Boraxbekk, C. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00336 · Cited by 226 · see citing works
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Self-citation
Is Alzheimer’s disease a systemic disease?
Morris, J. K., Honea, R. A., Vidoni, E. D., Swerdlow, R. H., & Burns, J. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.04.012 · Cited by 219 · see citing works
Self-citation
Cardiorespiratory Fitness and Preserved Medial Temporal Lobe Volume in Alzheimer Disease
Honea, R. A., Thomas, G., Harsha, A., Anderson, H. S., Donnelly, J. E., Brooks, W. M., & Burns, J. M. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31819cb8a2 · Cited by 211 · see citing works
Self-citation
Understanding verbal fluency in healthy aging, Alzheimer's disease, and Parkinson's disease.
McDowd, J. M., Hoffman, L., Rozek, E. K., Lyons, K. E., Pahwa, R., Burns, J. M., & Kemper, S. J. (2011) · Neuropsychology · doi:10.1037/a0021531 · Cited by 211 · see citing works
Self-citation
Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research
Herold, F., Müller, P., Gronwald, T., & Müller, N. G. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02338 · Cited by 196 · see citing works
Is physical activity a potential preventive factor for vascular dementia? A systematic review
Aarsland, D., Sardahaee, F. S., Anderssen, S., Ballard, C., & the Alzheimer's Society Systematic Review group (2010) · Aging & Mental Health · doi:10.1080/13607860903586136 · Cited by 195 · see citing works
Effects of physical exercise on cognitive function of older adults with mild cognitive impairment: A systematic review and meta-analysis
Biazus-Sehn, L. F., Schuch, F. B., Firth, J., & Stigger, F. D. S. (2020) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2020.104048 · Cited by 194 · see citing works
Effects of aerobic exercise training on cognitive function and cortical vascularity in monkeys
Rhyu, I. J., Bytheway, J. A., Kohler, S. J., Lange, H., Lee, K. J., Boklewski, J., McCormick, K. N., Williams, N. I., Stanton, G. B., Greenough, W. T., et al. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.03.003 · Cited by 182 · see citing works
Nutrition and neurodegeneration: epidemiological evidence and challenges for future research
Guyonnet, S., Secher, M., & Vellas, B. J. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12058 · Cited by 187 · see citing works
The role of serotonin in respiratory function and dysfunction
Hilaire, G., Voituron, N., Menuet, C., Ichiyama, R. M., Subramanian, H. H., & Dutschmann, M. (2010) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2010.08.017 · Cited by 173 · see citing works
The Association Between Midlife Cardiorespiratory Fitness Levels and Later-Life Dementia
DeFina, L. F., Willis, B. L., Radford, N. B., Gao, A., Leonard, D. S., Haskell, W. L., Weiner, M., & Berry, J. D. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-158-3-201302050-00005 · Cited by 170 · see citing works
Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners.
Wollen, K. A. (2010) · PubMed · Cited by 168 · see citing works
Does the brain shrink as the waist expands?
