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The MyoD family of transcription factors and skeletal myogenesis

Rudnicki, Michael A., Jaenisch, Rudolf·1995·BioEssays

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Abstract

Gene targeting has allowed the dissection of complex biological processes at the genetic level. Our understanding of the nuances of skeletal muscle development has been greatly increased by the analysis of mice carrying targeted null mutations in the Myf‐5, MyoD and myogenin genes, encoding members of the myogenic regulatory factor (MRF) family. These experiments have elucidated the hierarchical relationships existing between the MRFs, and established that functional redundancy is a feature of the MRF regulatory network. Either MyoD or Myf‐5 is sufficient for the formation or survival of skeletal myoblasts. Myogenin acts later in development and plays an essential in vivo role in the terminal differentiation of myotubes.

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See all 454

Authors: Rudnicki, M. A., & Jaenisch, R.
Venue: BioEssays
Publisher: Wiley
Published: 1995-03
Volume: 17
Issue: 3
Pages: 203-209
ISSN: 0265-9247 (ISSN-L)
1521-1878
DOI: 10.1002/bies.950170306
OpenAlex: W1971314280
Cited by: 454
References: 57
FWCI: 2.06
Type: journal article
Language: en
Open access: closed

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The MyoD family of transcription factors and skeletal myogenesis

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