Cited by 180Obsessive-Compulsive Spectrum DisordersNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

Dopaminergic dysfunction in tourette syndrome

Singer, Harvey S., Butler, Ian J., Tune, Larry E., Seifert, William E., Coyle, Joseph T.·1982·Annals of Neurology

Abstract

A prospective clinical and biochemical study on the effects of treatment with haloperidol has been performed in seven patients with Tourette syndrome. Pretteatment cerebrospinal fluid levels of homovanillic acid (CSF HV A) were significantly reduced in all patients, whereas 5‐hydroxyindoleacetic acid was reduced in only two. With haloperidol treatment, symptoms decreased in all cases (21 to 88%) and clinical improvement was associated withan increased level of CSF HV A, often returning to the normal range. Optimal therapeutic response was found with serum levels of haloperidol between 1 and 4 ng/ml; however, disturbing side effects also occurred within this range. These results support the hypothesis that Tourette syndrome may result form a supersensitivity of dopaminergic receptors.

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Crossref · 10.1002/ana.410120408

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Authors
Singer, H. S., Butler, I. J., Tune, L. E., Seifert, W. E., & Coyle, J. T.
Affiliations
  • Johns Hopkins University (US)
  • United States Public Health Service (US)
Corresponding author
Singer, Harvey S.
Venue
Annals of Neurology
Publisher
Wiley
Published
1982-10
Volume
12
Issue
4
Pages
361-366
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2011897114
Cited by
180
References
28
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 4 · 2013: 3 · 2012: 7
FWCI
8.36
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
Tourette syndrome, haloperidol, dopaminergic dysfunction, homovanillic acid, cerebrospinal fluid, 5-hydroxyindoleacetic acid, antipsychotic treatment response, adverse drug reactions
MeSH terms
Adolescent, Dopamine, Female, Tourette Syndrome, Haloperidol, Homovanillic Acid, Humans, Hydroxyindoleacetic Acid, Male, Methoxyhydroxyphenylglycol, Nervous System Diseases

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