Willette, A. A., & Kapogiannis, D. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2014.03.007 · Cited by 162 · see citing works
Cognitive and behavioural effects of physical exercise in psychiatric patients
Knöchel, C., Oertel‐Knöchel, V., O’Dwyer, L., Prvulovic, D., Alves, G. S., Kollmann, B., & Hampel, H. J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.11.007 · Cited by 164 · see citing works
Distinctive Effects of Aerobic and Resistance Exercise Modes on Neurocognitive and Biochemical Changes in Individuals with Mild Cognitive Impairment
Tsai, C., Pai, M., Ukropec, J., & Ukropcová, B. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190228125429 · Cited by 160 · see citing works
A review of cardiorespiratory fitness-related neuroplasticity in the aging brain
Hayes, S. M., Hayes, J. P., Cadden, M., & Verfaellie, M. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00031 · Cited by 154 · see citing works
Benefits of Multimodal Exercise Intervention for Postural Control and Frontal Cognitive Functions in Individuals with Alzheimer's Disease: A Controlled Trial
de Andrade, L. P., Gobbi, L. T. B., Coelho, F. G. M., Christofoletti, G., Costa, J. L. R., & Stella, F. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12531 · Cited by 150 · see citing works
The effects of physical activity, education, and body mass index on the aging brain
Ho, A. J., Raji, C. A., Becker, J. T., López, O. L., Kuller, L. H., Hua, X., Dinov, I. D., Stein, J. L., Rosano, C., Toga, A. W., et al. (2010) · Human Brain Mapping · doi:10.1002/hbm.21113 · Cited by 145 · see citing works
Alzheimer disease biomarkers are associated with body mass index
Vidoni, E. D., Townley, R. A., Honea, R. A., Burns, J. M., & Initiative, A. D. N. (2011) · Neurology · doi:10.1212/wnl.0b013e318238eec1 · Cited by 140 · see citing works
Self-citation
Semantic Memory Functional MRI and Cognitive Function after Exercise Intervention in Mild Cognitive Impairment
Smith, J. C., Nielson, K. A., Antuono, P., Lyons, J.-A., Hanson, R. J., Butts, A. M., Hantke, N. C., & Verber, M. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130467 · Cited by 138 · see citing works
Measuring the impact of exercise on cognitive aging: methodological issues
Miller, D. I., Taler, V., Davidson, P. S. R., & Messier, C. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.02.020 · Cited by 136 · see citing works
Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment
Köbe, T., Witte, A. V., Schnelle, A., Lesemann, A., Fabian, S., Tesky, V. A., Pantel, J., & Flöel, A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.09.050 · Cited by 135 · see citing works
Treadmill training as an augmentation treatment for Alzheimer?s disease: a pilot randomized controlled study
Arcoverde, C., Deslandes, A. C., Moraes, H., Almeida, C., de Araújo, N. B., Vasques, P. E., Silveira, H., & Laks, J. (2014) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20130231 · Cited by 131 · see citing works
Exercise, APOE genotype, and the evolution of the human lifespan
Raichlen, D. A., & Alexander, G. E. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.03.001 · Cited by 128 · see citing works
Cerebral changes improved by physical activity during cognitive decline: A systematic review on MRI studies
Haeger, A., Costa, A. S., Schulz, J. B., & Reetz, K. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101933 · Cited by 133 · see citing works
Bone Density and Brain Atrophy in Early Alzheimer's Disease
Loskutova, N., Honea, R. A., Vidoni, E. D., Brooks, W. M., & Burns, J. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1185 · Cited by 118 · see citing works
Self-citation
Effect of aerobic exercise on physical performance in patients with Alzheimer's disease
Sobol, N. A., Hoffmann, K., Frederiksen, K. S., Vogel, A., Vestergaard, K., Brændgaard, H., Gottrup, H., Lolk, A., Wermuth, L., Jakobsen, S., et al. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.05.004 · Cited by 114 · see citing works
Beyond vascularization: aerobic fitness is associated with N-acetylaspartate and working memory.
