Cited by 89Electrochemical sensors and biosensorsAdvanced Sensor and Energy Harvesting MaterialsAdvanced biosensing and bioanalysis techniques

A Stretchable Electrochemical Sensor for Inducing and Monitoring Cell Mechanotransduction in Real Time

Liu, Yan‐Ling, Qin, Yu, Jin, Zi‐He, Hu, Xue‐Bo, Chen, Miao‐Miao, Liu, Rong, Amatore, Christian, Huang, Wei‐Hua·2017·Angewandte Chemie International Edition

Abstract

Existing methods offer little direct and real‐time information about stretch‐triggered biochemical responses during cell mechanotransduction. A novel stretchable electrochemical sensor is reported that takes advantage of a hierarchical percolation network of carbon nanotubes and gold nanotubes (CNT‐AuNT). This hybrid nanostructure provides the sensor with excellent time‐reproducible mechanical and electrochemical performances while granting very good cellular compatibility, making it perfectly apt to induce and monitor simultaneously transient biochemical signals. This is validated by monitoring stretch‐induced transient release of small signaling molecules by both endothelial and epithelial cells cultured on this sensor and submitted to stretching strains of different intensities. This work demonstrates that the hybrid CNT‐AuNT platform offers a versatile and highly sensitive way to characterize and quantify short‐time mechanotransduction responses.

Integrity signals

Registry

Crossref · 10.1002/anie.201705215

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The electrochemical method is the most popular way for sweat analysis owing to relatively high sensitivity and selectivity, rapid response, and good compatibility.

    “The electrochemical method is the most popular way owing to advantages of relatively high sensitivity and selectivity, rapid response, as well as good compatibility (16–19).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Liu, Y., Qin, Y., Jin, Z., Hu, X., Chen, M., Liu, R., Amatore, C., & Huang, W.
Affiliations
  • Wuhan University (CN)
  • Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 China
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Huang, Wei‐Hua
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2017-07-06
Volume
56
Issue
32
Pages
9454-9458
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2719047365
Cited by
89
References
39
Citations by year
2026: 4 · 2025: 5 · 2024: 12 · 2023: 9 · 2022: 11 · 2021: 8 · 2020: 13 · 2019: 17 · 2018: 9
FWCI
4.43
Type
journal article
Language
en
Open access
closed
Locations
  • Angewandte Chemie International Edition (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
National Natural Science Foundation of China (21375099, 21675121)
Topics
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
Keywords
cell mechanotransduction, carbon nanotubes, gold nanotubes, hybrid nanostructures, percolation network, real-time monitoring, endothelial cells, epithelial cells, mechanobiology
MeSH terms
Cells, Cultured, Gold, Humans, Nitric Oxide, Particle Size, Time Factors, Biosensing Techniques, Nanotubes, Carbon, Mechanotransduction, Cellular, Nitric Oxide Synthase Type III, Metal Nanoparticles, Electrochemical Techniques, Human Umbilical Vein Endothelial Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review