A Stretchable Electrochemical Sensor for Inducing and Monitoring Cell Mechanotransduction in Real Time
Abstract
Existing methods offer little direct and real‐time information about stretch‐triggered biochemical responses during cell mechanotransduction. A novel stretchable electrochemical sensor is reported that takes advantage of a hierarchical percolation network of carbon nanotubes and gold nanotubes (CNT‐AuNT). This hybrid nanostructure provides the sensor with excellent time‐reproducible mechanical and electrochemical performances while granting very good cellular compatibility, making it perfectly apt to induce and monitor simultaneously transient biochemical signals. This is validated by monitoring stretch‐induced transient release of small signaling molecules by both endothelial and epithelial cells cultured on this sensor and submitted to stretching strains of different intensities. This work demonstrates that the hybrid CNT‐AuNT platform offers a versatile and highly sensitive way to characterize and quantify short‐time mechanotransduction responses.
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The electrochemical method is the most popular way for sweat analysis owing to relatively high sensitivity and selectivity, rapid response, and good compatibility.
“The electrochemical method is the most popular way owing to advantages of relatively high sensitivity and selectivity, rapid response, as well as good compatibility (16–19).”
From Integrated textile sensor patch for real-time and multiplex sweat analysis (2019) · cites this paper as [18]
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- Authors
- Liu, Y., Qin, Y., Jin, Z., Hu, X., Chen, M., Liu, R., Amatore, C., & Huang, W.
- Affiliations
- Wuhan University (CN)
- Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 China
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Huang, Wei‐Hua
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2017-07-06
- Volume
- 56
- Issue
- 32
- Pages
- 9454-9458
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2719047365
- Cited by
- 89
- References
- 39
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 12 · 2023: 9 · 2022: 11 · 2021: 8 · 2020: 13 · 2019: 17 · 2018: 9
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- National Natural Science Foundation of China (21375099, 21675121)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- cell mechanotransduction, carbon nanotubes, gold nanotubes, hybrid nanostructures, percolation network, real-time monitoring, endothelial cells, epithelial cells, mechanobiology
- MeSH terms
- Cells, Cultured, Gold, Humans, Nitric Oxide, Particle Size, Time Factors, Biosensing Techniques, Nanotubes, Carbon, Mechanotransduction, Cellular, Nitric Oxide Synthase Type III, Metal Nanoparticles, Electrochemical Techniques, Human Umbilical Vein Endothelial Cells
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