Erickson, K. I., Weinstein, A. M., Sutton, B. P., Prakash, R. S., Voss, M. W., Chaddock, L., Szabo, A. N., Mailey, E. L., White, S. M., Wojcicki, T. R., et al. (2012) · Brain and Behavior · doi:10.1002/brb3.30 · Cited by 110 · see citing works
Cardiorespiratory fitness is associated with brain structure, cognition, and mood in a middle-aged cohort at risk for Alzheimer’s disease
Boots, E. A., Schultz, S. A., Oh, J. M., Larson, J., Edwards, D. F., Cook, D. B., Koscik, R. L., Dowling, N. M., Gallagher, C. L., Carlsson, C. M., et al. (2014) · Brain Imaging and Behavior · doi:10.1007/s11682-014-9325-9 · Cited by 107 · see citing works
Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention
Peng, Y., Gao, P., Shi, L., Chen, L., Liu, J., & Long, J. (2020) · Antioxidants & Redox Signaling · doi:10.1089/ars.2019.7763 · Cited by 110 · see citing works
Reduced gray matter volume in normal adults with a maternal family history of Alzheimer disease
Honea, R. A., Swerdlow, R. H., Vidoni, E. D., Goodwin, J., & Burns, J. M. (2010) · Neurology · doi:10.1212/wnl.0b013e3181c918cb · Cited by 106 · see citing works
Self-citation
Cardiorespiratory fitness is associated with atrophy in Alzheimer's and aging over 2 years
Vidoni, E. D., Honea, R. A., Billinger, S. A., Swerdlow, R. H., & Burns, J. M. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.016 · Cited by 105 · see citing works
Self-citation
Physical Activity and Alzheimer Disease Course
Scarmeas, N., Luchsinger, J. A., Brickman, A. M., Cosentino, S., Schupf, N., Xin-Tang, M., Gu, Y., & Stern, Y. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181eb00a9 · Cited by 112 · see citing works
Exercise and Executive Function in Individuals With Chronic Stroke
Kluding, P. M., Tseng, B. Y., & Billinger, S. A. (2011) · Neurology Report · doi:10.1097/npt.0b013e318208ee6c · Cited by 100 · see citing works
Physical and Cognitive Stimulation Using an Exergame in Subjects with Normal Aging, Mild and Moderate Cognitive Impairment
Ben-Sadoun, G., Sacco, G., Manera, V., Bourgeois, J., König, A., Foulon, P., Fosty, B., Brémond, F., d’Arripe-Longueville, F., & Robert, P. H. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160268 · Cited by 97 · see citing works
The Long Run: Neuroprotective Effects of Physical Exercise on Adult Neurogenesis from Youth to Old Age
Saraulli, D., Costanzi, M., Mastrorilli, V., & Vecchioli, S. F. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160412150223 · Cited by 96 · see citing works
Effect of aerobic exercise on amyloid accumulation in preclinical Alzheimer’s: A 1-year randomized controlled trial
Vidoni, E. D., Morris, J. K., Watts, A. S., Perry, M., Clutton, J., Sciver, A. R. V., Kamat, A., Mahnken, J. D., Hunt, S. L., Townley, R. A., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0244893 · Cited by 94 · see citing works
Self-citation
Changes in cognitive function after a 12-week exercise intervention in adults with Down syndrome
Ptomey, L. T., Szabo‐Reed, A. N., Willis, E. A., Gorczyca, A. M., Greene, J. L., Danon, J. C., & Donnelly, J. E. (2018) · Disability and health journal · doi:10.1016/j.dhjo.2018.02.003 · Cited by 93 · see citing works
Self-citation
Reduced Limbic and Hypothalamic Volumes Correlate with Bone Density in Early Alzheimer's Disease
Loskutova, N., Honea, R. A., Brooks, W. M., & Burns, J. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1364 · Cited by 91 · see citing works
Self-citation
At least eighty percent of brain grey matter is modifiable by physical activity: A review study
Batouli, S. A. H., & Saba, V. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.06.002 · Cited by 92 · see citing works
Cardiorespiratory fitness and cognitive function in middle age
Zhu, N., Jacobs, D. R., Schreiner, P. J., Yaffe, K. S., Bryan, R. N., Launer, L. J., Whitmer, R. A., Sidney, S. S., Demerath, E. W., Thomas, W. T. B., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000310 · Cited by 92 · see citing works
