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p53-A natural cancer killer: Structural insights and therapeutic concepts

Römer, Lin, Klein, Christian, Dehner, Alexander, Kessler, Horst, Buchner, Johannes·2006·Angewandte Chemie International Edition
DOI 10.1002/anie.200600611
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Abstract

Every single day, the DNA of each cell in the human body is mutated thousands of times, even in absence of oncogenes or extreme radiation. Many of these mutations could lead to cancer and, finally, death. To fight this, multicellular organisms have evolved an efficient control system with the tumor‐suppressor protein p53 as the central element. An intact p53 network ensures that DNA damage is detected early on. The importance of p53 for preventing cancer is highlighted by the fact that p53 is inactivated in more than 50 % of all human tumors. Thus, for good reason, p53 is one of the most intensively studied proteins. Despite the great effort that has been made to characterize this protein, the complex function and the structural properties of p53 are still only partially known. This review highlights basic concepts and recent progress in understanding the structure and regulation of p53, focusing on emerging new mechanistic and therapeutic concepts.

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Metadata

Authors
Römer, L., Klein, C., Dehner, A., Kessler, H., & Buchner, J.
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2006-09-29
Volume
45
Issue
39
Pages
6440-6460
ISSN
  • 1433-7851
  • 1521-3773
DOI
10.1002/anie.200600611
Cited by
93
References
38
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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Römer, L., Klein, C., Dehner, A., Kessler, H., & Buchner, J. (2006). p53-A natural cancer killer: Structural insights and therapeutic concepts. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200600611

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