The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Mechanism of action of vitamin C in sepsis: Ascorbate modulates redox signaling in endothelium
Open accessAbstract
Circulating levels of vitamin C (ascorbate) are low in patients with sepsis. Parenteral administration of ascorbate raises plasma and tissue concentrations of the vitamin and may decrease morbidity. In animal models of sepsis, intravenous ascorbate injection increases survival and protects several microvascular functions, namely, capillary blood flow, microvascular permeability barrier, and arteriolar responsiveness to vasoconstrictors and vasodilators. The effects of parenteral ascorbate on microvascular function are both rapid and persistent. Ascorbate quickly accumulates in microvascular endothelial cells, scavenges reactive oxygen species, and acts through tetrahydrobiopterin to stimulate nitric oxide production by endothelial nitric oxide synthase. A major reason for the long duration of the improvement in microvascular function is that cells retain high levels of ascorbate, which alter redox‐sensitive signaling pathways to diminish septic induction of NADPH oxidase and inducible nitric oxide synthase. These observations are consistent with the hypothesis that microvascular function in sepsis may be improved by parenteral administration of ascorbate as an adjuvant therapy. © 2009 International Union of Biochemistry and Molecular Biology, Inc.
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Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660
Ceriello, A., Esposito, K., Piconi, L., Ihnat, M. A., Thorpe, J. E., Testa, R., Boemi, M., & Giugliano, D. (2008) · Diabetes · doi:10.2337/db08-0063 · Cited by 1,310
Tanaka, H. (2000) · Archives of Surgery · doi:10.1001/archsurg.135.3.326 · Cited by 438
Eskurza, I., Monahan, K. D., Robinson, J. A., & Seals, D. R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.057042 · Cited by 341
Ascorbic acid dynamics in the seriously ill and injured
Long, C. L., Maull, K. I., Krishnan, R. S., Laws, H. L., Geiger, J. W., Borghesi, L., Franks, W., Lawson, T. C., & Sauberlich, H. E. (2003) · Journal of Surgical Research · doi:10.1016/s0022-4804(02)00083-5 · Cited by 254
Ascorbyl radical formation in patients with sepsis: Effect of ascorbate loading
Galley, H. F., Davies, M. J., & Webster, N. R. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02022-5 · Cited by 199
Vitamin C Inhibits Endothelial Cell Apoptosis in Congestive Heart Failure
Rössig, L., Hoffmann, J., Hugel, B., Mallat, Z., Haase, A., Freyssinet, J.-M., Tedgui, A., Aicher, A., Zeiher, A. M., & Dimmeler, S. (2001) · Circulation · doi:10.1161/hc4301.098284 · Cited by 182
Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate
Vissers, M. C. M., Gunningham, S. P., Morrison, M. J., Dachs, G. U., & Currie, M. J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.11.023 · Cited by 125
Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation
Gaut, J. P., Belaaouaj, A., Byun, J., Roberts, L. J., Maeda, N., Frei, B., & Heinecke, J. W. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.12.013 · Cited by 48 · cited 1×
“Prior depletion of ascorbate decreases survival in mice injected with pathogenic bacteria [51].”
Background
Cited by
Vitamins C and E: Beneficial effects from a mechanistic perspective
Traber, M. G., & Stevens, J. F. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.017 · Cited by 1,076
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock
Marik, P. E., Khangoora, V., Rivera, R., Hooper, M. H., & Catravas, J. (2017) · Chest · doi:10.1016/j.chest.2016.11.036 · Cited by 887
Sepsis-associated encephalopathy
Gofton, T. E., & Young, G. B. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.183 · Cited by 821
Antioxidative and anti-inflammatory activity of ascorbic acid
Gęgotek, A., & Skrzydlewska, E. (2022) · Antioxidants · doi:10.3390/antiox11101993 · Cited by 420
Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock
De Backer, D., Orbegozo Cortes, D., Donadello, K., & Vincent, J.-L. (2014) · Virulence · doi:10.4161/viru.26482 · Cited by 393
Metadata
- Authors
- Wilson, J. X.
- Venue
- BioFactors
- Publisher
- Wiley
- Published
- 2009-01
- Volume
- 35
- Issue
- 1
- Pages
- 5-13
- ISSN
- 0951-6433 (ISSN-L)
- 1872-8081
- OpenAlex
- W1984372443
- Cited by
- 175
- References
- 9
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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