Association of Cardiovascular Risk Trajectory With Cognitive Decline and Incident Dementia
Farnsworth, B., Josefsson, M., Wåhlin, A., Nyberg, L. H., & Karalija, N. (2022) · Neurology · doi:10.1212/wnl.0000000000200255 · Cited by 92 · see citing works
What are the Benefits of Exercise for Alzheimer’s Disease? A Systematic Review of the Past 10 Years
Hernández, S. S. S., Sandreschi, P. F., da Silva, F. C., Arancibia, B. A. V., da Silva, R., Filho, P. J. B. G., & Andrade, A. (2014) · Journal of Aging and Physical Activity · doi:10.1123/japa.2014-0180 · Cited by 91 · see citing works
Advances in Vascular Cognitive Impairment
Bowler, J. V., & Gorelick, P. B. (2009) · Stroke · doi:10.1161/strokeaha.108.544650 · Cited by 90 · see citing works
Leisure-time physical activity associates with cognitive decline
Willey, J. Z., Gardener, H. E., Caunca, M. R., Moon, Y. P., Dong, C., Cheung, Y. K., Sacco, R. L., Elkind, M. S. V., & Wright, C. B. (2016) · Neurology · doi:10.1212/wnl.0000000000002582 · Cited by 87 · see citing works
Use of Physical and Intellectual Activities and Socialization in the Management of Cognitive Decline of Aging and in Dementia: A Review
Ruthirakuhan, M. T., Luedke, A. C., Tam, A., Goel, A., Kurji, A., & Garcia, A. A. (2012) · Journal of Aging Research · doi:10.1155/2012/384875 · Cited by 87 · see citing works
A Coordinated Multi-study Analysis of the Longitudinal Association Between Handgrip Strength and Cognitive Function in Older Adults
Zammit, A. R., Piccinin, A. M., Duggan, E. C., Koval, A. V., Clouston, S., Robitaille, A., Brown, C. L., Handschuh, P., Wu, C., Jarry, V., et al. (2019) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbz072 · Cited by 86 · see citing works
Physical Activity and Brain Function in Older Adults at Increased Risk for Alzheimer’s Disease
Smith, J., Nielson, K. A., Woodard, J. L., Seidenberg, M., & Rao, S. M. (2013) · Brain Sciences · doi:10.3390/brainsci3010054 · Cited by 81 · see citing works
Entorhinal volume, aerobic fitness, and recognition memory in healthy young adults: A voxel-based morphometry study
Whiteman, A., Young, D. E., Budson, A. E., Stern, C. E., & Schön, K. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.049 · Cited by 80 · see citing works
Design of a comprehensive Alzheimer's disease clinic and research center in Spain to meet critical patient and family needs
Boada, M., Tárraga, L., Hernández, I., Valero, S., Alegret, M., Ruiz, A., López, O. L., & Becker, J. T. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.03.006 · Cited by 79 · see citing works
Anti-Inflammatory Effects of Physical Activity in Relationship to Improved Cognitive Status in Humans and Mouse Models of Alzheimers Disease
Stranahan, A. M., Martin, B., & Maudsley, S. R. (2012) · Current Alzheimer Research · doi:10.2174/156720512799015019 · Cited by 78 · see citing works
Treadmill Running Reverses Cognitive Declines due to Alzheimer Disease
Cho, J., Shin, M., Kim, D., Lee, I., Kim, S., & Kang, H. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000612 · Cited by 77 · see citing works
Fitness, physical activity, and exercise in multiple sclerosis: a systematic review on current evidence for interactions with disease activity and progression
Proschinger, S., Kuhwand, P., Rademacher, A., Walzik, D., Warnke, C., Zimmer, P., & Joisten, N. (2022) · Journal of Neurology · doi:10.1007/s00415-021-10935-6 · Cited by 81 · see citing works
The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults
Tyndall, A. V., Davenport, M. H., Wilson, B., Burek, G. M., Arsenault‐Lapierre, G., Haley, E., Eskes, G. A., Friedenreich, C. M., Hill, M. D., Hogan, D. B., et al. (2013) · BMC Geriatrics · doi:10.1186/1471-2318-13-21 · Cited by 76 · see citing works
Change in Fitness and the Relation to Change in Cognition and Neuropsychiatric Symptoms After Aerobic Exercise in Patients with Mild Alzheimer’s Disease
