[99mTc]TRODAT-1/[123I]IBZM SPECT studies of the dopaminergic system in Tourette syndrome

Hwang, Wen-Juh; Yao, Wei-Jen; Fu, Ying-Kai; Yang, An-Shoei

doi:10.1016/j.pscychresns.2007.04.006

Cited by 29Obsessive-Compulsive Spectrum DisordersNeurotransmitter Receptor Influence on BehaviorNeurological disorders and treatments

[99mTc]TRODAT-1/[123I]IBZM SPECT studies of the dopaminergic system in Tourette syndrome

Hwang, Wen-Juh, Yao, Wei-Jen, Fu, Ying-Kai, Yang, An-Shoei·2008·Psychiatry Research: Neuroimaging

DOI 10.1016/j.pscychresns.2007.04.006

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Abstract

The good clinical effectiveness of dopamine depleter and receptor antagonists on tics suggests dopaminergic hyperactivity in Tourette syndrome (TS). In this case-control study of 10 TS patients and 15 age-matched healthy controls, we evaluated (i) presynaptic and postsynaptic striatal dopaminergic function using [(99m)Tc]TRODAT-1/[(123)I]IBZM single photon emission computed tomography (SPECT) and (ii) correlations between dopamine transporter (DAT)/D2 receptor binding sites and tic severity scores. Patients 1-5 were pretreated with haloperidol and were drug free for at least 3 months before SPECT imaging. Patients 6-10 were drug-naïve. We found no significant difference in DAT and D2 receptor binding sites between TS patients and healthy controls nor any association between striatal DAT or D2 receptor binding sites and tic severity assessed using the Modified Rush Videotape Rating Scale. Our findings provided no direct evidence of abnormally available striatal DAT or dopamine D2 receptors in TS. However, functional abnormalities of the dopaminergic system, e.g., alterations in the synaptic release of endogenous dopamine, cannot be completely ruled out.

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A handful of studies have found no differences in striatal DAT binding in TS.
“However, a handful of studies have found no differences in striatal DAT binding in TS [639,642-644].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [642]

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Yeh, C.-B., Lee, C.-H., Chou, Y.-H., Chang, C.-J., Ma, K.-H., & Huang, W.-S. (2006) · Nuclear Medicine Communications · doi:10.1097/01.mnm.0000239485.53780.16 · Cited by 29 · see citing works
Phasic dysfunction of dopamine transmission in Tourette's syndrome evaluated with 99mTc TRODAT-1 imaging
Yeh, C.-B., Lee, C.-S., Ma, K.-H., Lee, M.-S., Chang, C.-J., & Huang, W.-S. (2007) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.01.003 · Cited by 41 · see citing works
Dopamine D2 receptor imaging inGilles de la Tourette syndrome
Müller‐Vahl, K., Berding, G., KOLBE, H., Meyer, G.-J., Hundeshagen, H., Dengler, R., Knapp, W. H., & Emrich, H. M. (2000) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2000.101003165.x · Cited by 55 · see citing works

Authors: Hwang, W.-J., Yao, W.-J., Fu, Y.-K., & Yang, A.-S.
Affiliations: National Cheng Kung University (TW)
Institute of Nuclear Energy Research (TW)
Corresponding author: Hwang, Wen-Juh
Venue: Psychiatry Research: Neuroimaging
Publisher: Elsevier BV
Published: 2008-02
Volume: 162
Issue: 2
Pages: 159-166
ISSN: 0925-4927 (ISSN-L)
DOI: 10.1016/j.pscychresns.2007.04.006
OpenAlex: W1998902316
Cited by: 29
References: 58
Citations by year: 2026: 2 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 3
FWCI: 2.96
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychiatry Research Neuroimaging (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Council
Atomic Energy Council
Topics: Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords: Tourette syndrome, dopaminergic system, dopamine transporter, dopamine D2 receptor, striatum, tics, tic severity, dopamine release, haloperidol, 99mTc-TRODAT-1, [123I]IBZM
MeSH terms: Adolescent, Adult, Benzamides, Corpus Striatum, Female, Tourette Syndrome, Humans, Image Processing, Computer-Assisted, Iodine Radioisotopes, Magnetic Resonance Imaging, Male, Neurologic Examination, Pyrrolidines, Synapses, Tropanes, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Receptors, Dopamine D2, Receptors, Presynaptic, Dopamine Plasma Membrane Transport Proteins

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[99mTc]TRODAT-1/[123I]IBZM SPECT studies of the dopaminergic system in Tourette syndrome

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