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p53 in the game of transposons

Wylie, Annika, Jones, Amanda E., Abrams, John M.·2016·BioEssays
DOI 10.1002/bies.201600115PMC PMC5142446
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Abstract

Throughout the animal kingdom, p53 genes function to restrain mobile elements and recent observations indicate that transposons become derepressed in human cancers. Together, these emerging lines of evidence suggest that cancers driven by p53 mutations could represent “transpospoathies,” i.e. disease states linked to eruptions of mobile elements. The transposopathy hypothesis predicts that p53 acts through conserved mechanisms to contain transposon movement, and in this way, prevents tumor formation. How transposon eruptions provoke neoplasias is not well understood but, from a broader perspective, this hypothesis also provides an attractive framework to explore unrestrained mobile elements as inciters of late‐onset idiopathic disease. Also see the video abstract here.

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Metadata

Authors
Wylie, A., Jones, A. E., & Abrams, J. M.
Venue
BioEssays
Publisher
Wiley
Published
2016-09-19
Volume
38
Issue
11
Pages
1111-1116
ISSN
  • 0265-9247
  • 1521-1878
DOI
10.1002/bies.201600115
PMC
PMC5142446
Cited by
29
References
10
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
  • American Cancer Society (128847‐PF‐15‐160‐01‐DDC)
  • Welch Foundation (I‐1865)

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CoChat. (2026). Citation check: p53 in the game of transposons. https://app.cochat.ai/papers/10.1002/bies.201600115
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Wylie, A., Jones, A. E., & Abrams, J. M. (2016). p53 in the game of transposons. BioEssays. https://doi.org/10.1002/bies.201600115