Sobol, N. A., Dall, C. H., Høgh, P., Hoffmann, K., Frederiksen, K. S., Vogel, A., Siersma, V., Waldemar, G., Hasselbalch, S. G., & Beyer, N. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180253 · Cited by 75 · see citing works
Light physical activity is positively associated with cognitive performance in older community dwelling adults
Johnson, L. G., Butson, M. L., Polman, R. C. J., Raj, I. S., Borkoles, E., Scott, D. S., Aitken, D. A., & Jones, G. (2016) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2016.02.002 · Cited by 74 · see citing works
Relationship between frailty and Alzheimer's disease biomarkers: a scoping review
Wallace, L., Theou, O., Rockwood, K., & Andrew, M. K. (2018) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2018.05.002 · Cited by 72 · see citing works
Effects of Moderate Aerobic Exercise on Cognitive Abilities and Redox State Biomarkers in Older Adults
Alghadir, A. H., Gabr, S. A., & Al-Eisa, E. S. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2545168 · Cited by 76 · see citing works
Ventilatory Dysfunction in Parkinson’s Disease
Baille, G., Jesus, A. M. D., Perez, T., Devos, D., Dujardin, K., Charley, C. M., Defebvre, L., & Moreau, C. (2016) · Journal of Parkinson s Disease · doi:10.3233/jpd-160804 · Cited by 69 · see citing works
Physical Exercise and Cognitive Recovery in Acquired Brain Injury: A Review of the Literature
Devine, J. M., & ZAFONTE, R. D. (2009) · PM&R · doi:10.1016/j.pmrj.2009.03.015 · Cited by 70 · see citing works
Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer’s: A Multi-Modality Brain Imaging Study
Matthews, D. C., Davies, M., Murray, J., Williams, S., Tsui, W. H., Li, Y., Andrews, R. D., Lukic, A., McHugh, P. F., Vallabhajosula, S., et al. (2014) · Advances in Molecular Imaging · doi:10.4236/ami.2014.44006 · Cited by 70 · see citing works
Physical activity for people with dementia: a scoping study
Bowes, A. M., Dawson, A. S. F., Jepson, R. G., & McCabe, L. (2013) · BMC Geriatrics · doi:10.1186/1471-2318-13-129 · Cited by 70 · see citing works
Physical activity, body mass index, and brain atrophy in Alzheimer's disease
Boyle, C. P., Raji, C. A., Erickson, K. I., López, O. L., Becker, J. T., Gach, H. M., Longstreth, W. T., Teverovskiy, L., Kuller, L. H., Carmichael, O. T., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.05.036 · Cited by 70 · see citing works
The Impact of Physical and Mental Activity on Cognitive Aging
Jak, A. J. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_141 · Cited by 68 · see citing works
Physical fitness in institutionalized older adults with dementia: association with cognition, functional capacity and quality of life
Sampaio, A., Marques‐Aleixo, I., Seabra, A., Mota, J. A. P. S., Marques, E. A., & Carvalho, J. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01445-7 · Cited by 68 · see citing works
Promoting Motor Function by Exercising the Brain
Perrey, S. (2013) · Brain Sciences · doi:10.3390/brainsci3010101 · Cited by 67 · see citing works
Attenuation of neuropsychiatric symptoms and caregiver burden in Alzheimer's disease by motor intervention: a controlled trial
Stella, F., Canonici, A. P., Gobbi, S., Galduróz, J. C. F., Cação, J. D. C., & Gobbi, L. T. B. (2011) · Clinics · doi:10.1590/s1807-59322011000800008 · Cited by 65 · see citing works
Cardiorespiratory fitness and brain volume and white matter integrity
Zhu, N., Jacobs, D. R., Schreiner, P. J., Launer, L. J., Whitmer, R. A., Sidney, S., Demerath, E. W., Thomas, W. T. B., Bouchard, C., He, K., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001658 · Cited by 64 · see citing works
Complementary and Alternative Medicine Use for Treatment and Prevention of Late-Life Mood and Cognitive Disorders
Lavretsky, H. (2009) · Aging Health · doi:10.2217/1745509x.5.1.61 · Cited by 63 · see citing works
A 3-Month Aerobic Training Program Improves Brain Energy Metabolism in Mild Alzheimer’s Disease: Preliminary Results from a Neuroimaging Study
Castellano, C., Paquet, N., Dionne, I. J., Imbeault, H., Langlois, F., Croteau, É., Tremblay, S., Fortier, M., Matte, J. J., Lacombe, G., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161163 · Cited by 62 · see citing works

P4–369: Cardiorespiratory fitness and brain structure in nondemented aging and early Alzheimer's disease
Burns, J. M., Donnelly, J. E., Mayo, M. S., Anderson, H. S., Spencer-Gardner, L. S., Thomas, G. W., Klima, D., Hansen, D., & Brooks, W. M. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.2110
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IC–P–103: Cardiorespiratory fitness and brain structure in nondemented aging and early Alzheimer's disease
Burns, J. M., Donnelly, J. E., Mayo, M. S., Anderson, H. S., Spencer-Gardner, L. S., Thomas, G. W., Klima, D. A., Hansen, D., & Brooks, W. M. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.2309
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O1‐02–02: Physical fitness is associated with preservation of brain volume in Alzheimer's disease
Honea, R. A., Thomas, G., Harsha, A., Cronk, B. B., Donnelly, J. E., Brooks, W. M., & Burns, J. M. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.221 · Cited by 1 · see citing works
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IC‐P3‐183: Physical fitness is associated with preservation of brain volume in Alzheimer's disease
Honea, R. A., Thomas, G., Harsha, A., Cronk, B. B., Donnelly, J. E., Brooks, W. M., & Burns, J. M. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.127 · Cited by 2 · see citing works
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Cardiorespiratory fitness is associated with atrophy in Alzheimer's and aging over 2 years
Vidoni, E. D., Honea, R. A., Billinger, S. A., Swerdlow, R. H., & Burns, J. M. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.016 · Cited by 105 · see citing works
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Authors: Burns, J. M., Cronk, B. B., Anderson, H. S., Donnelly, J. E., Thomas, G. P., Harsha, A., Brooks, W. M., & Swerdlow, R. H.
Affiliations: University of Kansas (US)
ORCID: Burns, J. M.
Donnelly, J. E.
Thomas, G. P.
Brooks, W. M.
Swerdlow, R. H.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2008-07-15
Volume: 71
Issue: 3
Pages: 210-216
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000317094.86209.cb
PMC: PMC2657657
OpenAlex: W1963796716
Cited by: 363
References: 44
Citations by year: 2026: 7 · 2025: 10 · 2024: 14 · 2023: 10 · 2022: 17 · 2021: 13 · 2020: 24 · 2019: 23 · 2018: 15 · 2017: 23 · 2016: 24 · 2015: 21 · 2014: 29 · 2013: 34 · 2012: 24
FWCI: 17.52
Type: journal article
Language: en
Open access: green
pmc.ncbi.nlm.nih.gov
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
Funders: U.S. Public Health Service (C76HF00201)
National Institute on Aging (AG026482, R21AG029615, R03AG026374, R21AG026482)
National Institute of Mental Health (R01 MH71940, R01MH071940)
National Institute of Neurological Disorders and Stroke (NS 039123, K23NS058252, R01NS039123)
National Center for Research Resources (P41RR013642, U54RR021813, M01RR023940)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: cardiorespiratory fitness, brain atrophy, early Alzheimer's disease, peak oxygen uptake, total brain volume, white matter volume, cognitive performance, normal aging
MeSH terms: Aged, Aged, 80 and over, Aging, Alzheimer Disease, Atrophy, Brain, Cognition, Cross-Sectional Studies, Exercise Test, Female, Humans, Male, Physical Fitness, Time Factors, Respiratory Mechanics

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Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

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Cardiorespiratory fitness and brain atrophy in early Alzheimer disease.

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